Online filter and integrated chromatographic column

Abstract

The utility model discloses an on-line filter and an integrated chromatographic column. The on-line filter comprises a connecting cylinder, a sieve plate and a connecting piece, a filter cavity and a pipe cavity are arranged in the connecting cylinder, the filter cavity is communicated with the pipe cavity through a liquid discharge hole, and the pipe cavity is directly connected with the column pipe; the sieve plate is arranged in the filter cavity and is arranged at the liquid discharge hole; the bottom end of the connecting piece is installed in the filter cavity and abuts against the sieve plate, the connecting piece is provided with a through cavity used for installing the connector, the through cavity is provided with a liquid inlet hole correspondingly communicated with the sieve plate, and the connector is provided with a line pipe communicated with the outside and the liquid inlet hole; during use, a mobile phase flows into the sieve plate from the line pipe and the liquid inlet hole, and the mobile phase filtered by the sieve plate penetrates through the liquid discharge hole and the column pipe to be discharged, so that detection operation can be performed; compared with an existing product, the online filter is compact in structure, the number of accessories can be reduced, assembling is convenient, and the invalid size after assembling and forming can be reduced; the integrated chromatographic column formed by installing the two online filters at the two ends of the column body also has the advantages of being small in size, convenient to assemble and the like.

Description

Technical Field

[0001] The utility model belongs to the technical field of filters, and in particular relates to an online filter and an integrated chromatographic column. Background Art

[0002] A liquid chromatograph is an instrument that separates and identifies a mixture by utilizing the difference in the distribution ratio of a mixture between two immiscible liquids. When testing samples, the mobile phase is required to be filtered through an online filter before entering the chromatographic column to prevent impurities in the mobile phase from entering the column tube and contaminating the chromatographic column, thereby affecting the test results.

[0003] As attached Figure 1 As shown, as a core filtering component, the existing online filter has a complex structure and requires the use of many accessories such as connectors and wire pipes. It is inconvenient to assemble and there is a lot of invalid volume after assembly. Utility Model Content

[0004] 1. Technical issues to be resolved

[0005] The utility model provides an online filter and an integrated chromatographic column, which have a compact structure, can reduce the use of accessories, facilitate assembly, and reduce the ineffective volume after assembly.

[0006] (II) Technical solution

[0007] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0008] An online filter comprises a connecting tube, a sieve plate and a connecting piece; a filter cavity and a tube cavity are arranged inside the connecting tube, the filter cavity is connected to the tube cavity through a drainage hole, and the tube cavity is directly connected to a column tube; the sieve plate is installed in the filter cavity and placed at the drainage hole; the bottom end of the connecting piece is installed in the filter cavity and pressed against the sieve plate, and the connecting piece is provided with a through cavity for installing a connecting head, the through cavity is provided with a liquid inlet hole corresponding to the one connected to the sieve plate, and a wire tube connected to the outside and the liquid inlet hole is installed on the connecting head.

[0009] Preferably, the connecting tube is designed to be vertical, the filter cavity is located above the tube cavity, and the drainage hole is located between the filter cavity and the tube cavity.

[0010] Preferably, a slot for mounting the sieve plate is provided on the bottom side of the filter chamber.

[0011] Preferably, the connector is threadably connected to the through cavity.

[0012] Preferably, a vertically designed socket is provided in the connector, and one end of the wire tube is installed in the socket.

[0013] Preferably, the column tube is threadedly connected to the tubular cavity, and the bottom end of the connecting piece is threadedly connected to the filter cavity.

[0014] Preferably, a hexagonal flat portion is provided on the outer side of the connecting tube, and a bayonet is provided on the top of the connecting piece.

[0015] Preferably, the inner diameter of the hexagonal flat part is not less than the outer diameter of the connecting member.

[0016] An integrated chromatographic column comprises a column tube and an online filter. Two online filters are provided, and the connecting tubes of the two online filters are respectively connected to the two ends of the column tube.

[0017] Preferably, sieve blocks are installed at both ends of the column tube, and the two sieve blocks correspond one-to-one to the sieve plate designs of the two online filters.

[0018] Preferably, it also includes a fastening sleeve, the sieve block is located outside the column tube and abuts against and blocks the tube opening of the column tube, two fastening sleeves are provided and are respectively located at both ends of the column tube, and a fixing groove for placing the sieve block is provided in the fastening sleeve, and the column tube is connected by the fastening sleeve, so that the sieve block can be fixedly and tightly installed on the column tube.

[0019] (III) Beneficial effects

[0020] The utility model provides an online filter and an integrated chromatographic column. The online filter is designed with a tube cavity on a connecting tube for installing a column tube, a filter cavity on the connecting tube for placing a sieve plate and installing a connecting piece, and a through cavity on the connecting piece for installing a connector with a wire tube. Compared with existing products, the online filter has a compact structure and only needs to use a single connector with a wire tube, which can reduce the use of accessories, facilitate assembly, and reduce the invalid volume after assembly. The integrated chromatographic column formed by installing two online filters at both ends of the column also has the advantages of small size and easy assembly. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0022] Figure 1 A schematic diagram of the use status of the prior art is shown;

[0023] Figure 2 A schematic diagram of the use state of the utility model is shown;

[0024] Figure 3 The overall structure schematic diagram of the online filter of the utility model is shown;

[0025] Figure 4 Shows Figure 2 A cross-sectional view of

[0026] Figure 5 The exploded schematic diagram of the online filter of the utility model is shown;

[0027] Figure 6 Shows Figure 5 A cross-sectional view of

[0028] Figure 7 The overall structure schematic diagram of the integrated chromatographic column of the utility model is shown;

[0029] Figure 8 Shows Figure 7 Enlarged view of point A in the middle.

[0030] In the figure: 1 connecting cylinder, 10 drainage hole, 11 filter chamber, 110 card slot, 12 tube cavity, 13 hexagonal flat position, 2 column tube, 21 sieve block, 3 sieve plate, 4 connecting piece, 41 through cavity, 410 liquid inlet hole, 42 bayonet, 5 connector, 50 jack, 6 wire tube, 7 fastening sleeve, 71 fixing groove. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0032] See attached Figure 2 -Attached Figure 6 , an online filter, comprising a connecting tube 1, a sieve plate 3 and a connecting piece 4; a filter chamber 11 and a tube chamber 12 are arranged inside the connecting tube 1, the filter chamber 11 is connected to the tube chamber 12 through a drainage hole 10, and the tube chamber 12 is directly connected to the column tube 2; the sieve plate 3 is installed in the filter chamber 11 and placed at the drainage hole 10; the bottom end of the connecting piece 4 is installed in the filter chamber 11 and pressed against the sieve plate 3, and a through chamber 41 for installing a connecting head 5 is provided on the connecting piece 4, and a liquid inlet hole 410 corresponding to the liquid inlet hole 410 connected to the sieve plate 3 is provided on the through chamber 41, and a wire tube 6 connected to the outside and the liquid inlet hole 410 is installed on the connecting head 5.

[0033] Specifically, during installation, one end of the column tube 2 is installed in the tube cavity 12, the connector 5 with the wire tube 6 is installed in the through cavity 41 of the coupling 4, and then the bottom end of the coupling 4 is installed in the filter cavity 11 and pressed against the sieve plate 3.

[0034] When in use, the mobile phase flows into the sieve plate 3 from the line tube 6 and the liquid inlet hole 410, and the mobile phase filtered by the sieve plate 3 is discharged through the liquid discharge hole 10 and the column tube 2, and the detection operation can be carried out.

[0035] In summary, compared with the prior art (see Appendix Figure 1 ), the utility model designs a tube cavity 12 on the connecting tube 1 for installing the column tube 2, designs a filter cavity 11 on the connecting tube 1 for placing the sieve plate 3 and installing the connecting piece 4, and designs a through cavity 41 on the connecting piece 4 for installing the connector 5 with the wire tube 6; compared with the existing products, the online filter has a compact structure and only needs to use a single connector 5 with the wire tube 6, which can reduce the use of accessories and facilitate assembly, and can also reduce the invalid volume after assembly, with high space utilization.

[0036] See attached Figure 2 -Attached Figure 6 The connecting tube 1 is designed to be vertical, the filter chamber 11 is located above the tube chamber 12, and the drainage hole 10 is located between the filter chamber 11 and the tube chamber 12.

[0037] Specifically, the above design makes the connecting tube 1 compact and smaller in size; and when the online filter is installed vertically, the mobile phase can automatically flow along the line tube 6 and the column tube 2 under the action of gravity and air pressure without providing additional power to pump the mobile phase.

[0038] See attached Figure 2 -Attached Figure 6 A slot 110 for mounting the sieve plate 3 is provided at the bottom of the filter chamber 11 . The design of the slot 110 can limit the sieve plate 3 from shaking left and right and deviating from the drainage hole 10 , thereby improving the installation stability of the sieve plate 3 .

[0039] See attached Figure 2 -Attached Figure 6 The connector 5 can be installed in the through cavity 41 by means of snap connection, magnetic connection, threaded connection, etc. In order to ensure the sealing performance, the connector 5 and the through cavity 41 are preferably connected by thread in the utility model.

[0040] See attached Figure 2 -Attached Figure 6 A vertically designed socket 50 is provided in the connector 5, and one end of the wire tube 6 is installed in the socket 50; the socket 50 can limit the vertical placement of the wire tube 6 to ensure that the wire tube 6 remains unobstructed; the fixing method of the Guanyu wire tube 6 and the socket 50, the two can be fixed by transition matching, or glue is used for bonding and fixing, or plastic sealing is used for connection.

[0041] See attached Figure 2 -Attached Figure 6The column tube 2 can be installed in the tube cavity 12 by means of snap connection, magnetic connection, threaded connection, etc. Similarly, the bottom end of the connecting piece 4 can also be installed in the filter cavity 11 by means of snap connection, magnetic connection, threaded connection, etc. In order to ensure the sealing performance, in the utility model, the column tube 2 is threadedly connected to the tube cavity 12, and the bottom end of the connecting piece 4 is threadedly connected to the filter cavity 11.

[0042] See attached Figure 2 -Attached Figure 6 A hexagonal flat position 13 is provided on the outside of the connecting tube 1, and a bayonet 42 is provided on the top of the connecting piece 4. The design of the hexagonal flat position 13 and the bayonet 42 can provide a fulcrum. The user can use calipers and other tools to cooperate with the hexagonal flat position 13 and the bayonet 42, and then twist the connecting tube 1 and the connecting piece 4 to complete the assembly and disassembly between the connecting tube 1, the connecting piece 4 and the column tube 2.

[0043] See attached Figure 2 -Attached Figure 6 The inner diameter of the hexagonal flat part 13 is not less than the outer diameter of the connecting piece 4. Under this design, the user can use a hexagonal sleeve to cover the connecting piece 4 and then clamp the hexagonal flat part 13. At this time, the hexagonal sleeve does not contact the connecting piece 4, so that the connecting piece 4 can rotate together with the connecting tube 1, avoiding interference with the connecting piece 4 when rotating the connecting tube 1 and causing looseness between the two, so that the user can adjust the tightness between the connecting tube 1 and the column tube 2 separately.

[0044] See attached Figure 2 and 7 -Attached Figure 8 An integrated chromatographic column comprises a column tube 2 and an online filter. Two online filters are provided, and connecting tubes 1 of the two online filters are respectively connected to the two ends of the column tube 2.

[0045] Specifically, since online filters are installed at both ends of the column tube 2, and the two online filters are connected to the wire tube 6, when in use, the mobile phase can flow from the two wire tubes 6 to the two online filters, and enter the column tube 2 at the same time through the two online filters, thereby speeding up the filtration and filling of the mobile phase and improving work efficiency.

[0046] In addition, according to actual usage requirements, one of the online filters can be used to filter the mobile phase entering the column tube 2, and the other online filter can be used to filter the mobile phase flowing out of the column tube 2, thereby forming a secondary filtration effect. This design is used for the use of two integrated chromatographic columns in series.

[0047] In summary, since online filters are integrated at both ends of the column tube 2 of the chromatographic column, it has the advantages of small size and easy assembly of the online filter, which is convenient to carry and place; in addition, the integrated chromatographic column has a secondary filtration function and can be used as a filter, which unlocks the usage method and makes it suitable for more usage scenarios.

[0048] See attached Figure 7 -Attached Figure 8 , sieve blocks 21 are installed at both ends of the column tube 2, and the two sieve blocks 21 correspond to the sieve plates 3 of the two online filters one by one. The design of the sieve blocks 21 can further improve the filtering effect on the mobile phase, so that the mobile phase entering the column tube 2 can be filtered twice, and the mobile phase passing through the chromatographic column can be filtered four times to more perfectly filter out impurities.

[0049] See attached Figure 7 -Attached Figure 8 , and also includes a fastening sleeve 7, the sieve block 21 is located outside the column tube 2 and abuts against the tube opening of the column tube 2 to block the column tube 2, two fastening sleeves 7 are provided and are respectively located at both ends of the column tube 2, and a fixing groove 71 for placing the sieve block 21 is provided in the fastening sleeve 7. By connecting the column tube 2 with the fastening sleeve 7, the sieve block 21 can be fixedly installed on the column tube 2.

[0050] The fastening sleeve 7 can be fixed to the column tube 2 by bonding, threaded connection, clamping, etc. Due to the various methods, the present invention does not limit this.

[0051] It should also be noted that, although the embodiments of the present application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present application.

Claims

1. An online filter, characterized in that: include: A connecting tube (1), wherein a filter chamber (11) and a tube chamber (12) are provided inside the connecting tube (1), the filter chamber (11) is connected to the tube chamber (12) through a liquid discharge hole (10), and the tube chamber (12) is directly connected to the column tube (2); A sieve plate (3), the sieve plate (3) being installed in the filter chamber (11) and placed at the drainage hole (10); A connecting piece (4), the bottom end of which is installed in the filter cavity (11) and pressed against the sieve plate (3), and the connecting piece (4) is provided with a through cavity (41) for installing a connector (5), the through cavity (41) is provided with a liquid inlet hole (410) corresponding to the sieve plate (3), and the connector (5) is provided with a wire tube (6) connected to the outside and the liquid inlet hole (410).

2. An in-line filter according to claim 1, characterized in that: The connecting tube (1) is designed to be vertical, the filter chamber (11) is located above the tube chamber (12), and the drainage hole (10) is located between the filter chamber (11) and the tube chamber (12).

3. An in-line filter according to claim 2, characterized in that: A slot (110) for mounting the sieve plate (3) is provided on the bottom side of the filter chamber (11).

4. An in-line filter according to claim 1, characterized in that: The connecting head (5) is threadedly connected to the through cavity (41).

5. An in-line filter according to claim 4, characterized in that: A vertically designed plug hole (50) is provided in the connector (5), and one end of the wire tube (6) is installed in the plug hole (50).

6. An in-line filter according to claim 1, characterized in that: The column tube (2) is threadedly connected to the tube cavity (12), and the bottom end of the connecting piece (4) is threadedly connected to the filter cavity (11).

7. An in-line filter according to claim 6, characterized in that: The outer side of the connecting tube (1) is provided with a hexagonal flat portion (13), and the top end of the connecting piece (4) is provided with a bayonet (42).

8. An in-line filter according to claim 7, characterized in that: The inner diameter of the hexagonal flat part (13) is not less than the outer diameter of the connecting part (4).

9. An integrated chromatographic column, comprising a column tube (2), characterized in that: It also comprises an online filter as claimed in any one of claims 1 to 8, wherein two online filters are provided, and the connecting tubes (1) of the two online filters are respectively connected to the two ends of the column tube (2).

10. An integrated chromatographic column according to claim 9, characterized in that: Both ends of the column tube (2) are equipped with sieve blocks (21), and the two sieve blocks (21) are designed to correspond one to one to the sieve plates (3) of the two online filters.

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