Solid-phase extraction device for food and food contact material detection

Abstract

The utility model discloses a solid phase extraction device for food and food contact material detection, which comprises an extraction support, liquid storage devices and a receiving tube, the extraction support is provided with a first replacement partition plate and a second replacement partition plate from top to bottom, the first replacement partition plate is provided with a plurality of groups of liquid storage devices, and the second replacement partition plate is provided with a plurality of groups of liquid storage devices. The lower end of the liquid storage device is communicated with a liquid discharging multi-way valve through a liquid outlet pipe, a liquid outlet of the liquid discharging multi-way valve is connected with a liquid discharging pipe, an adjusting assembly used for driving the solid-phase extraction column to move is installed on the second replacement partition plate, and a box body is further arranged below the extraction support. The box body is internally provided with a receiving tube partition plate for inserting the receiving tubes, the upper end of the box body is also provided with a cover plate, and adapters are inserted in the positions, corresponding to the receiving tubes, on the cover plate. The device is reasonable in structure, and can effectively reduce the disassembly times in the extraction process, so that the detection efficiency is improved, and the use requirements can be better met.

Description

Technical Field

[0001] The utility model relates to the technical field of extraction equipment, in particular to a solid phase extraction device for detecting food and food contact materials. Background Art

[0002] The solid phase extraction device is a widely used sample pretreatment equipment. It uses various solid phase extraction columns (containing solid adsorbents, also known as purification columns) to selectively adsorb the target compounds in the sample extract, and then uses an eluent to elute the adsorbed target, thereby separating the matrix and interfering substances of the target sample. Some experimental standards also include a elution step, which can more thoroughly remove impurities, thereby achieving the purpose of separating and enriching the target. It has been widely used in food safety and food contact material testing, environmental pollutant analysis and other fields.

[0003] At present, the specifications and capacities of SPE columns commonly used in the testing of food and food contact materials are fixed. However, in the actual laboratory operation, if the volume of the activation solution, sample solution and eluent transferred to the SPE column exceeds the volume of the SPE column, the volume of the SPE column cannot meet the requirements of one-time transfer, and a disposable dropper must be used for multiple additions, which is labor-intensive and inefficient, and is prone to errors during multiple transfers, which will result in inaccurate experimental results and waste of consumables.

[0004] In order to transfer a large volume of activation solution, sample solution and eluent through the solid phase extraction column at one time, a negative pressure solid phase extraction device is usually used for the above extraction operation. For example, the utility model patent with the authorization announcement number CN202145203U discloses a solid phase extraction device, which can improve the accuracy of solid phase extraction, and the utility model patent with the authorization announcement number CN217526453U discloses a high-efficiency solid phase extraction device, which can improve the efficiency of solid phase extraction and reduce safety hazards.

[0005] Although the above scheme can realize the one-time transfer of activation liquid, sample liquid and eluent, in each step of transferring the activation liquid, sample liquid and eluent, it is necessary to repeatedly disassemble and dock the solid phase extraction column so that its inlet end is docked with the corresponding liquid reservoir (containing the activation liquid, sample liquid and eluent respectively), and its outlet end is also required to be docked with the corresponding collection container to complete the extraction operation. The overall extraction efficiency needs to be further improved. Utility Model Content

[0006] The purpose of the utility model is to provide a solid phase extraction device for detecting food and food contact materials, so as to solve the problems raised in the above background technology.

[0007] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0008] A solid phase extraction device for food and food contact material detection comprises: an extraction support, a liquid reservoir, a solid phase extraction column, and a receiving tube. The extraction support is provided with a replacement partition plate 1 and a replacement partition plate 2 from top to bottom. The replacement partition plate 1 is provided with multiple groups of liquid reservoirs. The lower end of the liquid reservoir is communicated with a liquid discharge multi-way valve through a liquid outlet pipe. The liquid outlet of the liquid discharge multi-way valve is connected with a liquid discharge pipe. The replacement partition plate 2 is provided with an adjustment component for driving the solid phase extraction column to move. A box body is also provided below the extraction support. A receiving tube partition for inserting a receiving tube is installed in the box body. A cover plate is also installed at the upper end of the box body. An adapter is inserted at the position corresponding to each receiving tube on the cover plate. The liquid outlet hose at the lower end of the adapter extends into the corresponding receiving tube. The lower end of the discharge pipe is sealed and connected to the upper end of the solid phase extraction column. A drainage pipe is also installed at the lower end of the solid phase extraction column. The drainage pipe is plugged with the corresponding adapter.

[0009] As a preferred solution, a plurality of mounting seats for placing liquid reservoirs are installed on the replacement partition, and the liquid reservoirs are installed in corresponding mounting seats.

[0010] As a preferred solution, a flow rate controller is also installed on the liquid outlet pipe.

[0011] As a preferred solution, the adjustment component includes a slide seat 1 slidably mounted on a replacement partition 2, a slide seat 2 slidably mounted on the slide seat 1, a through hole is opened in the middle position of the slide seat 2, and a ring for inserting a solid phase extraction column is installed in the through hole.

[0012] As a preferred solution, a vacuum connecting pipe is also installed on the side wall of the box body, the other end of the vacuum connecting pipe is connected to a vacuum regulating pump, and a vacuum regulating valve is also installed on the vacuum connecting pipe.

[0013] As a preferred solution, a sealing cover is inserted on each of the adapters.

[0014] As a preferred solution, it also includes a nitrogen bottle, the outlet end of the nitrogen bottle is equipped with an air inlet pipe, the other end of the air inlet pipe is equipped with an air inlet multi-way valve, the air outlet of the air inlet multi-way valve is connected to the liquid inlet pipe corresponding to the upper end of the liquid reservoir, and the air inlet pipe is also equipped with an air inlet regulating valve.

[0015] Compared with the prior art, the utility model has the following beneficial effects: by setting the multi-way valves for discharging liquids to be connected to the corresponding liquid reservoirs, the corresponding liquids can be discharged by simply controlling the switch of the valves, and the solid phase extraction column does not need to be frequently disassembled and docked during the detection process, which can effectively improve the detection efficiency. The utility model has a reasonable structure, can effectively reduce the number of disassembly times during the extraction process, thereby improving the detection efficiency and better meeting the use requirements. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic structural diagram of a first embodiment of a solid phase extraction device for food and food contact material detection;

[0017] Figure 2 It is a schematic diagram of the three-dimensional structure of the extraction support position of a solid phase extraction device for food and food contact material detection;

[0018] Figure 3 It is a schematic diagram of the structure of a solid phase extraction device for food and food contact material detection;

[0019] Figure 4 The present invention is a schematic structural diagram of a second embodiment of a solid phase extraction device for detecting food and food contact materials.

[0020] In the figure: 1-extraction bracket, 11-replacement partition one, 12-replacement partition two, 121-slide seat one, 122-slide seat two, 2-liquid reservoir, 21-liquid inlet pipe, 22-mounting seat, 3-flow rate controller, 4-liquid discharge multi-way valve, 41-liquid discharge pipe, 5-solid phase extraction column, 51-drainage tube, 6-receiving tube, 61-adapter, 62-cover plate, 63-sealing cap, 64-box, 65-receiving tube partition, 66-vacuum regulating pump, 67-vacuum regulating valve, 68-vacuum connecting pipe, 7-nitrogen bottle, 71-gas regulating valve, 72-inlet pipe, 73-inlet multi-way valve. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Example 1: Please refer to Figures 1 to 3A solid phase extraction device for food and food contact material detection, comprising: an extraction support 1, a liquid reservoir 2, a solid phase extraction column 5, and a receiving tube 6. The extraction support 1 is provided with a replacement partition 11 and a replacement partition 2 12 from top to bottom. The replacement partition 1 11 is provided with multiple groups of liquid reservoirs 2. The lower end of the liquid reservoir 2 is connected to a liquid discharge multi-way valve 4 through a liquid outlet pipe. The liquid outlet of the liquid discharge multi-way valve 4 is connected to a liquid discharge pipe 41. The replacement partition 2 12 is provided with an adjustment component for driving the solid phase extraction column 5 to move. A box body 64 is also provided below the extraction support 1, and a receiving tube partition 65 for inserting the receiving tube 6 is installed in the box body 64. A cover plate 62 is also installed on the upper end of the box body 64, and an adapter 61 is inserted at the position corresponding to each receiving tube 6 on the cover plate 62. The liquid outlet hose at the lower end of the adapter 61 extends into the corresponding receiving tube 6. The lower end of the drain pipe 41 is sealed and connected to the upper end of the solid phase extraction column 5. A drainage pipe 51 is also installed at the lower end of the solid phase extraction column 5, and the drainage pipe 51 is plugged together with the corresponding adapter 61.

[0023] As a further solution, the replacement partition 11 is provided with multiple groups of mounting seats 22 for placing the liquid reservoir 2, and the liquid reservoir 2 is inserted into the corresponding mounting seats 22. In this embodiment, the surface of the liquid reservoir 2 is provided with scale lines, and the liquid reservoir 2 is provided with three groups, which are respectively used to hold the activation solution, the sample solution and the eluent.

[0024] In order to conveniently control the liquid flow rate, a flow rate controller 3 is also installed on the liquid outlet pipe.

[0025] In order to facilitate the adjustment of the position of the drain pipe 41, the adjustment component includes a slide seat 121 slidably mounted on the replacement partition plate 12, a slide seat 122 slidably mounted on the slide seat 121, a through hole is provided in the middle of the slide seat 122, and a collar for inserting the solid phase extraction column 5 is installed in the through hole. In this embodiment, the drain pipe 41 and the drainage pipe 51 are both hoses and the drain pipe 41 and the drainage pipe 51 are both bent, so as to facilitate the docking of the drainage pipe 51 with the adapter 61. The solid phase extraction column 5 can be driven to move horizontally left and right through the slide seat 121, and the solid phase extraction column 5 can be driven to move forward and backward through the slide seat 122, so as to facilitate the docking of the drainage pipe 51 at the lower end of the solid phase extraction column 5 with different adapters 61.

[0026] As a further solution, a vacuum connecting pipe 68 is further installed on the side wall of the box body 64, and the other end of the vacuum connecting pipe 68 is connected to the vacuum regulating pump 66. A vacuum regulating valve 67 is also installed on the vacuum connecting pipe 68. In this embodiment, a sealing cap 63 is inserted on each of the adapters 61. By providing the sealing cap 63, the adapter 61 that is not connected can be sealed to ensure the sealing inside the box body 64, so as to facilitate the vacuum regulating pump 66 to guide the liquid in the liquid reservoir 2 into the solid phase extraction column 5 below.

[0027] Working principle of the utility model: When in use, first, add liquid into the liquid reservoir 2 through the liquid inlet pipe 21 above the liquid reservoir 2, then insert the liquid reservoir 2 into the mounting seat 22, and dock the lower end of the liquid reservoir 2 with the liquid outlet pipe, then dock the liquid outlet pipe with the corresponding inlet end of the liquid discharge multi-way valve 4, then dock the liquid discharge pipe 41 at the lower end of the liquid discharge multi-way valve 4 with the solid phase extraction column 5, then dock the drainage pipe 51 at the lower end of the solid phase extraction column 5 with the corresponding adapter 61, then open the liquid discharge multi-way valve 4 (corresponding to the reservoir 2 containing the activation liquid), the vacuum regulating pump 66 works to generate negative pressure in the box 64, thereby sucking out the activation liquid and allowing it to enter the solid phase extraction column 5, thereby removing impurities in the solid phase extraction column 5 and creating a certain solvent environment, and receiving the discharged liquid through the receiving tube 6 below. After the activation is completed, the left valve and the vacuum regulating pump 66 are closed, the drainage tube 51 is separated from the adapter 61, and the cover 63 is inserted into the adapter 61. Subsequently, the regulating group The solid phase extraction column 5 is driven to move by the component, and then the drainage tube 51 is connected to another adapter 61, and then the valve in the middle position of the discharge multi-way valve 4 is opened (corresponding to the reservoir 2 containing the sample liquid), and then a negative pressure is generated in the box 64 through the vacuum regulating pump 66, so that the sample liquid is sucked into the solid phase extraction column 5. At this time, most of the target compounds will flow out with the sample base liquid and enter the receiving tube 6 to complete the collection work, and the impurities will be retained on the solid phase extraction column 5, and then the valve in the middle position and the vacuum regulating pump 6 are closed. 6. Separate the drainage tube 51 from the adapter 61, then seal the adapter 61 with the cover 63, and drive the solid phase extraction column 5 to move through the adjustment component, and then dock the drainage tube 51 with another adapter 61, then open the valve on the right (corresponding to the liquid reservoir 2 containing the eluent), and then turn on the vacuum adjustment pump 66 to suck the eluent into the solid phase extraction column 5 for elution, elute the remaining target compounds, and complete the collection work through the receiving tube 6 below, and finally merge the collected liquids.

[0028] Example 2: Please refer to Figure 4A solid phase extraction device for food and food contact material detection is different from the first embodiment in that it also includes a nitrogen bottle 7, an air inlet pipe 72 is installed at the air outlet end of the nitrogen bottle 7, and an air inlet multi-way valve 73 is installed at the other end of the air inlet pipe 72. The air outlet of the air inlet multi-way valve 73 is connected to the liquid inlet pipe 21 corresponding to the upper end of the liquid reservoir 2, and an air inlet regulating valve 71 is also installed on the air inlet pipe 72.

[0029] By setting up a nitrogen bottle, nitrogen can be added to the liquid storage tank 2, thereby providing an inert gas atmosphere for the extraction system, which can effectively reduce the influence of oxygen during extraction and separation, and at the same time can make the pressure of the entire system more stable, which can improve the extraction efficiency.

[0030] In the present invention, terms such as "upper", "lower", "left", "right", "front", "back", "vertical", "horizontal", "side", "bottom" and the like indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings. They are relational words determined only for the convenience of describing the structural relationships of the various parts or elements of the present invention, and do not specifically refer to any part or element in the present invention and cannot be understood as limitations on the present invention.

Claims

1. A solid phase extraction device for food and food contact material detection, characterized in that: include: An extraction support (1), a liquid reservoir (2), a solid phase extraction column (5), and a receiving tube (6), wherein the extraction support (1) is provided with a replacement partition plate 1 (11) and a replacement partition plate 2 (12) from top to bottom, wherein the replacement partition plate 1 (11) is provided with a plurality of groups of liquid reservoirs (2), wherein the lower end of the liquid reservoir (2) is connected to a liquid discharge multi-way valve (4) via a liquid outlet pipe, wherein the liquid outlet of the liquid discharge multi-way valve (4) is connected to a liquid discharge pipe (41), wherein an adjustment component for driving the solid phase extraction column (5) to move is installed on the replacement partition plate 2 (12), and a box (6) is further provided below the extraction support (1) 4), a receiving tube partition (65) for inserting the receiving tube (6) is installed in the box body (64), and a cover plate (62) is also installed on the upper end of the box body (64). An adapter (61) is inserted at a position corresponding to each receiving tube (6) on the cover plate (62), and the liquid outlet hose at the lower end of the adapter (61) extends into the corresponding receiving tube (6), the lower end of the discharge pipe (41) is sealed and connected to the upper end of the solid phase extraction column (5), and a drainage pipe (51) is also installed at the lower end of the solid phase extraction column (5), and the drainage pipe (51) is inserted into the corresponding adapter (61) together.

2. A solid phase extraction device for food and food contact material detection according to claim 1, characterized in that: The replacement partition plate 1 (11) is provided with a plurality of mounting seats (22) for placing the liquid storage devices (2), and the liquid storage devices (2) are mounted in corresponding mounting seats (22).

3. A solid phase extraction device for food and food contact material detection according to claim 2, characterized in that: A flow rate controller (3) is also installed on the liquid outlet pipe.

4. A solid phase extraction device for food and food contact material detection according to claim 3, characterized in that: The adjustment assembly comprises a slide seat 1 (121) slidably mounted on a replacement partition plate 2 (12); a slide seat 2 (122) is slidably mounted on the slide seat 1 (121); a through hole is provided in the middle of the slide seat 2 (122); a collar for inserting a solid phase extraction column (5) is installed in the through hole.

5. A solid phase extraction device for food and food contact material detection according to claim 4, characterized in that: A vacuum connecting pipe (68) is also installed on the side wall of the box body (64), the other end of the vacuum connecting pipe (68) is connected to the vacuum regulating pump (66), and a vacuum regulating valve (67) is also installed on the vacuum connecting pipe (68).

6. A solid phase extraction device for food and food contact material detection according to claim 5, characterized in that: A sealing cover (63) is inserted into each adapter (61).

7. A solid phase extraction device for food and food contact material detection according to claim 6, characterized in that: The invention also comprises a nitrogen bottle (7), wherein an air inlet pipe (72) is installed at the air outlet end of the nitrogen bottle (7), an air inlet multi-way valve (73) is installed at the other end of the air inlet pipe (72), the air outlet of the air inlet multi-way valve (73) is connected to the liquid inlet pipe (21) corresponding to the upper end of the liquid reservoir (2), and an air inlet regulating valve (71) is also installed on the air inlet pipe (72).

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