Novel automatic liquid pipeline control system for cell factory

Abstract

The utility model belongs to the technical field of cell culture and pipeline control, and particularly relates to a novel automatic liquid pipeline control system for a cell factory. The utility model provides a novel automatic liquid pipeline control system for a cell factory, which aims at liquid operation of biological product preparation by operating a cell factory frame through fixed equipment, and realizes automatic control of clamping or loosening of a liquid pipeline and accurate liquid adding or discharging of a peristaltic pump. The system comprises a pneumatic pipeline valve for controlling the on-off of a pipeline, a pipeline main control vehicle for bearing the pipeline valve and a pipeline control beam, the pipeline control beam is arranged on a cell factory framework, and the pipeline main control vehicle is used for controlling the supply of liquid and the on-off of the pneumatic pipeline valve on the pipeline main control vehicle and the pipeline control beam. Clamping and loosening of the liquid pipeline are automatically controlled, and a stopping clamp short in service life and haemostatic forceps prone to damaging the liquid pipeline are replaced.

Description

Technical Field

[0001] The utility model belongs to the technical field of cell culture and pipeline control, and specifically relates to a novel cell factory automated liquid pipeline control system. Background Art

[0002] A cell factory is a cell culture device that maximizes the use of the culture surface within a limited space, thereby saving space; it can be used for industrial-scale production of vaccines, monoclonal antibodies or biopharmaceuticals.

[0003] At present, fixed equipment is generally used for the preparation of biological products using 40-layer cell factories, that is, the 40-layer cell factory is pushed onto a flipper for operations such as fluid replacement, shaking and rotation to complete various steps of cultivation.

[0004] When using fixed equipment to perform liquid operations for the preparation of biological products on the cell factory framework, it is necessary to dispense the liquid in the liquid bag or liquid tank into each cell factory in the cell factory framework, or to discharge the liquid in each cell factory in the cell factory framework and collect it into the liquid bag or liquid tank.

[0005] In the above liquid operation, the personnel need to connect the liquid pipeline at the raw liquid end or the collection end to each cell factory in the cell factory frame through a peristaltic pump. The raw liquid end has one or more liquid bags or liquid tanks (the collection end has one or more liquid bags or liquid tanks), and the pipelines of one or more liquid bags or liquid tanks are combined into one pipeline using a T-type or Y-type connector. After passing through the peristaltic pump, the pipeline is divided into multiple pipelines using a T-type or Y-type connector and connected to each cell factory in the frame.

[0006] Because each cell factory in the framework needs to be filled or drained in turn, each pipeline requires the operator to use hemostats or other clamps to open and close the liquid pipeline. When a cell factory is filled with liquid, the operator first clamps all pipelines that do not supply liquid with hemostats or other clamps, leaving only the pipelines that need to be filled or drained. Secondly, an operator is required to control the on and off of the peristaltic pump and an observer to observe the liquid addition scale in the cell factory. When the observer sees that the liquid volume meets the standard, he notifies the operator to turn off the peristaltic pump. Repeat this operation for the remaining cell factories.

[0007] During the above operations, the staff frequently use hemostatic forceps or clamps to clamp or loosen the liquid pipeline, and multiple people are required to cooperate in observing the liquid volume of the cell factory. The operation of the peristaltic pump is complicated, time-consuming, and prone to errors and inaccurate liquid addition.

[0008] There are also the following problems: the service life of the stop clip is short, and the replacement process after damage is cumbersome;

[0009] When the hemostatic forceps are shaken, rotated, or other actions performed on fixed equipment, the pipe may easily burst due to the heavy weight of the tool itself. Utility Model Content

[0010] To solve the above problems, the utility model proposes a new type of cell factory automated liquid pipeline control system for liquid operations of fixed equipment operating cell factory framework for preparation of biological products, which realizes automated control of clamping or loosening of liquid pipelines and precise addition or discharge of peristaltic pumps.

[0011] To achieve the above-mentioned purpose, the utility model adopts the following scheme, including a pneumatic pipeline valve for controlling the on-off of the pipeline, a pipeline main control vehicle for carrying the pipeline valve, and a pipeline control beam;

[0012] The pipeline master control vehicle comprises a vehicle body, casters are arranged at the bottom of the vehicle body, a peristaltic pump for controlling the pipeline to transport liquid, a pneumatic pipeline valve, a gas source connector for connecting with a main gas source, and a first multi-way quick plug for dividing the main gas source gas path into multiple gas paths are arranged on the vehicle body, the gas source connector and the first multi-way quick plug are connected through an air pipe inside the vehicle body, and the first multi-way quick plug is connected to the pipeline master control vehicle or the pneumatic pipeline valve through the air pipe;

[0013] The pipeline control beam comprises a sheet metal cross beam, on which a plurality of pneumatic pipeline valves are arranged, and the sheet metal cross beam is installed on the cell factory frame.

[0014] As a preferred solution of the utility model, the pipeline valve comprises a shell, one end of the shell is provided with a cavity, the other end of the shell is provided with two parallel sliding channels connected with the cavity, one end of the outer side of the shell close to the cavity is connected with an air pipe joint connected with the cavity, the air pipe joint is connected with an air source, a first telescopic rod and a second telescopic rod are respectively provided in the two sliding channels, and mounting grooves are radially provided at corresponding positions on the ends of the first telescopic rod and the second telescopic rod away from the cavity, a blocking rod is slidably connected through the mounting grooves corresponding to the two positions, a mounting hole is provided at one end of the blocking rod close to the second telescopic rod, a locking rod is installed through the mounting hole, a locking path for sliding the locking rod is provided at one end of the second telescopic rod close to the mounting groove, the mounting groove on the second telescopic rod is connected with the locking path, and a limiting space for clamping the liquid pipeline is formed between the blocking rod, the first telescopic rod, the second telescopic rod and the shell;

[0015] A first threaded hole for connecting with a pipeline main control vehicle or a pipeline control beam is arranged on the side of the shell.

[0016] As another preferred embodiment of the present invention, the pipeline master control vehicle also includes a main unit arranged inside the vehicle body, a control panel and a power socket arranged on the vehicle body, the power socket is connected to the main unit and the control panel, the control panel includes a touch screen, control buttons, an emergency stop button and a communication port, and an electromagnetic valve is arranged on the air pipe connected between the first multi-way quick plug and the pneumatic pipeline valve, and the electromagnetic valve is connected to the main unit.

[0017] Furthermore, the vehicle body is also provided with hooks reserved for installing other devices.

[0018] As a third preferred solution of the utility model, an annular groove is provided at one end of the blocking rod close to the first telescopic rod, and an anti-slip O-ring is installed through the annular groove.

[0019] As a fourth preferred embodiment of the present invention, the sheet metal crossbeam is connected to a second threaded hole reserved on the cell factory frame through a locking bolt.

[0020] As a fifth preferred embodiment of the present invention, a handle is provided on the side of the vehicle body for facilitating pulling or pushing the vehicle body.

[0021] As a sixth preferred embodiment of the present invention, a second multi-way quick connector is provided on the sheet metal crossbeam, and the other end of the second multi-way quick connector is connected to a plurality of pneumatic pipeline valves provided on the sheet metal crossbeam.

[0022] Beneficial effects of the utility model:

[0023] The utility model proposes a novel cell factory automated liquid pipeline control system for liquid operations of a cell factory frame for the preparation of biological products using fixed equipment, which realizes automated control of the clamping or loosening of the liquid pipeline and the precise addition or discharge of the peristaltic pump. The utility model has a simple structure and is easy to install, and can be adapted to various cell factory frames of different specifications.

[0024] The pneumatic pipeline valve proposed by the utility model solves the problem of short life of the previous hemostatic clamp and saves costs; it solves the problem of joint rupture caused by twisting of the hemostatic forceps when the cell factory is turned over. The pneumatic pipeline valve is a normally closed pneumatic valve, which is safe and has a fast valve opening and closing speed.

[0025] The pipeline master control vehicle of the utility model integrates structures such as a peristaltic pump and a pneumatic pipeline valve. The pneumatic pipeline valve and the peristaltic pump can be controlled by physical buttons and a touch screen according to actual conditions, and hooks for connecting to other devices are reserved. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of the utility model.

[0027] Figure 2 It is an axonometric view of a pneumatic pipeline valve.

[0028] Figure 3 It is a schematic diagram of the pneumatic line valve housing.

[0029] Figure 4 It is a schematic diagram of the pneumatic pipeline valve lever.

[0030] Figure 5 It is a schematic diagram of the locking rod of the pneumatic pipeline valve.

[0031] Figure 6 It is a schematic diagram of the extension and opening and closing state changes of the pneumatic pipeline valve.

[0032] Figure 7 It is a cross-sectional view of the internal cavity of a pneumatic pipeline valve.

[0033] Figure 8 It is an axonometric view of the pipeline master control vehicle.

[0034] Fig. 9 This is the left view of the pipeline master control vehicle.

[0035] Fig.10 It is the isometric view of the pipeline control beam.

[0036] Fig.11 It is a schematic diagram of the vertical installation of the pipeline control beam.

[0037] In the drawings, 1 is a pneumatic pipeline valve, 11 is a housing, 12 is a stop rod, 13 is a lock rod, 14 is a first telescopic rod, 15 is a second telescopic rod, 16 is an air pipe joint, 17 is a mounting hole, 18 is a first threaded hole, and 19 is an annular groove;

[0038] 2 is the pipeline master control vehicle, 21 is the vehicle body, 22 is the peristaltic pump, 23 is the caster, 24 is the air source connector, 25 is the communication port, 26 is the first multi-way quick plug, 27 is the second multi-way quick plug, 28 is the handle, 29 is the touch screen, 210 is the control button, 211 is the emergency stop button, 212 is the waterproof socket, and 213 is the hook;

[0039] 3 is a pipeline control beam, 31 is a sheet metal crossbeam, and 32 is a locking bolt;

[0040] 4 is the cell factory framework. DETAILED DESCRIPTION

[0041] The utility model adopts the following specific scheme, including a pneumatic pipeline valve 1 for controlling the on-off of a pipeline, a pipeline master control vehicle 2 for carrying the pipeline valve 1, and a pipeline control beam 3. The pneumatic pipeline valve 1 is a pipeline valve that can control the on-off of a liquid pipeline. The pipeline master control vehicle 2 carries a plurality of pneumatic pipeline valves 1. The pipeline master control vehicle 2 and the pipeline control beam 3 are used in conjunction with each other. The pipeline master control vehicle 2 is adapted to one or more pipeline control beams 3, and the pipeline control beam 3 is installed on a cell factory frame 4.

[0042] like Figure 8 and Fig. 9 As shown, the pipeline master control vehicle 2 includes a vehicle body 21, the main body of the vehicle body 21 is a mirror stainless steel box, and casters 23 are arranged at the bottom of the vehicle body 21 for easy movement; the vehicle body 21 is provided with a peristaltic pump 22 for controlling the pipeline to transport liquid, a pneumatic pipeline valve 1, an air source connector 24 for connecting to the main air source, and a first multi-way quick plug 26 for dividing the main air source air path into multiple air paths, the air source connector 24 and the first multi-way quick plug 26 are connected through an air pipe inside the vehicle body 21, and the first multi-way quick plug 26 is connected to the pipeline master control vehicle 2 or the pneumatic pipeline valve through the air pipe. A large amount of space is also reserved on the vehicle body 1 for later setting of other equipment, and the pipeline master control vehicle 2 is integrated into the operating system of the multi-axis robot for preparing biological products;

[0043] like Fig.10 and Fig.11 As shown, the pipeline control beam 3 includes a sheet metal crossbeam 31, which is a stainless steel sheet metal bent part. Four pneumatic pipeline valves 1 can be arranged on the sheet metal crossbeam 31, and two pneumatic pipeline valves 1 can be arranged on the side. The sheet metal crossbeam 31 is installed on the cell factory frame 4 through locking bolts 32.

[0044] As a preferred embodiment of the present invention, Figure 2 and Figure 3 As shown, the pipeline valve 1 includes a housing 11, and the housing 11 is an aluminum alloy shell. Figure 3 As shown, the aluminum alloy shell is oval in shape, and its upper and lower end faces are respectively provided with first threaded holes 18 for installation and fixation on the pipeline main control vehicle 2 and the pipeline control beam 3.

[0045] A cavity is provided at one end of the shell 1, and two parallel sliding channels communicating with the cavity are provided at the other end of the shell 1. An air pipe joint 16 communicating with the cavity is connected to one end of the outer side of the shell 11 close to the cavity, and the air pipe joint 16 is connected to the air source. A first telescopic rod 14 and a second telescopic rod 15 are respectively provided in the two sliding channels;

[0046] like Figure 7 As shown, the first telescopic rod 14 and the second telescopic rod 15 can be telescopically slid along the two sliding channels inside the housing 11 under pneumatic control to form a closed cavity structure, thereby reducing the possibility of oil leakage into the clean room environment;

[0047] The first telescopic rod 14 and the second telescopic rod 15 are provided with mounting grooves at corresponding positions on one end away from the cavity in a radial direction, and the blocking rod 12 is slidably connected to the mounting grooves at two corresponding positions. The blocking rod 12 has a structure as shown in FIG. Figure 4As shown, it is a stainless steel round rod. The end of the blocking rod 12 close to the second telescopic rod 15 is provided with a mounting hole 17, and a locking rod 13 is installed through the mounting hole 17. The structure of the locking rod 13 is as follows Figure 5 As shown, a lock track for sliding the lock rod 13 is provided at one end of the second telescopic rod 15 close to the mounting groove, and the mounting groove on the second telescopic rod 15 is connected to the lock track, and a limiting space for clamping the liquid pipeline is formed between the blocking rod 12, the first telescopic rod 14, the second telescopic rod 15 and the shell 11, forming a door-type bolt body clamping rod structure.

[0048] The use principle of pneumatic pipeline valve 1: Figure 6 As shown, when the air source is connected to the air pipe joint 16, the first telescopic rod 14 and the second telescopic rod 15 are extended at the same time under the action of air pressure, and the operator holds the locking rod 13 and rotates it along the locking track until the blocking rod 12 can slide automatically, and pulls the blocking rod 12 to one side of the first telescopic rod 14, puts the liquid pipeline into the empty space between the first telescopic rod 14 and the second telescopic rod 15, and then restores the position of the blocking rod 12 and rotates the locking rod 13. At this time, the blocking rod 12 cannot slide freely, and the clamping or loosening of the liquid pipeline in the state of adding or discharging liquid is achieved by controlling the on and off of the air source.

[0049] The pneumatic pipeline valve 1 is a pneumatic normally closed valve. The pneumatic pipeline valve 1 needs to use a clean and dry air source when working. The pneumatic pipeline valve 1 can replace hemostatic forceps or other clamps, and quickly complete the clamping and loosening of the pipeline by turning on and off the clean and dry air source.

[0050] As another preferred embodiment of the present invention, the pipeline master control vehicle 2 also includes a host computer arranged inside the vehicle body 1, a control panel and a power socket 212 arranged on the vehicle body 1, the power socket 212 is connected to the host computer and the control panel, the control panel includes a touch screen 29, a control button 210, an emergency stop button 211 and a communication port 25, and an electromagnetic valve is arranged on the air pipe connected between the first multi-way quick plug 26 and the pneumatic pipeline valve 1, and the electromagnetic valve is connected to the host computer, and the host computer has an audit tracking function, which records each step of the action to facilitate problem troubleshooting.

[0051] Furthermore, the vehicle body 1 is also provided with a hook 213 reserved for installing other devices.

[0052] As a third preferred solution of the present utility model, an annular groove 19 is provided at one end of the blocking rod 12 close to the first telescopic rod 14 , and an anti-slip O-ring is installed through the annular groove 19 .

[0053] As a fourth preferred embodiment of the present invention, a handle 28 is provided on the side of the vehicle body 1 for facilitating pulling or pushing the vehicle body 1 .

[0054] As a fifth preferred embodiment of the present invention, a second multi-way quick connector 27 is provided on the sheet metal cross beam 31 , and the other end of the second multi-way quick connector 27 is connected to a plurality of pneumatic pipeline valves 1 provided on the sheet metal cross beam 31 .

[0055] The overall working principle of the utility model:

[0056] According to the requirements of the biopharmaceutical product preparation process, the pipeline main control vehicle 2 is equipped with four pneumatic pipeline valves 1, which respectively control the first liquid adding pipeline, the second liquid adding pipeline, the liquid draining pipeline, and the waste liquid pipeline; the pipeline control beam 3 is mounted with six pipeline valves corresponding to the four cell factories and the liquid adding main pipeline and the liquid draining main pipeline;

[0057] The main gas source is connected to the gas source connector 24 on the pipeline master control vehicle 2, and the first multi-way quick plug 26 on the pipeline master control vehicle 2 is connected to the second multi-way quick plug 27 on the pipeline control beam 3. The operator selects the opening and closing state of each pneumatic pipeline valve 1 on the pipeline master control vehicle 2 and the pipeline control beam 3 through the touch screen control of the control panel.

[0058] It can be understood that the above specific description of the utility model is only used to illustrate the utility model and is not limited to the technical solution described in the embodiments of the utility model. Ordinary technicians in the field should understand that the utility model can still be modified or replaced by equivalents to achieve the same technical effect; as long as the use requirements are met, they are within the protection scope of the utility model.

Claims

1. A novel cell factory automated liquid pipeline control system, characterized in that: It comprises a pneumatic pipeline valve (1) for controlling the on-off of a pipeline, a pipeline main control vehicle (2) for carrying the pneumatic pipeline valve (1), and a pipeline control beam (3); The pipeline master control vehicle (2) comprises a vehicle body (21), a caster (23) is arranged at the bottom of the vehicle body (21), and a peristaltic pump (22) for controlling the pipeline to transport liquid, a pneumatic pipeline valve (1), a gas source connector (24) for connecting to a main gas source, and a first multi-way quick plug (26) for dividing the main gas source gas path into a plurality of gas paths are arranged on the vehicle body (21), the gas source connector (24) and the first multi-way quick plug (26) are connected inside the vehicle body (21) via an air pipe, and the first multi-way quick plug (26) is connected to a device arranged on the pipeline master control vehicle (2) or the pneumatic pipeline valve via an air pipe; The pipeline control beam (3) comprises a sheet metal crossbeam (31), a plurality of pneumatic pipeline valves (1) are arranged on the sheet metal crossbeam (31), and the sheet metal crossbeam (31) is installed on the cell factory frame (4).

2. A novel cell factory automated liquid pipeline control system as claimed in claim 1, characterized in that: The pneumatic pipeline valve (1) comprises a shell (11), a cavity is arranged at one end of the shell (11), two parallel sliding channels communicating with the cavity are arranged at the other end of the shell (11), an air pipe joint (16) communicating with the cavity is connected to the outer end of the shell (11) close to the cavity, the air pipe joint (16) is connected to an air source, a first telescopic rod (14) and a second telescopic rod (15) are arranged in the two sliding channels respectively, and mounting grooves are arranged radially at corresponding positions on the ends of the first telescopic rod (14) and the second telescopic rod (15) away from the cavity. A blocking rod (12) is slidably connected via two corresponding mounting grooves, an end of the blocking rod (12) close to the second telescopic rod (15) is provided with a mounting hole (17), a locking rod (13) is installed through the mounting hole (17), an end of the second telescopic rod (15) close to the mounting groove is provided with a locking track for the locking rod (13) to slide, the mounting groove on the second telescopic rod (15) is connected to the locking track, and a limiting space for clamping a liquid pipeline is formed between the blocking rod (12), the first telescopic rod (14), the second telescopic rod (15) and the housing (11); A first threaded hole (18) for connecting to a pipeline main control vehicle (2) or a pipeline control beam (3) is provided on the side of the housing (11).

3. A novel cell factory automated liquid pipeline control system as claimed in claim 1, characterized in that: The pipeline master control vehicle (2) further comprises a host computer arranged inside the vehicle body (21), a control panel and a power socket (212) arranged on the vehicle body (21); the power socket (212) is connected to the host computer and the control panel; the control panel comprises a touch screen (29), a control button (210), an emergency stop button (211) and a communication port (25); an electromagnetic valve is arranged on the air pipe connected between the first multi-way quick plug (26) and the pneumatic pipeline valve (1); the electromagnetic valve is connected to the host computer.

4. A novel cell factory automated liquid pipeline control system as claimed in claim 3, characterized in that: The vehicle body (21) is also provided with a hook (213) reserved for installing other devices.

5. A novel cell factory automated liquid pipeline control system as claimed in claim 2, characterized in that: An annular groove (19) is provided at one end of the blocking rod (12) close to the first telescopic rod (14), and an anti-slip O-ring is installed through the annular groove (19).

6. A novel cell factory automated liquid pipeline control system as claimed in claim 1, characterized in that: The sheet metal crossbeam (31) is connected to a second threaded hole reserved on the cell factory frame (4) through a locking bolt (32).

7. A novel cell factory automated liquid pipeline control system as claimed in claim 1, characterized in that: A handle (28) is provided on the side of the vehicle body (21) for facilitating pulling or pushing the vehicle body (21).

8. A novel cell factory automated liquid pipeline control system as claimed in claim 1, characterized in that: The sheet metal crossbeam (31) is provided with a second multi-way quick plug (27), and the other end of the second multi-way quick plug (27) is connected to a plurality of pneumatic pipeline valves (1) provided on the sheet metal crossbeam (31).

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