Hydroxypropyl-beta-cyclodextrin production system

Abstract

The utility model belongs to the technical field of cyclodextrin preparation, and particularly relates to a hydroxypropyl-beta-cyclodextrin production system which comprises a reaction kettle, a distillation tower, a nano-filter and a separation tower are sequentially connected to the bottom of the reaction kettle, an alkali liquor inlet, a cyclodextrin inlet, an acid liquor inlet and an epoxypropane inlet are formed in the top of the reaction kettle, a pH meter is arranged on the reaction kettle, and the pH meter is connected with the reaction kettle. An induction valve is arranged at the acid liquor inlet and is electrically connected with the pH meter, an upper packing layer, a middle packing layer and a lower packing layer are arranged in the distillation tower from top to bottom, the upper packing layer is connected with a condenser, the middle packing layer is connected with the bottom of the reaction kettle through a pipeline, and the lower packing layer is connected with a heat exchanger. By arranging the reaction kettle, the distillation tower, the nano-filter and the separation tower, fine production of the hydroxypropyl-beta-cyclodextrin is realized, a hydroxypropyl-beta-cyclodextrin solution with higher purity is obtained, the content of impurities is reduced, and the device is simple and suitable for industrial production.

Description

Technical Field

[0001] The utility model belongs to the technical field of cyclodextrin preparation, and specifically relates to a hydroxypropyl beta-cyclodextrin production system. Background Art

[0002] Hydroxypropyl-beta-cyclodextrin is a hydroxyalkylated derivative of beta-cyclodextrin, commonly used in the fields of drug carriers, food additives, etc. Hydroxypropyl-beta-cyclodextrin is very stable in alkaline media, can be decomposed by strong acids, has a molecular envelope effect, and has a high water solubility, generally exceeding 50%, so it cannot crystallize in alcohol-water solutions. It is basically not decomposed or accumulated in the human body, has low surface activity and hemolytic activity, and is safer to use. For example, the inclusion complex formed by enrofloxacin and hydroxypropyl-beta-cyclodextrin can increase the water solubility of enrofloxacin, making it more widely used in medicines.

[0003] Common raw materials for producing hydroxypropyl beta-cyclodextrin are beta-cyclodextrin and propylene oxide, and cyclodextrin and propylene oxide undergo condensation reaction under alkaline conditions. However, the purity and production efficiency of hydroxypropyl beta-cyclodextrin are currently low. Utility Model Content

[0004] In view of the above deficiencies in the prior art, the technical problem to be solved by the utility model is to provide a hydroxypropyl beta-cyclodextrin production system to improve the purity and production efficiency of hydroxypropyl beta-cyclodextrin.

[0005] The technical solution adopted by the utility model to solve its technical problems is:

[0006] The hydroxypropyl beta-cyclodextrin production system described in the utility model comprises a reactor, a distillation tower, a nanofilter and a separation tower are sequentially connected to the bottom of the reactor, an alkali solution inlet, a cyclodextrin inlet, an acid solution inlet and a propylene oxide inlet are arranged on the top of the reactor, a pH meter is arranged on the reactor, an induction valve is arranged at the acid solution inlet, the induction valve is electrically connected to the pH meter, an upper packing layer, a middle packing layer and a lower packing layer are arranged from top to bottom in the distillation tower, the upper packing layer is connected to a condenser, the middle packing layer is connected to the bottom of the reactor through a pipeline, and the lower packing layer is connected to a heat exchanger.

[0007] in:

[0008] The propylene oxide inlet is connected to a propylene oxide buffer tank.

[0009] A feed liquid outlet is arranged at the bottom of the reaction kettle, and the middle packing layer is connected with the feed liquid outlet through a pipeline.

[0010] A material pump 1 is arranged on the pipeline between the liquid outlet and the middle packing layer.

[0011] The reactor is provided with an agitator inside, and the agitator passes through the top of the reactor and is connected with a motor.

[0012] The bottom of the distillation tower is connected to the inlet of the nanofilter through a pipeline.

[0013] A second material pump is arranged on the pipeline between the distillation tower and the nanofilter.

[0014] The nanofilter outlet is connected to the top of the separation tower through a pipeline.

[0015] The outside of the reaction kettle is provided with a jacket.

[0016] The lower part of the jacket is provided with a circulating water inlet, and the upper part of the jacket is provided with a circulating water outlet.

[0017] The beneficial effects of the utility model are:

[0018] The utility model realizes the refined production of hydroxypropyl beta-cyclodextrin by arranging a reaction kettle, a distillation tower, a nanofilter and a separation tower, so as to obtain a hydroxypropyl beta-cyclodextrin solution with higher purity, reduce the content of impurities, and improve production efficiency at the same time. The arrangement of the reaction kettle can make cyclodextrin and propylene oxide react fully, and the pH value of the reaction solution can be accurately controlled to avoid affecting the product quality. After the reaction, operations such as distillation and nanofiltration of the reaction solution can further reduce the impurities in the hydroxypropyl beta-cyclodextrin. During the distillation process, the distillation effect of the material is controlled by three layers of filler layers, which can further improve the purity of the hydroxypropyl beta-cyclodextrin solution. The utility model has a simple device and is suitable for industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the structure of the utility model;

[0020] In the figure: 1, reactor; 2, jacket; 3, agitator; 4, alkali solution inlet; 5, cyclodextrin inlet; 6, motor; 7, induction valve; 8, acid solution inlet; 9, propylene oxide inlet; 10, pH meter; 11, propylene oxide buffer tank; 12, feed liquid outlet; 13, distillation tower; 14, nanofilter; 15, separation tower; 201, circulating water inlet; 202, circulating water outlet; 1201, material pump 1; 1301, heat exchanger; 1302, condenser; 1303, material pump 2; 1304, upper packing layer; 1305, middle packing layer; 1306, lower packing layer. DETAILED DESCRIPTION

[0021] The embodiments of the present utility model are further described below in conjunction with the accompanying drawings.

[0022] Example 1

[0023] like Figure 1As shown, the hydroxypropyl beta-cyclodextrin production system described in the utility model includes a reactor 1, the bottom of the reactor 1 is connected with a distillation tower 13, a nanofilter 14 and a separation tower 15 in sequence, the top of the reactor 1 is provided with an alkali solution inlet 4, a cyclodextrin inlet 5, an acid solution inlet 8, and a propylene oxide inlet 9, the reactor 1 is provided with a pH meter 10, the acid solution inlet 8 is provided with a sensing valve 7, the sensing valve 7 is electrically connected to the pH meter 10, the inside of the distillation tower 13 is provided with an upper packing layer 1304, a middle packing layer 1305 and a lower packing layer 1306 from top to bottom, the upper packing layer 1304 is connected with a condenser 1302, the middle packing layer 1305 is connected to the bottom of the reactor 1 through a pipeline, and the lower packing layer 1306 is connected with a heat exchanger 1301.

[0024] The combined use of the reactor 1, the distillation tower 13, the nanofilter 14 and the separation tower 15 can realize the refined production of hydroxypropyl-beta-cyclodextrin and improve the reaction efficiency; the pH meter 10 can detect the pH value in the reactor 1, and convert it into an electrical signal and transmit it to the sensing valve 7, thereby controlling the switch of the sensing valve 7 to achieve more accurate control of the pH value in the reactor 1; the reaction solution in the reactor 1 enters the distillation tower 13 from the middle packing layer 1305 for distillation, the condenser 1302 can condense the light phase material in the distillation tower 13, and transport it back to the upper packing layer 1304 for utilization, and the lower packing layer 1306 exchanges heat with the heat exchanger 1301, which can improve the distillation efficiency of the distillation tower 13.

[0025] The propylene oxide inlet 9 is connected to a propylene oxide buffer tank 11 .

[0026] A liquid feed outlet 12 is provided at the bottom of the reactor 1, and the middle packing layer 1305 is connected to the liquid feed outlet 12 through a pipeline.

[0027] A material pump 1201 is arranged on the pipeline between the liquid outlet 12 and the middle packing layer 1305.

[0028] An agitator 3 is arranged inside the reactor 1 , and the agitator 3 passes through the top of the reactor 1 and is connected to a motor 6 .

[0029] The bottom of the distillation tower 13 is connected to the inlet of the nanofilter 14 through a pipeline.

[0030] A material pump 1303 is provided on the pipeline between the distillation tower 13 and the nanofilter 14. Nanofiltration of the reaction solution after distillation can further improve the purity of hydroxypropyl-beta-cyclodextrin.

[0031] The outlet of the nanofilter 14 is connected to the top of the separation tower 15 through a pipeline.

[0032] A jacket 2 is arranged outside the reactor 1 .

[0033] A circulating water inlet 201 is provided at the lower portion of the jacket 2 , and a circulating water outlet 202 is provided at the upper portion of the jacket 2 .

[0034] Working principle and process:

[0035] Sodium hydroxide solution is added into the reactor 1 through the alkali solution inlet 4, the circulating water inlet 201 is opened to pass 65°C circulating water into the jacket 2, and then beta-cyclodextrin is added into the reactor 1 through the cyclodextrin inlet 5, and the motor 6 is turned on to drive the agitator 3 to stir until the beta-cyclodextrin is completely dissolved, and then ice water is transported into the jacket 2 and propylene oxide is added into the reactor 1 through the propylene oxide inlet 9 for reaction. After the reaction is completed, the pH value of the reaction solution in the reactor 1 is adjusted with hydrochloric acid to make the reaction solution neutral, and then the reaction solution is transported to the middle part of the distillation tower 13 through the material pump 1201 for distillation, and then sent to the nanofilter 14 and the separation tower 15 for purification to obtain a hydroxypropyl beta-cyclodextrin solution with higher purity, and then dried to obtain the hydroxypropyl beta-cyclodextrin product.

Claims

1. A hydroxypropyl-beta-cyclodextrin production system, comprising a reaction kettle (1), characterized in that: The bottom of the reactor (1) is connected in sequence to a distillation tower (13), a nanofilter (14) and a separation tower (15); the top of the reactor (1) is provided with an alkali solution inlet (4), a cyclodextrin inlet (5), an acid solution inlet (8) and a propylene oxide inlet (9); a pH meter (10) is provided on the reactor (1); a sensing valve (7) is provided at the acid solution inlet (8); the sensing valve (7) is electrically connected to the pH meter (10); an upper packing layer (1304), a middle packing layer (1305) and a lower packing layer (1306) are provided inside the distillation tower (13) from top to bottom; the upper packing layer (1304) is connected to a condenser (1302); the middle packing layer (1305) is connected to the bottom of the reactor (1) via a pipeline; and the lower packing layer (1306) is connected to a heat exchanger (1301).

2. The hydroxypropyl-beta-cyclodextrin production system according to claim 1, characterized in that: The propylene oxide inlet (9) is connected to a propylene oxide buffer tank (11).

3. The hydroxypropyl-beta-cyclodextrin production system according to claim 1, characterized in that: A liquid feed outlet (12) is provided at the bottom of the reaction kettle (1), and the middle packing layer (1305) is connected to the liquid feed outlet (12) via a pipeline.

4. The hydroxypropyl-beta-cyclodextrin production system according to claim 3, characterized in that: A material pump 1 (1201) is provided on the pipeline between the liquid outlet (12) and the middle packing layer (1305).

5. The hydroxypropyl-beta-cyclodextrin production system according to claim 1, characterized in that: A stirrer (3) is arranged inside the reaction kettle (1), and the stirrer (3) passes through the top of the reaction kettle (1) and is connected to a motor (6).

6. The hydroxypropyl-beta-cyclodextrin production system according to claim 1, characterized in that: The bottom of the distillation tower (13) is connected to the inlet of the nanofilter (14) through a pipeline.

7. The hydroxypropyl-beta-cyclodextrin production system according to claim 6, characterized in that: A material pump 2 (1303) is provided on the pipeline between the distillation tower (13) and the nanofilter (14).

8. The hydroxypropyl-beta-cyclodextrin production system according to claim 1, characterized in that: The outlet of the nanofilter (14) is connected to the top of the separation tower (15) through a pipeline.

9. The hydroxypropyl-beta-cyclodextrin production system according to claim 1, characterized in that: A jacket (2) is provided on the outside of the reaction kettle (1).

10. The hydroxypropyl-beta-cyclodextrin production system according to claim 9, characterized in that: A circulating water inlet (201) is provided at the lower part of the jacket (2), and a circulating water outlet (202) is provided at the upper part of the jacket (2).

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