Automatic processing module

Abstract

The utility model relates to the technical field of medical instruments, aims to solve the problems that in the prior art, layout is not clear, the function integration degree is low, transfer of different types of liquid and consumables cannot be well executed, space is limited, the sample detection and transfer efficiency is low, and automatic sample processing cannot be executed integrally and efficiently, and provides an automatic processing module. Comprising an operation layer, a system configuration layer and a processing layer, the operating layer is provided with a first span beam and a second span beam, the first span beam is provided with a first cooperation assembly capable of reciprocating, and the second span beam is provided with a second cooperation assembly capable of reciprocating; the system configuration layer is provided with a reagent storage area, a transfer channel area, a consumable storage area, a reaction liquid blending area and a centrifugal treatment area; the processing layer is provided with a packaging module used for packaging the consumable in the recovery system configuration layer. The scheme has the beneficial effects that the layout is clear, the function integration is high, the transfer of different types of liquids and consumables can be well executed, the space is not limited, the sample detection transfer efficiency is high, and the automatic sample treatment can be more integrally and efficiently executed.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to an automatic processing module. Background Art

[0002] Biological-related sample processing solutions involve a variety of diagnostic and treatment processes. Sample types include in vitro tissue fluid, blood or blood-related products, various types of swabs, secretions or excretions, etc. The entire preparation process from in vitro samples to the final test objects is relatively complicated. Manual processing of these in vitro samples has certain contamination risks, and manual processing has problems such as low efficiency. Therefore, more and more manufacturers are paying attention to automated processing equipment. The flow processing equipment in these devices has almost no intervention state to achieve basic continuous automated sample processing capabilities, which is more suitable for dealing with a certain scale of disease outbreaks or diseases with high testing necessity (such as early cancer screening, SMA early screening, etc.).

[0003] A streamlined automated system usually includes multiple integrated modules, each of which can run different sample processing operations and can be assembled on site. In the solution disclosed in CN109313209A, each module is configured as a plurality of easy-to-assemble module structures. A single module is easy to transport and relatively small in size. After delivery to the client, different modules can be quickly assembled by adjusting the feet to obtain a streamlined automated processing system with large-scale processing capabilities. Of course, some other influential in vitro diagnostic companies, such as Roche, Beckman, Siemens, etc., have designed streamlined automated processing systems. Automated processing systems of different companies can also perform detection of different targets and different projects. In fact, there are great differences in the overall layout and module design details. The system mainly includes a pre-processing module, which can mainly perform preliminary processing operations such as storage, circulation and recovery of sample tube racks; a pre-processing module, which can pre-process samples in sample tube racks, for example, Perform pretreatment such as transfer and extraction; the reaction system construction module can add different types of reaction reagents to the liquid to be analyzed obtained by pretreatment in the reaction container, and then construct a reaction system that can be suitable for different types of detection; the reaction module can perform different types of detection in the reaction container or flow-through into the circulation detection pool for the reaction system circulated by the previous module, and then output the detection results. The entire system requires almost no operator intervention throughout the process. The system is generally also equipped with an information control system to monitor the system operation status by scanning the barcode of the sample tube and / or the sample tube rack, including the temporary storage and subsequent re-testing of abnormal samples and the emergency treatment of emergency samples. The realization of all these functions depends on the design of highly integrated modules. Although the existing design has a certain degree of integration, the cost is very high and a relatively large amount of special consumables are used. In this way, the inspection cost of the detected object will be very high, which does not meet the overall requirements of my country's current medical development.

[0004] Therefore, a more integrated automated processing module is needed, and various types of operation processing layers arranged in different vertical positions can be used to perform various types of complex operations in a limited space to ensure that the pipelined detection system assembled using the module can perform sample automated processing more integratedly and efficiently. Utility Model Content

[0005] The utility model aims to provide an automated processing module to solve the problems in the prior art of unclear layout, low functional integration, inability to transfer different types of liquids and different types of consumables, space limitations, slow sample detection transfer efficiency, and inability to perform sample automated processing in a more integrated and efficient manner.

[0006] The embodiment of the utility model is achieved as follows:

[0007] The embodiment of the utility model provides an automated processing module, which includes an operation layer, a system configuration layer and a processing layer;

[0008] The operation layer, the system configuration layer and the processing layer are stacked one on another, the operation layer has a first span beam and a second span beam that can be driven to move, the first span beam is adapted to be equipped with a first cooperation component, the second span beam is adapted to be equipped with a second cooperation component, the first cooperation component and the second cooperation component can be driven to reciprocate along the length direction of the first span beam and the second span beam respectively;

[0009] The system configuration layer has a reagent storage area, a transfer channel area, a consumable storage area, a reaction liquid preparation area and a centrifugal treatment area, and the first cooperative component and the second cooperative component are movably adapted to the reagent storage area, the transfer channel area, the consumable storage area, the reaction liquid preparation area and the centrifugal treatment area;

[0010] The processing layer has a packaging module for sealing and recycling at least part of the consumables in the system configuration layer.

[0011] Optionally: the first span beam and the second span beam are parallel to each other, and a common extension rail is provided at one end of the first span beam and the second span beam in the length direction, and the first span beam and the second span beam at this end are slidably engaged and connected to the common extension rail;

[0012] The other ends of the first span beam and the second span beam in the length direction are respectively provided with a first roller group and a second roller group, and the ends of the first span beam and the second span beam are respectively rollingly connected to a common guide rod through the first roller group and the second roller group.

[0013] With such arrangement, when the first span beam and the second span beam are driven to move, the first roller group and the second roller group can not only play a supporting role but also enable the first span beam and the second span beam to run with low resistance.

[0014] Optionally: the first cooperative component has a tubular clamping unit and one or more first pipetting units, and the second cooperative component has a consumable clamping unit for a preset matching width range and one or more second pipetting units.

[0015] With such arrangement, different operations can be performed on various reagents and consumables on the above system configuration layer.

[0016] Optionally: the first span beam is provided with a first span beam common guide rail extending along the length direction thereof, a first span beam connecting base is provided between the tubular clamping unit and the first pipetting unit, the tubular clamping unit and the first pipetting unit are respectively connected to two sides of the first span beam connecting base, and the first span beam connecting base is movably straddled on the first span beam;

[0017] A first slider is provided at a position on the inner side of the first span beam connection base body corresponding to the first span beam common guide rail, and the first span beam connection base body is movably engaged with the first span beam common guide rail through the first slider.

[0018] With such an arrangement, the tubular clamping unit or the first pipetting unit can be driven to perform different transfer and pipetting operations simultaneously or separately.

[0019] Optionally: the second span beam is provided with a second span beam common guide rail extending along the length direction thereof, a second span beam connecting base is provided between the consumable material clamping unit and the second pipetting unit, the consumable material clamping unit and the second pipetting unit are respectively connected to two sides of the second span beam connecting base, and the second span beam connecting base is movably straddled on the second span beam;

[0020] A second slider is provided at a position on the inner side of the second span beam connection base body corresponding to the second span beam common guide rail, and the second span beam connection base body is movably engaged and connected to the second span beam common guide rail through the second slider.

[0021] Such an arrangement makes it easy to drive the consumable clamping unit or the second pipetting unit to perform different transfer and pipetting operations simultaneously or separately.

[0022] Optionally: the reagent storage area has a refrigeration module.

[0023] With such arrangement, the refrigeration module can provide the reagent storage area with a refrigerated temperature that is lower than the ambient temperature and suitable for preserving the reagents.

[0024] Optionally: the system configuration layer also has a reagent tube cover switch operation area, a reagent tube cover storage area, a transfer module receiving area that can connect the system configuration layer and the processing layer, and a first consumable material storage area is also provided adjacent to the reagent storage area. The transfer channel area is located in the middle position of the system configuration layer.

[0025] Such a configuration ensures maximum utilization of space and efficient execution of pipetting operations. At the same time, it can quickly transfer reagents or consumables, and can also enable the reagents and consumables transferred in this way to be quickly distributed to the required area.

[0026] Optionally: a movable suction cup is provided on one side of the packaging module, and a recovery plate is provided at the bottom of the suction cup.

[0027] With such arrangement, after the encapsulation module automatically encapsulates the items to be encapsulated, the suction cup is used to transfer the items to be encapsulated to the recovery tray for recovery. The use of the suction cup operation here can ensure that the encapsulated items to be encapsulated are tightly and neatly stacked in the recovery tray. The configuration of the three different functional layers of the encapsulation module, the suction cup and the recovery tray maximizes the use of the configuration space in the module, and the bottom configuration processing layer can complete the sealing film recovery processing relatively independently and without interference, which also ensures that the contamination risk of the entire recovery processing operation for other unprocessed samples can be basically ignored.

[0028] Optionally: the bottom substrate of the processing layer is further connected to a centrifugal module and a transfer module, and the centrifugal mechanism of the centrifugal module is adapted to the centrifugal processing area of ​​the system configuration layer;

[0029] The transfer module has a vertical substrate connecting the processing layer and the system configuration layer, a vertical slide rail is arranged on the vertical substrate, a transfer connection block which can slide up and down is provided on the vertical slide rail, a transfer substrate is fixedly connected to the transfer connection block, and the transfer substrate is engaged and connected with the vertical slide rail through the transfer connection block.

[0030] Such arrangement makes it easy for the items to be packaged in the system configuration layer to be transferred to the packaging module in the processing layer through the centrifugal module and the transfer module, thereby effectively realizing the packaging and recycling of consumables.

[0031] Optionally: at least one visual sensing unit is provided on the top of the module.

[0032] With such configuration, the visual sensing unit can be a CCD or CMOS type image sensor, and an image recognition algorithm can be used to perform image recognition processing on each visual sensing unit to detect whether the transfer process of pipetting consumables is normal. It can also monitor in real time whether the supply of consumables and reagents is normal and sufficient to ensure that consumables and reagents can be replenished in time. The ROI areas of multiple visual sensing units can have overlapping areas, so that it can also be realized whether each visual sensor is normal and whether the acquired image is accurate.

[0033] In summary, due to the adoption of the above technical solution, the beneficial effects of the present application are:

[0034] 1. The present application configures the module into the above-mentioned operation layer, the above-mentioned system configuration layer and the above-mentioned processing layer distributed from top to bottom, utilizes the limited space to reasonably arrange more functional modules, and configures the above-mentioned first span beam and the above-mentioned second span beam on the above-mentioned operation layer. Through the above-mentioned first collaboration component and the above-mentioned second collaboration component configured on the above-mentioned first span beam and the above-mentioned second span beam, the automatic circulation of sample liquid, reagents and consumables can be realized. The above-mentioned system configuration layer in the middle contains various types of reagents, consumables and circulation processing areas required for building a reaction system, and maximizes the reasonable use of various operation spaces to make the module have a higher integration advantage. The above-mentioned processing layer at the bottom can timely seal and recycle the consumables containing sample liquid or sample processing liquid that may cause contamination risks after use, thereby eliminating the risk of contamination within the module.

[0035] 2. Different types of clamping units and pipetting units for transferring different liquids are configured in the first collaborative component and the second collaborative component, so that each collaborative group can most reasonably configure different consumables or liquid transfer operation sequences within the same time period. In this way, the operation of the first span beam and the operation of the second span beam can maximize the optimal operation efficiency without interfering with each other, and the idle sequence of the first collaborative component and the second collaborative component is eliminated to the maximum extent. The clamping units and pipetting units in the first collaborative component and the second collaborative component can share the common span beam guide rail, and the structure of the system is more compact, and the risk of interference between different units is also smaller. The first span beam and the second span beam can also be connected to the common extension guide rail at one end in the length direction of the span beam, and the other end can be connected to the common guide rod through the first roller group and the second roller group respectively. In this way, the first span beam and the second span beam can be operated in the module with low resistance and reliability. At least one visual sensor unit configured on the top of the module can guide the accurate execution of each step, and enable the system to automatically obtain the consumption of reagents, consumables, etc. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the utility model and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying creative work.

[0037] Figure 1 This is a first structural schematic diagram of an automated processing module in an embodiment of the utility model;

[0038] Figure 2 This is a second structural schematic diagram of an automated processing module in an embodiment of the utility model;

[0039] Figure 3 A schematic diagram of the structure of the first cooperation component configured for the first span beam in the embodiment of the utility model from a first perspective;

[0040] Figure 4 A schematic diagram of the structure of the first cooperation component configured for the first span beam in the embodiment of the utility model from a second perspective;

[0041] Figure 5 It is a schematic structural diagram of the second cooperation component configured for the second span beam in the embodiment of the utility model from a first perspective;

[0042] Figure 6 It is a schematic structural diagram of a second cooperative component configured for a second span beam in an embodiment of the utility model from a second viewing angle;

[0043] Figure 7 This is a schematic diagram of the structure of the reagent storage area in the embodiment of the utility model;

[0044] Figure 8 This is a schematic diagram of the structure in which the first cooperative component and the second cooperative component cooperate with the reagent storage area to complete the transfer of reagents or consumables in the embodiment of the utility model;

[0045] Fig. 9 This is a layout diagram of the centrifugal module and the transfer module in the embodiment of the utility model;

[0046] Fig.10 This is a structural diagram of the processing layer layout in an embodiment of the utility model.

[0047] Icons: 10-operation layer, 20-system configuration layer, 30-processing layer, 101-first span beam, 102-second span beam, 110-first collaborative component, 120-second collaborative component, 201-reagent storage area, 205-transfer channel area, 202-consumable storage area, 2021-first consumable storage area, 2022-second consumable storage area, 206-centrifugal processing area, 301-packaging module, 103-shared extension rail, 1012-first roller group, 1022-second roller group, 104-shared guide rod, 111-tubular clamping unit , 112-first pipetting unit, 121-consumables clamping unit, 122-second pipetting unit, 1011-first span beam common guide rail, 1-first span beam connecting base, 1013-first slider, 1021-second span beam common guide rail, 2-second span beam connecting base, 1025-second slider, 203-reagent tube switch cover operation area, 204-reagent tube cover storage area, 207-transfer module receiving area, 303-suction cup, 302-recovery plate, 3-centrifugal module, 4-transfer module, 2072-transfer connection block, 2071-transfer substrate, 11 31-tube clamping drive motor, 1132-tube transmission screw, 1133-tube connecting block, 1142-first pipetting slide rail, 1141-first pipetting drive motor, 1153-first liquid receiving plate, 1151-first liquid receiving gear, 1152-first liquid receiving rack, 1023-second span beam driving wheel, 1024-second span beam transmission belt, 1171-clamping drive motor, 1172-clamping transmission mechanism, 1173-clamping slide rail, 1164-second pipetting type I drive motor, 1165-second pipetting type II drive motor, 1166-second Pipetting type I transmission mechanism, 1167-second pipetting type II transmission mechanism, 1163-second liquid receiving plate, 1161-second liquid receiving plate drive motor, 1162-second liquid receiving transmission mechanism, 2011-heat dissipation duct, 310-processing cross beam, 321-processing drive motor, 322-processing active wheel, 323-processing transmission belt, 325-processing driven wheel, 324-processing extension guide rail, 5-vibration absorbing base, 208-reaction container storage area, 1111-first tube clamp unit, 1112-second tube clamp unit, 1026-second cross beam drive motor. DETAILED DESCRIPTION

[0048] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Generally, the components of the embodiments of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0049] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0050] Example

[0051] See also Figures 1 to 10 , this embodiment proposes an automated processing module, including an operation layer 10, a system configuration layer 20 and a processing layer 30;

[0052] The operation layer 10, the system configuration layer 20 and the processing layer 30 are stacked one on another. The operation layer 10 has a first span beam 101 and a second span beam 102 that can be driven to move. The two span beams can be driven to reciprocate along the depth direction of the automated processing module. The first span beam 101 is adapted with a first cooperation component 110, and the second span beam 102 is adapted with a second cooperation component 120. The first cooperation component 110 and the second cooperation component 120 can be driven to reciprocate along the length direction of the first span beam 101 and the second span beam 102 respectively.

[0053] The system configuration layer 20 has a reagent storage area 201, a transfer channel area 205, a consumable storage area 202, a reaction solution preparation area (not shown) and a centrifugal treatment area 206, and the first cooperative component 110 and the second cooperative component 120 are movably adapted to the reagent storage area 201, the transfer channel area 205, the consumable storage area 202, the reaction solution preparation area and the centrifugal treatment area 206;

[0054] The processing layer 30 has a packaging module 301 for sealing and recycling at least part of the consumables in the system configuration layer 20. The first cooperative component 110 and the second cooperative component 120 in the operating layer 10 can be driven to perform operations such as pipetting, transfer, and opening and closing the lid in different areas of the system configuration layer 20.

[0055] See also Figures 1 to 10The first span beam 101 and the second span beam 102 are parallel to each other, and one end of the first span beam 101 and the second span beam 102 in the length direction is provided with a common extension guide rail 103, and this end of the first span beam 101 and the second span beam 102 can be slidably engaged and connected to the common extension guide rail 103; the other end of the first span beam 101 and the second span beam 102 in the length direction respectively has a first roller group 1012 and a second roller group 1022, and the outer side of the circumference of the first roller group 1012 and / or the second roller group 1022 is tangent to the common guide rod 104, and this end of the first span beam 101 and the second span beam 102 is rollingly connected to the common guide rod 104 through the first roller group 1012 and the second roller group 1022 respectively. When the first span beam 101 and the second span beam 102 are driven to move, the first roller group 1012 and the second roller group 1022 can not only play a supporting role but also enable the first span beam 101 and the second span beam 102 to run with low resistance.

[0056] In this embodiment, the first span beam 101 is connected to the common guide rod 104 via a first roller set 1012 , and the second span beam 102 is connected to the common guide rod 104 via a second roller set 1022 .

[0057] In this embodiment, the first span beam 101 and the second span beam 102 include two independent drive motors (not shown in the figure) and a transmission assembly (not shown in the figure). The two transmission assemblies are driven by the two independent drive motors to move. The first span beam 101 can be driven by the drive motor of the first span beam 101 to move in a direction perpendicular to its length direction (that is, the depth direction of the automated processing module), and the second span beam 102 can be driven by the drive motor of the second span beam 102 to move in a direction perpendicular to its length direction, and the motion trajectories of the two in this direction have an overlap of not less than 30%. By configuring the motion trajectories of the two span beams with a certain overlap, more complex operations can be performed on the same area, such as pipetting, opening and closing the cover, and transferring consumables. The configuration of the shared extension rail 103 and the shared guide rod 104 makes the system structure more compact, and the avoidance program designed to ensure that there is no mutual interference between the two span beams during operation is also simpler. A first cooperation component 110 is disposed on the first span beam 101, and a second cooperation component 120 is disposed on the second span beam 102, so that the two cooperation components can be driven by the two span beams to move independently in the depth direction of the automated processing module.

[0058] The first collaborative component 110 has a tubular clamping unit 111 and one or more first pipetting units 112, and the second collaborative component 120 has a consumable clamping unit 121 for a preset matching width range and one or more second pipetting units 122. Through this configuration, different operations can be performed on various types of reagents and consumables on the system configuration layer 20.

[0059] See also Figure 3 and Figure 4 The first span beam 101 is provided with a first span beam common guide rail 1011 extending along its length direction, a first span beam connecting base 1 is provided between the tubular clamping unit 111 and the first pipetting unit 112, the tubular clamping unit 111 and the first pipetting unit 112 are respectively connected to the two sides of the first span beam connecting base 1, and the first span beam connecting base 1 is movably spanned on the first span beam 101; a first slider 1013 is provided on the inner side of the first span beam connecting base 1 at a position corresponding to the first span beam common guide rail 1011, and the first span beam connecting base 1 is movably engaged and connected to the first span beam common guide rail 1011 through the first slider 1013, so that the tubular clamping unit 111 or the first pipetting unit 112 can be driven to perform different clamping transfer, pipetting and other operations simultaneously or separately.

[0060] In this embodiment, the driving component of the first span beam 101 can drive the first cooperative component 110 to slide along the length direction of the first span beam 101 through the driving motor configured therein, and a tubular clamping unit 111 and one or more first pipetting units 112 are respectively configured on both sides of the first span beam connecting base 1, so that the tubular clamping unit 111 and one or more first pipetting units 112 can operate smoothly, which is convenient for clamping and moving the items to be processed.

[0061] In this embodiment, the driving assembly of the tubular clamping unit 111 includes a tube clamping driving motor 1131, which drives a threaded tube connecting block 1133 to slide up and down through a tube transmission screw 1132, and the tube connecting block 1133 is also connected to the tubular clamping unit 111, so that it can independently drive it to slide with low resistance along the slide rail arranged on one side of the first span beam connecting base 1. The tubular clamping unit 111 is configured with a tube clamp driving motor (not shown in the figure), which can drive the two opposite first tube clamping units 1111 and the second tube clamping units 1112 to move closer to or away from each other; and the first pipetting unit 112 is configured on the other side of the first span beam connecting base 1, which is connected to the first pipetting connecting block (not shown in the figure) through the first pipetting connecting block (not shown in the figure). The first pipetting slide rail 1142 is interlocked and connected, and the first pipetting drive motor 1141 can be connected to the first pipetting connection block through a first pipetting transmission mechanism (not shown in the figure), so that the first pipetting unit 112 can be driven to slide in the vertical direction. In order to ensure the reliability of pipetting, a first liquid receiving tray 1153 is also arranged at the bottom of the first span beam connecting base 1. The driving motor of the first liquid receiving tray 1153 can drive the first liquid receiving gear 1151 to rotate, thereby driving the meshing first liquid receiving rack 1152 to reciprocate, thereby driving the first liquid receiving tray 1153 connected to the first liquid receiving rack 1152 to move to the bottom of the pipetting instrument, thereby preventing the risk of cross contamination caused by liquid dripping during the pipetting process.

[0062] See also Figure 5 and Figure 6The second span beam 102 is provided with a second span beam common guide rail 1021 extending along its length direction, a second span beam connecting base 2 is provided between the consumable clamping unit 121 and the second pipetting unit 122, the consumable clamping unit 121 and the second pipetting unit 122 are respectively connected to the two sides of the second span beam connecting base 2, and the second span beam connecting base 2 is movably spanned on the second span beam 102; a second slider 1025 is provided on the inner side of the second span beam connecting base 2 at a position corresponding to the second span beam common guide rail 1021, and the second span beam connecting base 2 is movably engaged and connected to the second span beam common guide rail 1021 through the second slider 1025, so that it is convenient to drive the consumable clamping unit 121 or the second pipetting unit 122 to perform different clamping transfer, pipetting and other operations simultaneously or separately.

[0063] In this embodiment, in order to adapt to different types of pipetting requirements, the number of first pipetting units 112 is less than the number of second pipetting units 122, so that a more continuous pipetting operation can be achieved and the operation efficiency of the entire module can be higher. Here, the two pipetting units can be connected to pipetting consumables with different pipetting capacities and pipetting accuracies to meet the needs of different pipetting scenarios; in order to ensure that the second cooperative component 120 can be reliably driven to move along the length direction of the second span beam 102, a second span beam driving motor 1026 is arranged on the upper end surface of the second span beam 102, and its output shaft is connected to the second span beam driving wheel 1023, and a second span beam driven wheel (not shown in the figure) is fixedly arranged at a preset distance, and the second span beam transmission belt 1024 is wound between the second span beam driving wheel 1023 and the second span beam driven wheel, and is connected to the second cooperative component 120 connecting block (not shown in the figure), where the connecting block The second slider 1025 can be directly or indirectly connected, and then the second collaborative component 120 can be driven to slide along the length direction of the second span beam 102 through the clockwise or counterclockwise rotation of the second span beam driving motor 1026 (of course, the first collaborative component 110 also adopts a similar drive and transmission configuration); here, the consumable clamping unit 121 can be driven by the clamping driving motor 1171 through the clamping transmission mechanism 1172 to slide vertically back and forth along the clamping slide rail 1173 arranged on the second span beam connecting base 2, thereby being able to drive the connected consumable clamping unit 121 to perform different types of consumable transfers at different vertical positions. Here, the preset matching width range is based on the width characteristics of the deep well plate consumables, and the preset width range is 0.5-1.5 times the width of the deep well plate consumables. In this way, the clamping jaws of the relative position of the consumable clamping unit 121 can be efficiently and quickly adjusted to a suitable width, thereby realizing efficient consumable transfer.

[0064] In the present embodiment, the number of the second pipetting units 122 is two. Of course, in other scenarios, the number of the second pipetting units 122 can be three or more, which is not limited here. The two second pipetting units 122 include two independent second pipetting drive components (not shown in the figure), wherein the second pipetting type I drive motor 1164 and the second pipetting type II drive motor 1165 can respectively drive the two second pipetting units 122 through the second pipetting type I transmission mechanism 1166 and the second pipetting type II transmission mechanism 1167 to achieve simultaneous or sequential pipetting control of the two. In order to ensure the reliability of the pipetting process, a second liquid receiving plate 1163 and a second liquid receiving plate drive motor 1161 are also arranged at the bottom of the second span beam connecting the base 2. The output of the second liquid receiving plate drive motor 1161 is connected to a second liquid receiving transmission mechanism 1162 composed of a gear rack, so that the second pipetting unit 122 can reliably and efficiently perform liquid transfer.

[0065] See also Figures 1 to 10 The reagent storage area 201 has a refrigeration module (not marked in the figure), which can provide the reagent storage area 201 with a refrigeration temperature that is lower than the ambient temperature and suitable for storing reagents.

[0066] In this embodiment, the storage temperature here can be a refrigeration temperature of -20°C, -15°C, -5°C, 0°C, etc. The refrigeration module here includes a heat dissipation duct 2011 extending along the width of the automated processing module, so that the waste heat generated by the refrigeration module can be quickly discharged, thereby ensuring the high efficiency and reliability of the refrigeration.

[0067] The system configuration layer 20 also has a reagent tube switch cover operation area 203, a reagent tube cover storage area 204, and a transfer module receiving area 207 that can connect the system configuration layer 20 and the processing layer 30. A first consumables storage area 2021 is also provided adjacent to the reagent storage area 201. The transfer channel area 205 is located in the middle position of the system configuration layer 20, which is arranged closer to the internal position of the automatic processing module relative to the reagent tube switch cover area 203. This ensures maximum utilization of space and efficient execution of pipetting operations. At the same time, it can quickly transfer reagents or consumables, and can also enable the reagents and consumables transferred in this way to be quickly distributed to the required area. By optimizing the transfer path, the exposure time is minimized to the greatest extent possible to reduce the risk of contamination caused by aerosols, etc.

[0068] In this embodiment, the system configuration layer 20 also has a second consumables storage area 2022, a centrifugal processing area 206 and a transfer module receiving area 207 that can connect the system configuration layer 20 and the processing layer 30. The transfer module receiving area 207 and the centrifugal processing area 206 are adjacent to the transfer channel area 205. The reaction liquid preparation area includes a reaction container storage area 208 and a reaction container switch cover operation area and is configured at the vertical edge of the module.

[0069] A movable suction cup 303 is provided in conjunction with the encapsulation module 301, and a recovery tray 302 is provided at the lower part of the suction cup 303. After the encapsulation module 301 automatically encapsulates the items to be encapsulated, the encapsulated items are transferred to the recovery tray 302 by means of the suction cup 303 to complete recovery. The use of the suction cup 303 here can ensure that the encapsulated items are tightly and neatly stacked in the recovery tray 302; the configuration of three different functional layers, namely the operation layer 10, the system configuration layer 20 and the processing layer 30, maximizes the use of the configuration space in the module, and the bottom configuration processing layer 30 can complete the sealing film recovery process relatively independently and without interference, which also ensures that the contamination risk of the entire recovery process operation for other unprocessed samples can be basically ignored.

[0070] The bottom substrate of the processing layer 30 is also connected to the centrifugal module 3 and the transfer module 4. The centrifugal mechanism of the centrifugal module 3 is adapted to the centrifugal processing area 206 of the system configuration layer 20; the transfer module 4 has a vertical substrate (not shown in the figure) connecting the processing layer 30 and the system configuration layer 20, and a vertical slide rail (not shown in the figure) is arranged on the vertical substrate. The vertical slide rail is provided with a transfer connection block 2072 that can slide up and down, and the transfer connection block 2072 is fixedly connected to a transfer substrate 2071. The transfer substrate 2071 is connected to the vertical slide rail through the transfer connection block 2072. This facilitates the transfer of the items to be packaged in the system configuration layer 20 to the packaging module 301 of the processing layer 30 through the transfer module 4, effectively realizing the packaging and recycling of consumables. At the same time, the centrifugal module 3 is connected to the bottom substrate through the vibration absorbing base 5, which can minimize the impact of centrifugal vibration.

[0071] The top of the module is provided with at least one visual sensing unit (not shown in the figure). The visual sensing unit may be a CCD or CMOS type image sensor. An image recognition algorithm may be used to perform image recognition processing on each visual sensing unit to detect whether the transfer process of the pipetting consumables is normal. It may also monitor in real time whether the supply of consumables and reagents is normal and sufficient to ensure that the consumables and reagents can be replenished in time. The ROI areas of multiple visual sensing units may overlap, so that it is possible to determine whether each visual sensor is normal and whether the acquired image is accurate.

[0072] See also Figures 1 to 10In the present technical solution, the present application utilizes limited space to reasonably arrange more functional modules by configuring the modules into an operation layer 10, a system configuration layer 20 and a processing layer 30 distributed from top to bottom, and configures a first span beam 101 and a second span beam 102 on the operation layer 10, and through the first span beam 101 and the second span beam 102, the first collaboration component 110 and the second collaboration component 120 are configured, so as to realize the automatic circulation of sample liquid, reagents and consumables, etc. The middle system configuration layer 20 contains various types of reagents, consumables and circulation processing areas required for constructing a reaction system, and maximizes the reasonable use of the operation space everywhere so that the module has a higher integration advantage. The lowest processing layer 30 can timely seal and recycle the consumables containing sample liquid or sample processing liquid that may cause contamination risks after use, thereby eliminating the risk of contamination within the module.

[0073] In the present technical solution, different types of clamping units and pipetting units for transferring different liquids are configured in the first collaborative component 110 and the second collaborative component 120, so that each collaborative group can most reasonably configure different consumables or liquid transfer operation sequences within the same time period, so that the operation of the first span beam 101 and the operation of the second span beam 102 can maximize the optimal operation efficiency without interfering with each other, and the idle sequence of the first collaborative component 110 and the second collaborative component 120 is eliminated to the maximum extent. The clamping units and pipetting units in the first collaborative component 110 and the second collaborative component 120 can be The shared span beam and shared guide rail make the system more compact and less likely to interfere with each other between different units. The first span beam 101 and the second span beam 102 can also be connected to the shared extension guide rail 103 at one end in the length direction of the span beam, and the other end can be connected to the shared guide rod 104 through the first roller group 1012 and the second roller group 1022 respectively. In this way, the first span beam 101 and the second span beam 102 can operate in the module with low resistance and reliability. At least one visual sensor unit configured on the top of the module can guide the accurate execution of each step and enable the system to automatically obtain the consumption status of reagents, consumables, etc.

[0074] See also Figure 1 and Figure 2 The first span beam 101 and the second span beam 102 can be made of the same material and configured to have the same size, which ensures that the span beams can be designed in a standardized manner and saves production costs.

[0075] In this embodiment, the core task of the processing layer 30 configured at the bottom is to seal and recover at least part of the consumables transferred by the system configuration layer 20, which is achieved through the packaging module 301. In this embodiment, the detection object can be a nucleic acid fragment, and the recovered object can be a deep-well plate extraction consumable that has completed the transfer of the eluent. Since the extraction deep-well plate has been in contact with the sample, it can be automatically sealed and packaged, which will greatly reduce the risk of contamination of the operator and can avoid the risk of cross-contamination to a great extent. The packaging module 301 can be an aluminum foil thermal packaging module 301. Under the action of thermal packaging, the aluminum foil can be reliably covered on the deep-well plate consumables, and the deep-well plate consumables that have completed the package can be further sucked by the suction cup 303.

[0076] See also Figure 7 The reagent storage area 201 includes a plurality of columns for storing reagent bottles, each column can store a reagent tube rack composed of a plurality of reagent bottles (not shown in the figure), and a relevant sensor can be configured in each column to detect whether the reagent tube rack configured in each column is correct. A RFID or similar sensor unit can be configured here. Since the liquid reagent in the reagent tube needs to be stored under low temperature conditions to ensure its activity, a refrigeration module is configured in this storage area. The heat dissipation duct 2011 of the refrigeration module can pass through the width direction of the automatic processing module. The refrigeration module here can be configured as a plurality of TEC The TEC is a module with a set cooling capacity composed of units. The hot end of the TEC is heat-transfer connected to the heat sink configured in the heat dissipation duct 2011, and the cold end can provide a refrigeration temperature lower than the ambient temperature and suitable for storing reagents. By configuring a number of fan units (not shown in the figure) in the heat dissipation duct 2011, the waste heat generated by the refrigeration module can be dissipated in time through the heat dissipation duct 2011. The heat dissipation duct 2011 configured along the automated processing module here has a shorter size feature, so the resistance in the heat dissipation duct 2011 is also lower, which can ensure that the waste heat of the refrigeration module is dissipated in time and efficiently.

[0077] See also Figure 8In this embodiment, the first span beam 101 can drive the tube clamping unit 111 to move to the top of the reagent storage area 201, and the tube clamping drive assembly drives the tube clamping unit 111 to descend to a suitable position to clamp the corresponding type of reagent tube, and drive it to move to the reagent tube cover opening and closing operation area 203, where the reagent tube cover opening and closing operation area 203 can be configured with a reagent tube fixing mechanism (not shown in the figure), the tube clamping unit 111 can be driven, and then the lid of the reagent tube is clamped and rotated, and the lid that has completed the opening and separation operation can be driven to the corresponding position of the reagent tube cover storage area 204 for storage. In order to ensure the convenience of operation and space saving, the tube clamping unit 111 can be driven to clamp the lid of the reagent tube and rotate it. In order to improve the utilization rate of the reagent tube cover, a reaction consumables receiving area (not shown in the figure) is reserved at the edge of the reagent tube cover storage area 204. The reaction consumables receiving area can receive the reaction consumables that have been opened. At this time, the second pipetting unit 122 on the second span beam 102 can be driven to the same area to perform the transfer operation of different types of reagents into the reaction consumables. In this way, the reagent pipetting can be performed efficiently and quickly, and the reaction consumables that have completed the pipetting can be clamped by the consumable clamping unit 121 and transferred to other areas for subsequent processing. Of course, the first collaborative component 110 and the second collaborative component 120 can be driven between different areas to perform other similar pipetting consumables transfer operations.

[0078] See also Fig. 9 In order to ensure that the vibration and noise during the operation of the centrifugal module 3 have the least impact on other functional modules, the centrifugal module 3 includes a vibration absorbing base 5 with a preset volume. The entire module has a certain height so that the core mechanism of the centrifugal module 3, that is, the centrifugal mechanism, can be configured in the centrifugal processing area 206 of the system configuration layer 20. The transfer module 4 can connect the processing layer 30 and the system configuration layer 20, and it includes a vertical substrate connecting the processing layer 30 and the system configuration layer 20. A vertical slide rail is configured on the vertical substrate. The transfer substrate 2071 is engaged with the vertical slide rail through a transfer connecting block 2072. The transfer drive motor (not shown in the figure) can also be connected to the transfer connecting block 2072 through a transfer transmission mechanism (not shown in the figure). In this way, the transfer substrate 2071 can be driven to vertically shuttle between the processing layer 30 and the system configuration layer 20 through the operation of the transfer drive motor, and the used deep well plate consumables can be transferred from the transfer module receiving area 207 to the processing layer 30 to complete the sealing and centralized recovery and processing operation.

[0079] See also Fig.10After the transfer module 4 transfers the deep-well plate consumables to be processed to the processing layer 30, the processing span beam 310 can drive the processing clamping unit (not shown in the figure) configured therein to transfer the consumables to the packaging area to be packaged of the packaging module 301. Here, the processing span beam 310 can be driven by the processing drive motor 321 through the processing transmission mechanism (not marked in the figure) to move along the vertical direction of the length of the processing span beam 310. The processing transmission mechanism includes a processing active wheel 322 connected to the shaft of the processing drive motor 321, a processing transmission belt 323 and a processing driven wheel 325. A processing connection is configured on the processing transmission belt 323. The processing connecting block is connected to one end of the processing cross beam 310 in the length direction, and the processing connecting block is also connected to the processing extension guide rail 324 in an engaging manner. The processing cross beam 310 drives the suction cup 303 configured thereon to attract the sealing unit such as the aluminum foil that can be connected by heat sealing, and transfer the aluminum foil to the deep-well plate consumables in the area to be packaged. After that, the packaging module 301 can realize the heat sealing connection between the aluminum foil and the deep-well plate consumables to form the packaged deep-well plate consumables. Finally, the suction cup 303 can use the vacuum adsorption effect to adsorb the packaged deep-well plate consumables, and transfer them to the recovery tray 302 to complete the recovery.

[0080] The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. An automated processing module, characterized in that: Includes operation layer, system configuration layer and processing layer; The operation layer, the system configuration layer and the processing layer are stacked one on another, the operation layer has a first span beam and a second span beam that can be driven to move, the first span beam is adapted to be equipped with a first cooperation component, the second span beam is adapted to be equipped with a second cooperation component, the first cooperation component and the second cooperation component can be driven to reciprocate along the length direction of the first span beam and the second span beam respectively; The system configuration layer has a reagent storage area, a transfer channel area, a consumable storage area, a reaction solution preparation area and a centrifugal treatment area, and the first cooperative component and the second cooperative component are movably adapted to the reagent storage area, the transfer channel area, the consumable storage area, the reaction solution preparation area and the centrifugal treatment area; The processing layer has a packaging module for sealing and recovering at least part of the consumables in the system configuration layer.

2. An automated processing module according to claim 1, characterized in that: The first span beam and the second span beam are parallel to each other, and a common extension guide rail is provided at one end of the first span beam and the second span beam in the length direction, and the first span beam and the second span beam at this end are slidably engaged and connected to the common extension guide rail; The other ends of the first span beam and the second span beam in the length direction are respectively provided with a first roller group and a second roller group, and the ends of the first span beam and the second span beam are respectively rollingly connected to a common guide rod through the first roller group and the second roller group.

3. An automated processing module according to claim 1, characterized in that: The first cooperative component comprises a tubular clamping unit and one or more first pipetting units, and the second cooperative component comprises a consumable clamping unit for a preset matching width range and one or more second pipetting units.

4. An automated processing module according to claim 3, characterized in that: The first span beam is provided with a first span beam common guide rail extending along the length direction thereof, a first span beam connecting base is provided between the tubular clamping unit and the first liquid transfer unit, the tubular clamping unit and the first liquid transfer unit are respectively connected to two sides of the first span beam connecting base, and the first span beam connecting base is movably straddled on the first span beam; A first sliding block is provided on the inner side of the first span beam connection base body at a position corresponding to the first span beam common guide rail, and the first span beam connection base body is movably engaged with the first span beam common guide rail through the first sliding block.

5. An automated processing module according to claim 3, characterized in that: The second span beam is provided with a second span beam common guide rail extending along the length direction thereof, a second span beam connecting base is provided between the consumable material clamping unit and the second liquid transfer unit, the consumable material clamping unit and the second liquid transfer unit are respectively connected to two sides of the second span beam connecting base, and the second span beam connecting base is movably straddled on the second span beam; A second sliding block is provided on the inner side of the second span beam connection base body at a position corresponding to the second span beam common guide rail, and the second span beam connection base body is movably engaged and connected to the second span beam common guide rail through the second sliding block.

6. An automated processing module according to claim 1, characterized in that: The reagent storage area has a refrigeration module.

7. An automated processing module according to claim 1, characterized in that: The system configuration layer also has a reagent tube cover opening and closing operation area, a reagent tube cover storage area, a transfer module receiving area that can connect the system configuration layer and the processing layer, and a first consumable material storage area is also provided adjacent to the reagent storage area. The transfer channel area is located in the middle of the system configuration layer.

8. An automated processing module according to claim 1, characterized in that: A movable suction cup is provided on one side of the packaging module, and a recovery tray is provided under the suction cup.

9. An automated processing module according to claim 1, characterized in that: The bottom substrate of the processing layer is also connected to a centrifugal module and a transfer module, and the centrifugal mechanism of the centrifugal module is adapted to the centrifugal processing area of ​​the system configuration layer; The transfer module has a vertical substrate connecting the processing layer and the system configuration layer, a vertical slide rail is arranged on the vertical substrate, a transfer connection block that can slide up and down is provided on the vertical slide rail, the transfer connection block is fixedly connected with the transfer substrate, and the transfer substrate is engaged and connected with the vertical slide rail through the transfer connection block.

10. An automated processing module according to claim 1, characterized in that: No less than one visual sensing unit is provided on the top of the module.

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