Sodium chloride cell infusion bag set with double-head infusion apparatus
By designing a sodium chloride cell return bag set with a double-head infusion set, the problem of being unable to effectively flush residual cells during the recovery of cell cryopreservation bags is solved, achieving more thorough flushing and mixing of cell preparations, and reducing cell waste.
Patent Information
- Application Number
- CN202420848958.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-23
- Publication Date
- 2025-01-24
- Estimated Expiration
- 2034-04-23
AI Technical Summary
The prior art cannot effectively rinse the residual cells during the recovery of cell freezing bags, resulting in cell waste and economic losses.
A sodium chloride cells containing sodium chloride cells containing a double -headed infusion device are designed to connect the cell frozen storage bag and salt water bottle through the double -headed infusion device. Cell residue.
This set can be fully washed and mixed with cell preparations before injection, to avoid cell residues and waste, and the washing method is more thorough, reducing cell residues in the cell frozen bags.
Smart Images
Figure CN222383754U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of cell freezing bags, in particular to a sodium chloride cell reinfusion bag set containing a double-head infusion device. Background Art
[0002] Cell cryopreservation is a continuation of the cell culture process. It uses cryopreservation technology and corresponding equipment or devices to store cells at low temperatures in liquid nitrogen to keep the cells dormant and out of growth and preserve the characteristics of the cells. When these cells are needed, the frozen cells are revived. At present, cryopreservation bags are usually used to package frozen cells for use during resuscitation. During the resuscitation process, the cells in the cryopreservation bags cannot be drained clean, and there will be residual cells in the bag. If they are not rinsed, the residual cells will cause waste, which is both a waste of medicine and an economic waste for patients.
[0003] There are two existing methods for cell reinfusion: one is to directly use a cell freezing bag, take it out of liquid nitrogen, quickly place it in a 37-degree water bath for rapid recovery, and then reinfuse it, and then rinse it with saline; the other is to inject the cell preparation into an ordinary saline bag, connect it with a double-head infusion set, introduce a portion of the saline into the cell preparation bag, and rinse the bag repeatedly; when using the second method, there is no set of reinfusion bag sets specifically for cell transfusion. As a large number of dry and cell-free drugs are entering the clinical trial stage, related cell products will be launched in the future and will be more widely used. There is an urgent need for cell transfusion flushing bags to fill this gap. Summary of the invention
[0004] The utility model aims to provide a sodium chloride cell reinfusion bag set containing a double-head infusion device in view of the problems existing in the prior art.
[0005] In order to achieve the above purpose, the technical solution adopted by the utility model is:
[0006] A sodium chloride cell reinfusion bag set containing a double-head infusion set, comprising a cell freezing bag and a saline bag, and a double-head infusion set connecting the cell freezing bag and the saline bag; one side of the cell freezing bag is provided with a plurality of puncture connectors, and the other side is provided with a first plug-in terminal, one side of the saline bag is provided with a puncture connector and a second plug-in terminal side by side, and the two ends of the double-head infusion set are respectively connected to the first plug-in terminal and the second plug-in terminal; the two ends of the double-head infusion set are respectively provided with a plurality of infusion holes, and after the double-head infusion set is plugged in place, at least one of the infusion holes is located at the intersection of the inner end of the first plug-in terminal and the inner cavity of the cell freezing bag.
[0007] The sodium chloride cell reinfusion bag set containing a double-head infusion device improves the cell freezing bag and the saline bag and their connection method, so that the set can use the saline bag for cell reinfusion and injection, greatly reducing the cell residues in the cell freezing bag.
[0008] By setting it in this way, on the one hand, the cell preparation can be fully rinsed and mixed before injection to avoid the cell preparation remaining in the cell freezing bag and sticking to the wall; on the other hand, the cell freezing bag and the saline bag can be laid flat, and the cell preparation can be fully taken away by the saline by repeated rubbing and squeezing, which is also convenient for manual operation; compared with the method of rinsing by the weight of the saline in the hanging state, the flushing method of the present application will be more thorough.
[0009] Furthermore, the double-head infusion pump includes a double-head main body, wherein both ends of the double-head main body are respectively provided with a plug-in rod portion, the end of the plug-in rod portion is provided with a plug-in tip, the outer periphery of the plug-in rod portion is provided with a plurality of infusion holes, the outer diameter of the plug-in rod portion is smaller than the outer diameter of the double-head main body, and the plug-in rod portion and the double-head main body are internally provided with an infusion channel connecting the infusion holes.
[0010] Furthermore, assuming that the distance between the end of the infusion hole close to the double-headed body and the end face of the double-headed body is a, the distance between the midpoint of the infusion hole and the end face of the double-headed body is b, and the distance between the outer end face of the first plug-in end and the nearest point of the inner cavity of the cell freezing bag at the first plug-in end is c, then a<c<b.
[0011] Furthermore, the outer periphery of the double-headed main body is provided with anti-slip textures, which is convenient for users to hold and perform plug-in operations.
[0012] In some embodiments, the inner circumference of the double-headed main body is provided with a curved surface protrusion structure that protrudes toward the middle.
[0013] In some embodiments, the arc-surface raised structure is an elastic structure, and a cavity is provided inside the arc-surface raised structure.
[0014] Furthermore, the infusion holes are strip holes, flat holes or elliptical holes, and there are 2 to 5 infusion holes that are centrally symmetrically arranged.
[0015] Furthermore, a hanging hole is provided on a side of the saline bag away from the second plug-in terminal, so that the saline bag can be hung on an infusion stand for use.
[0016] In some embodiments, the saline bag is further provided with a third plug-in terminal at the end where the second plug-in terminal is located, and the inner cavity of the saline bag is provided with a secondary cavity near the third plug-in terminal, and the secondary cavity is also provided with saline.
[0017] Furthermore, the four corners of the inner cavity of the cell freezing bag and the four corners of the inner cavity of the saline bag are respectively rounded structures.
[0018] Compared with the prior art, the beneficial effects of the utility model are as follows: 1. The sodium chloride cell reinfusion bag set containing the double-head infusion set improves the cell freezing bag and the saline bag and their connection method, so that the set can use the saline bag for cell reinfusion, which greatly reduces the cell residue in the cell freezing bag; 2. Through this arrangement, on the one hand, the cell preparation can be fully rinsed and mixed before injection to avoid the cell preparation remaining in the cell freezing bag and hanging on the wall; on the other hand, the cell freezing bag and the saline bag can be laid flat, and the cell preparation can be fully taken away by the saline by repeated rubbing and squeezing, which is also convenient for manual operation; 3. Compared with the method of flushing by the dead weight of saline in the hanging state, this flushing method of the present application will be more thorough; 4. The arc-shaped ridge structure can change the inner diameter size of the infusion channel in the double-head infusion set, so that it can change the flow rate and flow rate of the liquid passing there. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 This is a schematic diagram of the overall structure of a sodium chloride cell reinfusion bag set containing a double-head infusion device of the utility model;
[0020] Figure 2 This is a schematic diagram of the split structure of a sodium chloride cell reinfusion bag set containing a double-head infusion device of the utility model;
[0021] Figure 3 It is a schematic cross-sectional structure diagram of the double-head infusion set of the utility model;
[0022] Figure 4 This is a schematic cross-sectional structure diagram of another double-head infusion set of the utility model;
[0023] Figure 5 This is a schematic cross-sectional structure diagram of another double-head infusion set of the utility model;
[0024] Figure 6 for Figure 5 Schematic diagram of the AA section structure;
[0025] Figure 7 for Figure 5 Another structural diagram of the AA section;
[0026] Figure 8 This is another structural schematic diagram of the sodium chloride cell reinfusion bag set with a double-head infusion device of the utility model;
[0027] In the figure: 1. cell freezing bag; 2. saline bag; 3. double-head infusion set; 301. double-head body; 302. plug-in rod; 303. plug-in tip; 304. infusion channel; 4. puncture connector; 5. first plug-in terminal; 6. second plug-in terminal; 7. infusion hole; 8. hanging hole; 9. arc-surface ridge structure; 10. cavity; 11. third plug-in terminal; 12. auxiliary cavity. DETAILED DESCRIPTION
[0028] The following will be combined with the drawings in the utility model to clearly and completely describe the technical solution of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0029] In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "middle", "upper", "lower", "left", "right", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.
[0030] like Figure 1 to Figure 3 As shown, a sodium chloride cell reinfusion bag set containing a double-head infusion set includes a cell freezing bag 1 and a saline bag 2, and a double-head infusion set 3 connecting the cell freezing bag 1 and the saline bag 2; a plurality of puncture connectors 4 are provided on one side of the cell freezing bag 1, and a first plug-in terminal 5 is provided on the other side; a puncture connector 4 and a second plug-in terminal 6 are provided side by side on one side of the saline bag 2, and the two ends of the double-head infusion set 3 are respectively connected to the first plug-in terminal 5 and the second plug-in terminal 6; a plurality of infusion holes 7 are respectively provided on the two ends of the double-head infusion set 3, and after the double-head infusion set 3 is plugged in, at least one of the infusion holes 7 is located at the intersection of the inner end of the first plug-in terminal 5 and the inner cavity of the cell freezing bag 1.
[0031] The sodium chloride cell reinfusion bag set containing a double-head infusion device improves the cell freezing bag 1 and the saline bag 2 and their connection method, so that the set can use the saline bag for cell reinfusion, greatly reducing the cell residues in the cell freezing bag.
[0032] Normally, the cell freezing bag is used for cell injection. During the injection process, the saline bag needs to be used as a flushing bag to flush the cell freezing bag, so as to flush the cells remaining on its inner wall for injection, so as to avoid cell waste. The present application is to use the double-headed infusion device 3 to connect the cell freezing bag 1 and the saline bag 2 before injection, inject the cell preparation in the cell freezing bag 1 into the saline bag 2 for mixing, and also allow the physiological saline in the saline bag 2 to introduce a part into the cell freezing bag 1, repeatedly flush and mix the cell preparation in the cell freezing bag 1, and then allow all the liquids to enter the saline bag for injection. By setting in this way, on the one hand, the cell preparation can be fully flushed and mixed before injection, so as to avoid the cell preparation from remaining and hanging on the wall in the cell freezing bag; on the other hand, the cell freezing bag and the saline bag can be laid flat, and the cell preparation can be fully taken away by the saline by repeated rubbing and squeezing, which is also convenient for manual operation; compared with the method of flushing by saline deadweight in the hanging state, this flushing method of the present application will be more thorough.
[0033] The structures of the first plug-in terminal 5 and the second plug-in terminal 6 are basically similar, both of which are normally closed structures. When the double-head infusion set 3 is inserted therein, the two can be connected, and the liquids in the two bags can flow or exchange. Under the action of external force, the flow rate of the liquid can be accelerated and the direction of the liquid flow can be controlled.
[0034] After the double-head infusion device 3 is plugged into place, the infusion hole 7 is exactly at the intersection of the inner end of the first plug-in terminal and the inner cavity of the cell freezing bag or the inner end of the second plug-in terminal and the inner cavity of the saline bag, that is, a part of the infusion hole 7 is at the plug-in channel. The purpose of this arrangement is to allow all the liquid in the bag body to flow out and avoid residual liquid between the infusion hole and the inner cavity. Under normal circumstances, the infusion hole is completely located in the inner cavity, so there will be a small gap between the infusion hole and the lowest point of the inner cavity, and liquid will accumulate in this place. For very expensive cell preparations, this accumulated liquid is also a waste. Therefore, through this method of the present application, it can be ensured that all the liquid in the cell freezing bag flows out from the infusion hole. In actual operation, the double-head infusion device 3 can also be connected to the puncture connector or plug-in terminal at other positions on the bag body.
[0035] Furthermore, the double-head infusion device 3 includes a double-head main body 301, and the two ends of the double-head main body 301 are respectively provided with a plug-in rod portion 302, and the end of the plug-in rod portion 302 is provided with a plug-in tip 303, and the outer periphery of the plug-in rod portion 302 is provided with a plurality of infusion holes 7, and the outer diameter of the plug-in rod portion 302 is smaller than the outer diameter of the double-head main body 301, and the plug-in rod portion 302 and the double-head main body 301 are provided with an infusion channel 304 connected to the infusion hole 7.
[0036] The configuration of the plug-in tip 303 facilitates the insertion of the double-head infusion set 3 from the first plug-in end into the cell freezing bag and from the second plug-in end into the saline bag; the plug-in rod portion 302 can form a stable plug-in structure and a sealing structure at each plug-in end, while ensuring that it has a certain insertion depth; the double-head body 301 and the plug-in rod portion 302 have different sizes, and can form a step structure at the intersection of the two, and can form a limiting structure when cooperating with the respective plug-in ends, so that the infusion hole reaches the expected position.
[0037] Further, such as Figure 2 As shown, assuming that the distance between the end of the infusion hole 7 close to the double-headed main body 301 and the end face of the double-headed main body 301 is a, the distance between the midpoint of the infusion hole 7 and the end face of the double-headed main body 301 is b, and the distance between the outer end face of the first plug-in terminal 5 and the nearest point of the inner cavity of the cell freezing bag 1 at the first plug-in terminal is c, then a<c<b.
[0038] Through the above-mentioned size limitation, it can be ensured that when the double-head infusion set 3 is inserted in place, the infusion hole 7 can be located at the insertion channel of the inner cavity, most of the infusion hole is located in the inner cavity, at least a part of its edge is in the insertion channel, so that it can be ensured that the liquid in the inner cavity can flow out completely.
[0039] Furthermore, the outer periphery of the double-headed main body 301 is provided with anti-slip textures, which can improve the hand feel and facilitate the user to hold and perform plug-in operations.
[0040] In other embodiments, Figure 4 As shown, the inner circumference of the double-head body 301 is provided with a curved surface bulge structure 9 that bulges toward the middle. The curved surface bulge structure 9 can change the inner diameter size of the infusion channel 304 in the double-head infusion device, so that the middle part has a narrowing part. Such a setting can change the flow rate and flow velocity of the liquid passing through the part, and when the liquid is transferred between the two bags, the liquid can be sprayed out from the infusion hole.
[0041] The double-head infusion set 3 is made of plastic. Although it has a certain strength (ensuring that it can be plugged in and out), it can still be deformed under the action of external force. In some processing methods, such as when saline enters the cell freezing bag for repeated flushing, a certain pressure can be artificially applied to reduce the inner circumference of the double-head body or even close it, so that the saline can remain in the cell freezing bag for a while to repeatedly flush its inner cavity.
[0042] In some embodiments, Figure 5 As shown, the arc surface ridge structure 9 is an elastic structure, and a cavity 10 is provided in the arc surface ridge structure 9. The arc surface ridge structure 9 is set as an elastic structure and cooperates with the setting of the cavity 10, so that the inner circumference size at this place is more variable, and its inner diameter will change significantly according to the extrusion pressure.
[0043] The cavity 10 may be a ring-shaped cavity structure (such as Figure 6 As shown), it can also be multiple small, independent arc-shaped cavities (such as Figure 7 shown).
[0044] Furthermore, the infusion hole 7 is an elliptical hole, and there are four infusion holes 7 arranged symmetrically with respect to the center.
[0045] Furthermore, a hanging hole 8 is provided on a side of the saline bag 2 away from the second plug-in terminal, so that the saline bag 2 can be hung on an infusion stand during injection.
[0046] Furthermore, the four corners of the inner cavity of the cell freezing bag 1 and the four corners of the inner cavity of the saline bag 2 are rounded structures. Through such a configuration, the right angles and acute angles of the inner cavity of each bag can be reduced, liquid residue in the corners can be avoided, and liquid flow is also facilitated.
[0047] In some embodiments, Figure 8 As shown, the saline bag 2 is further provided with a third plug-in terminal 11 at the end where the second plug-in terminal is located, and the inner cavity of the saline bag 2 is provided with a secondary cavity 12 near the third plug-in terminal 11, and the secondary cavity 12 is also provided with saline.
[0048] By setting the auxiliary cavity 12, after the liquid in the cell freezing bag 1 is transferred to the saline bag 2, the saline in the auxiliary cavity 12 can be continuously used to finally rinse the cell freezing bag 1, thereby minimizing cell residues.
[0049] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A sodium chloride cell reinfusion bag set containing a double-head infusion set, characterized in that: It comprises a cell freezing bag and a saline bag, and a double-head infusion set connecting the cell freezing bag and the saline bag; one side of the cell freezing bag is provided with a plurality of puncture connectors, and the other side is provided with a first plug-in terminal, one side of the saline bag is provided with a puncture connector and a second plug-in terminal side by side, and the two ends of the double-head infusion set are respectively connected to the first plug-in terminal and the second plug-in terminal; the two ends of the double-head infusion set are respectively provided with a plurality of infusion holes, and after the double-head infusion set is plugged in place, at least one of the infusion holes is located at the intersection of the inner end of the first plug-in terminal and the inner cavity of the cell freezing bag.
2. The sodium chloride cell reinfusion bag set containing a double-head infusion set according to claim 1, characterized in that: The double-head infusion device includes a double-head main body, with plug-in rods at both ends of the double-head main body, plug-in tips at the ends of the plug-in rods, a plurality of infusion holes at the periphery of the plug-in rods, an outer diameter of the plug-in rods smaller than an outer diameter of the double-head main body, and an infusion channel connecting the infusion holes is provided inside the plug-in rods and the double-head main body.
3. The sodium chloride cell reinfusion bag set containing a double-head infusion set according to claim 2, characterized in that: Assume that the distance between the end of the infusion hole close to the double-headed main body and the end face of the double-headed main body is a, the distance between the midpoint of the infusion hole and the end face of the double-headed main body is b, and the distance between the outer end face of the first plug-in end and the nearest point of the inner cavity of the cell freezing bag at the first plug-in end is c, then a<c<b.
4. The sodium chloride cell reinfusion bag set containing a double-head infusion set according to claim 2, characterized in that: The outer periphery of the double-headed main body is provided with anti-slip textures.
5. The sodium chloride cell reinfusion bag set containing a double-head infusion set according to claim 2, characterized in that: The inner circumference of the double-headed main body is provided with an arc-surface protrusion structure which protrudes toward the middle.
6. The sodium chloride cell reinfusion bag set containing a double-head infusion set according to claim 5, characterized in that: The arc surface raised structure is an elastic structure, and a cavity is arranged inside the arc surface raised structure.
7. The sodium chloride cell reinfusion bag set with a double-head infusion set according to claim 1, characterized in that: The infusion holes are strip holes, flat holes or elliptical holes, and there are 2 to 5 infusion holes that are centrally symmetrically arranged.
8. The sodium chloride cell reinfusion bag set with a double-head infusion set according to claim 1, characterized in that: A hanging hole is also provided on one side of the saline bag away from the second plug-in end.
9. The sodium chloride cell reinfusion bag set with a double-head infusion set according to claim 1, characterized in that: The saline bag is also provided with a third plug-in terminal at the end where the second plug-in terminal is located, and the inner cavity of the saline bag is provided with a secondary cavity near the third plug-in terminal, and the secondary cavity is also provided with saline.
10. The sodium chloride cell reinfusion bag set with a double-head infusion set according to claim 1, characterized in that: The four corners of the inner cavity of the cell freezing bag and the four corners of the inner cavity of the saline bag are respectively rounded structures.