Mouse fixing device for functional magnetic resonance imaging in waking state

Abstract

The utility model relates to the technical field of medical equipment, and particularly discloses a mouse fixing device for functional magnetic resonance imaging in a waking state, which comprises an object carrying platform, a mouse fixing device and a mouse fixing device, the thread fixing platform comprises a fixing seat, and the fixing seat is fixedly mounted on the outer wall of the top of the carrying plate; fixing blocks are fixedly mounted on the two sides of the outer wall of the top of the fixing base, threaded mounting bases are mounted on the outer walls of the tops of the two fixing blocks, clamping arms are mounted at the top ends of the two threaded mounting bases, and the same bonding platform protruding forwards is mounted on the outer walls of the opposite sides of the two clamping arms; when the mouse is in a waking state, the mouse head movement and rotation range is limited, the mouse brain activity level and the nucleus activation state can be researched more deeply, the influence of sedative and anesthetic drugs on functional magnetic resonance imaging is effectively reduced, and the imaging time is shortened.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a mouse fixing device used for awake state functional magnetic resonance imaging. Background Art

[0002] At present, functional magnetic resonance imaging has been widely used in basic and clinical research on brain cognition and brain diseases. Especially in the field of basic research, rodents are often selected as model animals for functional magnetic resonance imaging experiments. In previous studies, anesthesia or sedation was mostly used. This is mainly because the functional magnetic resonance imaging scan time is long and requires the head to remain fixed for a long time. Anesthesia and sedation can keep the mouse head fixed, but both anesthesia and sedation will inevitably change the whole brain activity and metabolic level, and to a certain extent will inhibit the activation state of the whole brain nuclei. Although the depth of anesthesia or sedation can be evaluated by auxiliary means such as heart rate, blood pressure, and respiratory monitoring under anesthesia or sedation, it is still difficult to unify the standards, which makes it difficult to eliminate the differences between different studies. Therefore, a device that can effectively fix mice in a waking state is particularly important.

[0003] In a Chinese patent with publication number CN206333899U, a small animal head fixing device for magnetic resonance imaging is mentioned, including a body restraint tube, a head restraint tube, a back cover, a body restraint tube outer wall thread, and a head restraint tube outer wall thread. The body restraint tube is a cylinder, and a quarter of the lower part of the cylinder is a cross-sectional plane for convenient placement on a plane. There is a back cover at the tail of the body restraint tube, and the head restraint tube is a cylinder, which is slightly larger than the head of a normal small animal. The outer walls of the body restraint tube and the head restraint tube have body restraint tube outer wall threads and head restraint tube outer wall threads, and the threads facilitate the fixed connection of the magnetic resonance imaging device to the body restraint tube and the head restraint tube.

[0004] However, when the above device is in use, the body of the small animal is fixed by a body restraint tube and a head restraint tube, but its head can still move. Functional magnetic resonance imaging takes a long time and requires the head to remain fixed for a long time, so the above device cannot meet the requirements.

[0005] Therefore, those skilled in the art have proposed a mouse fixation device for awake functional magnetic resonance imaging to solve the above-mentioned problems. Utility Model Content

[0006] The utility model aims to provide a mouse fixing device for awake functional magnetic resonance imaging to solve the problems raised in the above background technology.

[0007] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0008] A mouse fixation device for awake functional magnetic resonance imaging, comprising:

[0009] A loading platform, the loading platform comprising a loading plate;

[0010] A threaded fixing platform, the threaded fixing platform comprising a fixing seat, the fixing seat being fixedly mounted on the top outer wall of the loading plate;

[0011] Fixed blocks are fixedly installed on both sides of the top outer wall of the fixing seat, threaded mounting seats are installed on the top outer walls of the two fixing blocks, clamping arms are installed on the tops of the two threaded mounting seats, and the same forward-protruding bonding platform is installed on the outer wall on the opposite side of the two clamping arms, and the bonding platform is located directly above the fixing seat.

[0012] Preferably, side panels are fixedly mounted on both sides of the top outer wall of the loading plate close to the fixing seat.

[0013] Preferably, blocking bars are fixedly installed on the inner sides of both ends of the top outer wall of the loading plate close to the side plates.

[0014] Preferably, a raised groove is fixedly installed on the top outer wall of the loading plate near the front of the fixing seat, a toothed fixing platform is sleeved on the top outer wall of the raised groove, an inclined plane is arranged on the top of the toothed fixing platform, and a through hole is arranged on the surface of the toothed fixing platform.

[0015] Preferably, one end of the bonding platform close to the tooth fixing platform is located obliquely above the inclined plane.

[0016] Compared with the prior art, the beneficial effects of the utility model are:

[0017] (1) The utility model provides a clamping arm and a bonding platform, places the entire device on the surface of a nuclear magnetic resonance imaging device, shaves the mouse and exposes the skull bone, applies dental resin to the exposed skull bone, and fits the mouse skull to the bottom of the bonding platform through the dental resin. After the dental resin is photocured, the mouse skull is fixed under the bonding platform, and then the clamping arm is fixed to the surface of the threaded mounting seat by a non-magnetic resin bolt, so that the mouse is fixed between the fixing seat and the bonding platform.

[0018] (2) The utility model sets a raised groove and a tooth fixing platform, fixes the tooth fixing platform through the raised groove, places the mouse head on the inclined plane of the tooth fixing platform, aligns the mouse head with the through hole, and then fixes the mouse with the adhesive platform, so that the mouse can be limited in the range of movement and rotation of the mouse head when the mouse is awake, which facilitates more in-depth research on the mouse brain activity level and the activation state of the nucleus, effectively reduces the influence of sedatives and anesthetics on functional magnetic resonance imaging, and reduces imaging time. The device adopts non-magnetic resin material, and has the characteristics of low cost and rapid promotion. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the main structure of the utility model;

[0021] Figure 3 It is a partial three-dimensional structural schematic diagram of the utility model;

[0022] In the figure: 1, loading platform; 2, threaded fixing platform; 3, clamping arm; 4, bonding platform; 5, raised groove; 6, tooth fixing platform; 7, inclined plane;

[0023] 101, loading board; 102, side board; 103, stop bar;

[0024] 201, fixing seat; 202, fixing block; 203, threaded mounting seat. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1-Figure 3 As shown, a mouse fixation device for awake functional magnetic resonance imaging comprises:

[0027] The object-carrying platform 1 includes an object-carrying plate 101;

[0028] The threaded fixing platform 2 includes a fixing seat 201, and the fixing seat 201 is fixedly mounted on the top outer wall of the loading plate 101;

[0029] Fixed blocks 202 are fixedly installed on both sides of the top outer wall of the fixed seat 201, threaded mounting seats 203 are installed on the top outer walls of the two fixed blocks 202, clamping arms 3 are installed on the tops of the two threaded mounting seats 203, and the same forward-protruding bonding platform 4 is installed on the outer wall on the opposite side of the two clamping arms 3, and the bonding platform 4 is located directly above the fixed seat 201.

[0030] As can be seen from the above, the mouse is shaved and the skull bone is exposed, and the dental resin is applied to the exposed skull bone. The mouse skull is attached to the bottom of the bonding platform 4 through the dental resin. After the dental resin is photocured, the mouse skull is fixed under the bonding platform 4, and then the clamping arm 3 is fixed to the surface of the threaded mounting seat 203 by a non-magnetic resin bolt, and the mouse is fixed between the fixing seat 201 and the bonding platform 4.

[0031] Specifically, side panels 102 are fixedly mounted on both sides of the top outer wall of the loading plate 101 close to the fixing seat 201 .

[0032] It can be seen from the above that the side panels 102 on both sides provide a protective effect.

[0033] Specifically, blocking bars 103 are fixedly installed on the inner sides of both ends of the top outer wall of the loading plate 101 close to the side plates 102 .

[0034] It can be seen from the above that the blocking bars 103 arranged on both sides play a role of limiting and blocking.

[0035] Specifically, a raised groove 5 is fixedly installed on the top outer wall of the loading plate 101 near the front of the fixing seat 201, a toothed fixing platform 6 is sleeved on the top outer wall of the raised groove 5, an inclined plane 7 is arranged on the top of the toothed fixing platform 6, and a through hole is arranged on the surface of the toothed fixing platform 6.

[0036] As can be seen from the above, the provision of the raised groove 5 facilitates the fixing of the tooth fixing platform 6 , and the provision of the inclined plane 7 and the through hole on the surface of the tooth fixing platform 6 facilitates the fixing of the mouse head on the surface of the tooth fixing platform 6 .

[0037] Specifically, one end of the bonding platform 4 close to the tooth fixing platform 6 is located obliquely above the inclined plane 7 .

[0038] As can be seen from the above, fixing the mouse by the bonding platform 4 and the tooth fixing platform 6 makes it easier for the mouse to shake its head, thereby facilitating a more in-depth study of the mouse's brain activity level and the activation state of the nuclei.

[0039] Working principle: place the entire device on the surface of the nuclear magnetic resonance imaging equipment, shave the mouse and expose the skull bone, apply dental resin to the exposed skull bone, fit the mouse skull to the bottom of the bonding platform 4 through the dental resin, light-cure the dental resin, fix the mouse skull under the bonding platform 4, and then fix the clamping arm 3 to the surface of the threaded mounting seat 203 through non-magnetic resin bolts, fix the mouse between the fixing seat 201 and the bonding platform 4, place the mouse head on the inclined plane 7 of the tooth fixing platform 6, so that the mouse head is aligned with the through hole, and then cooperate with the bonding platform 4 to complete the fixation of the mouse, place the ultra-low temperature head coil above the bonding platform 4, and cooperate with the nuclear magnetic resonance imaging equipment to perform functional magnetic resonance imaging experiments on the mouse head, so that the mouse is in an awake state, and the movement and rotation range of the mouse head is limited, which is convenient for more in-depth research on the mouse brain activity level and the activation state of the nuclei.

[0040] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A mouse fixation device for awake functional magnetic resonance imaging, characterized in that: include: A loading platform (1), the loading platform (1) comprising a loading plate (101); A threaded fixing platform (2), the threaded fixing platform (2) comprising a fixing seat (201), the fixing seat (201) being fixedly mounted on the top outer wall of the loading plate (101); Fixed blocks (202) are fixedly mounted on both sides of the top outer wall of the fixing seat (201); threaded mounting seats (203) are mounted on the top outer walls of the two fixing blocks (202); clamping arms (3) are mounted on the top ends of the two threaded mounting seats (203); and a common bonding platform (4) protruding forward is mounted on the outer walls on the opposite sides of the two clamping arms (3); the bonding platform (4) is located directly above the fixing seat (201).

2. A mouse fixation device for awake functional magnetic resonance imaging according to claim 1, characterized in that: Side plates (102) are fixedly mounted on both sides of the top outer wall of the object loading plate (101) close to the fixing seat (201).

3. The mouse fixation device for awake functional magnetic resonance imaging according to claim 1, characterized in that: Baffle bars (103) are fixedly mounted on the inner sides of both ends of the top outer wall of the loading plate (101) close to the side plates (102).

4. The mouse fixation device for awake functional magnetic resonance imaging according to claim 1, characterized in that: A raised groove (5) is fixedly installed on the top outer wall of the loading plate (101) near the front of the fixing seat (201), a toothed fixing platform (6) is sleeved on the top outer wall of the raised groove (5), an inclined plane (7) is arranged on the top of the toothed fixing platform (6), and a through hole is arranged on the surface of the toothed fixing platform (6).

5. The mouse fixation device for awake functional magnetic resonance imaging according to claim 4, characterized in that: One end of the bonding platform (4) close to the tooth fixing platform (6) is located obliquely above the inclined plane (7).

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