Fixing device for mouse back acupuncture point electroacupuncture stimulation

Abstract

The utility model discloses a fixing device for mouse back acupoint electroacupuncture stimulation, the fixing device comprises a fixing piece, a fixer and a fixing support, the fixing piece is used for being fixed on the back of a mouse, the fixing piece is provided with a first avoiding hole, the fixer is installed on the fixing piece, the fixer is provided with a second avoiding hole corresponding to the first avoiding hole, and the fixing support is fixed on the fixing piece. The fixing support is installed on the fixing part and used for fixing the electric needle electrode, the electric needle electrode is used for clamping the needle instrument, and the needle instrument can penetrate through the second avoiding hole and the first avoiding hole to penetrate through the back acupuncture points of the mouse. The fixing device can conveniently perform electroacupuncture stimulation on acupuncture points on the back of the mouse on the premise of ensuring that the experimental mouse has a certain free activity space, and the real-time recording of the mouse brain calcium signal change by the optical fiber is not influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental equipment, in particular to a fixing device for electroacupuncture stimulation of acupuncture points on the back of mice. Background Art

[0002] Mouse electroacupuncture stimulation is a method used in the laboratory to study the effects of acupuncture. It simulates the process of human acupuncture by applying a weak current to specific acupuncture points on mice. The principle of mouse electroacupuncture is based on the theory of meridians in traditional Chinese medicine. It is believed that there are twelve main meridians in the human body, each with several acupuncture points, which are closely related to the internal organs of the human body. By stimulating these acupuncture points, the circulation of qi and blood in the human body can be regulated to achieve the purpose of treating and preventing diseases. The advantages of mouse electroacupuncture are that it can reduce trauma and pain to mice, and at the same time, the intensity and time of the current can be more accurately controlled, thereby improving the repeatability and comparability of the experiment. Mouse electroacupuncture has been used to study a variety of diseases, such as neurodegenerative diseases, cardiovascular diseases, tumors, inflammation, etc., and has achieved some positive results. However, the use of mice in experiments to restore the clinical acupuncture process still faces some problems. For example, in clinical practice, patients can follow the doctor's requirements to place fixed positions to cooperate with the acupuncture process (such as supine, prone, sitting, etc.), but animal experiments including mouse experiments cannot meet this requirement. The selection of appropriate fixation method in mouse acupuncture experiments is one of the major problems that cannot be avoided in current basic acupuncture experiments.

[0003] There are three technical solutions for electroacupuncture stimulation of mouse back acupoints that may be used for real-time calcium ion fiber optic recording: (1) Operation after mouse anesthesia. Mouse anesthesia is a commonly used operation in laboratory animal research, which can reduce pain and discomfort in mice. General anesthesia methods include inhalation anesthesia, injection anesthesia and oral anesthesia. After anesthesia, calcium ion fiber optic recording is performed and electroacupuncture is performed on the mouse back acupoints at the same time. (2) The mouse is fixed with a mouse whole body fixator. The mouse whole body fixator can fix the mouse's head in a specific position for acupuncture or other operations. (3) The mouse is fixed with a mouse limb restraint fixator. The mouse limb restraint fixator is an instrument used in laboratory animal experiments. The mouse's limbs can be fixed on a flat plate for various operations or observations.

[0004] The above three methods have the following disadvantages: (1) The existing real-time calcium ion fiber optic recording and back acupuncture point electroacupuncture stimulation under anesthesia of mice are inconsistent with clinical acupuncture conditions; and the neuronal activity under anesthesia is completely different from that under awake state, which will have an adverse effect on the objectivity of the experimental results. (2) The head component of the existing mouse overall fixator affects the fixation of the optical fiber pin; and the fixation method will cause pressure stress, affecting the experimental results. (3) The existing mouse limb restraint fixator causes pressure stress, affecting the experimental results.

[0005] In summary, there is an urgent need to propose a fixing device that can perform electroacupuncture stimulation on the acupuncture points on the back of mice while ensuring that the experimental mice have a certain amount of free movement space, and does not affect the real-time recording of calcium signal changes in the mouse brain by optical fiber. Utility Model Content

[0006] The purpose of the utility model is to provide a fixing device for electroacupuncture stimulation of acupuncture points on the back of mice. The fixing device can conveniently perform electroacupuncture stimulation on acupuncture points on the back of mice while ensuring that the experimental mice have a certain amount of free movement space, and does not affect the real-time recording of calcium signal changes in the mouse brain by optical fiber.

[0007] In order to achieve the above technical effects, the technical solution of the utility model is as follows:

[0008] The utility model discloses a fixing device for electroacupuncture stimulation of acupuncture points on the back of a mouse, comprising: a fixing piece, the fixing piece is used to be fixed on the back of the mouse, the fixing piece is provided with a first avoidance hole; a fixer, the fixing piece is installed on the fixing piece, and the fixer is provided with a second avoidance hole corresponding to the first avoidance hole; a fixing bracket, the fixing bracket is installed on the fixing piece, the fixing bracket is used to fix the electroacupuncture electrode, the electroacupuncture electrode is used to clamp a needle, and the needle can pass through the second avoidance hole and the first avoidance hole to pierce the back acupuncture point of the mouse.

[0009] In some embodiments, the fixing member includes a fixing strap, and the fixing strap is mounted on the mouse.

[0010] In some specific embodiments, one end of the fixing strap is provided with Velcro.

[0011] In some specific embodiments, one end of the fixing strap is provided with a plurality of insertion holes spaced apart along the length direction of the fixing strap, and the other end is provided with an insertion protrusion matched with one of the plurality of insertion holes.

[0012] In some embodiments, the fixing member is provided with a first mounting hole, the fixer is provided with a second mounting hole, and the connecting member passes through the second mounting hole and the first mounting hole to fix the fixer on the fixing member.

[0013] In some specific embodiments, there are multiple first mounting holes and multiple second mounting holes, the multiple second mounting holes are arranged in one-to-one correspondence with the multiple first mounting holes, and the multiple second mounting holes are arranged around the second avoidance hole.

[0014] In some embodiments, the side of the fixer facing the fixing member has an adhesive layer, and the fixer is bonded to the fixing member.

[0015] In some embodiments, the fixing bracket is provided with a fixing hole, and the fixing hole is used to fix the electrode clamp that clamps the electroacupuncture electrode.

[0016] In some embodiments, the fixing bracket and the fixing device are integrally formed.

[0017] In some embodiments, the fixing bracket and the fixing device are both plastic parts.

[0018] The beneficial effects of the fixture for electroacupuncture stimulation of acupuncture points on the back of mice of the utility model are as follows: since the fixture is fixed on the back of the mouse, compared with the limb fixture and head fixture in the prior art, on the one hand, it can allow the mouse to have a certain degree of freedom of movement, reducing the impact of pressure stress on the experimental results, and on the other hand, it will not have any adverse effects on the optical fiber pins on the head. In the actual experimental process, it is not necessary to anesthetize the mouse, and it is possible to perform electroacupuncture stimulation and calcium ion optical fiber recording on the experimental mouse in a conscious state at the same time, thereby realizing that the fixture can conveniently perform electroacupuncture stimulation on the acupuncture points on the back of the mouse while ensuring that the experimental mouse has a certain amount of free movement space, and does not affect the real-time recording of calcium signal changes in the mouse brain by the optical fiber.

[0019] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic structural diagram of a fixing device for electroacupuncture stimulation of acupuncture points on the back of mice according to an embodiment of the utility model.

[0021] Reference numerals:

[0022] 100, fixing part; 110, Velcro; 120, first avoidance hole; 200, fixing device; 210, second avoidance hole; 300, fixing bracket; 310, fixing hole; 400, connecting part. DETAILED DESCRIPTION

[0023] In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved more clearly, the technical solutions of the present invention are further explained below with reference to the accompanying drawings and through specific implementation methods.

[0024] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0025] In addition, features defined as "first" or "second" may explicitly or implicitly include one or more of the features, and are used to distinguish and describe features, without distinction of order or importance. In the description of the present utility model, unless otherwise specified, "plurality" means two or more.

[0026] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0027] Reference below Figure 1 The specific structure of the fixing device for electroacupuncture stimulation of acupuncture points on the back of mice according to an embodiment of the utility model is described.

[0028] The utility model discloses a fixing device for electroacupuncture stimulation of acupuncture points on the back of mice (hereinafter referred to as the fixing device), the fixing device comprises a fixing piece 100, a fixing device 200 and a fixing bracket 300, the fixing piece 100 is used to be fixed on the back of the mouse, the fixing piece 100 is provided with a first avoidance hole 120, the fixing device 200 is installed on the fixing piece 100, and the fixing device 200 is provided with a second avoidance hole 210 corresponding to the first avoidance hole 120, the fixing bracket 300 is installed on the fixing piece 100, the fixing bracket 300 is used to fix the electroacupuncture electrode, the electroacupuncture electrode is used to clamp the needle, and the needle can pass through the second avoidance hole 210 and the first avoidance hole 120 to pierce the back acupuncture point of the mouse.

[0029] It is understandable that, since the fixture 200 of this embodiment is fixed on the back of the mouse, compared with the limb fixture and head fixture in the prior art, on the one hand, it can allow the mouse to have a certain degree of freedom of movement, reducing the impact of pressure stress on the experimental results, and on the other hand, it will not have any adverse effects on the head optical fiber pin. In the actual experimental process, it is not necessary to anesthetize the mouse, and the experimental mouse can be subjected to electroacupuncture stimulation and calcium ion optical fiber recording at the same time in the awake state, so that the fixture can conveniently perform electroacupuncture stimulation on the acupuncture points on the back of the mouse while ensuring that the experimental mouse has a certain amount of free movement space, and does not affect the real-time recording of calcium signal changes in the mouse brain by the optical fiber.

[0030] refer to Figure 1 As shown, the fixing member 100 includes a fixing strap, which is sleeved on the mouse. It is understandable that the fixing member 100 is set as a fixing strap, which can stably fix the entire fixing device to the mouse on the one hand, and can also allow the mouse to have a certain degree of freedom of movement on the other hand, thereby reducing the impact of pressure stress on the experimental results.

[0031] Further, refer to Figure 1 As shown, one end of the fixing strap is provided with a Velcro 110. It is understandable that the Velcro 110 can be used to adjust the size of the space defined by the fixing strap during the actual experiment, so that the mouse can have a better comfort after the fixing strap is put on, thereby reducing the impact of pressure stress on the experimental results.

[0032] In an alternative embodiment, one end of the fixing strap is provided with a plurality of plug holes spaced along the length direction of the fixing strap, and the other end is provided with a plug protrusion that matches one of the plurality of plug holes. It is understandable that in the actual experiment, the plug protrusion can be inserted into different plug holes to adjust the size of the space defined by the fixing strap, so that the mouse can have a better comfort after putting on the fixing strap, thereby reducing the impact of pressure stress on the experimental results. Of course, in other embodiments of the utility model, the fixing member 100 can also be a structure such as an elastic band, and is not limited to the above-mentioned fixing strap.

[0033] refer to Figure 1As shown, the fixing member 100 is provided with a first mounting hole, the fixing device 200 is provided with a second mounting hole, and the connecting member 400 passes through the second mounting hole and the first mounting hole to fix the fixing device 200 on the fixing member 100. It can be understood that in the actual installation process, the fixing device 200 is attached to the surface of the fixing member 100, and then the connecting member 400 passes through the second mounting hole and the first mounting hole to fix the fixing device 200 on the fixing member 100. This connection method, on the one hand, facilitates the connection between the fixing member 100 and the fixing device 200, and on the other hand, ensures the connection stability between the fixing member 100 and the fixing device 200. In the embodiment of the utility model, the connecting member 400 can be a screw or a pin. The specific type of the connecting member 400 can be selected according to actual needs, and the specific type of the connecting member 400 is not limited here.

[0034] Optionally, there are multiple first mounting holes and multiple second mounting holes, and the multiple second mounting holes are arranged in one-to-one correspondence with the multiple first mounting holes, and the multiple second mounting holes are arranged around the second avoidance hole 210. It can be understood that there are multiple first mounting holes and multiple second mounting holes. In the actual assembly process, the use of multiple connectors 400 to connect the fixing member 100 and the fixture 200 can improve the connection stability of the fixing member 100 and the fixture 200, thereby ensuring the stability of the electroacupuncture electrode.

[0035] In an alternative embodiment, the side of the fixture 200 facing the fixture 100 has an adhesive layer, and the fixture 200 is bonded to the fixture 100. It can be understood that, compared with the connection using the connecting member 400, the fixture 200 is bonded to the fixture 100, which facilitates the experimenter to fix the fixture 200 to the fixture 100 and simplifies the assembly operation.

[0036] refer to Figure 1 As shown, the fixing bracket 300 is provided with a fixing hole 310, and the fixing hole 310 is used to fix the electroacupuncture electrode. It is understandable that in the actual assembly process, after the needle is installed on the electroacupuncture electrode, the tail of the electroacupuncture electrode is then inserted into the fixing hole 310. The plug-in method can simplify the connection structure while ensuring the stability of the electroacupuncture electrode.

[0037] In an optional embodiment, the fixing bracket 300 and the fixer 200 are integrally formed. It is understandable that the fixing bracket 300 and the fixer 200 are integrally formed, which can simplify the structure of the entire fixing device and reduce the manufacturing cost of the fixing device.

[0038] In an optional embodiment, the fixing bracket 300 and the fixing device 200 are both plastic parts, thereby reducing the manufacturing cost of the fixing device.

[0039] In the description of this specification, the description with reference to the terms "some embodiments", "other embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0040] The above contents are only preferred embodiments of the present invention. For ordinary technicians in this field, according to the concept of the present invention, there will be changes in the specific implementation methods and application scopes. The contents of this specification should not be understood as limiting the present invention.

Claims

1. A fixation device for electroacupuncture stimulation of acupuncture points on the back of mice, characterized in that: include: A fixing member (100), the fixing member (100) being used to be fixed to the back of a mouse, the fixing member (100) being provided with a first avoidance hole (120); A fixer (200), the fixer (200) being mounted on the fixing member (100), and the fixer (200) having a second avoidance hole (210) corresponding to the first avoidance hole (120); A fixing bracket (300), wherein the fixing bracket (300) is mounted on the fixing member (100), and the fixing bracket (300) is used to fix the electroacupuncture electrode, and the electroacupuncture electrode is used to clamp the needle, and the needle can pass through the second avoidance hole (210) and the first avoidance hole (120) to pierce the back acupuncture point of the mouse.

2. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 1, characterized in that: The fixing member (100) comprises a fixing strap, and the fixing strap is sleeved on the mouse.

3. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 2, characterized in that: One end of the fixing strap is provided with a Velcro (110).

4. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 2, characterized in that: One end of the fixing strap is provided with a plurality of inserting holes spaced apart along the length direction of the fixing strap, and the other end is provided with an inserting protrusion matched with one of the plurality of inserting holes.

5. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 1, characterized in that: The fixing member (100) is provided with a first mounting hole, the fixer (200) is provided with a second mounting hole, and the connecting member (400) passes through the second mounting hole and the first mounting hole to fix the fixer (200) on the fixing member (100).

6. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 5, characterized in that: There are multiple first mounting holes and multiple second mounting holes, and the multiple second mounting holes are arranged in a one-to-one correspondence with the multiple first mounting holes. The multiple second mounting holes are arranged around the second avoidance hole (210).

7. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 1, characterized in that: The side of the fixer (200) facing the fixing member (100) has an adhesive layer, and the fixer (200) is bonded to the fixing member (100).

8. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 1, characterized in that: The fixing bracket (300) is provided with a fixing hole (310), and the fixing hole (310) is used to fix the electroacupuncture electrode.

9. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 1, characterized in that: The fixing bracket (300) and the fixer (200) are integrally formed parts.

10. The fixation device for electroacupuncture stimulation of acupoints on the back of mice according to claim 1, characterized in that: The fixing bracket (300) and the fixing device (200) are both plastic parts.

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