Fixing device for laboratory mouse
By designing a fixing device for experimental mice including a fixing table, glass plate and fixing mechanism, the existing device is complicated to operate and difficult to clean, and the rapid fixing and efficient cleaning of experimental mice of different sizes is achieved, which improves the convenience of experiments and sanitary conditions.
Patent Information
- Application Number
- CN202510272907.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-10
- Publication Date
- 2025-05-27
AI Technical Summary
The existing experimental mouse fixtures are too complex or too simple, resulting in cumbersome operation and unable to meet the diverse experimental needs. It is difficult to clean up quickly when the experimental mouse defecates and urinates, resulting in inconvenience in the use of the equipment.
An experimental mouse fixing device including a fixing table, a glass plate, and a fixing mechanism is designed. The fixing mechanism consists of a fixing plate, a motor, a bidirectional screw, a sliding sleeve, an extension rod and a fixing clip. The fast fixing and full-body scanning of the experimental mice is achieved through an electric sliding table and a live scanner. The electric push rod and a nozzle are used to clean up the excrement on the glass plate.
It realizes rapid fixation of experimental mice of different sizes, facilitates drug delivery operations in different parts, improves experimental convenience and sanitary conditions, and solves the problems of complex structure and difficulty in cleaning the existing device.
Smart Images
Figure CN120036983A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of animal experiments, and specifically to a fixing device for experimental mice. Background Art
[0002] Experimental research in fields such as medical research, drug development, neuroscience, physiology, and genetics often cannot or is not suitable to be directly carried out on the human body. Therefore, animal experiments have become an important research method. Among various experimental animals, experimental mice are widely favored by researchers due to their moderate body size, strong reproductive ability, and high genetic similarity to humans. However, experimental mice are easily affected by operation stimuli during the experiment, showing abnormal behaviors, heart rate changes, etc., and even death. In order to prevent animals from changing physiological indicators due to stress, researchers need to properly fix experimental mice before the experiment to provide reliable data support for medical research and the like.
[0003] Chinese Patent Application No. 2023110975702 discloses a fixing device for experimental mice in medical experimental zoology, which includes a bearing substrate, a restraint cable, a binding cover, and a control mechanism. One end of the restraint cable is fixedly connected to the upper end of the bearing substrate, and the other end of the restraint cable penetrates through the bearing substrate. The binding cover is detachably installed on the upper end surface of the bearing substrate. The control mechanism includes a control cylinder, an elastic member, and a protective layer. The protective layer is arranged on the outer wall of the restraint cable. One end of the elastic member is fixedly connected to the outer wall of the restraint cable, and the other end of the elastic member is fixedly connected to the bottom surface of the bearing substrate. The control cylinder is fixedly installed on the bottom surface of the bearing substrate, and the movable end of the control cylinder is fixedly connected to the outer wall of the restraint cable. An installation rod is fixedly installed on the bottom surface of the bearing substrate, and a fixed pulley is rotatably installed on the side wall of the installation rod. The outer wall of the fixed pulley is in contact with the outer wall of the restraint cable. Through the cooperation of the above structures, the efficiency of binding mice can be effectively improved in this application. However, the structure of this device is too complex and the operation is cumbersome, increasing the workload of experimental personnel.
[0004] Chinese Patent Application No. 202310207832X discloses a fixing device for experimental mice in medical experimental zoology, which includes a bottom plate. A support seat is fixedly connected to the upper end of the bottom plate. A rotatable first turntable is arranged at the rear of the support seat. A support ring is arranged at the front of the support seat. The support ring can swing left and right as the first turntable rotates. A rotatable second runner is arranged at the lower end of the support ring. The support ring can rotate back and forth as the second runner rotates. A support plate is fixedly connected to the upper end of the support ring. The design of this device is too simple and the function is single, unable to meet the diversified experimental needs.
[0005] It can be seen from this that there are some obvious limitations in the existing fixing devices for experimental mice: on the one hand, the structures of some devices are too complex and the operations are cumbersome, increasing the workload of experimental personnel; on the other hand, the designs of some devices are too simple and the functions are single, unable to meet the experimental requirements. The above devices are difficult to fix experimental mice of different sizes, nor can they perform drug administration operations on different parts of experimental mice (such as subcutaneous and intravenous injections). In addition, during the experiment, the experimental mice may have stress reactions of defecation and urination, resulting in contamination of the test substances. To address these problems, we have proposed a new fixing device for experimental mice, aiming to solve the deficiencies of the existing devices and improve the convenience and hygiene conditions of experimental operations. Summary of the Invention
[0006] In view of the deficiencies of the existing technology, the present invention designs a new fixing device for experimental mice. This device simplifies the operation process of fixing experimental mice, can fix experimental mice of different sizes, facilitates drug administration operations on different parts of experimental mice (such as subcutaneous and intravenous injections), improves the convenience of the experiment, and also solves problems such as the complex structure and difficult cleaning of the existing devices. Especially after the experimental mice have stress reactions of defecation and urination, it can quickly clean the stains on the tabletop, providing a more efficient and hygienic operation environment for animal experiments.
[0007] To achieve the above object, the present invention provides the following technical solutions: A fixing device for experimental mice, comprising a fixing table, a glass plate is fixedly installed on the top of the fixing table, a water outlet is opened on the top of the fixing table, and a fixing mechanism is arranged on the top of the fixing table; The fixing mechanism includes a fixing plate, fixing plates are fixedly installed on both the front and rear sides of the fixing table, a motor is installed outside the fixing plate, a bidirectional screw is connected to the output shaft of the motor, a sliding sleeve is sleeved outside the bidirectional screw, an extension rod is installed on the top of the sliding sleeve, a fixing clip is installed on the top of the extension rod, and a tail clip is installed on the top of the glass plate.
[0008] Further, a water collecting tank is installed at the bottom of the fixing table, a drain pipe is connected to the right side of the water collecting tank, and an electric push rod is installed on the top of the fixing table.
[0009] Further, an electric sliding table is installed on the top of the electric push rod, a sliding seat is slidably connected to the bottom of the electric sliding table, a living body scanner is fixedly installed at the bottom of the sliding seat, a water collecting box is fixedly installed at the bottom of the sliding seat, and no less than five spray heads are fixedly installed at the bottom of the water collecting box.
[0010] Further, a water tank is fixedly installed on the left side of the fixing table, a water inlet pipe is connected to the top of the water tank, and the side of the water inlet pipe away from the water tank is connected to the water collecting box.
[0011] Furthermore, the top of the extension rod extends to the outside of the fixed plate. The fixed clamp is a C-shaped clamp, and the limiting angle of the C-shaped clamp can be finely adjusted. There are no less than four groups of the fixed clamps.
[0012] Furthermore, the number of each group of the fixed clamps is two, and the two fixed clamps of each group are respectively located on the front and rear sides of the fixed table.
[0013] Furthermore, the two groups of fixed clamps are of the same size and opposite in direction. The side of the bidirectional screw rod away from the motor is rotatably connected to the inner left wall of the fixed plate.
[0014] Compared with the prior art, the technical solution of the present application has the following beneficial effects: 1. For the fixing device of the experimental mouse, by placing the experimental mouse on the glass plate, at this time, the whole body of the mouse is scanned by the in vivo scanner. According to the scanning result, the controller drives the electric sliding table to start to fix the experimental mouse.
[0015] 2. For the fixing device of the experimental mouse, through the mutual cooperation of the structures of the fixing mechanism, it can quickly fix experimental mice of different sizes, ensuring a more efficient experiment.
[0016] 3. By manually finely adjusting the fixed clamp, various drug administration operations can be carried out on different parts of the experimental mouse. Description of the Drawings
[0017] Figure 1 is the structural diagram of the fixing device of the experimental mouse of the present invention; Figure 2 is the side view of the fixing device of the experimental mouse of the present invention; Figure 3 is the structural diagram of the fixed clamp of the fixing device of the experimental mouse of the present invention; Figure 4 is the bottom view of the electric sliding table structure of the fixing device of the experimental mouse of the present invention.
[0018] In the figure: 1 fixed table, 2 glass plate, 3 water outlet, 4 fixing mechanism, 401 fixed plate, 402 motor, 403 bidirectional screw rod, 404 sliding sleeve, 405 extension rod, 406 fixed clamp, 407 tail clamp, 5 water collecting tank, 6 electric push rod, 7 electric sliding table, 8 in vivo scanner, 9 water tank, 10 water collecting box. Detailed Embodiment
[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.
[0020] Please refer to Figures 1-4 , a fixing device for experimental mice in this embodiment, including a fixing table 1, characterized in that: a glass plate 2 is fixedly installed on the top of the fixing table 1, a water outlet 3 is opened on the top of the fixing table 1, and a fixing mechanism 4 is arranged on the top of the fixing table 1; The fixing mechanism 4 includes a fixing plate 401. Fixing plates 401 are fixedly installed on both the front and rear sides of the fixing table 1. A motor 402 is installed outside the fixing plate 401. A bidirectional screw 403 is connected to the output shaft of the motor 402. A sliding sleeve 404 is sleeved outside the bidirectional screw 403. An extension rod 405 is installed on the top of the sliding sleeve 404. A fixing clip 406 is installed on the top of the extension rod 405. A tail clip 407 is installed on the top of the glass plate 2.
[0021] In Figure 1 and Figure 2 , a water collecting tank 5 is installed at the bottom of the fixing table 1. A drain pipe is connected to the right side of the water collecting tank 5. An electric push rod 6 is installed on the top of the fixing table 1.
[0022] Specifically, by setting the electric push rod 6, the controller drives the electric push rod 6 to retract, which can drive the living body scanner 8 closer to the experimental mouse, thus facilitating the scanning of the experimental mouse.
[0023] In Figure 1 and Figure 2 , an electric sliding table 7 is installed on the top of the electric push rod 6. A sliding seat is slidably connected to the bottom of the electric sliding table 7. The living body scanner 8 is fixedly installed at the bottom of the sliding seat. A water collecting box 10 is fixedly installed at the bottom of the sliding seat. No less than five spray heads are fixedly installed at the bottom of the water collecting box 10.
[0024] Specifically, the controller drives the electric sliding table 7 to drive the sliding seat to move left and right, which can make the water collecting box 10 and the living body scanner 8 move left and right, so as to perform a full-body scan on the experimental mouse. At the same time, the moving water collecting box 10 can drive the spray heads to move left and right to spray and wash the glass plate 2, removing the excrement of the experimental mouse on the glass plate 2.
[0025] In Figure 1 , Figure 2 and Figure 4 , a water tank 9 is fixedly installed on the left side of the fixing table 1. A water inlet pipe is connected to the top of the water tank 9. The side of the water inlet pipe away from the water tank 9 is connected to the water collecting box 10.
[0026] Specifically, by setting up the water tank 9, the controller drives the booster pump to start. Water reaches the water collecting box 10 through the water inlet pipe, and the water flow is sprayed out by the nozzle onto the glass plate 2. The excrement of the experimental mouse can then reach the water tank 5 through the drain opening 3 and be discharged through the drain pipe.
[0027] In Figure 2 and Figure 3 the top of the extension rod 405 extends to the outside of the fixing plate 401. The fixing clip 406 is a C-shaped clip, and there are no less than four groups of fixing clips 406.
[0028] Specifically, by setting up the fixing plate 401 to limit the bidirectional screw 403, the controller drives the motor 402 to start, which can drive two sliding sleeves 405 in each group to drive two fixing clips 406 to move in opposite or away directions, thus facilitating the limitation of experimental mice of different sizes and solving the problem that the existing experimental mouse fixing device cannot effectively fix experimental mice of different sizes.
[0029] In Figure 2 and Figure 3 each group of fixing clips 406 has two in number, and the two fixing clips 406 in each group are respectively located on the front and back sides of the fixing table 1.
[0030] Specifically, through the joint cooperation of the fixing clip 406 and the tail clip 407, the head, neck, abdomen and tail of the experimental mouse are limited and fixed.
[0031] In Figure 2 and Figure 4 the two groups of fixing clips 406 are of the same size and opposite in direction. The side of the bidirectional screw 403 away from the motor 402 is rotatably connected to the inner left wall of the fixing plate 401.
[0032] During implementation, the following steps are taken for operation: When in use, first place the glass plate 2 on the fixing table 1, then place the experimental mouse on the glass plate 2 and gently press it by the experimenter. The controller drives the electric push rod 6 to drive the in vivo scanner 8 to move downward, so as to scan the experimental mouse. After the scanning is completed, according to the scanned image, the controller drives two motors 402 to start, which can drive multiple groups of fixing clips 406 to move in opposite directions, so as to ensure that each group of fixing clips 406 limits and fixes the head and neck, back and abdomen of the experimental mouse, and fixes the tail of the experimental mouse through the tail clip 407. During or after the experiment, the controller can drive the booster pump to start, and the water in the water tank 9 is introduced into the water collecting box 10 through the water inlet pipe and sprayed out by the nozzle to wash the excrement or experimental stains of the experimental mouse on the glass plate 2.
[0033] In summary, by setting the fixing plate 401 to limit the bidirectional screw 403, when the controller drives the motor 402 to start, it can drive two sliding sleeves 405 in each group to drive two fixing clips 406 to move towards or away from each other, thus facilitating the limitation of mice of different sizes. By setting the tail clip 407, the tail of the experimental mouse can be fixed stably to prevent the tail of the experimental mouse from sweeping during the experiment. By setting the electric push rod 6, when the controller drives the electric push rod 6 to retract, it can drive the living body scanner 8 close to the experimental mouse. At this time, the controller drives the electric slide table 7 to start and drive the sliding seat to move left and right to scan the experimental mouse. By setting the water tank 9, when the controller drives the booster pump to start, water reaches the water collecting box 10 through the water inlet pipe, and is sprayed and rinsed on the bottom glass plate 2 by the nozzle. The excrement of the experimental mouse can reach the water tank 5 through the water outlet 3 and be discharged through the drain pipe, thus solving the problem that most of the existing experimental mouse fixing devices are too complex in structure and cannot quickly clean the tabletop after the experimental mouse is frightened and excretes, resulting in very inconvenient use of the equipment.
[0034] The electrical components appearing in this article are all electrically connected to an external controller and 220V mains power, and the controller can be a conventional known device such as a computer for control. The specific model specifications of each device in this article need to be selected according to the actual specifications of the device, etc. The specific selection calculation method adopts the existing technology in this field, so it will not be elaborated in detail.
[0035] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of additional identical elements in the process, method, article or device including the element.
[0036] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A fixing device for experimental mice, comprising a fixing platform (1), characterized in that: A glass plate (2) is fixedly mounted on the top of the fixing platform (1), a water outlet (3) is provided on the top of the fixing platform (1), and a fixing mechanism (4) is provided on the top of the fixing platform (1); The fixing mechanism (4) comprises a fixing plate (401), the fixing plates (401) being fixedly mounted on both the front and rear sides of the fixing platform (1), a motor (402) being mounted on the outside of the fixing plate (401), a bidirectional screw rod (403) being connected to the output shaft of the motor (402), a sliding sleeve (404) being sleeved on the outside of the bidirectional screw rod (403), an extension rod (405) being mounted on the top of the sliding sleeve (404), a fixing clamp (406) being mounted on the top of the extension rod (405), and a tail clamp (407) being mounted on the top of the glass plate (2).
2. The fixing device for experimental mice according to claim 1, characterized in that: A water collecting trough (5) is installed at the bottom of the fixed platform (1), a drainage pipe is connected to the right side of the water collecting trough (5), and an electric push rod (6) is installed at the top of the fixed platform (1).
3. The fixing device for laboratory mice according to claim 2, characterized in that: An electric slide (7) is mounted on the top of the electric push rod (6), the bottom of the electric slide (7) is slidably connected to a slide seat, a living body scanner (8) is fixed to the bottom of the slide seat, a water collection box (10) is fixedly mounted on the bottom of the slide seat, and no less than five nozzles are fixedly mounted on the bottom of the water collection box (10).
4. The fixing device for laboratory mice according to claim 3, characterized in that: A water tank (9) is fixedly mounted on the left side of the fixed platform (1), a water inlet pipe is connected to the top of the water tank (9), and a side of the water inlet pipe away from the water tank (9) is connected to the water collecting box (10).
5. The fixing device for laboratory mice according to claim 1, characterized in that: The top of the extension rod (405) extends to the outside of the fixing plate (401), the fixing clips (406) are C-shaped clips, and there are no less than four groups of the fixing clips (406).
6. The fixing device for laboratory mice according to claim 1, characterized in that: The number of the fixing clips (406) in each group is two, and the two fixing clips (406) in each group are respectively located on the front and rear sides of the fixing platform (1).
7. The fixing device for laboratory mice according to claim 1, characterized in that: The two groups of fixing clamps (406) are of the same size and opposite directions, and the side of the bidirectional screw (403) away from the motor (402) is rotatably connected to the inner left wall of the fixing plate (401).