Filling device of glycosylated hemoglobin chromatographic column

Abstract

The utility model provides a filling device of a glycosylated hemoglobin chromatographic column, and belongs to the technical field of chromatographic column filling. The filling device of the glycosylated hemoglobin chromatographic column comprises a workbench used for glycosylated hemoglobin chromatography, a support is placed on the top of the workbench, a plurality of chromatographic column bodies are installed on the support, a placing frame is further placed on the top of the workbench, and a plurality of stock solution conveying mechanisms are placed in the placing frame. The bracket is arranged on the workbench, the bracket can be used for mounting a plurality of chromatographic column bodies, and meanwhile, the placement frame is also arranged on the workbench and is used for placing the stock solution conveying mechanism, so that the stock solution conveying mechanism can convey stock solution into the plurality of chromatographic column bodies, and the filling efficiency of the chromatographic column bodies can be improved; and in addition, the wire arranging device is mounted on the base, so that a plurality of infusion pipelines sequentially penetrate through the wire arranging device, and the situation that the infusion pipelines are placed disorderly can be avoided.

Description

Technical Field

[0001] The present application relates to the field of chromatography column filling, and in particular to a filling device for a glycated hemoglobin chromatography column. Background Art

[0002] Glycated hemoglobin is the product of the non-enzymatic reaction between hemoglobin in red blood cells and sugars (mainly glucose) in serum. Microcolumn ion exchange chromatography is the current mainstream detection method of glycated hemoglobin analyzers. The HbA1 c in the blood sample is separated by gradient elution technology using a chromatographic column device as a carrier, and then the content is calibrated by chromatographic analysis.

[0003] During the chromatography column filling process, the glycated hemoglobin reagent needs to be poured into the chromatography column manually. The specific process is to remove the glass rod from the top of the chromatography column into the inside of the device with one hand, and lift the stock liquid tank with the other hand to pour the glycated hemoglobin reagent on the glass rod, so that the glycated hemoglobin flows down along the glass rod into the chromatography column. However, this method has the problem of low efficiency when several chromatography columns need to be filled at the same time. At the same time, the manual pouring method has low stability. For this reason, we propose a glycated hemoglobin chromatography column filling device. Utility Model Content

[0004] In order to make up for the above shortcomings, the present application provides a filling device for a glycated hemoglobin chromatography column, aiming to improve the problem of low efficiency of the above filling method.

[0005] An embodiment of the present application provides a filling device for a glycated hemoglobin chromatography column, comprising a workbench for glycated hemoglobin chromatography, a bracket being placed on the top of the workbench, a plurality of chromatography column bodies being mounted on the bracket, a placement rack being placed on the top of the workbench, a plurality of stock solution conveying mechanisms being placed in the placement rack, and the stock solution conveying mechanisms being connected to the plurality of chromatography column bodies.

[0006] In a specific embodiment, the support includes a base placed on the top of the workbench, a plurality of pillars are fixedly installed on the top of the base, elastic jackets are installed on the plurality of pillars, and the plurality of elastic jackets respectively clamp a plurality of the chromatography column bodies.

[0007] In a specific implementation manner, a support rod is fixedly installed on the top of the base, and a cable organizer is fixedly connected to the top of the support rod.

[0008] In a specific implementation, the cable organizer includes a vertically arranged cable management plate, and a plurality of wiring grooves are fixedly mounted on a side wall at one end of the cable management plate.

[0009] In a specific embodiment, the raw liquid delivery mechanism includes a plurality of peristaltic pumps, the outlet ends of the plurality of peristaltic pumps are connected to infusion pipes, and the inlet ends thereof are connected to inlet pipes, and the plurality of infusion pipes are respectively passed through a plurality of the wiring grooves and are respectively connected to a plurality of the chromatography column bodies.

[0010] In a specific implementation manner, the placement rack includes a placement seat placed on the top of the workbench, a front side of the placement seat is provided with a plurality of placement slots, and a plurality of the peristaltic pumps are respectively placed in the plurality of the placement slots.

[0011] In a specific implementation, a plurality of support plates are slidably connected to the side wall of one end of the placement seat, a plurality of raw liquid tanks are placed on the support plates, and one ends of a plurality of the liquid inlet pipes are respectively placed in the plurality of raw liquid tanks.

[0012] In a specific implementation manner, a plurality of limiting grooves are provided on a side wall at one end of the placement seat, and limiting blocks are installed on a plurality of the support plates, and the limiting blocks are respectively slidably disposed in the plurality of limiting grooves.

[0013] The beneficial effects of the present application are as follows: by placing a bracket on the workbench, the bracket can be used to install several chromatography column bodies, and a placement rack is also placed on the workbench, the placement rack is used to place the raw liquid delivery mechanism, so that the raw liquid delivery mechanism can deliver the raw liquid to several chromatography column bodies, thereby improving the chromatography column body filling efficiency, and in addition, a cable organizer is installed on the base, and then several infusion pipes are passed through the cable organizer in sequence, thereby avoiding the infusion pipes from being placed in a messy manner. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions of the implementation methods of the present application, the drawings required for use in the implementation methods will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0015] Figure 1 This is a schematic structural diagram of a first-view of a filling device for a glycated hemoglobin chromatography column provided in an embodiment of the present application;

[0016] Figure 2 A schematic structural diagram of a filling device for a glycated hemoglobin chromatography column provided in an embodiment of the present application from a second perspective;

[0017] Figure 3 A schematic diagram of the front structure of a filling device for a glycosylated hemoglobin chromatography column provided in an embodiment of the present application;

[0018] Figure 4 for Figure 3 A partial enlarged view of point A in the middle.

[0019] In the figure: 10-workbench; 20-bracket; 210-base; 220-pillar; 230-elastic jacket; 240-support rod; 30-chromatography column body; 40-placing rack; 410-placing seat; 420-placing slot; 430-support plate; 440-raw liquid tank; 450-limiting slot; 460-limiting block; 50-raw liquid conveying mechanism; 510-peristaltic pump; 520-infusion pipeline; 530-liquid inlet pipeline; 60-cable organizer; 610-cable management board; 620-wiring slot. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be described below in conjunction with the drawings in the embodiments of the present application.

[0021] See also Figure 1-4 The present application provides a filling device for a glycated hemoglobin chromatography column, comprising a workbench 10 for glycated hemoglobin chromatography, a bracket 20 is placed on the top of the workbench 10, and a plurality of chromatography column bodies 30 are installed on the bracket 20. A placement rack 40 is also placed on the top of the workbench 10, and a plurality of stock liquid conveying mechanisms 50 are placed in the placement rack 40. The stock liquid conveying mechanisms 50 are connected to the plurality of chromatography column bodies 30. Specifically, the bracket 20 can simultaneously install a plurality of chromatography column bodies 30, so that the stock liquid conveying mechanisms 50 simultaneously convey glycated hemoglobin reagents into the plurality of chromatography column bodies 30, so as to improve the filling efficiency of the chromatography column bodies 30.

[0022] See also Figure 2 The bracket 20 includes a base 210 placed on the top of the workbench 10, and a plurality of pillars 220 are fixedly installed on the top of the base 210. The plurality of pillars 220 are each installed with an elastic jacket 230. The plurality of elastic jackets 230 are respectively arranged to clamp a plurality of chromatography column bodies 30. When arranged, the elastic jackets 230 are arranged in a U-shape, so that the elastic jackets 230 can clamp the chromatography column body 30, so as to achieve the purpose of facilitating the disassembly and assembly of the chromatography column body 30.

[0023] See also Figure 2A support rod 240 is fixedly installed on the top of the base 210, and a cable organizer 60 is fixedly connected to the top of the support rod 240. The cable organizer 60 includes a vertically arranged cable management plate 610, and a plurality of wiring grooves 620 are fixedly installed on the side wall of one end of the cable management plate 610. In the present embodiment, since the number of infusion pipes 520 is large and the length is long, the support rod 240 is installed on the base 210, and the cable management plate 610 is installed on the top of the support rod 240, and a plurality of wiring grooves 620 are installed on the side wall of the cable management plate 610, so that the infusion pipes 520 pass through the plurality of wiring grooves 620 respectively, thereby achieving the purpose of arranging the infusion pipes 520, thereby avoiding the mess of the infusion pipes 520, and the wiring grooves 620 are specifically U-shaped.

[0024] See also Figure 2 The raw liquid delivery mechanism 50 includes a plurality of peristaltic pumps 510, the outlet ends of the plurality of peristaltic pumps 510 are connected to a liquid infusion pipe 520, and the inlet ends thereof are connected to a liquid inlet pipe 530, the plurality of liquid infusion pipes 520 are respectively arranged through a plurality of wiring grooves 620, and are respectively connected to a plurality of chromatography column bodies 30. In the specific arrangement, the connection method between the liquid infusion pipe 520 and the chromatography column body 30 is the existing technology. Through the peristaltic pump 510, the glycated hemoglobin reagent in the raw liquid tank 440 can be sucked through the liquid inlet pipe 530 and delivered to the chromatography column body 30 through the liquid infusion pipe 520.

[0025] See also Figure 1 The placement rack 40 includes a placement seat 410 placed on the top of the workbench 10, and a plurality of placement grooves 420 are opened on the front of the placement seat 410. A plurality of peristaltic pumps 510 are respectively placed in the plurality of placement grooves 420. Specifically, the plurality of peristaltic pumps 510 are arranged on the placement seat 410 from bottom to top in sequence, so that the plurality of peristaltic pumps 510 are placed flat for easy use.

[0026] See also Figure 1 and 2 A plurality of support plates 430 are slidably connected to the side wall at one end of the placement seat 410, and a raw liquid tank 440 is placed on each of the support plates 430. One ends of a plurality of liquid inlet pipes 530 are respectively placed in the plurality of raw liquid tanks 440. It should be noted that two through openings are provided on the support plate 430, and the raw liquid tank 440 is placed in the through openings, and the head of the raw liquid tank 440 is placed on the support plate 430 to achieve the purpose of supporting the raw liquid tank 440.

[0027] See also Figure 4A plurality of limiting grooves 450 are provided on the side wall at one end of the placement seat 410, and limiting blocks 460 are installed on the plurality of support plates 430. The plurality of limiting blocks 460 are respectively slidably arranged in the plurality of limiting grooves 450. When setting, when the support plate 430 is installed on the placement seat 410, the limiting blocks 460 are aligned with the limiting grooves 450 and inserted.

[0028] When the filling device of the glycated hemoglobin chromatography column is in use: the glycated hemoglobin reagent is poured into a plurality of stock liquid tanks 440, and then one end of a plurality of liquid inlet pipes 530 is respectively placed in a plurality of stock liquid tanks 440, and a plurality of infusion pipes 520 are respectively passed through a plurality of wiring grooves 620, and then respectively connected with a plurality of chromatography column bodies 30, and the filling process can be carried out. During the filling, a plurality of peristaltic pumps 510 can be used to absorb the glycated hemoglobin reagent in the stock liquid tank 440, and the glycated hemoglobin reagent can be transported to the chromatography column body 30 through the infusion pipes 520.

[0029] It should be noted that the specific model and specifications of the peristaltic pump 510 need to be selected and determined based on the actual specifications of the device, and the specific selection calculation method adopts the existing technology in the field, so it will not be described in detail.

[0030] The power supply and principle of the peristaltic pump 510 are clear to those skilled in the art and will not be described in detail here.

[0031] The above description is only an embodiment of the present application and is not intended to limit the scope of protection of the present application. For those skilled in the art, the present application may have various changes and variations. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application. It should be noted that similar reference numerals and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further defined and explained in the subsequent drawings.

Claims

1. A filling device for a glycosylated hemoglobin chromatography column, characterized in that: The invention comprises a workbench (10) for glycated hemoglobin chromatography, wherein a support (20) is placed on the top of the workbench (10), and a plurality of chromatography column bodies (30) are mounted on the support (20); a placement rack (40) is also placed on the top of the workbench (10), and a plurality of stock solution conveying mechanisms (50) are placed in the placement rack (40), and the stock solution conveying mechanisms (50) are connected to the plurality of chromatography column bodies (30).

2. A filling device for a glycosylated hemoglobin chromatography column according to claim 1, characterized in that: The support (20) comprises a base (210) placed on the top of the workbench (10), a plurality of pillars (220) are fixedly mounted on the top of the base (210), and elastic jackets (230) are mounted on the plurality of pillars (220), and the plurality of elastic jackets (230) are respectively arranged to clamp a plurality of the chromatography column bodies (30).

3. A filling device for a glycosylated hemoglobin chromatography column according to claim 2, characterized in that: A support rod (240) is fixedly mounted on the top of the base (210), and a cable organizer (60) is fixedly connected to the top of the support rod (240).

4. A filling device for a glycosylated hemoglobin chromatography column according to claim 3, characterized in that: The cable organizer (60) comprises a vertically arranged cable management plate (610), and a plurality of wiring grooves (620) are fixedly mounted on a side wall at one end of the cable management plate (610).

5. A filling device for a glycosylated hemoglobin chromatography column according to claim 4, characterized in that: The raw liquid conveying mechanism (50) comprises a plurality of peristaltic pumps (510), the outlet ends of the plurality of peristaltic pumps (510) are all connected to a liquid infusion pipeline (520), and the inlet ends thereof are all connected to a liquid inlet pipeline (530), and the plurality of liquid infusion pipelines (520) are respectively arranged through a plurality of the wiring grooves (620) and are respectively connected to a plurality of the chromatography column bodies (30).

6. A filling device for a glycosylated hemoglobin chromatography column according to claim 5, characterized in that: The placement rack (40) comprises a placement seat (410) placed on the top of the workbench (10), a plurality of placement slots (420) are provided on the front of the placement seat (410), and a plurality of peristaltic pumps (510) are respectively placed in the plurality of placement slots (420).

7. A filling device for a glycosylated hemoglobin chromatography column according to claim 6, characterized in that: A plurality of support plates (430) are slidably connected to a side wall at one end of the placement seat (410), a raw liquid tank (440) is placed on each of the support plates (430), and one end of each of the liquid inlet pipes (530) is placed in each of the raw liquid tanks (440).

8. A filling device for a glycosylated hemoglobin chromatography column according to claim 7, characterized in that: A plurality of limiting grooves (450) are provided on a side wall at one end of the placement seat (410), and limiting blocks (460) are installed on the plurality of support plates (430), and the plurality of limiting blocks (460) are slidably disposed in the plurality of limiting grooves (450), respectively.

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