Medicine hot-melt extrusion granulation device

Abstract

The utility model discloses a medicine hot melt extrusion granulation device which comprises an extruder module, a conveying module arranged at the outlet end of the extruder module, a granulation module arranged at the tail end of the conveying module, a cooling module arranged on the upper side of the conveying module, and a negative pressure isolation cover, the air cooler is arranged outside the negative pressure isolation cover, a cold air outlet of the air cooler is connected to an air distribution pipe arranged in the negative pressure isolation cover, and the air distribution pipe is arranged above the conveying module and extends in the length direction of the conveying module. According to the medicine hot-melt extrusion granulation device disclosed by the utility model, medicine raw materials are subjected to hot-melt extrusion molding through the extruder module, and cooled medicines can be uniformly granulated through the cutting gear; according to the device, the cooling module is arranged above the conveying module, an air cooler circularly refrigerates air in a negative pressure isolation hood and directly blows the air to extruded medicine strips from a cold air opening, and therefore medicine can be cooled and formed.

Description

Technical Field

[0001] The utility model relates to the field of extrusion granulation equipment, in particular to a medicine hot-melt extrusion granulation device. Background Art

[0002] Screw extruder is a commonly used polymer product processing equipment with simple structure, easy operation, efficient and continuous mixing and molding process. Therefore, its scope of use is not limited to the processing of rubber and plastic products, but is widely used in new material research and development, food, pharmaceuticals, fine chemicals and other fields.

[0003] However, the research and development and production process of screw extruders used in pharmaceutical preparations is different from the production of common rubber and plastic products. The production of drugs has strict requirements on the cleanliness of the production environment, and the drugs cannot be immersed in cooling water for cooling and molding after being extruded by the extruder like rubber and plastic products. Therefore, when the extrusion granulation device is used in pharmaceutical granulation, it not only requires conditional isolation from the outside world; secondly, it must be able to perform good cooling and molding of the drugs after extrusion granulation.

[0004] In view of the above, it is necessary to propose a pharmaceutical hot melt extrusion granulation device to solve the above problems. Utility Model Content

[0005] The purpose of the utility model is to solve the above technical problems and provide a medicine hot melt extrusion granulation device.

[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a pharmaceutical hot melt extrusion granulation device, comprising an extruder module, a conveying module is provided at the outlet end of the extruder module, a granulation module is provided at the end of the conveying module, a cooling module is provided on the upper side of the conveying module, and the cooling module is used to air cool the medicine extruded on the conveying module; it also includes a negative pressure isolation cover, which separates the extruder module, the conveying module, and the granulation module from the external space; the cooling module includes an air cooler and an air distribution duct, the air cooler is arranged outside the negative pressure isolation cover, and the cold air outlet of the air cooler is connected to the air distribution duct arranged in the negative pressure isolation cover, the air distribution duct is arranged above the conveying module, and the air distribution duct is extended in the length direction of the conveying module.

[0007] Furthermore, the extruder module includes a frame, an extruder body, a feed port, and an extrusion port. The frame is provided with the extruder body, one end of the extruder body close to the conveying module is provided with an extrusion port, and the upper side of the other end is provided with a feed port.

[0008] Furthermore, the conveying module includes a conveyor frame, a conveyor belt, and a drive motor. The conveyor belt is arranged in the conveyor frame. A drive motor is provided at one end of the conveyor frame. The drive motor is connected to one end of the conveyor belt through a chain. One end of the conveyor belt is connected to the outlet end of the extruder module, and the other end is connected to the granulation module.

[0009] Furthermore, the granulation module includes a feed guide wheel, a clamping wheel group, a cutting table, and a cutting gear. The feed part of the granulation module faces the outlet side of the conveying module, and the feed guide wheel is rotatably connected and arranged below the feed part to support the extruded linear material; the clamping wheel group is arranged on the inner side of the feed part, and the clamping wheel group includes a pressure wheel and a fine gear, and a clamping gap is formed between the pressure wheel and the fine gear to clamp the linear material; the discharge side of the clamping wheel group is provided with a cutting table, and the cutting gear is controlled and rotatably arranged inside the granulation module, the wheel edge of the cutting gear is arranged close to the cutting table, and a material guide port is provided on the lower side of the cutting gear.

[0010] Furthermore, the negative pressure isolation cover includes a screw machine cover part, a conveying cover part, and a granulation cover part that are internally connected. The screw machine cover part, the conveying cover part, and the granulation cover part are all provided with a separation cover body. The surrounding side walls of the separation cover body are sealed, and an openable sealing door is provided on the side of the separation cover body facing the operating surface. The sealing door is made of transparent material; an operating port is provided on the sealing door, and an operating glove is connected to the inner side of the operating port.

[0011] Furthermore, a partition layer is provided inside the conveying hood and the granulation hood, and the partition layer includes an upper partition and a rear partition. The upper partition and the rear partition divide the interior of the conveying hood and the granulation hood into an operating area and a circulation area. A circulating fan is provided on the upper partition, and a circulating air outlet is provided at the lower part of the rear partition. The circulating air outlet connects the operating area and the circulation area; the air inlet of the circulating fan is located in the circulation area, and the air outlet faces the operating area.

[0012] Furthermore, the air outlet of the circulation fan is located on the upper partition, and a first air filter is provided on the upper partition, and an air supply inlet is provided on the top of the granulation cover.

[0013] Furthermore, an exhaust device is connected to the upper portion of the screw machine cover, and a second air filter and an exhaust fan are arranged in the exhaust device.

[0014] Furthermore, a plurality of cold air outlets are radially arranged on the lower side of the air distribution duct, and a plurality of the cold air outlets are evenly spaced.

[0015] Furthermore, the length of the cold air outlet is 80 mm, the width is 5 mm, and the distance between two adjacent cold air outlets is 100 mm.

[0016] Compared with the prior art, the utility model has the following beneficial effects: the utility model pharmaceutical hot melt extrusion granulation device uses an extruder module to hot-melt extrude the pharmaceutical raw materials into shape, and is sent to the granulation module by a conveying module in the form of strips, and the cooled medicine can be evenly granulated by a cutting gear; the device is provided with a cooling module above the conveying module, and the air cooler circulates and cools the air in the negative pressure isolation cover and blows it directly onto the extruded medicine strips from the cold air outlet, thereby cooling and molding the medicine; since it is separated from the outside world by the negative pressure isolation cover, it can be ensured that the production environment of the medicine meets the requirements. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the structure of a pharmaceutical hot melt extrusion granulation device of the utility model;

[0018] Figure 2 This is a structural diagram of a negative pressure isolation cover of a pharmaceutical hot melt extrusion granulation device of the utility model;

[0019] Figure 3 For this utility model Figure 2 The enlarged view of point A in the middle;

[0020] Figure 4 for Figure 1 Structural diagram of the middle AA section;

[0021] Figure 5 for Figure 1 Structural diagram of the middle BB section;

[0022] Figure 6 This is the bottom view structure of the air distribution duct;

[0023] In the figure: 1. extruder module; 2. conveying module; 3. granulation module; 4. cooling module; 5. negative pressure isolation cover; 6. cold air blower; 7. air distribution duct; 8. extruder body; 9. feed port; 10. extrusion port; 11. conveyor belt; 12. drive motor; 13. feed guide wheel; 14. cutting table; 15. cutting gear; 16. pressure wheel; 17. fine gear; 18. guide port; 19. screw machine cover; 20. conveying cover; 21. granulation cover; 22. sealing door; 23. operation port; 24. operation gloves; 25. upper partition; 26. rear partition; 27. working area; 28. circulation area; 29. ​​circulation fan; 30. circulation air outlet; 31. first air filter; 32. air supply inlet; 33. exhaust device; 34. second air filter; 35. cold air outlet; 36. exhaust fan. DETAILED DESCRIPTION

[0024] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments.

[0025] A pharmaceutical hot melt extrusion granulation device, such as Figure 1-6 As shown, it includes an extruder module 1, a conveying module 2 is provided at the outlet end of the extruder module 1, a granulating module 3 is provided at the end of the conveying module 2, a cooling module 4 is provided on the upper side of the conveying module 2, and the cooling module 4 is used to perform air cooling on the medicine extruded on the conveying module 2;

[0026] Specifically, Figure 1 , 2 As shown, the extruder module 1 includes a frame, an extruder body 8, a feed port 9, and an extrusion port 10. The frame is provided with an extruder body 8, and an extrusion port 10 is provided at one end of the extruder body 8 close to the conveying module 2, and a feed port 9 is provided on the upper side of the other end. When in use, the drug raw material is put in through the feed port 9, the extruder body 8 performs hot melt extrusion on the drug, and the strip drug is extruded through the extrusion port 10, and the drug is placed on the conveyor belt 11 of the conveying module 2, and the drug is transferred to the granulation module 3 through the conveying module 2 for granulation, and the drug is cooled and formed through the cooling module 4 during the conveying process.

[0027] Specifically, the conveying module 2 includes a conveyor frame, a conveyor belt 11, and a driving motor 12. The conveyor belt 11 is arranged in the conveyor frame. A driving motor 12 is arranged at one end of the conveyor frame. The driving motor 12 is connected to one end of the conveyor belt 11 through a chain. One end of the conveyor belt 11 is connected to the outlet end of the extruder module 1, and the other end is connected to the granulation module 3. The driving motor 12 drives the conveyor belt 11 to operate through the chain. It can be understood that the conveying speed is controllable, so that the conveying speed of the conveyor belt 11 is adapted to the extrusion speed of the extruder body 8, so that continuous extrusion and conveying can be achieved.

[0028] Further, such as Figure 3 As shown, the granulation module 3 includes a feed guide wheel 13, a clamping wheel group, a cutting table 14, and a cutting gear 15. The feed part of the granulation module 3 faces the outlet side of the conveying module 2, and the feed guide wheel 13 is rotatably connected and arranged below the feed part to support the extruded linear material; the cooled strip-shaped medicine is sent to the feed of the granulation module 3, and the feed guide wheel 13 supports the medicine strip, and as the medicine enters, the feed guide wheel 13 rotates to guide it;

[0029] The clamping wheel set is arranged inside the feeding part, and the drug strip is clamped in the clamping wheel set. Specifically, the clamping wheel set includes a pressing wheel 16 and a fine gear 17. A clamping gap for clamping the linear material is formed between the pressing wheel 16 and the fine gear 17. The drug strip passes through the clamping gap. The pressing wheel 16 presses the drug strip on the tooth surface of the fine gear 17. The tooth surface can increase the friction force on the drug strip, pull the drug tangent material gear 15 to move, and prevent it from moving backward. And the feeding speed can be controlled; a cutting table 14 is provided on the discharge side of the clamping wheel group, and the cutting gear 15 is controlled to rotate and is arranged inside the granulation module 3. The wheel edge of the cutting gear 15 is arranged close to the cutting table 14. When cutting, the clamping wheel group conveys the drug strip to the end of the cutting table 14. When the drug strip extends out, the protruding drug strip is cut off by the cutting gear 15, thereby granulating. A guide port 18 is provided on the lower side of the cutting gear 15, and the drug particles fall from the guide port 18 into the collecting trough below.

[0030] like Figure 2 As shown, it also includes a negative pressure isolation cover 5, which separates the extruder module 1, the conveying module 2, and the granulation module 3 from the external space; the negative pressure isolation cover 5 includes a screw machine cover part 19, a conveying cover part 20, and a granulation cover part 21 that are internally connected, and the screw machine cover part 19, the conveying cover part 20, and the granulation cover part 21 are all provided with a separation cover body, and the side walls of the separation cover body are sealed. The side of the separation cover body facing the operating surface is provided with an openable sealing door 22, and the sealing door 22 is made of transparent material; the sealing door 22 is provided with an operating port 23, as shown Figure 5 As shown, an operating glove 24 is connected to the inner side of the operating port 23. When actually in use, the operator passes the arm through the operating port 23 and wears the operating glove 24 to perform isolated operations on the internal device of the negative pressure isolation cover 5. The sealing door 22 can be opened to perform maintenance and other operations on the internal equipment. During normal operation, the internal part can be operated through the operating glove 24 set on the operating port 23, which can separate the drug production process from the external environment and keep the internal cleanliness level in compliance with the requirements. In addition, the modular design of the negative pressure isolation cover 5 can form a negative pressure gradient between different modules. Specifically, the pressure in the screw machine cover 19 can be controlled to -20pa; the conveying cover 20 is controlled to -10pa; and the granulation cover 21 is controlled to -5pa.

[0031] The conveying hood 20 and the granulating hood 21 are provided with a partition layer inside, and the partition layer includes an upper partition 25 and a rear partition 26. The upper partition 25 and the rear partition 26 divide the inside of the conveying hood 20 and the granulating hood 21 into an operation area 27 and a circulation area 28. The upper partition 25 is provided with a circulation fan 29, and the lower part of the rear partition 26 is provided with a circulation air port 30. The circulation air port 30 connects the operation area 27 and the circulation area 28. The air inlet of the circulation fan 29 is located in the circulation area 28, and the air outlet faces the operation area 27. The air outlet of the circulation fan 29 is located on the upper partition 25, and a first air filter 31 is provided on the upper partition 25, such as Figure 4 As shown, the upper partition 25 and the rear partition 26 form an operating area 27 and a circulation area 28 inside the conveying hood 20 and the granulation hood 21. The circulation fan 29 at the top blows the wind downward from the top. The wind enters the circulation area 28 at the back from the circulation air port 30 at the bottom rear side of the operating area 27 and flows upward back to the inlet of the circulation fan 29, thus forming an internal air circulation, which is a gas circulation in the vertical direction.

[0032] The upper part of the screw machine cover 19 is connected with an exhaust device 33, and a second air filter 34 and an exhaust fan 36 are arranged in the exhaust device 33. The exhaust device 33 provides the power of lateral gas circulation for the entire negative pressure isolation cover 5, so that the gas flows from the granulation module 3 to the extruder module 1 and is sent out by the exhaust fan 36. It can be understood that in the process of this lateral movement, a pressure gradient difference is formed between each module, and a supplementary air inlet 32 ​​is arranged at the top of the granulation cover 21; the supplementary fresh air can be clean air after purification.

[0033] The cooling module 4 includes an air cooler 6 and an air distribution duct 7. The air cooler 6 is arranged outside the negative pressure isolation cover 5. Figure 2 , 4 As shown, the cold air outlet of the air cooler 6 is connected to the air distribution duct 7 provided in the negative pressure isolation cover 5, and the air distribution duct 7 is provided above the conveying module 2, and the air distribution duct 7 is extended in the length direction of the conveying module 2. The air cooler 6 can absorb the air in the negative pressure isolation cover 5 and send it out through the air distribution duct 7 after internal circulation refrigeration, so as to maintain the cleanliness requirements in the negative pressure isolation cover 5. The lower side of the air distribution duct 7 is provided with a plurality of cold air ports 35 in the radial direction, and the cold air ports 35 are evenly spaced. Figure 6 As shown, the length of the cold air outlet 35 is 80 mm, the width is 5 mm, and the distance between two adjacent cold air outlets 35 is 100 mm. The evenly spaced cold air outlets 35 can make the cold air directly and evenly dispersed on the medicine strip, thereby improving the cooling effect of the medicine.

[0034] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A pharmaceutical hot melt extrusion granulation device, comprising an extruder module (1), characterized in that: The outlet end of the extruder module (1) is provided with a conveying module (2), the end of the conveying module (2) is provided with a granulating module (3), the upper side of the conveying module (2) is provided with a cooling module (4), and the cooling module (4) is used to air cool the medicine extruded on the conveying module (2); it also includes a negative pressure isolation cover (5), and the negative pressure isolation cover (5) separates the extruder module (1), the conveying module (2), and the granulating module (3) from the external space; the cooling module (4) includes a cold air fan (6) and an air distribution duct (7), the cold air fan (6) is arranged outside the negative pressure isolation cover (5), and the cold air outlet of the cold air fan (6) is connected to the air distribution duct (7) arranged in the negative pressure isolation cover (5), and the air distribution duct (7) is arranged above the conveying module (2), and the air distribution duct (7) is extended in the length direction of the conveying module (2).

2. A pharmaceutical hot melt extrusion granulation device according to claim 1, characterized in that: The extruder module (1) comprises a frame, an extruder body (8), a feed port (9), and an extrusion port (10); the frame is provided with the extruder body (8); one end of the extruder body (8) close to the conveying module (2) is provided with the extrusion port (10); and the upper side of the other end is provided with the feed port (9).

3. A pharmaceutical hot melt extrusion granulation device according to claim 1, characterized in that: The conveying module (2) comprises a conveyor frame, a conveyor belt (11), and a drive motor (12); the conveyor belt (11) is arranged in the conveyor frame; a drive motor (12) is arranged at one end of the conveyor frame; the drive motor (12) is connected to one end of the conveyor belt (11) through a chain; one end of the conveyor belt (11) is connected to the outlet end of the extruder module (1), and the other end is connected to the granulation module (3).

4. A pharmaceutical hot melt extrusion granulation device according to claim 1, characterized in that: The granulation module (3) comprises a feed guide wheel (13), a clamping wheel group, a cutting table (14), and a cutting gear (15). The feed portion of the granulation module (3) faces the outlet side of the conveying module (2). The feed guide wheel (13) is rotatably connected and arranged below the feed portion for supporting the extruded linear material. The clamping wheel group is arranged inside the feed portion. The clamping wheel group comprises a pressure wheel (16) and a fine gear (17). A clamping gap for clamping the linear material is formed between the pressure wheel (16) and the fine gear (17). The discharge side of the clamping wheel group is provided with a cutting table (14). The cutting gear (15) is rotatably arranged inside the granulation module (3). The wheel edge of the cutting gear (15) is arranged close to the cutting table (14). A material guide port (18) is provided on the lower side of the cutting gear (15).

5. A pharmaceutical hot melt extrusion granulation device according to claim 1, characterized in that: The negative pressure isolation cover (5) comprises a screw machine cover part (19), a conveying cover part (20), and a granulation cover part (21) which are interconnected internally. The screw machine cover part (19), the conveying cover part (20), and the granulation cover part (21) are all provided with a separation cover body. The surrounding side walls of the separation cover body are of a sealing design. The separation cover body is provided with an openable sealing door (22) on the side facing the operating surface. The sealing door (22) is made of a transparent material. The sealing door (22) is provided with an operating port (23). An operating glove (24) is connected to the inner side of the operating port (23).

6. A pharmaceutical hot melt extrusion granulation device according to claim 5, characterized in that: A partition layer is provided inside the conveying hood (20) and the granulating hood (21), and the partition layer includes an upper partition (25) and a rear partition (26). The upper partition (25) and the rear partition (26) divide the interior of the conveying hood (20) and the granulating hood (21) into an operating area (27) and a circulation area (28). A circulating fan (29) is provided on the upper partition (25), and a circulating air port (30) is provided at the lower part of the rear partition (26). The circulating air port (30) connects the operating area (27) and the circulation area (28); the air inlet of the circulating fan (29) is located in the circulation area (28), and the air outlet faces the operating area (27).

7. A pharmaceutical hot melt extrusion granulation device according to claim 6, characterized in that: The air outlet of the circulation fan (29) is located on the upper partition (25), and a first air filter (31) is provided on the upper partition (25). The top of the granulation cover (21) is provided with an air supply inlet (32).

8. A pharmaceutical hot melt extrusion granulation device according to claim 5, characterized in that: An exhaust device (33) is connected to the upper portion of the screw machine cover (19), and a second air filter (34) and an exhaust fan (36) are arranged in the exhaust device (33).

9. A pharmaceutical hot melt extrusion granulation device according to claim 1, characterized in that: A plurality of cold air outlets (35) are radially arranged on the lower side of the air distribution pipe (7), and a plurality of the cold air outlets (35) are evenly spaced.

10. A pharmaceutical hot melt extrusion granulation device according to claim 9, characterized in that: The cold air outlet (35) has a length of 80 mm and a width of 5 mm, and a distance between two adjacent cold air outlets (35) is 100 mm.

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