Squeezing type sample injection bottle

Abstract

The utility model discloses an extrusion type sample injection bottle which comprises a sample bottle (1) and an adapter (2), the adapter (2) is arranged in the sample bottle (1), one end of the adapter (2) close to a bottle opening of the sample bottle (1) is provided with a limiting ring (28), an exhaust hole (21) and a first sealing rib (24) are arranged below the limiting ring (28), the sealing rib is located above the exhaust hole (21), and the first sealing rib (24) is connected with the exhaust hole (21). The limiting ring (28) abuts against the bottle opening. Treatment processes such as filtering and purifying can be achieved in the bottle through the adapter (2), when the adapter (2) is pressed into the sample bottle (1), compressed air in the bottle can be released through the exhaust hole (21), the internal air pressure and the external air pressure are kept consistent, the sealing performance of the bottle body is enhanced through the first sealing rib (24), and the extrusion type sample injection bottle of a full-sealing structure is formed. The volatilization of reagents in the bottle can be prevented to the greatest extent, and the storage time of samples is prolonged.

Description

Technical Field

[0001] The utility model relates to the field of liquid chromatography and mass spectrometry analysis, in particular to an extrusion type sample injection bottle. Background Art

[0002] Injection bottles are commonly used in the chemical and medical fields to hold analytical substances. They are widely used in the fields of chemical analysis and inspection and testing. For example, with the popularization of liquid phase, liquid spectrometry, gas phase, gas phase-mass spectrometry, etc., the use of injection bottles is becoming more and more extensive. Every laboratory uses a large number of injection bottles for experiments every day. Injection bottles are generally made of hydrolyzed glass or borosilicate, and the specifications are generally 1ml-60ml.

[0003] Traditional injection bottles use wide-mouth threaded openings, and the injection bottle caps are threaded opening caps. When in use, a silicone gasket is installed under the opening cap to prevent the reagent from volatilizing. As a container for the target analyte liquid, the traditional injection bottle only has the most basic container holding function, and does not have the processing and pressure application functions.

[0004] The applicant has conducted in-depth research in this field: two solid-liquid separation devices have been disclosed, such as the "Natural Osmosis Solid-Liquid Separation Device" with publication number "CN220860848U", which can achieve the function of filtering and purifying the bottle by natural osmosis from the outside to the inside while containing the target analyte liquid. The "Two-stage Ultrafiltration Bottle" with publication number "CN220861111U" can grade and filter some samples with particularly high viscosity, complex impurities, and a wide range of particle size dispersion that are difficult to filter with a single pore size, to achieve better solid-liquid separation. However, the top cover of the above filter device adapter is provided with a cross-slot opening, which is not completely sealed.

[0005] The applicant has made further improvements on this basis and proposed a squeeze-type sample injection bottle with a fully sealed structure. Utility Model Content

[0006] In view of the deficiencies in the prior art, the purpose of the utility model is to provide a fully sealed squeeze-type injection bottle, which has the injection function of containing the target analyte liquid, and can also perform positive pressure filtration in the sample bottle, purification in the bottle, treatment in the bottle, simplify the sealing installation steps and reduce the difficulty of sealing installation.

[0007] The technical solution of the utility model is: an extrusion type sample injection bottle, comprising a sample bottle and an adapter, the adapter is placed inside the sample bottle, a limiting ring is provided at one end of the adapter close to the mouth of the sample bottle, an exhaust hole and a first sealing rib are provided below the limiting ring, the sealing rib is located above the exhaust hole, and the limiting ring abuts against the mouth of the bottle. The adapter is directly placed in the sample bottle to achieve filtering, purification and other treatments in the bottle; the exhaust hole makes it smoother when pressing down the adapter, and the first sealing rib is used to seal the bottle body.

[0008] Preferably, the lower end of the adapter is open and the interior is hollow to form a cavity, and a filter membrane is provided at one end of the adapter away from the bottle mouth for filtering the sample in the bottle.

[0009] Preferably, the cavity includes a connected cylindrical cavity and a conical cavity, the cylindrical cavity is close to the bottle mouth, the small end of the conical cavity faces the filter membrane, and the diameter of the large end of the conical cavity is equal to the diameter of the cylindrical cavity. It is suitable for sampling when the sample amount of the analysis equipment is small.

[0010] Preferably, the end surface of the adapter away from the bottle mouth is provided with an annular groove, and the outer edge of the filter membrane is embedded in the annular groove, which is suitable for filtering small-volume sample liquids.

[0011] Preferably, a filter groove is provided in the annular groove, and the filter groove is communicated with the cavity to maintain a good filter area.

[0012] Preferably, the adapter comprises a first sealing section, an overflow section and a second sealing section, the exhaust hole and the first sealing rib are located in the first sealing section, the diameter of the first sealing section is equal to the diameter of the second sealing section, and the diameter of the overflow section is smaller than the diameter of the first sealing section. The gap between the overflow section and the bottle body is used to store overflow liquid.

[0013] Preferably, a second sealing rib is provided on the outer side wall of the second sealing section to form a closed extraction space.

[0014] Preferably, the end of the adapter away from the filter membrane is a closed structure and can be integrally formed to reduce processing costs.

[0015] In another embodiment, a cavity opening is provided at the upper end of the adapter, a sealing cover is provided at the end of the adapter away from the filter membrane, the sealing cover is embedded in the cavity opening, and a third sealing rib is provided on the outer wall of the sealing cover to further seal the bottle cap to prevent the reagent in the bottle from volatilizing.

[0016] Compared with the prior art, the advantages of the utility model are:

[0017] 1. A micro exhaust hole is provided on the upper side of the adapter, so that when the adapter is pressed into the sample bottle as a whole, the air pressure inside and outside the bottle is kept consistent. When the adapter is pressed down, the air pressure inside the bottle will become larger and larger due to compression. At this time, the pressure can be released from the exhaust hole to keep the air pressure inside and outside consistent. The adapter can be pressed to the bottom normally. When the adapter is pressed to the bottom, the exhaust hole also enters the bottle body and fits against the inner wall of the bottle body, thus being in a sealed state.

[0018] 2. A sealing rib is provided above the exhaust hole to prevent a gap from existing when the exhaust hole is fitted with the bottle body and not being completely sealed.

[0019] 3. The top of the adapter adopts a fully sealed structure design (there is no cross groove on the top of the bottle cap). It can be integrally formed or made into an embedded structure. The fully sealed structure can prevent the volatilization of the reagent in the bottle to the greatest extent, extend the storage time of the sample, and improve the stability of the sample. At the same time, the injection needle of the analysis equipment can directly penetrate from the top of the adapter into the bottle for sample aspiration and injection.

[0020] The detailed structure of the utility model is further described below in conjunction with the accompanying drawings and specific implementation methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall appearance of the utility model;

[0022] Figure 2 It is a side sectional view of the utility model;

[0023] Figure 3 It is a partial view of the side sectional view A of the utility model;

[0024] Figure 4 It is a partial view of the side sectional view B of the utility model;

[0025] Figure 5 It is a partial view of the side sectional view C of the utility model;

[0026] Figure 6 It is a side sectional view of the adapter of the utility model;

[0027] Figure 7 It is a partial view of the side sectional view D of the adapter of the utility model;

[0028] Figure 8 It is a bottom view of the adapter of the utility model.

[0029] The names of the components and their corresponding serial numbers are as follows: 1. Sample bottle; 2. Adapter; 21. Exhaust hole; 22. Cavity; 221. Cylindrical cavity; 222. Conical cavity; 23. Filter membrane; 24. First sealing rib; 25. Second sealing rib; 26. Third sealing rib; 27. Sealing cover; 28. Limiting ring; 29. ​​Annular groove; 30. Filter groove; 31. First sealing section; 32. Overflow section; 33. Second sealing section. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical scheme and advantages of the embodiment of the utility model clearer, the technical scheme in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. The components of the embodiment of the utility model generally described and shown in the drawings here can be arranged and designed in various different configurations. The following detailed description of the embodiment of the utility model provided in the drawings is not intended to limit the scope of the utility model claimed for protection, but merely represents the selected embodiment of the utility model. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model. Example

[0031] like Figure 1-8 As shown: a squeeze-type sample injection bottle, including a sample bottle 1 and an adapter 2, the adapter 2 is placed inside the sample bottle 1, a limiting ring 28 is provided at one end of the adapter 2 close to the bottle mouth of the sample bottle 1, an exhaust hole 21 and at least one first sealing rib 24 are provided below the limiting ring 28, the sealing rib is located above the exhaust hole 21, and the limiting ring 28 abuts against the bottle mouth.

[0032] Specifically in this embodiment, the lower end of the adapter 2 is open and the interior is hollow to form a cavity 22, and a filter membrane 23 is provided at one end of the adapter 2 away from the bottle mouth. When the adapter 2 is pressed into the sample bottle 1, the air gradually compressed at the bottom of the bottle can pass through the filter membrane 23 at the bottom of the adapter 2 and the cavity 22 inside the adapter 2 and be discharged from the bottle through the exhaust hole 21. When the adapter 2 is completely pressed into the sample bottle 1, the second sealing rib 25 can be tightly attached to the inner wall of the sample bottle 1 to form an interference seal; when the adapter is pressed down, the sample to be tested at the bottom of the sample bottle 1 passes through the filter membrane 23 and enters the inner cavity of the adapter and is separated, thereby improving the filtering efficiency.

[0033] The design of the vent hole 21 and the first sealing rib 24 is applicable to any type of adapter and is generally arranged in the upper section of the adapter. The lower section of the adapter can be various types of adapters previously disclosed by the applicant, such as several adapters in the embodiments of patent application No. 202322212192X, a natural osmosis solid-liquid separation device, 2023222121648, a solid-liquid separation filter cartridge, and a sleeve-type solid-liquid separation device, and several adapters in the embodiments of "a two-stage ultrafiltration bottle" with publication No. "CN220861111U", as well as the two adapters disclosed in the appearance design: "CN308554679S" and "CN308554680S" can be provided with the above-mentioned vent hole 21 and the first sealing rib 24.

[0034] Specifically in this embodiment, the cavity 22 includes a cylindrical cavity 221 and a tapered cavity 222, the cylindrical cavity 221 is close to the bottle mouth, the small end of the tapered cavity 222 faces the filter membrane 23, and the diameter of the large end of the tapered cavity 222 is equal to the diameter of the cylindrical cavity 221. This shape of the adapter 2 is suitable for small volume processing with a small amount of sample.

[0035] Specifically in this embodiment, the end surface of the adapter 2 away from the bottle mouth is provided with an annular groove 29, and the outer edge of the filter membrane 23 is embedded in the annular groove 29. The actual filtering area is controlled on the end surface of the adapter 2, which reduces the amount of the key material filter membrane 23, and is more suitable for small volume processing with less sample quantity.

[0036] Specifically in this embodiment, a filter groove 30 is provided in the annular groove 29, and the filter groove 30 is connected to the cavity 22, thereby ensuring a sufficient filtering area.

[0037] Specifically in this embodiment, the adapter 2 includes a first sealing section 31, an overflow section 32 and a second sealing section 33, the exhaust hole 21 and the first sealing rib 24 are located in the first sealing section 31, the diameter of the first sealing section 31 is equal to the diameter of the second sealing section 33, and the diameter of the overflow section 32 is smaller than the diameter of the first sealing section 31.

[0038] Specifically in this embodiment, at least one second sealing rib 25 is provided on the outer side wall of the second sealing section 33. When there is too much liquid inside or the sealing rib is not effective, when the adapter 2 is pressed downward, most of the filtrate enters the adapter 2, and a small amount of liquid may penetrate the second sealing rib 25 and overflow upward. A small amount of overflowed liquid can be stored between the overflow section 32 and the bottle body, thereby preventing the overflowed liquid from directly overflowing the bottle mouth or flowing back into the adapter 2 from the exhaust hole 21 to contaminate the sample.

[0039] Specifically in this embodiment, the end of the adapter 2 away from the filter membrane 23 is a closed structure, which can be integrally formed to reduce processing costs and reduce processing difficulty. Alternatively, the upper end of the adapter 2 is provided with a cavity 22, and the end of the adapter 2 away from the filter membrane 23 is provided with a sealing cover 27, which is embedded in the cavity 22, and the outer wall of the sealing cover 27 is provided with at least one third sealing rib 26. The fully sealed structure can prevent the volatilization of the reagent in the bottle to the greatest extent, prolong the storage time of the sample, and improve the stability of the sample. The injection needle of the analysis equipment can directly pass through the sealing cover 27 and insert into the bottle for sampling.

[0040] The working process of the squeeze-type sample injection bottle in this embodiment:

[0041] 1. When in use, add the specimen directly into the sample bottle 1 pre-filled with the treatment reagent. The specimen is generally a supernatant such as blood or human tissue fluid. After mixing, the injection vial contains a solid-liquid mixed sample.

[0042] 2. Insert the adapter 2 into the sample bottle 1 containing the mixed sample, and slowly press the adapter of the sample bottle 1 from top to bottom. The gas in the bottle is slowly discharged from the exhaust hole 21, and the sample passes through the filter membrane 23 from the outside to the inside, enters the filter tank 30, and then enters the inner cavity of the adapter 2 for filtration.

[0043] 3. After standing for a period of time, the mixed sample achieves solid-liquid separation, and the adapter 2 contains a transparent and clear liquid to be tested.

[0044] The above is a specific implementation method of the utility model, but the protection scope of the utility model is not limited thereto. Any technician familiar with the technical field can make equivalent substitutions or changes within the technical scope disclosed by the utility model according to the technical solution and concept of the utility model, which should be covered by the protection scope of the claims of the utility model.

Claims

1. A squeeze-type sample injection bottle, comprising a sample bottle (1) and an adapter (2), wherein the adapter (2) is placed inside the sample bottle (1), characterized in that: A limiting ring (28) is provided at one end of the adapter (2) close to the mouth of the sample bottle (1), and an exhaust hole (21) and a first sealing rib (24) are provided below the limiting ring (28). The sealing rib is located above the exhaust hole (21), and the limiting ring (28) abuts against the mouth of the sample bottle.

2. A squeeze-type sample injection bottle according to claim 1, characterized in that: The adapter (2) has an open lower end and is hollow inside to form a cavity (22); a filter membrane (23) is provided at one end of the adapter (2) away from the bottle mouth.

3. A squeeze-type sample injection bottle according to claim 2, characterized in that: The cavity (22) comprises a connected columnar cavity (221) and a conical cavity (222); the columnar cavity (221) is close to the bottle mouth, the small end of the conical cavity (222) faces the filter membrane (23), and the diameter of the large end of the conical cavity (222) is equal to the diameter of the columnar cavity (221).

4. The squeeze-type sample injection bottle according to claim 2, characterized in that: An annular groove (29) is provided on the end surface of the adapter (2) away from the bottle mouth, and the outer edge of the filter membrane (23) is embedded in the annular groove (29).

5. The squeeze-type sample injection bottle according to claim 4, characterized in that: A filter groove (30) is provided in the annular groove (29), and the filter groove (30) is communicated with the cavity (22).

6. The squeeze-type sample injection bottle according to claim 1, characterized in that: The adapter (2) comprises a first sealing section (31), an overflow section (32) and a second sealing section (33); the exhaust hole (21) and the first sealing rib (24) are located in the first sealing section (31); the diameter of the first sealing section (31) is equal to the diameter of the second sealing section (33); and the diameter of the overflow section (32) is smaller than the diameter of the first sealing section (31).

7. The squeeze-type sample injection bottle according to claim 6, characterized in that: A second sealing rib (25) is provided on the outer side wall of the second sealing section (33).

8. A squeeze-type sample injection bottle according to any one of claims 2 to 5, characterized in that: The end of the adapter (2) away from the filter membrane (23) is a closed structure.

9. A squeeze-type sample injection bottle according to any one of claims 2 to 5, characterized in that: The upper end of the adapter (2) is provided with a cavity (22) opening, and the end of the adapter (2) away from the filter membrane (23) is provided with a sealing cover (27), the sealing cover (27) is embedded in the cavity (22) opening, and the outer side wall of the sealing cover (27) is provided with a third sealing rib (26).

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