Intermittent column punching system for chromatographic column

Abstract

The utility model relates to the technical field of chromatographic columns, and discloses a chromatographic column intermittent column punching system which comprises a working table, a chromatographic column is arranged on one side of the working table, and a column punching assembly for performing intermittent column punching on the chromatographic column is arranged on one side of the chromatographic column; by arranging the column flushing assembly, the driving assembly and the adding assembly, when the chromatographic column is used, the driving assembly can enable the column flushing assembly to push flushing liquid into the chromatographic column in an intermittent motion mode for flushing, and the adding assembly can supplement the liquid to the column flushing assembly in the moving process of the column flushing assembly; by means of the arrangement, accumulated substances in the chromatographic column can be removed in time when the chromatographic column is used, the chromatographic column is kept clean and stable, the washing frequency and mode can be set according to specific experiment conditions and the using condition of the chromatographic column, and the device is more flexible and high in adaptability.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic columns, in particular to an intermittent column flushing system for chromatographic columns. Background Art

[0002] At present, the chromatographic column is composed of a column tube, a pressure cap, a ferrule, a sieve plate, a joint, screws, etc. Chromatography is a separation and analysis method, and separation is the core. Therefore, the chromatographic column responsible for separation is the heart of the chromatographic system. The requirements for the chromatographic column are high column efficiency, good selectivity, and fast analysis speed. The intermittent flushing system of the chromatographic column is an operating mode that flushes the chromatographic column regularly or irregularly during the chromatographic analysis process.

[0003] An LED packaging device is disclosed in a Chinese utility model patent with announcement number CN204045622U. Although the above-mentioned prior art is convenient for cleaning the inner surface of the chromatographic column, and the overflow prevention component can make the overflowed water flow out from the drain hole, making the cleaning effect more comprehensive, ordinary flushing is usually only performed after each use of the chromatographic column or after the analysis is completed. This means that during long-term use, some impurities and residues will accumulate inside the chromatographic column. These substances will reduce the column efficiency and affect the separation effect. Therefore, it is necessary to design a chromatographic column intermittent flushing system that can perform intermittent flushing on the chromatographic column in use. Utility Model Content

[0004] In order to solve the technical problem that some impurities and residues may accumulate inside a chromatographic column during use and cannot be cleaned in time, the utility model provides an intermittent flushing system for a chromatographic column.

[0005] The utility model is implemented by the following technical scheme: a chromatographic column intermittent flushing system, comprising a workbench, a chromatographic column is arranged on one side of the workbench, a flushing assembly for intermittently flushing the chromatographic column is arranged on one side of the chromatographic column, a driving assembly for driving the flushing assembly to move intermittently is arranged on one side of the flushing assembly, and an adding assembly is arranged on the flushing assembly for adding liquid to the interior of the flushing assembly when the flushing assembly moves.

[0006] Through the above technical solution, when the chromatographic column is cleaned, starting the driving component can allow the flushing component to perform intermittent flushing cleaning on the chromatographic column.

[0007] As a further improvement of the above scheme, the punch column assembly includes a first pipe fixedly connected to one end of the chromatographic column, a punch column tube fixedly connected to one end of the first pipe, and a pushing block arranged inside the punch column tube, and a sealing block is provided on the outside of the pushing block, and the circumferential surface of the sealing block is in contact with the inner wall of the punch column tube.

[0008] Through the above technical solution, the push block can move to allow the liquid in the column barrel to enter the chromatographic column.

[0009] As a further improvement of the above solution, a push rod is provided on one side of the punch column tube, one end of the push rod passes through the punch column tube and is fixedly installed on one side of the push block, and a push plate is fixedly installed on the other end of the push rod.

[0010] Through the above technical solution, the push plate allows the push rod to move, which can move the push block, thereby pushing the liquid into the interior of the chromatographic column.

[0011] As a further improvement of the above scheme, the driving assembly includes a servo motor fixedly mounted on one side of the workbench, a driving rod fixedly mounted on the output end of the servo motor and a cam fixedly mounted on one end of the driving rod, and a rotating groove matching the cam is opened on one side of the workbench.

[0012] Through the above technical solution, the rotation of the cam will push the push plate, thereby pushing the liquid into the interior of the chromatographic column.

[0013] As a further improvement of the above solution, the push rod is sleeved with a push spring, one end of which is fixedly mounted on the push plate and the other end of which is in contact with the punch cylinder.

[0014] Through the above technical solution, when the cam does not push the push plate, the push spring will bring the push rod to reset the push block.

[0015] As a further improvement of the above solution, the adding component includes a second pipeline fixedly connected to one side of the punch cylinder, a first one-way valve installed on the second pipeline, and a second one-way valve installed on the first pipeline.

[0016] Through the above technical solution, when the push block moves forward, the liquid will be squeezed into the chromatographic column, and when the push block moves backward, the external liquid will enter the interior of the flushing column.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] The utility model provides a flushing component, a driving component and an adding component. When the chromatographic column is in use, the driving component will allow the flushing component to push the flushing liquid into the interior of the chromatographic column in an intermittent motion manner for flushing. The adding component will replenish the liquid in the flushing component during the movement of the flushing component. This arrangement can timely clear the accumulation inside the chromatographic column when it is in use, keep the chromatographic column clean and stable, and can set the flushing frequency and method according to specific experimental conditions and the use of the chromatographic column. It is more flexible and adaptable. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1It is a schematic diagram of the three-dimensional structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the structure of the utility model with a push block;

[0021] Figure 3 It is a schematic structural diagram of the utility model with a cross-section of the punch column assembly.

[0022] Description of main symbols:

[0023] 1. Workbench; 2. Chromatographic column; 301. First pipeline; 302. Column punch; 303. Push block; 401. Servo motor; 402. Drive rod; 403. Cam; 501. Second pipeline; 502. First one-way valve; 503. Second one-way valve; 6. Sealing block; 7. Push rod; 8. Push plate; 9. Push spring. DETAILED DESCRIPTION

[0024] The present invention is further described below in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0025] Please combine Figure 1-Figure 3 A chromatographic column intermittent flushing system of the present embodiment includes a workbench 1, a chromatographic column 2 is provided on one side of the workbench 1, a flushing assembly for intermittently flushing the chromatographic column 2 is provided on one side of the chromatographic column 2, a driving assembly for driving the flushing assembly to move intermittently is provided on one side of the flushing assembly, and an adding assembly is provided on the flushing assembly for adding liquid to the interior of the flushing assembly when the flushing assembly moves.

[0026] Combination Figure 1-Figure 3 The column assembly includes a first pipe 301 fixedly connected to one end of the chromatographic column 2, a column cylinder 302 fixedly connected to one end of the first pipe 301, and a pushing block 303 arranged inside the column cylinder 302. A sealing block 6 is sleeved on the outside of the pushing block 303. The circumferential surface of the sealing block 6 fits with the inner wall of the column cylinder 302. A pushing rod 7 is provided on one side of the column cylinder 302. One end of the pushing rod 7 passes through the column cylinder 302 and is fixedly installed on one side of the pushing block 303. A pushing plate 8 is fixedly installed on the other end of the pushing rod 7. The pushing plate 8 allows the pushing rod 7 to move so that the pushing block 303 can move. The pushing block 303 moves so that the liquid inside the column cylinder 302 can enter the interior of the chromatographic column 2.

[0027] Combination Figure 1 and Figure 3The driving assembly includes a servo motor 401 fixedly mounted on one side of the workbench 1, a driving rod 402 fixedly mounted on the output end of the servo motor 401, and a cam 403 fixedly mounted on one end of the driving rod 402. A rotating groove adapted to the cam 403 is provided on one side of the workbench 1. A pushing spring 9 is sleeved on the pushing rod 7, one end of which is fixedly mounted on the pushing plate 8 and the other end is fitted with the punching column tube 302. When the cam 403 rotates, the pushing plate 8 is pushed, thereby pushing the liquid into the chromatographic column 2. When the cam 403 does not push the pushing plate 8, the pushing spring 9 will bring the pushing rod 7 to reset the pushing block 303.

[0028] Combination Figure 1 The additional components include a second pipe 501 fixedly connected to one side of the punching column 302, a first one-way valve 502 installed on the second pipe 501, and a second one-way valve 503 installed on the first pipe 301. When the push block 303 moves forward, the liquid will be squeezed into the chromatographic column 2, and when the push block 303 moves backward, the external liquid will enter the inside of the punching column 302.

[0029] The implementation principle of an intermittent flushing system for a chromatographic column in the embodiment of the present application is as follows: when the chromatographic column 2 is in use, the servo motor 401 is started, and the rotation of the driving rod 402 will cause the cam 403 to rotate as well. The rotation of the cam 403 will push the pushing plate 8 when it contacts the pushing plate 8. The pushing plate 8 will cause the pushing rod 7 to push the pushing block 303 to move together, thereby injecting the flushing liquid inside the flushing cylinder 302 into the interior of the chromatographic column 2 through the first pipe 301 for flushing and cleaning. When the raised portion of the cam 403 is separated from the pushing plate 8, the pushing plate 8 will be reset under the push of the pushing spring 9. During the resetting process, the movement of the pushing block 303 will generate suction inside the flushing cylinder 302, thereby allowing the supplementary liquid to enter the interior of the flushing cylinder 302 from the second pipe 501. Because the second one-way valve 503 is installed on the first pipe 301 and the first one-way valve 502 is installed on the second pipe 501, the forward movement of the pushing block 303 will allow the liquid to enter the interior of the chromatographic column 2 from the first pipe 301, and the backward movement of the pushing block 303 will allow the external liquid to enter the interior of the flushing tube 302 from the second pipe 501. This arrangement can timely remove the accumulation inside the chromatographic column 2 when it is in use, keep the chromatographic column 2 clean and stable, and the flushing frequency and method can be set according to the specific experimental conditions and the use of the chromatographic column 2, which is more flexible and adaptable.

[0030] The above-mentioned implementation modes are only preferred implementation modes of the present invention, and cannot be used to limit the protection scope of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A chromatographic column intermittent flushing system, comprising a workbench (1), a chromatographic column (2) being arranged on one side of the workbench (1), characterized in that: A column flushing assembly for intermittently flushing the chromatographic column (2) is provided on one side of the column flushing assembly, a driving assembly for driving the column flushing assembly to intermittently move is provided on one side of the column flushing assembly, and an adding assembly for adding liquid to the inside of the column flushing assembly when the column flushing assembly moves is provided on the column flushing assembly.

2. A chromatographic column intermittent flushing system as claimed in claim 1, characterized in that: The column punch assembly comprises a first pipe (301) fixedly connected to one end of the chromatographic column (2), a column punch tube (302) fixedly connected to one end of the first pipe (301), and a pushing block (303) arranged inside the column punch tube (302), wherein a sealing block (6) is sleeved on the outside of the pushing block (303), and a circumferential surface of the sealing block (6) is in contact with the inner wall of the column punch tube (302).

3. A chromatographic column intermittent flushing system as claimed in claim 2, characterized in that: A push rod (7) is provided on one side of the punch column cylinder (302), one end of the push rod (7) passes through the punch column cylinder (302) and is fixedly installed on one side of the push block (303), and the other end of the push rod (7) is fixedly installed with a push plate (8).

4. A chromatographic column intermittent flushing system as claimed in claim 1, characterized in that: The driving assembly comprises a servo motor (401) fixedly mounted on one side of a workbench (1), a driving rod (402) fixedly mounted on an output end of the servo motor (401), and a cam (403) fixedly mounted on one end of the driving rod (402); a rotating groove matched with the cam (403) is provided on one side of the workbench (1).

5. A chromatographic column intermittent flushing system as claimed in claim 3, characterized in that: The push rod (7) is sleeved with a push spring (9) whose one end is fixedly mounted on the push plate (8) and the other end is in contact with the punch column tube (302).

6. A chromatographic column intermittent flushing system as claimed in claim 2, characterized in that: The adding assembly comprises a second pipe (501) fixedly connected to one side of the punch cylinder (302), a first one-way valve (502) installed on the second pipe (501), and a second one-way valve (503) installed on the first pipe (301).

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