Emulsifying structure for vinorelbine liposome preparation

Abstract

The vinorelbine liposome preparation emulsification structure comprises an emulsification tank, a tank cover detachably arranged at the top of the emulsification tank, a feed port formed in one end of the top of the tank cover and a discharge port formed in the lower end of one side of the emulsification tank, a stirring mechanism is arranged on the inner side of the emulsifying tank, the stirring mechanism comprises a hollow main shaft which is rotationally connected to the middle of the emulsifying tank, a hollow first stirring rod is arranged on the side wall of the main shaft, an auxiliary shaft is rotationally connected to the inner side of the main shaft, and a first bevel gear is arranged on the auxiliary shaft. According to the vinorelbine liposome preparation emulsification structure, the arranged first motor can drive the main shaft to rotate, then the first stirring rod performs stirring and mixing, the second motor drives the auxiliary shaft to rotate during rotation of the main shaft, the auxiliary shaft drives the rotating rod to rotate through the first bevel gear and the second bevel gear, and then the rotating rod drives the second stirring rod to rotate to realize stirring; double stirring is achieved, the stirring effect is good, and efficiency is high.

Description

Technical Field

[0001] The utility model relates to the field of emulsification devices, in particular to an emulsification structure for preparing vinorelbine liposomes. Background Art

[0002] Vinorelbine tartrate is a semi-synthetic vinca alkaloid anti-tumor new drug with high anti-cancer activity and a broad anti-tumor spectrum. Vinorelbine tartrate is a white or off-white powder or crystalline powder. Liposomes have a structure similar to that of cell membranes. The hydrophilic head of the lipids that constitute the bilayer forms the inner surface of the membrane, while the lipophilic tail is in the middle of the membrane. Liposomes are a directional drug carrier that not only protects the drug, but also improves the targeting of the drug to specific parts of the body. Therefore, they have many superior properties in improving drug efficacy.

[0003] At present, when preparing liposome drugs, it is necessary to emulsify the oil phase solution and the water phase solution to form liposomes. Emulsification is the process of evenly dispersing a liquid in another immiscible liquid in the form of extremely small droplets. Emulsification is the process of two immiscible liquids, such as oil and water, being separated into two layers in a container, with the oil with low density in the upper layer and the water with high density in the lower layer. If an appropriate surfactant is added and stirred strongly, the oil is dispersed in the water to form an emulsion. This process is called emulsification. Therefore, a drug emulsification device is required for emulsification when making liposome drugs.

[0004] The emulsification device in the prior art generally has a motor driving a stirring shaft to rotate and stir, thereby achieving emulsification. The stirring device has a single stirring form, and the stirring forms a vortex, and the peripheral materials are mixed relatively slowly, thereby affecting the emulsification effect and efficiency. In addition, the existing emulsification device usually puts all the drug liquid into the emulsification at one time, so that the drug is easily accumulated at the bottom of the cavity of the emulsification device, resulting in the stirring rod being unable to contact all the liquid, which will cause the two immiscible drug liquids to mix slowly, thereby affecting the progress of drug emulsification.

[0005] Therefore, it is necessary to propose an emulsified structure of vinorelbine liposomes to solve the above problems. Utility Model Content

[0006] The main purpose of the utility model is to provide an emulsified structure for preparing vinorelbine liposomes, which can effectively solve the problems in the background technology.

[0007] In order to achieve the above purpose, the technical solution adopted by the utility model is:

[0008] An emulsification structure for preparing vinorelbine liposomes, comprising an emulsification tank, a tank cover detachably arranged on the top of the emulsification tank, a feed port arranged at one end of the top of the tank cover, and a discharge port arranged at the lower end of one side of the emulsification tank;

[0009] The inner side of the emulsification tank is provided with a stirring mechanism, and the stirring mechanism includes a hollow main shaft rotatably connected to the middle of the emulsification tank, a hollow first stirring rod is provided on the side wall of the main shaft, a secondary shaft is rotatably connected to the inner side of the main shaft, a first bevel gear is provided on the secondary shaft, a rotating rod is rotatably connected to the inner side of the first stirring rod, one end of the rotating rod extends to the inner side of the main shaft and is provided with a second bevel gear, and a second stirring rod is provided at one end of the rotating rod away from the main shaft;

[0010] It also includes a power device, which includes a first motor arranged on the top of the tank cover to drive the main shaft to rotate, and a second motor arranged at the bottom of the main shaft to drive the secondary shaft to rotate.

[0011] Preferably, the first motor drives the main shaft to rotate via the rotating shaft; the upper and lower ends of the main shaft are rotatably connected to the tank cover and the emulsification tank respectively via sealed bearings; the two ends of the rotating rod are rotatably connected to the first stirring rod and the main shaft via sealed bearings.

[0012] Preferably, the first stirring rod is symmetrically arranged on the side wall of the main shaft; the first bevel gear corresponds to the first stirring rod, and the second bevel gear is meshed with the first bevel gear.

[0013] Preferably, the second stirring rod is arranged perpendicular to the first stirring rod.

[0014] Preferably, it also includes an intermittent feeding mechanism, which includes an installation cavity arranged on the inner side of the tank cover, a sealing block is movably arranged at a position on the inner side of the installation cavity corresponding to the feed port, a first through hole is arranged on the sealing block, a second through hole connected with the emulsification tank and corresponding to the feed port is arranged on the tank cover, a compression spring is arranged on one side of the sealing block, and a cam is arranged on the rotating shaft.

[0015] Preferably, a protrusion cooperating with the cam is provided on one side of the sealing block, so that when the first motor drives the cam to rotate, the sealing block can be driven to move back and forth.

[0016] Preferably, the second through hole corresponds to the first through hole, and the first through hole and the second through hole are in a staggered state when the cam is not in contact with the sealing block.

[0017] Beneficial Effects

[0018] Compared with the prior art, the utility model provides an emulsified structure for preparing vinorelbine liposomes, which has the following beneficial effects:

[0019] 1. The vinorelbine liposome emulsified structure is prepared by a first motor that can drive the main shaft to rotate, and then the first stirring rod is stirred and mixed. During the rotation of the main shaft, the second motor drives the secondary shaft to rotate, and the secondary shaft drives the rotating rod to rotate through the first bevel gear and the second bevel gear, and then the rotating rod drives the second stirring rod to rotate to achieve stirring, double stirring, good stirring effect, and high efficiency.

[0020] 2. The vinorelbine liposome emulsification structure can realize intermittent feeding through the cooperation of the arranged installation cavity, the sealing block, the compression spring, the first through hole, the second through hole and the cam, so that the materials can be fully stirred and mixed to prevent accumulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural schematic diagram of the utility model;

[0022] Figure 2 It is a schematic diagram of the internal structure of the utility model;

[0023] Figure 3 It is a schematic diagram of the overall structure of the stirring mechanism and the power device of the utility model;

[0024] Figure 4 It is a schematic diagram of the partial cross-sectional structure of the connection between the main shaft and the first stirring rod of the utility model;

[0025] Figure 5 It is a schematic diagram of the cross-sectional structure of the can cover of the utility model.

[0026] In the figure: 1. emulsifying tank; 2. feed port; 3. discharge port; 4. first motor; 5. second motor; 6. tank cover; 7. main shaft; 8. first stirring rod; 9. second stirring rod; 10. rotating shaft; 11. first bevel gear; 12. secondary shaft; 13. rotating rod; 14. second bevel gear; 15. mounting cavity; 16. sealing block; 17. compression spring; 18. first through hole; 19. second through hole; 20. cam. DETAILED DESCRIPTION

[0027] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0028] Example

[0029] like Figure 1-Figure 5As shown, in this embodiment, a vinorelbine liposome preparation emulsification structure comprises an emulsification tank 1, a tank cover 6 detachably arranged on the top of the emulsification tank 1, a feed port 2 arranged at one end of the top of the tank cover 6, and a discharge port 3 arranged at the lower end of one side of the emulsification tank 1; a stirring mechanism is arranged on the inner side of the emulsification tank 1, and the stirring mechanism comprises a hollow main shaft 7 rotatably connected to the middle of the emulsification tank 1, a hollow first stirring rod 8 is arranged on the side wall of the main shaft 7, and the first stirring rod 8 is symmetrically arranged on the side wall of the main shaft 7, and the inner side of the main shaft 7 is rotatably connected to a secondary shaft 1 2. A first bevel gear 11 is provided on the secondary shaft 12, and the first bevel gear 11 corresponds to the first stirring rod 8. A rotating rod 13 is rotatably connected to the inner side of the first stirring rod 8. Both ends of the rotating rod 13 are rotatably connected to the first stirring rod 8 and the main shaft 7 through sealed bearings. One end of the rotating rod 13 extends to the inner side of the main shaft 7 and is provided with a second bevel gear 14. The second bevel gear 14 is meshed with the first bevel gear 11. A second stirring rod 9 is provided at one end of the rotating rod 13 away from the main shaft 7, and the second stirring rod 9 is vertically arranged with the first stirring rod 8.

[0030] Furthermore, it also includes a power device, which includes a first motor 4 arranged on the top of the tank cover 6 to drive the main shaft 7 to rotate, the first motor 4 drives the main shaft 7 to rotate through the rotating shaft 10, the upper and lower ends of the main shaft 7 are respectively rotatably connected to the tank cover 6 and the emulsification tank 1 through sealed bearings, and the bottom of the main shaft 7 is provided with a second motor 5 for driving the secondary shaft 12 to rotate.

[0031] Furthermore, it also includes an intermittent feeding mechanism, which includes an installation cavity 15 arranged on the inner side of the tank cover 6, a sealing block 16 is movably arranged at the inner side of the installation cavity 15 corresponding to the feed port 2, and a first through hole 18 is arranged on the sealing block 16. A second through hole 19 connected with the emulsification tank 1 and corresponding to the feed port 2 is arranged on the tank cover 6, and the second through hole 19 corresponds to the first through hole 18. A compression spring 17 is arranged on one side of the sealing block 16, a cam 20 is arranged on the rotating shaft 10, and a protrusion cooperating with the cam 20 is arranged on one side of the sealing block 16, so that when the first motor 4 drives the cam 20 to rotate, it can drive the sealing block 16 to move back and forth, and when the cam 20 is not in contact with the sealing block 16, the first through hole 18 and the second through hole 19 are in a staggered state.

[0032] Working principle: when in use, the raw materials are stored in the feed port 2, the first motor 4 is started to drive the main shaft 7 to rotate through the rotating shaft 10, and the main shaft 7 drives the first stirring rod 8 to achieve material stirring. During this period, the second motor 5 drives the secondary shaft 12 to rotate, and the secondary shaft 12 drives the second bevel gear 14 and the rotating rod 13 to rotate through the first bevel gear 11. The rotating rod 13 drives the second stirring rod 9 to rotate and stir on the inner periphery of the emulsification tank 1, and the sleeve rotating shaft 10 drives the cam 20 to rotate. The cam 20 intermittently touches one end of the sealing block 16, thereby causing the sealing block 16 to move back and forth. When the first through hole 18 coincides with the second through hole 19, the raw materials in the feed port 2 are discharged, and when the first through hole 18 and the second through hole 19 are staggered, the raw materials in the feed port 2 stop falling. The device has good stirring and emulsification effect and a simple and compact structure.

[0033] The above shows and describes the basic principle and main features of the utility model and the advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only for explaining the principle of the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection claimed by the utility model is defined by the attached claims and their equivalents.

Claims

1. An emulsified structure for preparing vinorelbine liposomes, comprising an emulsification tank (1), a tank cover (6) detachably arranged on the top of the emulsification tank (1), a feed port (2) arranged at one end of the top of the tank cover (6), and a discharge port (3) arranged at the lower end of one side of the emulsification tank (1); It is characterized in that The inner side of the emulsification tank (1) is provided with a stirring mechanism, the stirring mechanism comprising a hollow main shaft (7) rotatably connected to the middle part of the emulsification tank (1), a first hollow stirring rod (8) is provided on the side wall of the main shaft (7), the inner side of the main shaft (7) is rotatably connected to a secondary shaft (12), a first bevel gear (11) is provided on the secondary shaft (12), a rotating rod (13) is rotatably connected to the inner side of the first stirring rod (8), one end of the rotating rod (13) extends to the inner side of the main shaft (7) and is provided with a second bevel gear (14), and a second stirring rod (9) is provided at one end of the rotating rod (13) away from the main shaft (7); It also includes a power device, which includes a first motor (4) arranged on the top of the tank cover (6) to drive the main shaft (7) to rotate, and a second motor (5) is arranged at the bottom of the main shaft (7) to drive the secondary shaft (12) to rotate.

2. The method for preparing an emulsified structure of vinorelbine liposomes according to claim 1, characterized in that: The first motor (4) drives the main shaft (7) to rotate via the rotating shaft (10); the upper and lower ends of the main shaft (7) are rotatably connected to the tank cover (6) and the emulsification tank (1) respectively via sealed bearings; and the two ends of the rotating rod (13) are rotatably connected to the first stirring rod (8) and the main shaft (7) via sealed bearings.

3. The method for preparing an emulsified structure of vinorelbine liposomes according to claim 2, characterized in that: The first stirring rod (8) is symmetrically arranged on the side wall of the main shaft (7); the first bevel gear (11) corresponds to the first stirring rod (8), and the second bevel gear (14) is meshed with the first bevel gear (11).

4. The method for preparing an emulsified structure of vinorelbine liposomes according to claim 3, characterized in that: The second stirring rod (9) is arranged vertically to the first stirring rod (8).

5. The vinorelbine liposome emulsified structure according to claim 2, characterized in that: The invention also comprises an intermittent feeding mechanism, the intermittent feeding mechanism comprising a mounting cavity (15) arranged on the inner side of the tank cover (6), a sealing block (16) movably arranged at a position on the inner side of the mounting cavity (15) corresponding to the feed port (2), the sealing block (16) being provided with a first through hole (18), the tank cover (6) being provided with a second through hole (19) communicating with the emulsification tank (1) and corresponding to the feed port (2), a compression spring (17) being arranged on one side of the sealing block (16), and a cam (20) being arranged on the rotating shaft (10).

6. The vinorelbine liposome emulsified structure according to claim 5, characterized in that: A protrusion cooperating with the cam (20) is provided on one side of the sealing block (16), so that when the first motor (4) drives the cam (20) to rotate, the sealing block (16) can be driven to move back and forth.

7. The vinorelbine liposome emulsified structure according to claim 6, characterized in that: The second through hole (19) corresponds to the first through hole (18), and when the cam (20) is not in contact with the sealing block (16), the first through hole (18) and the second through hole (19) are in a staggered state.

Images