Solid-phase extraction frame and solid-phase extraction device

Abstract

The utility model relates to the technical field of solid-phase extraction, and discloses a solid-phase extraction frame and a solid-phase extraction device.The solid-phase extraction frame comprises a supporting frame and a containing plate, the containing plate is horizontally fixed to the supporting frame in the mode that the vertical height of the containing plate can be adjusted, the containing plate is used for containing an extraction column, and a receiving container is arranged on the supporting frame located below the containing plate; according to the utility model, the placing plate for placing the extraction column is horizontally fixed on the support frame in a manner that the vertical height can be adjusted, so that the distance between the extraction column and the receiving container can be conveniently adjusted, and the liquid flowing through the extraction column can smoothly enter the receiving container; and the problem of cross contamination caused by liquid splashing to the outside of the receiving container is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of solid phase extraction, in particular to a solid phase extraction rack and a solid phase extraction device. Background Art

[0002] Solid phase extraction is a sample pretreatment technology, mainly used for sample separation, purification and concentration. This technology combines liquid-solid extraction and liquid chromatography technology to enrich, separate and purify samples by selective adsorption and selective elution. The core of solid phase extraction is to use solid adsorbents to adsorb target compounds in liquid samples, separate them from the matrix and interfering compounds of the sample, and then elute with eluent or heat desorb to achieve the purpose of separation and enrichment of target compounds.

[0003] For different target compounds, due to their different physical and chemical properties, different types of solid adsorbents need to be loaded in the extraction column, and the loading amount of the solid adsorbent also varies significantly. Therefore, the specifications of the extraction columns used for different target compounds are different, and the specifications of the corresponding receiving containers (such as liquid receiving tubes or waste liquid receiving containers) are also different. The existing solid phase extraction rack has poor applicability to extraction columns of different specifications, and it is easy for the liquid flowing through the extraction column to splash to the outside of the receiving container and cause cross contamination. Utility Model Content

[0004] The purpose of the utility model is to overcome the problem that when the existing solid phase extraction rack is suitable for extraction columns of different specifications, the liquid flowing through the extraction column is easily splashed to the outside of the receiving container to cause cross contamination, and to provide a solid phase extraction rack and a solid phase extraction device. The solid phase extraction rack can be well applied to extraction columns of different specifications, effectively avoiding the occurrence of the above-mentioned problem.

[0005] In order to achieve the above-mentioned purpose, the utility model provides a solid phase extraction rack, including a support frame and a placement plate, wherein the placement plate is horizontally fixed on the support frame with an adjustable vertical height, the placement plate is used to place an extraction column, and a receiving container is arranged on the support frame below the placement plate, and the receiving container is used to receive liquid flowing through the extraction column.

[0006] Optionally, strip-shaped mounting holes extending in the vertical direction are respectively provided on both sides of the support frame, and both ends of the placement plate are detachably fixed in the strip-shaped mounting holes on both sides of the support frame through locking pieces.

[0007] Optionally, the locking member is a fixing nut, and end plates perpendicular to the placing plate are respectively provided at both ends of the placing plate, and screw rods extending outward along the length direction of the placing plate are provided on the end plates, and the screw rods pass through the strip mounting holes and are locked and fixed by the fixing nuts.

[0008] Optionally, the fixing nut is a butterfly nut.

[0009] Optionally, the placement plate is provided with a placement hole which passes through from top to bottom for the extraction column to be inserted from top to bottom.

[0010] Optionally, a plurality of the placement holes are provided, and the plurality of placement holes are spaced apart on the placement plate.

[0011] Optionally, the receiving container includes a liquid receiving tube and a waste liquid collection box, and the solid phase extraction rack also includes a placement rack for placing the liquid receiving tube;

[0012] The support frame is provided with a bottom plate for placing the placement rack or the waste liquid collection box, and the bottom plate is provided with a positioning mechanism for positioning the placement rack or the waste liquid collection box so that the liquid flowing through the extraction column can drip into the waste liquid collection box or the liquid receiving tube on the placement rack.

[0013] Optionally, the positioning mechanism includes a baffle plate arranged on a side of the support frame, and at least two baffle plates are provided, and at least two baffle plates are arranged at intervals along the length direction of the support frame.

[0014] Optionally, the placement rack includes a first limiting plate, a second limiting plate and a supporting plate which are arranged in sequence from top to bottom, the first limiting plate is provided with a plurality of first limiting holes, the second limiting plate is provided with a plurality of second limiting holes, the plurality of second limiting holes correspond one to one with the plurality of first limiting holes and are arranged concentrically, and the supporting plate is used to support the liquid receiving tube inserted in the first limiting holes and the second limiting holes from top to bottom.

[0015] The utility model also provides a solid phase extraction device, which has the solid phase extraction frame.

[0016] Through the above technical solution, the placement plate for placing the extraction column is fixed horizontally on the support frame in an adjustable vertical height, so that the distance between the extraction column and the receiving container can be conveniently adjusted, thereby ensuring that the liquid flowing through the extraction column enters the receiving container smoothly, avoiding the problem of cross contamination caused by liquid splashing to the outside of the receiving container. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a structural schematic diagram of a solid phase extraction rack provided with a placement plate and a placement rack provided by the utility model;

[0018] Figure 2 It is a structural schematic diagram of a solid phase extraction rack provided with a placement plate and a waste liquid collection box provided by the utility model;

[0019] Figure 3 It is a schematic diagram of a solid phase extraction rack provided by the utility model in a use state.

[0020] Description of Reference Numerals

[0021] 1. Extraction column; 2. Liquid receiving tube; 3. Waste liquid collection box; 10. Support frame; 101. Strip mounting hole; 11. Bottom plate; 12. Baffle plate; 13. Vertical plate; 20. Placement plate; 201. Placement hole; 21. End plate; 211. Screw; 30. Placement frame; 31. First limit plate; 311. First limit hole; 32. Second limit plate; 321. Second limit hole; 33. Support plate; 34. Side plate; 40. Fixing nut. DETAILED DESCRIPTION

[0022] The specific implementation of the present invention is described in detail below in conjunction with the accompanying drawings. It should be understood that the specific implementation described here is only used to illustrate and explain the present invention, and is not used to limit the present invention.

[0023] The utility model provides a solid phase extraction rack, through which the distance between the extraction column 1 and the receiving container can be conveniently adjusted, thereby ensuring that the liquid flowing through the extraction column 1 does not splash to the outside of the receiving container, effectively avoiding the problem of cross contamination.

[0024] See also Figure 1 , Figure 2 and Figure 3 As shown, the solid phase extraction rack provided by the utility model includes a support frame 10 and a placement plate 20, wherein the placement plate 20 is horizontally fixed on the support frame 10 with adjustable vertical height, the placement plate 20 is used to place the extraction column 1, and a receiving container is arranged on the support frame 10 below the placement plate 20, and the receiving container is used to receive the liquid flowing through the extraction column 1.

[0025] In the utility model, the receiving container comprises a liquid receiving tube 2 and a waste liquid collection box 3.

[0026] After careful observation, the inventors of the present application found that the reason why the liquid flowing through the extraction column 1 is easy to splash to the outside of the receiving container is that when the existing solid phase extraction rack is suitable for extraction columns 1 of different specifications, some shorter extraction columns 1 are far away from the receiving container, resulting in splashing after the liquid drips into the receiving container. Especially when there is a lot of liquid in the receiving container, the splashing problem caused by the liquid dripping is particularly serious.

[0027] In the technical solution provided by the utility model, the placement plate 20 for placing the extraction column 1 is fixed horizontally on the support frame 10 in an adjustable vertical height, so that the distance between the extraction column 1 and the receiving container can be conveniently adjusted, thereby ensuring that the liquid flowing through the extraction column 1 smoothly enters the receiving container, avoiding the problem of cross contamination caused by splashing of the liquid to the outside of the receiving container.

[0028] Taking the receiving container as the liquid receiving tube 2 as an example, through the solid phase extraction stand provided by the utility model, during the solid phase extraction process, by lowering the height of the placement plate 20, the bottom of the extraction column 1 can be extended below the tube mouth of the liquid receiving tube 2, ensuring that the liquid flowing through the extraction column 1 can smoothly flow into the liquid receiving tube 2. Therefore, the solid phase extraction stand provided by the utility model can effectively avoid the problem of liquid splashing to the outside of the receiving container and causing cross contamination when it is suitable for extraction columns 1 of different specifications.

[0029] In the present invention, the support frame 10 mainly plays a supporting and fixing role. In a specific embodiment of the present invention, the support frame 10 includes a base plate 11 extending in the horizontal direction and vertical plates 13 arranged at both ends of the base plate 11 and extending in the vertical direction. The vertical plates 13 are fixed to the base plate 11 by bolts.

[0030] In the present invention, the placement plate 20 is fixed on the support frame 10 in a vertically adjustable manner, so that the height of the placement plate 20 on the support frame 10 can be adjusted. It should be noted that the placement plate 20 can be fixed on the support frame 10 in a vertically adjustable manner in any appropriate structural form. In some embodiments, strip-shaped mounting holes 101 extending in the vertical direction are respectively provided on both sides of the support frame 10, and the two ends of the placement plate 20 are detachably fixed in the strip-shaped mounting holes 101 on both sides of the support frame 10 by locking members.

[0031] Through the above structure, when it is necessary to adjust the height of the placement plate 20 on the support frame 10, the placement plate 20 is moved along the length direction of the strip-shaped mounting hole 101, and when it is moved to the required height, the placement plate 20 is locked and fixed by the locking member. It can be seen that based on the above structure provided by the utility model, during the solid phase extraction process, the placement plate 20 can be adjusted to any suitable position, that is, it has the advantage of a wide adjustment range.

[0032] It can be understood that in the present invention, in order to ensure that the placement plate 20 is reliably fixed on the support frame 10, at least two strip mounting holes 101 are respectively provided on both sides of the support frame 10, and at least two strip mounting holes 101 are spaced apart on the side of the support frame 10.

[0033] In some embodiments, the locking member is a fixing nut 40, and end plates 21 perpendicular to the placing plate 20 are respectively provided at both ends of the placing plate 20, and a screw rod 211 extending outward along the length direction of the placing plate 20 is provided on the end plate 21, and the screw rod 211 passes through the strip mounting hole 101 and is locked and fixed by the fixing nut 40.

[0034] It is understandable that the end plate 21 is provided with a threaded hole for connecting the screw 211. In the present invention, by providing end plates 21 perpendicular to the placement plate 20 at both ends of the placement plate 20, the end plates 21 can be attached to both sides of the support frame 10, thereby increasing the contact area between the placement plate 20 and the support frame 10, and ensuring the reliability of locking and fixing the placement plate 20 by the locking member.

[0035] It should be noted that the utility model does not specifically limit the orientation of the end plate 21, for example, it can be downward, or upward, or both upward and downward. In some embodiments, in order to avoid affecting the operation of placing the extraction column 1 above the placement plate 20, the end plate 21 is perpendicular to the placement plate 20 and is arranged downward.

[0036] Furthermore, for ease of operation, the fixing nut 40 is a butterfly nut.

[0037] In the present utility model, as a specific implementation method of placing the extraction column 1 on the placement plate 20, the placement plate 20 is provided with a placement hole 201 that runs through from top to bottom for the extraction column 1 to be inserted from top to bottom. It can be understood that the aperture specifications of the placement hole 201 are different for extraction columns 1 of different specifications. The placement plate 20 in the present utility model is opened according to the specifications of the extraction column 1 used in daily life to form the placement hole 201. Furthermore, in order to ensure reliable fixation of the extraction column 1, in some embodiments, an annular bushing is also provided in the placement hole 201, and the annular bushing can form an interference fit with the surface of the extraction column 1 to ensure the clamping of the extraction column 1. Exemplarily, the annular bushing is made of silicone material, so as to avoid damage to the extraction column 1.

[0038] Furthermore, in the present invention, the placement holes 201 are provided in plurality, and the plurality of placement holes 201 are arranged at intervals on the placement plate 20. It is understandable that, in order to adapt to extraction columns 1 of different specifications, the aperture specifications of the plurality of placement holes 201 are also different; and, for convenience of use, when the placement holes 201 are provided on the placement plate 20, the placement holes 201 with apertures from small to large can be provided along the length direction of the placement plate 20.

[0039] In some embodiments, the receiving container includes a liquid receiving tube 2 and a waste liquid collection box 3, and the solid phase extraction rack also includes a placement rack 30 for placing the liquid receiving tube 2; a bottom plate 11 is provided on the support frame 10 for placing the placement rack 30 or the waste liquid collection box 3, and a positioning mechanism is provided on the bottom plate 11 for positioning the placement rack 30 or the waste liquid collection box 3, so that the liquid flowing through the extraction column 1 can drip into the waste liquid collection box 3 or the liquid receiving tube 2 on the placement rack 30.

[0040] It is understandable that the solid phase extraction rack provided by the utility model can select a suitable receiving container according to the solid phase extraction step. For example, in the activation step, the waste liquid collection box 3 with an upper opening is selected to receive the liquid flowing through the extraction column 1.

[0041] In addition, by providing the bottom plate 11 and the positioning mechanism, the waste liquid collection box 3 and the placement rack 30 with the liquid receiving tube 2 can be conveniently positioned to ensure that the liquid flowing through the extraction column 1 can smoothly flow into the waste liquid collection box 3 or the liquid receiving tube 2.

[0042] In the present invention, the positioning mechanism can adopt any appropriate structural form, as long as it can realize the positioning of the placement rack 30 or the waste liquid collection box 3 placed on the bottom plate 11. In some embodiments, the positioning mechanism includes a baffle 12 arranged on the side of the support frame 10, and at least two baffles 12 are provided, and at least two baffles 12 are arranged at intervals along the length direction of the support frame 10. When the placement rack 30 or the waste liquid collection box 3 is placed on the bottom plate 11, the baffle 12 arranged on the side of the support frame 10 can realize the blocking and limiting of the placement rack 30 or the waste liquid collection box 3.

[0043] In some embodiments, the placement rack 30 includes a first limiting plate 31, a second limiting plate 32 and a supporting plate 33 which are arranged in sequence from top to bottom. The first limiting plate 31 is provided with a plurality of first limiting holes 311, and the second limiting plate 32 is provided with a plurality of second limiting holes 321. The plurality of second limiting holes 321 correspond one-to-one to the plurality of first limiting holes 311 and are arranged concentrically. The supporting plate 33 is used to support the liquid receiving tube 2 inserted in the first limiting hole 311 and the second limiting hole 321 from top to bottom.

[0044] In the utility model, the liquid receiving tube 2 passes through the first limiting hole 311 and the second limiting hole 321 from top to bottom and is supported and fixed by the supporting plate 33. The first limiting plate 31 and the second limiting plate 32 are provided to constrain the tube wall of the liquid receiving tube 2, thereby effectively avoiding the liquid receiving tube 2 from tilting, tipping, etc. during the solid phase extraction process, and preventing the liquid flowing through the extraction column 1 from dripping to the outside of the liquid receiving tube 2.

[0045] In the utility model, the first limit plate 31, the second limit plate 32 and the support plate 33 can be fixed together in any appropriate form, and the relative positions of the plates can be maintained to achieve the limiting and fixing of the liquid receiving tube 2. In a specific embodiment of the utility model, the two ends of the first limit plate 31, the second limit plate 32 and the support plate 33 are respectively fixed on two parallel and spaced side plates 34, and the first limit plate 31, the second limit plate 32 and the support plate 33 are fixed together by the side plates 34 to form an integral placement rack 30.

[0046] In the utility model, the placement rack 30 is positioned by the positioning mechanism on the bottom plate 11, so that the first limiting hole 311 and the second limiting hole 321 for positioning the liquid receiving tube 2 can be conveniently arranged concentrically with the placement hole 201 on the placement plate 20 for placing the extraction column 1, thereby allowing the liquid flowing through the extraction column 1 to flow smoothly into the liquid receiving tube 2.

[0047] The utility model also provides a solid phase extraction device, which has the solid phase extraction frame.

[0048] It can be understood that the solid phase extraction device also includes multiple extraction columns 1, multiple liquid receiving tubes 2, and a waste liquid collection box 3; the multiple extraction columns 1 are suitable for being placed on the placement plate 20 of the solid phase extraction rack, and the multiple liquid receiving tubes 2 are suitable for being placed on the placement rack 30.

[0049] It should be noted that since the solid phase extraction operation steps are generally divided into four steps of activation, loading, rinsing and elution, and the amount of liquid generated in each step is different, for example, in the activation step, more activation solvent is needed to remove impurities in the extraction column 1 and create a certain solvent environment. At this time, the amount of waste liquid generated is large. The waste liquid collection box 3 is directly placed under the placement plate 20 to collect the waste liquid generated by the activation. After the activation step is completed, the waste liquid collection box 3 is withdrawn and the placement rack 30 with the liquid receiving tube 2 is installed. When the placement rack 30 is in place, the liquid receiving tube 2 is facing the extraction column 1, and the subsequent solid phase extraction operation can be carried out.

[0050] The solid phase extraction device provided by the utility model can be applicable to the solid phase extraction operation of extraction columns 1 of different specifications, and can prevent the problem of cross contamination caused by splashing of liquid flowing through the extraction column 1 during the solid phase extraction process.

[0051] The preferred embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited thereto. Within the technical concept of the present invention, the technical solution of the present invention can be subjected to a variety of simple modifications. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations. However, these simple modifications and combinations should also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention.

Claims

1. A solid phase extraction rack, characterized in that: The invention comprises a support frame (10) and a placement plate (20), wherein the placement plate (20) is horizontally fixed on the support frame (10) in an adjustable vertical height, the placement plate (20) is used to place an extraction column (1), and a receiving container is provided on the support frame (10) below the placement plate (20), and the receiving container is used to receive liquid flowing through the extraction column (1).

2. The solid phase extraction rack according to claim 1, characterized in that: Strip-shaped mounting holes (101) extending in the vertical direction are respectively provided on both sides of the support frame (10), and both ends of the placement plate (20) are detachably fixed in the strip-shaped mounting holes (101) on both sides of the support frame (10) via locking pieces.

3. The solid phase extraction rack according to claim 2, characterized in that: The locking member is a fixing nut (40), and end plates (21) perpendicular to the placement plate (20) are respectively provided at both ends of the placement plate (20), and the end plates (21) are provided with screw rods (211) extending outwardly along the length direction of the placement plate (20), and the screw rods (211) pass through the strip-shaped mounting holes (101) and are locked and fixed by the fixing nut (40).

4. The solid phase extraction rack according to claim 3, characterized in that: The fixing nut (40) is a butterfly nut.

5. The solid phase extraction rack according to claim 1, characterized in that: The placement plate (20) is provided with a placement hole (201) which passes through from top to bottom for the extraction column (1) to be inserted from top to bottom.

6. The solid phase extraction rack according to claim 5, characterized in that: A plurality of the placement holes (201) are provided, and the plurality of placement holes (201) are arranged at intervals on the placement plate (20).

7. The solid phase extraction rack according to any one of claims 1 to 6, characterized in that: The receiving container comprises a liquid receiving tube (2) and a waste liquid collection box (3), and the solid phase extraction rack further comprises a placement rack (30) for placing the liquid receiving tube (2); The support frame (10) is provided with a bottom plate (11) for placing the placement frame (30) or the waste liquid collection box (3), and the bottom plate (11) is provided with a positioning mechanism for positioning the placement frame (30) or the waste liquid collection box (3), so that the liquid flowing through the extraction column (1) can drip into the waste liquid collection box (3) or the liquid receiving tube (2) on the placement frame (30).

8. The solid phase extraction rack according to claim 7, characterized in that: The positioning mechanism comprises a baffle (12) arranged on the side of the support frame (10), at least two baffles (12) are provided, and at least two baffles (12) are arranged at intervals along the length direction of the support frame (10).

9. The solid phase extraction rack according to claim 7, characterized in that: The placement rack (30) comprises a first limiting plate (31), a second limiting plate (32) and a supporting plate (33) which are arranged in sequence from top to bottom. The first limiting plate (31) is provided with a plurality of first limiting holes (311), and the second limiting plate (32) is provided with a plurality of second limiting holes (321). The plurality of second limiting holes (321) correspond to the plurality of first limiting holes (311) one by one and are arranged concentrically. The supporting plate (33) is used for supporting the liquid receiving tube (2) which is inserted into the first limiting hole (311) and the second limiting hole (321) from top to bottom.

10. A solid phase extraction device, characterized in that: The solid phase extraction device comprises the solid phase extraction rack according to any one of claims 1 to 9.

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