Rapid defoaming device for microneedle preparation

Abstract

The utility model provides a quick defoaming device for microneedle preparation, which comprises a cover body, a sliding surface with the gradient larger than 60 degrees and smaller than 90 degrees is arranged in the cover body, a spraying device is mounted in the cover body above the sliding surface, and the spraying device is connected with a defoaming agent solvent bottle through a communicating pipe; an electric injection pump is mounted above the sliding surface, and an outlet of the electric injection pump is close to the sliding surface; a conveying mechanism is arranged below the sliding face, and a microneedle mold is placed on the conveying mechanism. The cover body is arranged to centralize defoaming agent spray to create a spray environment, the sliding surface is arranged in the cover body, injection molding liquid is extruded into spherical particle liquid drops at the top of the sliding surface through the electric injection pump, the particle liquid drops slide down along the sliding surface under the action of gravity, and the surfaces of the particle liquid drops are in contact with the defoaming agent spray during the process, so that the permeation of a defoaming agent is facilitated; therefore, quick defoaming for shortening the subsequent standing time is realized.

Description

Technical Field

[0001] The utility model relates to the field of microneedle preparation, in particular to a rapid defoaming device used for microneedle preparation. Background Art

[0002] In the preparation of soluble microneedles or swellable microneedles, the main component of the injection molding liquid used for preparation is a polymer material, such as sodium hyaluronate HA, carboxymethyl cellulose CMC, sodium alginate SA, polyvinyl alcohol PVA, polyvinyl pyrrolidone PVP, etc. After injection molding by centrifugation or vacuum extraction, a large number of bubbles will be generated in the base layer. Due to the high viscosity of the injection molding liquid, it is difficult for bubbles to escape and break, so that the base layer of the microneedle patch will produce a large number of cavitations after drying, affecting the appearance and performance. There is a fast defoaming device for microneedle preparation, which accelerates the bubble breaking process by spraying an atomized defoaming agent on the surface of the microneedle. However, the injection molding liquid is placed in the mold and only the surface is in contact with the defoaming agent spray. It still takes time for the defoaming agent to penetrate downwards, so it still needs to stand for a period of time to break all the bubbles. Utility Model Content

[0003] The purpose of the present application is to provide a rapid defoaming device for microneedle preparation, aiming to solve the above-mentioned problems in the prior art.

[0004] An embodiment of the present application provides a rapid defoaming device for preparing microneedles, comprising a cover body, a slippery surface with a slope greater than 60° and less than 90° being provided in the cover body, a spray device being installed in the cover body above the slippery surface, and the spray device being connected to a defoaming agent solvent bottle through a connecting pipe; an electric injection pump being installed above the slippery surface, and an outlet of the electric injection pump being close to the slippery surface; a conveying mechanism being provided below the slippery surface, and a microneedle mold being placed on the conveying mechanism.

[0005] Furthermore, a front-to-back through passage is provided below the cover body, and the left and right sides of the passage are separated into recovery grooves by partitions.

[0006] Furthermore, there are two sliding surfaces, which are symmetrically distributed in the front-rear direction, and the two sliding surfaces are fixed on a middle support frame, which is located in the channel.

[0007] Furthermore, a cushion block is arranged below the middle support frame, and a conveying mechanism is arranged on both the front and rear sides of the cushion block. The height of the conveying mechanism is smaller than the height of the cushion block, so that the conveying mechanism is supported below the sliding surface.

[0008] Furthermore, a support foot is provided at the lower end of the cover body, the height of the support foot is greater than the height of the conveying mechanism, the support foot is located at the front and rear ends of the cover body, and there is a gap between the front and rear ends of the support foot.

[0009] Furthermore, a feeding mechanism is arranged on the outer side of the cover body in parallel with the conveying mechanism, a connecting platform is arranged between the feeding mechanism and the conveying mechanism, and a push rod is arranged on the side of the feeding mechanism corresponding to the connecting platform.

[0010] The beneficial effects of the utility model are as follows: the utility model arranges a cover body to concentrate the defoaming agent spray to create a spray environment, arranges a slippery surface in the cover body, and squeezes the injection molding liquid into spherical microparticle droplets on the top of the slippery surface through an electric injection pump. Under the action of gravity, the microparticle droplets slide down the slippery surface, during which the surface of the microparticle droplets contacts with the defoaming agent spray, which helps the penetration of the defoaming agent, thereby achieving rapid defoaming with shortened subsequent standing time. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Figure 1 It is a schematic diagram of the overall structure of the utility model.

[0012] Figure 2 It is a schematic diagram of the structure of the cover.

[0013] Figure 3 It is a structural diagram of the transmission mechanism and the feeding mechanism.

[0014] In the figure:

[0015] 1. Cover body; 2. Sliding surface; 3. Spray device; 4. Electric injection pump; 5. Conveying mechanism; 6. Microneedle mold; 7. Channel; 8. Discharge port; 9. Partition plate; 10. Recovery trough; 11. Middle support frame; 12. Pad block; 13. Support foot; 14. Loading mechanism; 15. Connecting platform; 16. Push rod. DETAILED DESCRIPTION

[0016] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0017] like Figure 1A rapid defoaming device for preparing microneedles is shown, comprising a cover body 1, wherein a sliding surface 2 with a slope greater than 60° and less than 90° is provided in the cover body 1, and a spray device 3 is installed in the cover body 1 above the sliding surface 2, and the spray device 3 is connected to the defoaming agent solvent bottle through a connecting pipe, and the spray device 3 is provided with a pressure device to atomize the liquid defoaming agent through the spray device 3 and spray it in the cover body 1, so as to form a defoaming agent spray environment in the cover body 1. An electric injection pump 4 is installed above the sliding surface 2, and the electric injection pump 4 is filled with polymer injection molding liquid. The outlet of the electric injection pump 4 is close to the sliding surface 2, and the injection molding liquid particles are squeezed onto the sliding surface 2 by the electric injection pump 4; a conveying mechanism 5 is provided below the sliding surface 2, and a microneedle mold 6 is placed on the conveying mechanism 5. The extruded injection molding liquid particles roll down along the sliding surface 2 under the action of gravity, and are fully contacted with the defoaming agent spray on all sides during the rolling process, and finally fall into the microneedle mold 6, and then are conveyed out of the cover body 1 by the conveying mechanism 5.

[0018] like Figure 2 As shown, a channel 7 is provided at the bottom of the cover body 1, which is connected to the front and rear sides of the cover body 1, and a discharge port 8 is formed on the front and rear sides of the cover body 1. The left and right sides of the channel 7 are separated by a partition 9 to form a recovery tank 10. The mist defoaming agent can fall into the recovery tank 10 for recovery.

[0019] In this embodiment, there are two sliding surfaces 2, which are symmetrically distributed in the front-to-back direction, and the two sliding surfaces 2 are fixed on the middle support frame 11, and the overall side surface is triangular, and the middle support frame 11 is located in the channel 7. The width of the middle support frame 11 is smaller than the width of the channel 7, so that the middle support frame 11 can be accommodated in the channel 7. Correspondingly, there are two conveying mechanisms 5 and electric injection pumps 4, and the two groups work simultaneously to operate twice the number of injection molding liquid particles in the same time.

[0020] A cushion block 12 is provided below the middle support frame 11, and the cushion block 12 cushions the middle support frame 11. A conveying mechanism 5 is provided on both the front and rear sides of the cushion block 12, and the height of the conveying mechanism 5 is less than the height of the cushion block 12, so that the conveying mechanism 5 is supported below the sliding surface 2, and the shape is as follows: Figure 1 As shown, the injection molding liquid particles can fall along the sliding surface 2 into the microneedle mold 6 on the surface of the conveying mechanism 5.

[0021] The lower end of the cover body 1 is provided with a support leg 13. Figure 2 As shown, the height of the support legs 13 is greater than the height of the conveying mechanism 5 , and the support legs 13 are located at the front and rear ends of the cover body 1 , with a gap between the front and rear ends of the support legs 13 .

[0022] A feeding mechanism 14 is arranged on the outer side of the cover body 1 in parallel with the conveying mechanism 5. Figure 3As shown, the feeding mechanism 14 is also a conveying device, and the conveying direction is opposite to that of the conveying mechanism 5. A connecting platform 15 is provided between the feeding mechanism 14 and the conveying mechanism 5, and the connecting platform 15 is located between the front and rear legs 13. A push rod 16 is provided on the side of the feeding mechanism 14 corresponding to the connecting platform 15, and the push rod 16 is driven by a cylinder. The feeding mechanism 14 is used to convey the microneedle mold 6 to the conveying mechanism 5.

[0023] When in use, the feeding mechanism 14 transfers the empty microneedle mold 6 to the end, at which time the microneedle mold 6 is aligned with the connecting platform 15 and is located between the connecting platform 15 and the push rod 16. At this time, the push rod 16 starts to push the microneedle mold 6 from the feeding mechanism 14 through the connecting platform 15 to the conveying mechanism 5. At this time, the position of the conveying mechanism 5 where the microneedle mold 6 is located is just below the sliding surface 2. The electric injection pump 4 squeezes out the amount of injection liquid required for a microneedle mold 6 to form injection liquid particles. The injection liquid particles slide downward along the sliding surface 2 under the action of gravity, slide to the bottom and fall into the microneedle mold 6. At this time, the conveying mechanism 5 starts to convey the microneedle mold 6 out of the cover body 1 for subsequent processes.

[0024] Since the defoamer spray environment is formed in the cover body 1, both the space inside the cover body 1 and the surface of the sliding surface 2 are covered with the defoamer spray, so that the outer surface of the extruded injection molding liquid particles will contact with the defoamer spray, effectively increasing the contact area. Secondly, the amount of defoamer can be adjusted by the caliber and flow rate of the spray device 3. Since the injection molding liquid is extruded each time for a single mold, the defoamer spray concentration can be reduced to prevent the defoamer concentration in the injection molding liquid from being too high.

[0025] It is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be regarded as exemplary and non-restrictive from any point of view, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention. Any reference numeral in a claim should not be regarded as limiting the claim to which it relates.

Claims

1. A rapid defoaming device for microneedle preparation, characterized in that: It comprises a cover body, wherein a sliding surface with a slope greater than 60° and less than 90° is arranged in the cover body, a spray device is installed in the cover body above the sliding surface, and the spray device is connected to a defoaming agent solvent bottle through a connecting pipe; an electric injection pump is installed above the sliding surface, and the outlet of the electric injection pump is close to the sliding surface; a transmission mechanism is arranged below the sliding surface, and a microneedle mold is placed on the transmission mechanism.

2. The rapid defoaming device for preparing microneedles according to claim 1, characterized in that: A front-to-back through passage is provided below the cover body, and a recovery groove is formed by dividing the left and right sides of the passage by a partition.

3. The rapid defoaming device for preparing microneedles according to claim 2, characterized in that: There are two sliding surfaces, which are symmetrically distributed in the front-to-back direction. The two sliding surfaces are fixed on a middle support frame, and the middle support frame is located in the channel.

4. The rapid defoaming device for preparing microneedles according to claim 3, characterized in that: A cushion block is arranged below the middle support frame, and a conveying mechanism is arranged on both the front and rear sides of the cushion block. The height of the conveying mechanism is smaller than the height of the cushion block, so that the conveying mechanism is supported below the sliding surface.

5. The rapid defoaming device for preparing microneedles according to claim 4, characterized in that: The lower end of the cover body is provided with a support foot, the height of the support foot is greater than the height of the conveying mechanism, the support foot is located at the front and rear ends of the cover body, and there is a gap between the front and rear ends of the support foot.

6. The rapid defoaming device for preparing microneedles according to claim 5, characterized in that: A feeding mechanism is arranged on the outer side of the cover body in parallel with the conveying mechanism, a connecting platform is arranged between the feeding mechanism and the conveying mechanism, and a push rod is arranged on the side of the feeding mechanism corresponding to the connecting platform.

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