Serum protein dialysis device

Abstract

The utility model provides a serum protein dialysis device which comprises a dialysis box used for containing dialysate, a placing plate used for bearing dialysis cups is fixedly connected to the inner wall of the dialysis box, and a plurality of limiting assemblies used for supporting and stabilizing the dialysis cups are arranged on the placing plate in an array at equal intervals. Firstly, the dialysis cup is suspended in the through hole, the driving piece drives the limiting assembly to do inward closing motion and be attached to the cup wall of the dialysis cup, at the moment, the dialysis cup is put down, the bottom side of the cup edge of the dialysis cup is attached to the upper side of the limiting assembly so that the dialysis cup can be stabilized and supported, and at the moment, other dialysis cups can be placed in the through holes respectively. The limiting assemblies support the bottom sides of the cup edges of the dialysis cups, the structure can stably support the multiple dialysis cups, shaking or instability of the dialysis cups is avoided to a certain degree, and batched dialysis treatment of serum protein can be achieved.

Description

Technical Field

[0001] The utility model relates to the technical field related to serum protein dialysis, in particular to a serum protein dialysis device. Background Art

[0002] Serum protein dialysis technology is a biotechnology used to separate and purify serum proteins. It utilizes the physical and chemical properties of serum proteins such as molecular size, charge and hydrophilicity to separate serum proteins through the selective filtration of dialysis membranes. Serum protein dialysis technology has a wide range of applications in biopharmaceuticals, clinical diagnosis and research.

[0003] A dialysis cup is required in the dialysis process of serum protein. The dialysis cup is made of a semipermeable membrane material with a specific pore size. These pores allow small molecules and solvents (such as water) to pass freely, but prevent large molecules (such as serum proteins) from passing through. It has selective permeability and can separate serum proteins from small molecules. When dialyzing serum proteins, serum is added to the dialysis cup, and the dialysis cup is immersed in a dialysis buffer at a constant temperature of 37 degrees for dialysis. Through this process, the large molecular weight VWF protein is sheared under the action of the ADAMTS13 enzyme, and short fragments of VWF protein enter the buffer, while the long fragments remain in the serum. By detecting the residual amount of large molecular weight VWF protein in the serum after dialysis in the dialysis cup, the content of active ADAMTS13 enzyme can be calculated.

[0004] The existing dialysis cup is generally placed in an EP tube containing a constant temperature 37-degree buffer solution, but the EP tube is not convenient for stabilizing the dialysis cup, which may cause the dialysis cup to shake or become unstable during the dialysis process, resulting in poor dialysis effect. In addition, there is no device in the prior art for holding the dialysate and stabilizing multiple dialysis cups.

[0005] Therefore, it is necessary to provide a new serum protein dialysis device to solve the above technical problems. Utility Model Content

[0006] In order to solve the above technical problems, the utility model provides a serum protein dialysis device.

[0007] The serum protein dialysis device provided by the utility model comprises: a dialysis box for containing dialysis fluid, a placement plate for carrying a dialysis cup is fixedly connected to the inner wall of the dialysis box, a plurality of limit assemblies for supporting and stabilizing the dialysis cup are equidistantly arranged in an array on the placement plate, and the plurality of limit assemblies can be closed inwardly and opened outwardly by a driving member arranged in the dialysis box to stabilize and support the bottom side of the cup edge of the dialysis cup.

[0008] Preferably, the limiting assembly includes a fixed plate, a movable plate, a connecting shaft, a plurality of movable parts and a plurality of limiting plates, the side wall of the fixed plate is fixedly connected to the inner wall of the mounting groove provided on the placement plate, the movable plate is rotatably connected to the bottom side of the fixed plate and the movable plate and the fixed plate are provided with through holes of the same size, the side wall of the movable plate is fixedly connected to a connecting shaft, the connecting shaft rotates under the drive of the driving member, the movable plate is provided with a plurality of sliding grooves, the fixed plate is provided with a plurality of arc grooves, the plurality of movable parts are movably arranged in the plurality of sliding grooves and the plurality of arc grooves, respectively, a limiting plate for supporting the bottom side of the dialysis cup is provided on one side above the movable part, and one side of the limiting plate is arc-shaped and elastic.

[0009] Preferably, the movable part includes a movable plate, a movable shaft and a sliding plate, one side of the movable plate is fixedly connected to one side of the limiting plate, the upper end of the movable shaft is fixedly connected to the bottom end of the movable plate, the lower end of the movable shaft is fixedly connected to the upper side of the sliding plate, the side wall of the movable shaft is movably arranged in the arc groove, and the side wall of the sliding plate is slidably arranged in the sliding groove.

[0010] Preferably, the driving member includes a threaded rod, a knob and multiple driving plates, one end of the multiple driving plates is slidably set on the inner side wall of the dialysis box, and the other ends of the multiple driving plates respectively slide in multiple through grooves opened on one side of the dialysis box, and the multiple driving plates are threadedly connected to the threaded rod, one end of the threaded rod is rotatably connected to a first mounting plate fixedly set on one side of the dialysis box, and the other end of the threaded rod movably passes through a second mounting plate fixedly set on one side of the dialysis box and is fixedly connected to one end of the knob, and multiple driving plates are provided with multiple movable grooves, and the bottom ends of multiple connecting shafts are movably set in the movable grooves and the side walls of the connecting shafts are in contact with the inner side walls of the movable grooves.

[0011] Preferably, a cover plate is fixedly connected to one side of the upper end of the dialysis box, and a plurality of grooves corresponding to the positions of the plurality of through holes are formed on the cover plate, and elastic pads for sealing the upper end of the dialysis cup are provided on the inner side walls of the plurality of grooves.

[0012] Preferably, a liquid inlet for adding dialysate is provided on the side wall of the dialysis box, a liquid outlet for discharging dialysate is provided at the bottom of the dialysis box, and a transparent plate for observing the liquid level is provided on the side wall of the dialysis box.

[0013] Preferably, the dialysis box is made of a high temperature resistant material, and the high temperature resistant material may be stainless steel, ceramic, quartz glass, etc.

[0014] Compared with the related art, the serum protein dialysis device provided by the utility model has the following beneficial effects:

[0015] The utility model provides a serum protein dialysis device. When dialysis is performed on serum protein, the dialysis cup is first suspended in a through hole, and a driving component drives a limiting component to perform an inward closing movement and abut against the cup wall of the dialysis cup. At this time, the dialysis cup is put down, and the bottom side of the cup edge of the dialysis cup is abutted against the upper side of the limiting component to achieve stability and support for the dialysis cup. At this time, other dialysis cups can be placed in the through holes respectively, and the limiting components all support the bottom side of the cup edge of the dialysis cup. This structure can provide stable support for multiple dialysis cups, avoid shaking or instability of the dialysis cups to a certain extent, and can achieve batch dialysis treatment of serum protein. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the overall structure of the serum protein dialysis device provided by the utility model;

[0017] Figure 2 This is a schematic diagram of the serum protein dialysis device provided by the utility model in an open state;

[0018] Figure 3 for Figure 2 The enlarged view of point A is shown;

[0019] Figure 4 A schematic diagram of a serum protein dialysis device and a dialysis cup provided by the utility model;

[0020] Figure 5 Schematic diagram of the placement plate, limit assembly and drive structure provided by the utility model Figure 1 ;

[0021] Figure 6 Schematic diagram of the placement plate, limit assembly and drive structure provided by the utility model Figure 2 ;

[0022] Figure 7 for Figure 6 Schematic diagram of structural decomposition shown;

[0023] Figure 8 A schematic diagram of the local structure of the limit assembly and the driving member provided by the utility model;

[0024] Fig. 9 The utility model provides a schematic diagram of the structure of the movable parts.

[0025] Numbers in the figure: 1. dialysis box; 2. cover plate; 3. placement plate; 4. fixed plate; 5. movable plate; 6. connecting shaft; 7. limit plate; 8. movable plate; 9. movable shaft; 10. sliding plate; 11. sliding groove; 12. arc groove; 13. threaded rod; 14. knob; 15. driving plate; 16. through groove; 17. movable groove; 18. elastic pad; 19. liquid inlet; 20. transparent plate; 21. dialysis cup. DETAILED DESCRIPTION

[0026] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the present invention will be further described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] The utility model is further described below in conjunction with the accompanying drawings and implementation modes.

[0028] Please refer to Figure 1-Figure 9 ,in, Figure 1 This is a schematic diagram of the overall structure of the serum protein dialysis device provided by the utility model; Figure 2 This is a schematic diagram of the serum protein dialysis device provided by the utility model in an open state; Figure 3 for Figure 2 The enlarged view of point A is shown; Figure 4 A schematic diagram of a serum protein dialysis device and a dialysis cup provided by the utility model; Figure 5 Schematic diagram of the placement plate, limit assembly and drive structure provided by the utility model Figure 1 ; Figure 6 Schematic diagram of the placement plate, limit assembly and drive structure provided by the utility model Figure 2 ; Figure 7 for Figure 6 Schematic diagram of structural decomposition shown; Figure 8 A schematic diagram of the local structure of the limit assembly and the driving member provided by the utility model; Fig. 9 The utility model provides a schematic diagram of the structure of the movable parts.

[0029] In the specific implementation process, Figure 1-Figure 9As shown, a serum protein dialysis device includes a dialysis box 1 for containing dialysis fluid, a placement plate 3 for carrying a dialysis cup 21 is fixedly connected to the inner wall of the dialysis box 1, and a plurality of limit assemblies for supporting and stabilizing the dialysis cup 21 are arranged in an array and equidistantly on the placement plate 3, and the plurality of limit assemblies can be moved inwardly closed and outwardly opened by a driving member arranged in the dialysis box 1 to stabilize and support the bottom side of the cup edge of the dialysis cup 21, and the limit assembly includes a fixed plate 4, a movable plate 5, a connecting shaft 6, a plurality of movable parts and a plurality of limit plates 7, and the side wall of the fixed plate 4 is fixedly connected to the inner wall of the mounting groove opened on the placement plate 3 The movable disk 5 is rotatably connected to the bottom side of the fixed disk 4, and the movable disk 5 and the fixed disk 4 are provided with through holes of the same size. A connecting shaft 6 is fixedly connected to the side wall of the movable disk 5, and the connecting shaft 6 rotates under the drive of the driving member. A plurality of sliding grooves 11 are provided on the movable disk 5, and a plurality of arc grooves 12 are provided on the fixed disk 4. A plurality of movable members are movably arranged in the plurality of sliding grooves 11 and the plurality of arc grooves 12, respectively. A limiting plate 7 for supporting the dialysis cup 21 along the bottom side is provided on one side above the movable member. One side of the limiting plate 7 is arc-shaped and elastic. The design of the limiting plate 7 enables its inner side to better fit the dialysis cup 21. The movable member includes a movable plate 8, a movable shaft 9 and a sliding plate 10. One side of the movable plate 8 is fixedly connected to one side of the limit plate 7. The upper end of the movable shaft 9 is fixedly connected to the bottom end of the movable plate 8. The lower end of the movable shaft 9 is fixedly connected to the upper side of the sliding plate 10. The side wall of the movable shaft 9 is movably arranged in the arc groove 12. The side wall of the sliding plate 10 is slidably arranged in the sliding groove 11. When the serum protein is dialyzed, the dialysis cup 21 is first suspended in the through hole, the driving member drives the connecting shaft 6 to rotate, the connecting shaft 6 drives the movable disk 5 to rotate, the movable disk 5 rotates, the movable shaft 9 is subjected to the extrusion force exerted by the inner wall of the arc groove 12, so that the sliding plate 5 can be moved. The plate 10 slides in the sliding groove 11, and the movable plate 8 fixedly connected to the upper side of the movable shaft 9 moves along the direction of the sliding groove 11. At this time, the plurality of limiting plates 7 all make relatively closed movements, and the inner sides of the plurality of limiting plates 7 are in contact with the cup wall of the dialysis cup 21. At this time, the dialysis cup 21 is put down, and the bottom side of the cup edge of the dialysis cup 21 is in contact with the upper sides of the plurality of limiting plates 7 to achieve stability and support for the dialysis cup 21. At this time, other dialysis cups 21 can be placed in the through holes respectively, and the plurality of limiting plates 7 all support the bottom side of the cup edge of the dialysis cup 21. This structure can provide stable support for the plurality of dialysis cups 21, and avoid shaking or instability of the dialysis cup 21 to a certain extent.

[0030] The driving member includes a threaded rod 13, a knob 14 and a plurality of driving plates 15, one end of the plurality of driving plates 15 is slidably arranged on the inner side wall of the dialysis box 1, and the other ends of the plurality of driving plates 15 slide in a plurality of through grooves 16 respectively provided on one side of the dialysis box 1, and the plurality of driving plates 15 are all threadedly connected with the threaded rod 13, one end of the threaded rod 13 is rotatably connected to a first mounting plate fixedly provided on one side of the dialysis box 1, and the other end of the threaded rod 13 movably passes through a second mounting plate fixedly provided on one side of the dialysis box 1 and is fixedly connected with one end of the knob 14, and a plurality of movable grooves 17 are provided on the plurality of driving plates 15, and the bottom ends of the plurality of connecting shafts 6 are movably arranged in the movable grooves 17 and the side walls of the connecting shafts 6 are fitted with the inner side walls of the movable grooves 17, and the threaded rod 13 can be driven to rotate by rotating the knob 14, and the rotation of the threaded rod 13 drives the plurality of driving plates 15 to move toward one side, and the inner walls of the plurality of through grooves 16 respectively squeeze the bottom ends of the plurality of connecting shafts 6, thereby driving the movable disk 5 to rotate synchronously;

[0031] A cover plate 2 is fixedly connected to one side of the upper end of the dialysis box 1. The cover plate 2 is provided with a plurality of grooves corresponding to the positions of the plurality of through holes. The inner side walls of the plurality of grooves are provided with elastic pads 18 for sealing the upper end of the dialysis cup 21. The cover plate 2 can be closed and a counterweight can be placed thereon so that the elastic pad 18 can fit tightly on the dialysis cup 21.

[0032] A liquid inlet 19 for adding dialysate is provided on the side wall of the dialysis box 1, and a liquid outlet for discharging dialysate is provided at the bottom of the dialysis box 1. Buffer can be added into the liquid inlet 19 through a catheter, and the buffer can be discharged through the liquid outlet after dialysis is completed. A transparent plate 20 for observing the liquid level is provided on the side wall of the dialysis box 1, and the height of the buffer liquid level can be observed through the transparent plate 20;

[0033] The dialysis box 1 is made of high temperature resistant material, such as stainless steel, ceramic, quartz glass, etc. The above materials have strong chemical stability, certain mechanical strength and high temperature resistance, and can be stable for a long time at a constant temperature of 37 degrees, meeting the need to simulate the human body environment;

[0034] The dialysis cup 21 is a Slide-A-Lyzer mini dialysis cup 21 .

[0035] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A serum protein dialysis device, characterized in that: include: A dialysis box (1) for containing dialysis fluid, wherein a placement plate (3) for carrying a dialysis cup (21) is fixedly connected to the inner wall of the dialysis box (1), and a plurality of position limiting components for supporting and stabilizing the dialysis cup (21) are arranged in an array and at equal intervals on the placement plate (3), wherein the plurality of position limiting components can be moved inwardly closed and outwardly opened by a driving member arranged in the dialysis box (1) to stabilize and support the bottom side of the cup edge of the dialysis cup (21).

2. The serum protein dialysis device according to claim 1, characterized in that: The limiting assembly comprises a fixed plate (4), a movable plate (5), a connecting shaft (6), a plurality of movable parts and a plurality of limiting plates (7); the side wall of the fixed plate (4) is fixedly connected to the inner wall of the mounting groove provided on the placement plate (3); the movable plate (5) is rotatably connected to the bottom side of the fixed plate (4); and the movable plate (5) and the fixed plate (4) are both provided with through holes of the same size; the side wall of the movable plate (5) is fixedly connected to the connecting shaft (6); the connecting shaft (6) rotates under the drive of the driving member; the movable plate (5) is provided with a plurality of sliding grooves (11); the fixed plate (4) is provided with a plurality of arc grooves (12); the plurality of movable parts are respectively movably arranged in the plurality of sliding grooves (11) and the plurality of arc grooves (12); a limiting plate (7) for supporting the bottom side of the dialysis cup (21) is provided on one side above the movable part; one side of the limiting plate (7) is arc-shaped and elastic.

3. The serum protein dialysis device according to claim 2, characterized in that: The movable part comprises a movable plate (8), a movable shaft (9) and a sliding plate (10); one side of the movable plate (8) is fixedly connected to one side of the limiting plate (7); the upper end of the movable shaft (9) is fixedly connected to the bottom end of the movable plate (8); the lower end of the movable shaft (9) is fixedly connected to the upper side of the sliding plate (10); the side wall of the movable shaft (9) is movably arranged in the arc groove (12); and the side wall of the sliding plate (10) is slidably arranged in the sliding groove (11).

4. The serum protein dialysis device according to claim 3, characterized in that: The driving member comprises a threaded rod (13), a knob (14) and a plurality of driving plates (15), one end of each of the driving plates (15) being slidably disposed on the inner side wall of the dialysis box (1), and the other ends of each of the driving plates (15) respectively sliding in a plurality of through grooves (16) provided on one side of the dialysis box (1), and each of the driving plates (15) being threadedly connected to the threaded rod (13), one end of each of the threaded rod (13) being rotatably connected to a first mounting plate fixedly provided on one side of the dialysis box (1), and the other end of each of the threaded rod (13) being movably penetrated through a second mounting plate fixedly provided on one side of the dialysis box (1) and being fixedly connected to one end of the knob (14), and each of the driving plates (15) being provided with a plurality of movable grooves (17), and the bottom ends of each of the connecting shafts (6) being movably disposed in the movable grooves (17) and the side walls of the connecting shafts (6) being in contact with the inner side walls of the movable grooves (17).

5. The serum protein dialysis device according to claim 4, characterized in that: A cover plate (2) is fixedly connected to one side of the upper end of the dialysis box (1), and a plurality of grooves corresponding to the positions of the plurality of through holes are provided on the cover plate (2), and elastic pads (18) for sealing the upper end of the dialysis cup (21) are provided on the inner side walls of the plurality of grooves.

6. The serum protein dialysis device according to claim 5, characterized in that: The side wall of the dialysis box (1) is provided with a liquid inlet (19) for adding dialysis fluid, the bottom of the dialysis box (1) is provided with a liquid outlet for discharging dialysis fluid, and the side wall of the dialysis box (1) is provided with a transparent plate (20) for observing the liquid level.

7. The serum protein dialysis device according to claim 6, characterized in that: The dialysis box (1) is made of high temperature resistant material.

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