Frame type chromatography workstation

Abstract

The utility model relates to the field of chromatography work stations, and discloses a frame type chromatography work station which comprises a frame, an industrial personal computer is arranged on one side of the frame, a button assembly is arranged at the position, corresponding to the industrial personal computer, of one side of a stainless steel damping adjusting foot cup, the frame is divided into an upper layer and a lower layer, a column position valve is arranged on the upper layer frame, and a column position valve is arranged on the lower layer frame. The outer side of the column position valve is connected with a sensor assembly, a first flow meter is fixedly installed on the lower-layer vehicle frame, one side of the first flow meter is connected with an anti-mixing valve, a second flow meter, an inlet and outlet valve and a bubble trap assembly are fixedly installed on the upper-layer vehicle frame, and one side of the second flow meter is connected with an air detector. A second inlet-outlet valve and a first inlet-outlet valve are arranged on the lower-layer frame, a second quaternary diaphragm pump is arranged on one side of the second inlet-outlet valve, and an air detector and a first quaternary diaphragm pump are connected to one side of the first inlet-outlet valve and the lower portion of the first inlet-outlet valve respectively.

Description

Technical Field

[0001] The utility model relates to the field of chromatography workstations, in particular to a frame-type chromatography workstation. Background Art

[0002] Chromatography is a technology that uses the differences in the physical and chemical properties of different substances. All chromatography systems are composed of two phases: one is the stationary phase and the other is the mobile phase. When the mixture to be separated passes through the stationary phase with the mobile phase, due to the differences in the physical and chemical properties of each component, the ability to interact with the two phases (adsorption, dissolution, binding, etc.) is different, the distribution (content ratio) in the two phases is different, and as the mobile phase moves forward, the components are constantly redistributed in the two phases. By collecting the effluent in parts, each single component contained in the sample can be obtained, thereby achieving the purpose of separating the components. The existing chromatography equipment is composed of multiple sets of valves and diaphragms, so a large number of pipeline connections are required, resulting in the internal pipeline arrangement of the equipment not being rigorous and occupying area. In addition, if the internal pipeline is damaged in subsequent use, the entire outer pipeline needs to be dismantled for investigation and repair, so the repair is troublesome. For this reason, we propose a frame-type chromatography workstation. Utility Model Content

[0003] In view of the deficiencies in the prior art, the utility model provides a frame-type chromatography workstation to solve the above-mentioned problems.

[0004] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a frame-type chromatography workstation, comprising a frame, an industrial computer is arranged on one side of the frame, a button assembly is arranged on one side of a stainless steel shock-absorbing adjustment foot cup at a position corresponding to the industrial computer, the frame is divided into an upper and lower layer, a column position valve is arranged on the upper frame, a sensor assembly is connected to the outer side of the column position valve, a flow meter 1 is fixedly installed on the lower frame, a mixing prevention valve is connected to one side of the flow meter 1, a flow meter 2, an inlet and outlet valve and a bubble trap assembly are fixedly installed on the upper frame, a second air detector is connected to one side of the flow meter 2, an inlet and outlet valve 2 and an inlet and outlet valve 1 are arranged on the lower frame, a quaternary diaphragm pump 2 is arranged on one side of the inlet and outlet valve 2, and a first air detector and a quaternary diaphragm pump 1 are respectively connected to one side and the bottom of the inlet and outlet valve 1.

[0005] Preferably, the bubble trap assembly comprises a bubble trap, a bubble trap valve and a two-way diaphragm valve, the two-way diaphragm valve is fixedly mounted on the top of the bubble trap, and the bubble trap valve is fixedly mounted on the lower end of the bubble trap.

[0006] Preferably, the sensor assembly includes a first pH sensor, a first conductivity sensor, a pressure sensor, a UV detector, a second pH sensor and a second conductivity sensor.

[0007] Preferably, the button assembly includes a power indicator light, an operating status indicator light, an alarm indicator light and an emergency stop button arranged in a line.

[0008] Preferably, one side of the frame is an open structure, and the other side is provided with an equipment cabinet. In the open frame structure, the execution structure and piping structure of all core electrical components are completely exposed, which is convenient for operators to observe, adjust, clean, inspect, repair, replace and change the model, composition, position, etc. of components as needed, so as to maximize the clean, safe and flexible system operation requirements of GMP pharmaceutical factories.

[0009] Preferably, a main switch is fixedly mounted on one side of the frame, and a cooling fan is arranged on the side of the cabinet end of the frame.

[0010] Preferably, four sets of stainless steel shock-absorbing and adjusting foot cups are fixedly installed on the bottom of the frame, and four sets of universal wheels are fixedly installed on the bottom of the frame.

[0011] Compared with the prior art, the utility model provides a frame-type chromatography workstation, which has the following beneficial effects:

[0012] 1. The frame-type chromatography workstation has an open structure on one side of the frame and an equipment cabinet on the other side. With the open frame structure, the execution structure and pipeline structure of all core electrical components are completely exposed, which is convenient for operators to observe, adjust, clean, inspect, repair, replace and change the model, composition, position, etc. of components as needed, so as to meet the clean, safe and flexible system operation requirements of GMP pharmaceutical factories to the greatest extent.

[0013] 2. The frame-type chromatography workstation has a narrow layout equipment structure that extends backwards, and the equipment width is no more than 1.2m (the width of the standard specification series equipment is no more than 90cm). It is convenient for the equipment to move in and out of different workshops of the pharmaceutical factory. The horizontal layout of the frame is inspired by the "high-speed rail" carriage. The frame can be extended at the rear end to place more pumps (such as sample pumps, online dilution pumps, etc.), more functional components (such as online filters, online sensors, multi-channel valves, etc.);

[0014] This frame-type chromatography workstation has standardized components and modular functional units: all pipelines, joints, and components are standard universal parts, connected in the form of sanitary chucks, and almost no welding process for pipelines is introduced. All functional units have standard liquid interfaces and electrical interfaces, which can maximize the feasibility and flexibility of increasing, reducing, changing, exchanging, and relocating system functional components.

[0015] The frame-type chromatography workstation has the shortest piping design: there are almost no redundant piping, and the functional components are directly connected to each other in space, ensuring the minimum system residual volume and improving the operating accuracy of the user's chromatography process. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a front and side stereoscopic schematic diagram of the utility model;

[0017] Figure 2 It is a schematic diagram of the back side of the utility model.

[0018] In the figure: 1. Stainless steel shock-absorbing adjustment foot cup; 2. Cooling fan; 3. Flow meter 1; 4. Anti-mixing valve; 5. First PH sensor; 6. First conductivity sensor; 7. Column valve; 8. Pressure sensor; 9. UV detector; 10. Second PH sensor; 11. Second conductivity sensor; 12. Power indicator light; 13. Operation status indicator light; 14. Alarm indicator light; 15. Emergency stop button; 16. Industrial computer; 17. Master switch; 18. Flow meter 2; 19. Inlet and outlet valve 1; 20. First air detector; 21. Four-element diaphragm pump 1; 22. Inlet and outlet valve 2; 23. Bubble trap valve; 24. Second air detector; 25. Four-element diaphragm pump 2; 26. Inlet and outlet valves; 27. Two-way diaphragm valve; 28. Bubble trap. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0020] See also Figure 1-2 A frame-type chromatography workstation includes a frame, an industrial computer 16 is arranged on one side of the frame, a button assembly is arranged on one side of a stainless steel shock-absorbing adjustment foot cup 1 at a position corresponding to the industrial computer 16, the frame is divided into an upper and lower layer, a column position valve 7 is arranged on the upper frame, a sensor assembly is connected to the outer side of the column position valve 7, a flow meter 3 is fixedly installed on the lower frame, a mixing prevention valve 4 is connected to one side of the flow meter 3, a flow meter 2 18, an inlet and outlet valve 26 and a bubble trap assembly are fixedly installed on the upper frame, a second air detector 24 is connected to one side of the flow meter 2 18, an inlet and outlet valve 2 22 and an inlet and outlet valve 1 19 are arranged on the lower frame, a quaternary diaphragm pump 2 25 is arranged on one side of the inlet and outlet valve 22, and a first air detector 20 and a quaternary diaphragm pump 21 are respectively connected to one side and below the inlet and outlet valve 19.

[0021] Furthermore, the bubble trap assembly includes a bubble trap 28 , a bubble trap valve 23 and a two-way diaphragm valve 27 . The two-way diaphragm valve 27 is fixedly mounted on the top of the bubble trap 28 , and the bubble trap valve 23 is fixedly mounted on the lower end of the bubble trap 28 .

[0022] Furthermore, the sensor assembly includes a first pH sensor 5 , a first conductivity sensor 6 , a pressure sensor 8 , an ultraviolet detector 9 , a second pH sensor 10 and a second conductivity sensor 11 .

[0023] Furthermore, the button assembly includes a power indicator light 12 , an operation status indicator light 13 , an alarm indicator light 14 and an emergency stop button 15 arranged in a line.

[0024] Furthermore, one side of the frame is an open structure, and the other side is equipped with an equipment cabinet. The open frame structure has the core electrical components and the execution structure and piping structure completely exposed, which is convenient for operators to observe, adjust, clean, inspect, repair, replace and change the model, composition, position, etc. of the components as needed, so as to maximize the clean, safe and flexible system operation requirements of the GMP pharmaceutical factory.

[0025] Furthermore, a main switch 17 is fixedly mounted on one side of the frame, and a cooling fan 2 is arranged on the side of the cabinet end of the frame.

[0026] Furthermore, four sets of stainless steel shock-absorbing and adjusting foot cups 1 are fixedly installed at the bottom of the frame, and four sets of universal wheels are fixedly installed at the bottom of the frame.

[0027] Working principle: Emergency stop button, only when it is impossible to stop the system normally in an emergency, should the emergency stop button be used. If it is necessary to stop the system in an emergency, please press the emergency stop button 15, and do not use the system power main switch 17 to shut down the system.

[0028] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A frame-type chromatography workstation, comprising a frame, characterized in that: An industrial computer (16) is arranged on one side of the frame, and a button assembly is arranged on one side of the stainless steel shock-absorbing adjustment foot cup (1) at a position corresponding to the industrial computer (16). The frame is divided into an upper and lower layer. A column position valve (7) is arranged on the upper frame, and a sensor assembly is connected to the outer side of the column position valve (7). A flow meter (3) is fixedly installed on the lower frame, and a mixing prevention valve (4) is connected to one side of the flow meter (3). A flow meter (18), an inlet and outlet valve (26) and a bubble trap assembly are fixedly installed on the upper frame, and a second air detector (24) is connected to one side of the flow meter (18). An inlet and outlet valve (22) and an inlet and outlet valve (19) are arranged on the lower frame, and a quaternary diaphragm pump (25) is arranged on one side of the inlet and outlet valve (22). A first air detector (20) and a quaternary diaphragm pump (21) are connected to one side and below the inlet and outlet valve (19) respectively.

2. A frame-type chromatography workstation according to claim 1, characterized in that: The bubble trap assembly comprises a bubble trap (28), a bubble trap valve (23) and a two-way diaphragm valve (27); the two-way diaphragm valve (27) is fixedly mounted on the top of the bubble trap (28), and the bubble trap valve (23) is fixedly mounted on the bottom of the bubble trap (28).

3. A frame-type chromatography workstation according to claim 1, characterized in that: The sensor assembly comprises a first pH sensor (5), a first conductivity sensor (6), a pressure sensor (8), an ultraviolet detector (9), a second pH sensor (10) and a second conductivity sensor (11).

4. A frame-type chromatography workstation according to claim 1, characterized in that: The button assembly comprises a power indicator light (12), an operation status indicator light (13), an alarm indicator light (14), and an emergency stop button (15) arranged in a line.

5. The frame-type chromatography workstation according to claim 1, characterized in that: One side of the frame is an open structure, and the other side is equipped with an equipment cabinet, an open frame structure.

6. A frame-type chromatography workstation according to claim 1, characterized in that: A main switch (17) is fixedly mounted on one side of the vehicle frame, and a cooling fan (2) is arranged on the side of the cabinet end of the vehicle frame.

7. The frame-type chromatography workstation according to claim 1, characterized in that: Four sets of stainless steel shock-absorbing adjustment foot cups (1) are fixedly mounted on the bottom of the frame, and four sets of universal wheels are fixedly mounted on the bottom of the frame.

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