Osmotic pressure drug-loading microneedle patch device

Abstract

The utility model discloses an osmotic pressure drug-loading microneedle patch device, and belongs to the field of microneedle patches. Comprising an upper cover, a fastener, an elastic sealing ring, a base and a plurality of hollow microneedles, a mounting groove for mounting a filter membrane is formed in the inner side of the upper cover, the filter membrane is fixed through the fastener, and a liquid injection opening communicated with the top of the mounting groove is formed in the outer side of the upper cover; the base is in threaded connection with the upper cover, a stepped groove is formed in the inner side of the base, the top of the stepped groove is communicated with the mounting groove, a semi-permeable membrane is mounted on the stepped table top of the stepped groove, the semi-permeable membrane is fixed through an elastic sealing ring, the semi-permeable membrane divides the stepped groove into a liquid storage chamber on the upper side and a medicine carrying bin on the lower side, and the hollow microneedle is mounted at the bottom of the base and communicated with the medicine carrying bin. According to the osmotic pressure drug-loading microneedle patch, the reliability and convenience of the osmotic pressure drug-loading microneedle patch in practical application are improved, a convenient, sterile and self-transdermal injection administration solution which does not affect daily activities is provided for patients, and the osmotic pressure drug-loading microneedle patch is good in sealing performance and simple in structure.

Description

Technical Field

[0001] The utility model relates to the field of microneedle patches, in particular to an osmotic pressure drug-loaded microneedle patch device. Background Art

[0002] An ideal drug-loaded microneedle device should comprehensively consider sealing and simplicity, and while ensuring drug stability and safety, it should also take into account the user experience and promote wider acceptance and application. Existing drug-loaded microneedles are difficult to form a sealed environment, have a complex overall structure, are not convenient to use, and have many problems in use. Utility Model Content

[0003] In order to overcome the above problems, the utility model provides an osmotic pressure drug-loaded microneedle patch device, which improves the reliability and convenience of the osmotic pressure drug-loaded microneedle patch in practical applications, and provides patients with a convenient, sterile, and self-transdermal injection drug delivery solution that does not affect daily activities. The device has good sealing performance and a simple structure.

[0004] The technical solution adopted by the utility model is as follows:

[0005] An osmotic pressure drug-loaded microneedle patch device comprises an upper cover, a fastener, an elastic sealing ring, a base and a plurality of hollow microneedles, wherein the inner side of the upper cover is provided with a mounting groove for mounting a filter membrane, the filter membrane is fixed by a fastener, and the outer side of the upper cover is provided with a liquid injection port connected to the top of the mounting groove; the base is threadedly connected to the upper cover, the inner side of the base is provided with a stepped groove, the top of the stepped groove is connected to the mounting groove, the stepped table of the stepped groove is provided with a semipermeable membrane, the semipermeable membrane is fixed by an elastic sealing ring, the semipermeable membrane divides the stepped groove into an upper liquid storage chamber and a lower drug loading chamber, the hollow microneedles are installed at the bottom of the base, and the hollow microneedles are connected to the drug loading chamber.

[0006] Preferably, the elastic sealing ring is located on the semipermeable membrane and fits tightly with the bottom of the upper cover.

[0007] Preferably, the inner wall of the installation groove is provided with an internal thread, the fastener is an annular structure with an external thread and a central through hole, and the external thread of the fastener matches the internal thread of the installation groove.

[0008] Preferably, a slot or a cross slot is provided at the bottom of the fastener.

[0009] Preferably, a clamping groove is provided on the inner wall of the installation groove, and the fastener is a buckle structure with a central through hole, and the buckle structure matches the clamping groove in the installation groove.

[0010] Preferably, an interference washer is provided inside the buckle structure.

[0011] Preferably, the diameter of the central through hole is not less than the diameter of the liquid injection port.

[0012] Preferably, the bottom of the fastener is flush with the bottom of the upper cover.

[0013] Preferably, the drug loading chamber contains tablets in a semi-solid state or in a hollow center state.

[0014] Preferably, a breathable film is attached to the outer side of the liquid injection port of the upper cover, and a sticky layer is provided at the bottom of the base.

[0015] The beneficial effects of the utility model are as follows: the osmotic pressure microneedle patch device provided by the utility model has a simple structure, adopts a threaded rotation connection method to simplify the installation process, achieves high integration, portability and sealing, and greatly improves the safety and effectiveness of the microneedle patch in practical applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a way to realize the osmotic pressure drug-loaded microneedle patch device;

[0017] Figure 2 yes Figure 1 Exploded diagram of

[0018] Figure 3 It is another way to realize the osmotic pressure drug-loaded microneedle patch device;

[0019] Figure 4 It is a schematic diagram of the structure of the upper cover;

[0020] Figure 5 It is a structural schematic diagram of one implementation method of a fastener;

[0021] Figure 6 It is a schematic diagram of the structure of the base;

[0022] In the figure, 1-upper cover, 2-fastener, 3-elastic sealing ring, 4-base, 5-hollow microneedle, 6-filter membrane, 7-liquid injection port, 8-semipermeable membrane, 9-liquid storage chamber, 10-drug loading chamber, 11-interference gasket. DETAILED DESCRIPTION

[0023] The present invention is further described below through the accompanying drawings and embodiments, but the present invention is not limited to the scope of the embodiments.

[0024] The utility model provides an osmotic pressure drug-loaded microneedle patch device, which is mainly composed of five key parts, namely an upper cover 1, a fastener 2, an elastic sealing ring 3, a base 4 and a plurality of hollow microneedles 5.

[0025] Among them, the upper cover 1 is the upper structure of the device. The inner side of the upper cover 1 is provided with a mounting groove for mounting the filter membrane 6. The filter membrane 6 is fixed by a fastener 2. The outer side of the upper cover 1 is provided with a liquid injection port 7 connected to the top of the mounting groove. The liquid injection port is a round hole structure, which matches the syringe. The liquid medicine can be injected into the device through the liquid injection port. The liquid medicine is filtered through the filter membrane 6. The liquid injection port 7 can be exposed or fitted with a breathable and impermeable membrane. The base 4 is the lower structure of the device. As the basic part of the device, the base 4 is threadedly connected to the upper cover 1. After the connection, the outside of the device is guaranteed to be smooth and flat. The inner side of the base is provided with a stepped groove, the top of the stepped groove is connected to the mounting groove, and the stepped table of the stepped groove is installed with a semipermeable membrane 8, the semipermeable membrane 8 is fixed by an elastic sealing ring 3, the elastic sealing ring 3 is located on the semipermeable membrane 8, and is tightly fitted with the bottom of the upper cover 1, the elastic sealing ring 3 is an elastic component made of a polymer material, and has excellent sealing performance. When the base 4 is connected to the upper cover 1 by a thread, the elastic sealing ring can effectively prevent liquid or gas from leaking from the joint, ensuring the stability of the internal environment of the osmotic pressure drug-loaded microneedle patch. The semipermeable membrane 8 divides the stepped groove into a liquid storage chamber 9 on the upper side and a drug-loading chamber 10 on the lower side. The drug-loading chamber 10 is used to store drugs, preferably in a semi-solid state or a central hollow tablet, so that the liquid and the drug are fully mixed to trigger the drug activity. The hollow microneedle 5 is installed at the bottom of the base 4, and the hollow microneedle 5 is connected to the drug-loading chamber 10. The bottom of the base 4 can be provided with a sticky layer to achieve that the entire drug-loaded microneedle does not fall off when it is applied to the human body surface. The device achieves efficient transdermal drug delivery while maintaining good sealing and stability through the coordinated cooperation of fasteners and sealing rings. The threaded rotation connection between the upper cover and the base ensures the structural stability of the device, and can be easily assembled and disassembled as needed to prevent the inside of the device from being contaminated or damaged.

[0026] An optional implementation of the utility model is as follows Figure 1 and Figure 2 The inner wall of the installation groove for installing the filter membrane 6 on the inner side of the upper cover 1 of the device is provided with an internal thread. The structure of the upper cover 1 is as shown in FIG. Figure 4 As shown, the mounting groove is a groove with a smaller diameter at the upper part, and the inner wall of the groove is provided with an internal thread. In addition, the internal thread at the lower inner side of the mounting groove is used to cooperate with the external thread of the base. Figure 5 As shown, it is an annular structure with external threads and a central through hole. The external threads of the fastener 2 match the internal threads of the mounting groove, and the bottom of the annular structure is flush with the bottom of the upper cover 1. The filter membrane 6 is placed in the mounting groove, and the fastener is installed by rotating the thread to fix the filter membrane 6. In order to facilitate installation, a straight groove or a cross groove is provided at the bottom of the fastener 2. Figure 5What is shown is a straight groove structure. In addition, in order to facilitate the faster flow of the liquid medicine injected from the injection port to the liquid storage chamber 9, the central through hole of the fastener 2 should not be smaller than the injection port diameter.

[0027] Another optional implementation of the present invention is as follows Figure 3 As shown. Figure 1 The difference is that a slot is provided on the inner wall of the installation groove for installing the filter membrane 6 on the inner side of the upper cover 1 of the device, and the fastener 2 adopts a buckle structure with a central through hole, the buckle structure matches the slot in the installation groove, and the bottom of the buckle is flush with the bottom of the upper cover 1. This design can reduce the thickness of the installation groove, and achieve a sealing effect by using the interference gasket 11 provided inside the buckle structure.

[0028] like Figure 6 As shown, the upper part of the base is provided with an external thread for connecting the upper cover, the lower part is smooth and flat on the outside, and a stepped groove is provided on the inside. The hollow microneedles 5 can be arranged in an array or in other ways. In this embodiment, three hollow microneedles are arranged in an equilateral triangle. Three microholes for installing hollow microneedles are provided at the bottom of the base. The top of the hollow microneedle 5 is connected to the drug loading chamber 10 through the microhole, and the bottom of the hollow microneedle 5 is exposed on the outside. The length of the hollow microneedle 5 adopts the traditional standard design.

[0029] The device provided by the utility model has a simple structure and forms a stable sealed environment as a whole. When in use, the drug solution is injected through the injection port 7 of the upper cover 1, and the drug solution is filtered through the filter membrane 6 and fills the entire liquid storage chamber 9. The drug solution in the liquid storage chamber 9 slowly penetrates into the drug loading chamber 10 through the semipermeable membrane, and the drug solution dissolves the drug and triggers the drug activity. One side of the hollow microneedle is applied to the surface of the human body. Due to the difference in osmotic pressure between the drug solution and the human tissue, the drug solution can passively diffuse through the hollow microneedle into the subcutaneous tissue to achieve efficient transdermal absorption. The sealing ring located at the connection between the upper cover and the base in the device ensures that the drug solution in the microneedle patch does not leak, maintains a constant osmotic pressure environment, and ensures the effective transmission of the drug.

[0030] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any changes or substitutions that are not conceived through creative work should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope defined in the claims.

Claims

1. An osmotic pressure drug-loaded microneedle patch device, characterized in that: The invention comprises an upper cover (1), a fastener (2), an elastic sealing ring (3), a base (4) and a plurality of hollow microneedles (5); the inner side of the upper cover (1) is provided with a mounting groove for mounting a filter membrane (6); the filter membrane (6) is fixed by a fastener (2); the outer side of the upper cover (1) is provided with a liquid injection port (7) connected to the top of the mounting groove; the base (4) is threadedly connected to the upper cover (1); the inner side of the base is provided with a stepped groove; the top of the stepped groove is connected to the mounting groove; a semipermeable membrane (8) is installed on the stepped table of the stepped groove; the semipermeable membrane (8) is fixed by an elastic sealing ring (3); the semipermeable membrane (8) divides the stepped groove into an upper liquid storage chamber (9) and a lower drug loading chamber (10); the hollow microneedles (5) are mounted at the bottom of the base (4); the hollow microneedles (5) are connected to the drug loading chamber (10).

2. The osmotic pressure drug-loaded microneedle patch device according to claim 1, characterized in that: The elastic sealing ring (3) is located on the semipermeable membrane (8) and is tightly fitted to the bottom of the upper cover (1).

3. The osmotic pressure drug-loaded microneedle patch device according to claim 1, characterized in that: The inner wall of the installation groove is provided with an internal thread, the fastener (2) is an annular structure with an external thread and a central through hole, and the external thread of the fastener (2) matches the internal thread of the installation groove.

4. The osmotic pressure drug-loaded microneedle patch device according to claim 3, characterized in that: The bottom of the fastener (2) is provided with a slot or a cross slot.

5. The osmotic pressure drug-loaded microneedle patch device according to claim 1, characterized in that: The inner wall of the installation groove is provided with a clamping groove, and the fastener (2) is a clamping structure with a central through hole, and the clamping structure matches the clamping groove in the installation groove.

6. The osmotic pressure drug-loaded microneedle patch device according to claim 5, characterized in that: An interference washer (11) is provided inside the buckle structure.

7. The osmotic pressure drug-loaded microneedle patch device according to claim 3 or 5, characterized in that: The diameter of the central through hole is not less than the diameter of the liquid injection port (7).

8. The osmotic pressure drug-loaded microneedle patch device according to claim 1, characterized in that: The bottom of the fastener (2) is flush with the bottom of the upper cover (1).

9. The osmotic pressure drug-loaded microneedle patch device according to claim 1, characterized in that: The drug loading chamber (10) contains tablets in a semi-solid state or in a hollow center.

10. The osmotic pressure drug-loaded microneedle patch device according to claim 1, characterized in that: A breathable film is attached to the outer side of the liquid injection port (7) of the upper cover (1), and a sticky layer is provided at the bottom of the base (4).

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