Auxiliary extraction device for nano antibody preparation

Abstract

The utility model relates to the technical field of nano antibody preparation, in particular to an extraction auxiliary device for nano antibody preparation, which comprises an auxiliary extraction box body, partition plates are arranged between two sides in the auxiliary extraction box body, and a test tube clamping component is arranged on the bottom surface in the auxiliary extraction box body close to one side; the device has the beneficial effects that an antibody solution can be heated and a magnetic field is applied by using the heating seat and the magnetic control seat, an antibody and an antigen are specifically combined to form a nano antibody under the action of a proper temperature and the magnetic field, normal operation of nano antibody preparation is guaranteed, a test tube can be prevented from shaking by using the test tube clamping assembly, and the test tube clamping assembly is convenient to operate. And the internal reagent can not be influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of nano antibody preparation, in particular to an extraction auxiliary device for nano antibody preparation. Background Art

[0002] Nanobodies are a type of heavy chain antibody variable region found in camelids discovered by scientists in 1989. Their molecular weight is only 15 ku, which is 1 / 10 of the molecular weight of conventional antibodies. The length of its protein crystal structure is 4 nm and its diameter is 2.5 nm, making it the smallest antibody known to date.

[0003] However, in the prior art, when the existing extraction auxiliary device is used, the reagent is generally placed inside the test tube, and most test tubes do not have a fixed structure, which easily causes the internal reagent to shake, affecting the subsequent use of the reagent. Nanoantibody preparation requires a heating structure and a magnetic structure, and traditional auxiliary equipment cannot guarantee the normal operation of nanoantibody preparation. Utility Model Content

[0004] The utility model provides an extraction auxiliary device for nano antibody preparation, which solves the above-mentioned structural technical problems that the reagent inside the test tube shakes due to the lack of a fixed structure and the heating structure and magnetic structure required for nano antibody preparation.

[0005] The utility model solves the above-mentioned technical problems as follows: an extraction auxiliary device for preparing nanoantibodies, comprising an auxiliary extraction box, partitions are arranged between the two sides of the interior of the auxiliary extraction box, a test tube clamping assembly is arranged near one side of the inner bottom surface of the auxiliary extraction box, an operating table is arranged near the other side of the inner bottom surface of the auxiliary extraction box, a heating seat is arranged on the top of the operating table, heating nets are arranged between the two sides of the interior of the heating seat, and a magnetic control seat is arranged on the top of the operating table near the other side.

[0006] The beneficial effects of the utility model are as follows: the auxiliary extraction box mainly serves to facilitate carrying and transportation, the partitions provided can facilitate isolation and division of areas, the test tube clamping components provided can ensure that the test tubes placed therein will not cause the internal reagents to shake due to shaking, the operating table provided can facilitate control of the operation and use of the heating seat and the magnetic control seat, the heating net provided can conduct heat, the heating seat provided can facilitate increasing the temperature during the reaction, and under the action of the magnetic field of the magnetic control seat, the antibody and antigen undergo specific binding to form nano-antibodies.

[0007] On the basis of the above technical solution, the present invention can also be improved as follows.

[0008] Furthermore, the test tube clamping assembly includes five limiting tubes, and the inner bottom surfaces of the five limiting tubes are all provided with suction cup seats.

[0009] The beneficial effect of adopting the above further solution is that the limiting tube can limit the approximate position of the test tube into the area, and the provided suction cup seat can adsorb and fix the bottom of the test tube.

[0010] Furthermore, two spring pieces are arranged on both sides of the interior of the five limiting tubes, and ten arc-shaped clamping plates are connected to both sides of the interior of the five limiting tubes through twenty spring pieces.

[0011] The beneficial effect of adopting the above further solution is that the arranged spring piece can utilize elasticity to drive the arc-shaped clamping plate to move repeatedly horizontally, and the arc-shaped clamping plate can clamp and fix the two sides of the test tube.

[0012] Furthermore, a temperature monitor is provided at one side of the partition, and a box cover is rotatably connected to the top of the auxiliary extraction box body through a hinge.

[0013] The beneficial effects of adopting the above further solution are: the temperature monitor can be used to monitor the temperature condition inside the device, and the box cover can seal and protect the auxiliary extraction box.

[0014] Furthermore, a handle is provided on the top of the box cover near both sides, and a box door is rotatably connected to the front surface of the auxiliary extraction box body near both sides through hinges.

[0015] The beneficial effect of adopting the above further solution is that the No. 1 handle can facilitate opening the box cover, and the box door can facilitate opening the auxiliary extraction box from the front.

[0016] Furthermore, a second handle is provided on one side of each of the box doors, and a display screen is provided on one side of the operating table.

[0017] The beneficial effect of adopting the above further solution is that the provided No. 2 handle can facilitate pulling the box door, and the provided display screen can facilitate displaying data.

[0018] Furthermore, a button area is provided on one side of the operating table close to the display screen, and temperature insulation layers are provided on both sides of the partition.

[0019] The beneficial effect of adopting the above further solution is that the set key area can facilitate the control of the programming and running program of the operating table, and the set thermal insulation layer plays a role in heat preservation.

[0020] Beneficial effects: By using a heating seat and a magnetic control seat, the antibody solution can be heated and a magnetic field can be applied. Under the action of appropriate temperature and magnetic field, the antibody and antigen specifically bind to form nanoantibodies, ensuring the normal operation of nanoantibody preparation. The test tube clamping component can prevent the test tube from shaking, and the internal reagents will not be affected.

[0021] The above description is only an overview of the technical solution of the utility model. In order to more clearly understand the technical means of the utility model and implement it according to the contents of the specification, the following is a detailed description of the preferred embodiment of the utility model with the accompanying drawings. The specific implementation method of the utility model is given in detail by the following embodiments and their drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of the present application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation on the present invention. In the drawings:

[0023] Figure 1 A three-dimensional diagram of an extraction auxiliary device for preparing nano-antibodies proposed in the utility model;

[0024] Figure 2 This is a schematic diagram of the front view and cross-section structure of an extraction auxiliary device for preparing nano-antibodies proposed by the utility model;

[0025] Figure 3 The utility model provides a schematic diagram of a top view and cross-sectional structure of an extraction auxiliary device for preparing nano-antibodies;

[0026] Figure 4 The utility model proposes an extraction auxiliary device for preparing nano-antibodies Figure 3 Enlarged stereogram of part A in the middle.

[0027] Legend:

[0028] 1. Auxiliary extraction box; 2. Partition; 3. Test tube clamping assembly; 4. Operating table; 5. Heating seat; 6. Heating net; 7. Magnetic control seat; 31. Limiting tube; 32. Suction cup seat; 33. Shrapnel; 34. Arc splint; 8. Temperature monitor; 9. Box cover; 10. Handle No. 1; 11. Box door; 12. Handle No. 2; 13. Display screen; 14. Keypad area; 15. Insulation layer. DETAILED DESCRIPTION

[0029] The following is combined with Figure 1-4The principles and features of the present invention are described, and the examples given are only used to explain the present invention, and are not used to limit the scope of the present invention. The present invention is described in more detail in the following paragraphs by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer according to the following description and claims. It should be noted that the drawings are all in a very simplified form and are not in precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0030] Example 1

[0031] like Figure 1-4 As shown, the utility model is an extraction auxiliary device for preparing nano antibodies, comprising an auxiliary extraction box 1, a partition 2 is arranged between the two sides of the interior of the auxiliary extraction box 1, a test tube clamping assembly 3 is arranged near one side of the inner bottom surface of the auxiliary extraction box 1, an operating table 4 is arranged near the other side of the inner bottom surface of the auxiliary extraction box 1, a heating seat 5 is arranged on the top of the operating table 4, a heating net 6 is arranged between the two sides of the interior of the heating seat 5, and a magnetic control seat 7 is arranged on the top of the operating table 4 near the other side.

[0032] Example 2

[0033] like Figure 1-4 As shown, the test tube clamping assembly 3 includes five limiting tubes 31, the inner bottom surfaces of the five limiting tubes 31 are each provided with a suction cup seat 32, two spring clips 33 are each provided on both sides of the inner part of the five limiting tubes 31, ten arc-shaped clamping plates 34 are connected to both sides of the inner part of the five limiting tubes 31 through twenty spring clips 33, a temperature monitor 8 is provided on one side of the partition 2, and the top of the auxiliary extraction box body 1 is connected to a box cover 9 through a hinge rotation.

[0034] In this embodiment, the limiting tube 31 can limit the approximate position of the test tube into the area, the provided suction cup seat 32 can adsorb and fix the bottom of the test tube, the provided spring piece 33 can use elasticity to drive the arc-shaped clamping plate 34 to move repeatedly horizontally, the arc-shaped clamping plate 34 can clamp and fix the two sides of the test tube, the provided temperature monitor 8 can facilitate the monitoring of the temperature conditions inside the device, and the box cover 9 can seal and protect the auxiliary extraction box 1.

[0035] Example 3

[0036] like Figure 1-4 As shown, a handle No. 1 10 is provided on the top of the box cover 9 near both sides, a box door 11 is rotatably connected to the front surface of the auxiliary extraction box body 1 near both sides through hinges, a handle No. 2 12 is provided on one side of each box door 11, a display screen 13 is provided on one side of the operating table 4, a button area 14 is provided on one side of the operating table 4 near the display screen 13, and a thermal insulation layer 15 is provided on both sides of the partition 2.

[0037] In this embodiment, the set handle 10 can facilitate opening the box cover 9, the set door 11 can facilitate opening the auxiliary extraction box 1 from the front, the set handle 12 can facilitate pulling the box door 11, the set display screen 13 can facilitate displaying data, the set button area 14 can facilitate controlling the programming and running program of the operating table 4, and the set insulation layer 15 can play a role in heat preservation.

[0038] Working principle:

[0039] When in use, in order to protect the reagent inside the test tube, the limiting tube 31 on the test tube clamping assembly 3 can be used to first fix the regional placement position of the test tube, and then the bottom of the test tube can be adsorbed and fixed by the suction cup seat 32. The elasticity of the spring 33 can push the arc clamping plate 34 to clamp and fix the test tube, which can prevent the internal reagent from shaking to a certain extent and will not affect the subsequent use of the reagent. The heating seat 5 and the magnetic control seat 7 can be used to heat the antibody solution and apply a magnetic field. Under the action of suitable temperature and magnetic field, the antibody and antigen specifically combine to form nano antibodies, thereby ensuring the normal operation of nano antibody preparation.

[0040] The above are only preferred embodiments of the present invention and are not intended to limit the present invention in any form. Any ordinary technician in the industry can smoothly implement the present invention as shown in the drawings and described above. However, any equivalent changes, modifications and evolutions made by technicians familiar with the profession without departing from the scope of the technical solution of the present invention using the technical content disclosed above are all equivalent embodiments of the present invention. At the same time, any equivalent changes, modifications and evolutions made to the above embodiments based on the essential technology of the present invention are still within the protection scope of the technical solution of the present invention.

Claims

1. An extraction auxiliary device for preparing nanoantibodies, comprising an auxiliary extraction box (1), characterized in that: A partition (2) is provided between both sides of the interior of the auxiliary extraction box (1); a test tube clamping assembly (3) is provided on one side of the interior bottom surface of the auxiliary extraction box (1); an operating table (4) is provided on the other side of the interior bottom surface of the auxiliary extraction box (1); a heating seat (5) is provided on the top of the operating table (4); a heating net (6) is provided between both sides of the interior of the heating seat (5); and a magnetic control seat (7) is provided on the other side of the top of the operating table (4).

2. The extraction auxiliary device for preparing nanoantibodies according to claim 1, characterized in that: The test tube clamping assembly (3) comprises five position limiting tubes (31), and the inner bottom surfaces of the five position limiting tubes (31) are all provided with suction cup seats (32).

3. The extraction auxiliary device for preparing nanoantibodies according to claim 2, characterized in that: Two spring sheets (33) are arranged on both sides of the interior of the five limiting tubes (31), and ten arc-shaped clamping plates (34) are connected to both sides of the interior of the five limiting tubes (31) via twenty spring sheets (33).

4. The extraction auxiliary device for preparing nanoantibodies according to claim 1, characterized in that: A temperature monitor (8) is provided on one side of the partition (2), and a box cover (9) is rotatably connected to the top of the auxiliary extraction box (1) via a hinge.

5. The extraction auxiliary device for preparing nanobodies according to claim 4, characterized in that: A handle (10) is provided on the top of the box cover (9) near both sides, and a box door (11) is rotatably connected to the front surface of the auxiliary extraction box body (1) near both sides through hinges.

6. The extraction auxiliary device for preparing nanobodies according to claim 5, characterized in that: A second handle (12) is provided on one side of each of the cabinet doors (11), and a display screen (13) is provided on one side of the operating table (4).

7. The extraction auxiliary device for preparing nanobodies according to claim 1, characterized in that: A key area (14) is provided on one side of the operating table (4) close to the display screen (13), and temperature insulation layers (15) are provided on both sides of the partition (2).

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