Detachable solid-phase extraction plate

Abstract

The utility model discloses a detachable solid-phase extraction plate, which belongs to the field of extraction and comprises a plate body and a movable plate fixed on the plate body through a fixing component, and a plurality of extraction columns are inserted on the movable plate; a through mounting groove is formed in the plate body, and a groove matched with the mounting groove is formed in the bottom of the movable plate; the fixing assembly comprises a threaded rod rotationally connected to the plate body, the threaded rod is sleeved with a threaded sleeve plate in a threaded mode, and the movable plate is fixedly connected with a clamping plate matched with the threaded rod in a clamped mode. According to the solid-phase extraction plate, a traditional detachable solid-phase extraction plate is improved, a plate connected with an extraction column serves as a movable plate frame and serves as a plate body, only the movable plate needs to be replaced every time, then the solid-phase extraction plate can be detached, the movable plate in direct contact with a sample is regularly replaced, and the solid-phase extraction plate is convenient to replace. The risk of cross contamination caused by long-term use can be effectively reduced, and the accuracy and reproducibility of analysis are kept.

Description

Technical Field

[0001] The utility model relates to the technical field of extraction, in particular to a detachable solid phase extraction plate. Background Art

[0002] Solid phase extraction purification technology is a technology that uses the different forces of solid adsorbents, solvents in liquid samples and eluents on target compounds to separate target compounds from interfering substances in the sample and purify the sample. As a sample pretreatment technology, solid phase extraction has been widely used in the market and has derived a series of commercial products.

[0003] The extraction columns on the current porous solid phase extraction plates are non-detachable, and the extraction columns on each orifice plate can only be of the same specification, that is, all the holes on the orifice plate have the same size. The structure of the porous extraction plate with the same specification is single. When extraction columns of different sizes are needed, the extraction plate needs to be replaced as a whole, which is a cumbersome process and has high costs. The Chinese utility model patent with publication number CN219614941U discloses a detachable solid phase extraction plate and a solid phase extraction device. By providing a limiting portion extending radially along the mounting hole on the plate body, the plate body can be placed on the extraction column, and the extraction column can be easily replaced. In addition, the surface of the limiting portion is also provided with a groove, which can provide deformation space during processing to prevent the mounting hole from being unable to match the extraction column after deformation. However, the device realizes the detachable connection between the solid phase extraction plate and the extraction column by replacing extraction columns of different diameters in the mounting hole. However, when extraction columns of different diameters and different reagents are replaced in the same mounting hole, the bottom outlet of the extraction column is likely to come into contact and friction with the inner wall of the mounting hole due to the different diameters, which may then easily lead to partial drug solution residue, and easily cause cross infection when replacing different extraction columns.

[0004] Therefore, the utility model provides a detachable solid phase extraction plate to solve the above problems. Utility Model Content

[0005] 1. Technical issues to be resolved

[0006] The utility model provides a detachable solid phase extraction plate, aiming to solve the problems proposed in the background art that when replacing extraction columns with different diameters and different medicines in the same installation hole, due to the different diameters, the bottom outlet of the extraction column is likely to contact and rub with the inner wall of the installation hole, which in turn is likely to cause part of the medicine liquid to remain, and cross infection is likely to occur when replacing different extraction columns.

[0007] (II) Technical solution

[0008] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a detachable solid phase extraction plate, comprising a plate body and a detachable movable plate fixed on the plate body by a fixing assembly, wherein a plurality of extraction columns are inserted and arranged on the movable plate;

[0009] The difference from the existing solid phase extraction plate is that: the plate body is provided with a through installation groove, and the bottom of the movable plate is provided with a groove adapted to the installation groove; wherein the installation groove is T-shaped, and the shape of the bottom of the movable plate is consistent with the shape of the inner wall of the installation groove, so that the movable plate can be conveniently embedded and installed on the plate body; the device uses the plate connected to the extraction column as the plate of the movable plate frame as the plate body, and then can realize the detachability of the solid phase extraction plate;

[0010] The fixing assembly is provided with two, and the fixing assembly comprises a threaded rod rotatably connected to the plate body, a threaded sleeve is provided on the threaded rod, and a clamping plate which is clamped and matched with the threaded rod is fixedly connected to the movable plate; the threaded rod, the threaded sleeve and the clamping plate are used to facilitate the movable plate to be detachably mounted on the plate body, and the installation or disassembly is convenient and quick, the structure is simple, and the threaded connection method has the characteristics of firm connection; the replacement process is faster and simpler, which reduces the experimental preparation time and downtime, thereby improving the overall efficiency and throughput of the experiment;

[0011] In order to reduce the gap between the installation groove and the movable plate, a first sealing ring in contact with the bottom of the movable plate is embedded in the installation groove; the first sealing ring can be used to fill and seal the gap between the installation groove and the movable plate, thereby improving the sealing between the installation groove and the movable plate.

[0012] Preferably, the mounting groove is T-shaped, and the shape of the bottom of the movable plate is consistent with the shape of the inner wall of the mounting groove.

[0013] Preferably, a positioning groove for positioning and installing the first sealing ring is provided in the installation groove.

[0014] Preferably, an arc-shaped groove for hinged connection of the threaded rod is formed at the top of the plate body.

[0015] Preferably, the solid phase extraction plate also includes a convex cylinder which is sleeved on the outside of the extraction column and fixed on the top of the movable plate, the extraction column is installed on the convex cylinder and the movable plate by means of threaded insertion, a positioning plate is fixedly sleeved on the extraction column, and a second sealing ring is sleeved on the outside of the extraction column between the convex cylinder and the positioning plate; the extraction column is mounted on the movable plate by means of threaded connection, which facilitates the individual replacement of the used or contaminated extraction column, avoids the replacement of the unused or uncontaminated extraction column, prevents the waste of materials, reduces the cost, and improves the practicality of the device.

[0016] Preferably, an annular groove for installing the second sealing ring is formed at the top end of the convex cylinder.

[0017] Preferably, a plurality of protruding rods are fixedly connected to the outer wall of the positioning plate at equal intervals in the circumferential direction.

[0018] (III) Beneficial effects

[0019] The solid phase extraction plate is improved on the traditional detachable solid phase extraction plate, and uses the plate connected to the extraction column as the plate frame of the movable plate as the plate body. Only the movable plate needs to be replaced each time, thereby achieving the detachability of the solid phase extraction plate. By regularly replacing the movable plate that directly contacts the sample, the risk of cross contamination caused by long-term use can be effectively reduced, and the accuracy and reproducibility of the analysis can be maintained.

[0020] The utility model utilizes a threaded connection to mount the extraction column on a movable plate, so that used or contaminated extraction columns can be replaced individually, and the replacement of unused or uncontaminated extraction columns can be avoided, thereby preventing waste of materials, reducing costs, and improving the practicability of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of a detachable solid phase extraction plate;

[0022] Figure 2 for Figure 1 The enlarged structural diagram at A in the middle;

[0023] Figure 3 for Figure 1 Bottom view of the middle structure;

[0024] Figure 4 for Figure 1 The middle part of the structure is sectional view;

[0025] Figure 5 for Figure 4 The enlarged structural diagram at B in the middle;

[0026] Figure 6 It is a schematic diagram of the plate structure;

[0027] Figure 7 It is a schematic diagram of the connection structure between the movable plate and the extraction column;

[0028] Figure 8 is a schematic diagram of the structure of the first sealing ring;

[0029] Fig. 9 This is an exploded diagram of the movable plate and extraction column structure.

[0030] In the figure:

[0031] 1. Plate body; 11. Mounting groove; 111. Positioning groove; 2. Movable plate; 3. Extraction column; 31. Positioning plate; 311. Protruding rod; 4. Fixing assembly; 41. Threaded rod; 42. Threaded sleeve plate; 43. Snap-on plate; 5. First sealing ring; 6. Protruding cylinder; 7. Second sealing ring. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0033] Example 1

[0034] The utility model provides a detachable solid phase extraction plate, such as Figure 1-9 As shown, the solid phase extraction plate comprises a plate body 1 and a detachable movable plate 2 fixed on the plate body 1 by a fixing assembly 4, and a plurality of extraction columns 3 are inserted and connected to the movable plate 2;

[0035] The plate body 1 is provided with a through installation groove 11, and the bottom of the movable plate 2 is provided with a groove adapted to the installation groove 11; wherein the installation groove 11 is T-shaped, and the shape of the bottom of the movable plate 2 is consistent with the shape of the inner wall of the installation groove 11, so that the movable plate 2 can be conveniently embedded and installed on the plate body 1; the device uses the plate connected to the extraction column 3 as the plate of the frame of the movable plate 2 as the plate body 1, and then the solid phase extraction plate can be detachable;

[0036] Two fixing components 4 are provided, and the fixing components 4 include a threaded rod 41 rotatably connected to the plate body 1, a threaded sleeve 42 is threadedly sleeved on the threaded rod 41, and a clamping plate 43 that is clamped and matched with the threaded rod 41 is fixedly connected to the movable plate 2; the threaded rod 41, the threaded sleeve 42 and the clamping plate 43 are conveniently used to install the movable plate 2 on the plate body 1 in a detachable manner, and the installation or disassembly is convenient and fast, the structure is simple, and the threaded connection method has the characteristics of firm connection; the replacement process is faster and simpler, which reduces the experimental preparation time and downtime, thereby improving the overall efficiency and throughput of the experiment;

[0037] By regularly replacing the movable plate 2 that directly contacts the sample, the risk of cross contamination caused by long-term use can be effectively reduced, and the accuracy and reproducibility of the analysis can be maintained. The replacement of the movable plate 2 alone makes maintenance more flexible and convenient, and facilitates rapid troubleshooting and targeted repairs without having to deal with the complexity of the entire system. This design allows flexible selection or replacement of adsorption materials (located on the movable plate 2) of different properties according to different experimental requirements, so as to adapt to the characteristics of different samples or optimize the extraction efficiency of specific targets.

[0038] When the movable plate 2 needs to be replaced, first rotate the threaded sleeve 42 counterclockwise, then disengage the threaded rod 41 from the clamping plate 43, then remove the movable plate 2 from the plate body 1 through the clamping plate 43, and then install the required movable plate 2 on the plate body 1, and then clamp the threaded rod 41 on the clamping plate 43, and then rotate the threaded sleeve 42 clockwise to make the movable plate 2 stably embedded in the plate body 1.

[0039] A first sealing ring 5 in contact with the bottom of the movable plate 2 is embedded in the installation groove 11 ; the gap between the movable plate 2 and the plate body 1 can be reduced by the elasticity of the first sealing ring 5 .

[0040] Furthermore, a positioning groove 111 for positioning and installing the first sealing ring 5 is provided in the installation groove 11 ; the first sealing ring 5 can be conveniently fixed by the positioning groove 111 .

[0041] Furthermore, an arc-shaped groove for the threaded rod 41 to be hinged is formed at the top of the plate body 1 .

[0042] Example 2

[0043] See attached Figure 1 , Attachment Figure 4 , Attachment Figure 5 and attached Fig. 9 As shown, the solid phase extraction plate also includes a convex cylinder 6 which is sleeved on the outside of the extraction column 3 and fixed on the top of the movable plate 2. The extraction column 3 is installed on the convex cylinder 6 and the movable plate 2 by means of threaded insertion. A positioning plate 31 is fixedly sleeved on the extraction column 3, and a second sealing ring 7 which is arranged between the convex cylinder 6 and the positioning plate 31 is sleeved on the outside of the extraction column 3. The extraction column 3 is installed on the movable plate 2 by means of threaded connection, which is convenient for replacing the used or contaminated extraction column 3 separately, avoiding the replacement of the unused or uncontaminated extraction column 3, preventing the waste of materials, reducing costs, and improving the practicality of the device.

[0044] When replacing, it is only necessary to rotate the extraction column 3 counterclockwise, and when installing, it is only necessary to rotate the extraction column 3 clockwise, which is simple and convenient to operate.

[0045] Furthermore, an annular groove for installing the second sealing ring 7 is formed at the top of the convex cylinder 6 ; the gap between the positioning plate 31 and the convex cylinder 6 can be reduced by the elasticity of the second sealing ring 7 .

[0046] Furthermore, a plurality of protruding rods 311 are fixedly connected to the outer wall of the positioning plate 31 at equal intervals in the circumferential direction; the protruding rods 311 can increase the friction between the hand and the positioning plate 31 , thereby facilitating manual installation or removal of the extraction column 3 .

[0047] It should be noted that the first sealing ring 5 and the second sealing ring 7 are both made of epoxy resin paint.

[0048] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A detachable solid phase extraction plate, comprising a plate body (1) and a detachable movable plate (2) fixed to the plate body (1) by a fixing assembly (4), wherein a plurality of extraction columns (3) are inserted and arranged on the movable plate (2); Features: The plate body (1) is provided with a through installation groove (11), and the bottom of the movable plate (2) is provided with a groove matching the installation groove (11); The fixing assembly (4) is provided with two, and the fixing assembly (4) comprises a threaded rod (41) rotatably connected to the plate body (1), a threaded sleeve plate (42) is threadedly sleeved on the threaded rod (41), and a clamping plate (43) clamped and matched with the threaded rod (41) is fixedly connected to the movable plate (2); Wherein, a first sealing ring (5) in contact with the bottom of the movable plate (2) is embedded in the installation groove (11).

2. The detachable solid phase extraction plate according to claim 1, characterized in that: The installation groove (11) is T-shaped, and the shape of the bottom of the movable plate (2) is consistent with the shape of the inner wall of the installation groove (11).

3. The detachable solid phase extraction plate according to claim 1, characterized in that: A positioning groove (111) for positioning and installing the first sealing ring (5) is provided in the installation groove (11).

4. The detachable solid phase extraction plate according to claim 1, characterized in that: The top end of the plate body (1) is provided with an arc-shaped groove for hinged connection of the threaded rod (41).

5. The detachable solid phase extraction plate according to claim 1, characterized in that: The solid phase extraction plate further comprises a convex cylinder (6) which is sleeved on the outside of the extraction column (3) and fixed on the top of the movable plate (2); the extraction column (3) is installed on the convex cylinder (6) and the movable plate (2) by means of threaded plug-in; a positioning plate (31) is fixedly sleeved on the extraction column (3); and a second sealing ring (7) which is arranged between the convex cylinder (6) and the positioning plate (31) is sleeved on the outside of the extraction column (3).

6. The detachable solid phase extraction plate according to claim 5, characterized in that: The top end of the convex cylinder (6) is provided with an annular groove for installing the second sealing ring (7).

7. The detachable solid phase extraction plate according to claim 5, characterized in that: The outer wall of the positioning plate (31) is fixedly connected with a plurality of protruding rods (311) at equal intervals in the circumferential direction.

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