Preparation device of 2-chlorophenylglycine
By designing a preparation device including a centrifuge and a drying mechanism, the combination of a rotatable rotating shaft, an electric heating plate, agitating rod and a circular plate is solved, and the problems of excessive drying of the outer layer and internal moisture during the drug drying process are achieved, achieving uniform drying and quality assurance of the drug.
Patent Information
- Application Number
- CN202421967331.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-14
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2034-08-14
AI Technical Summary
In the existing drug drying technology, drugs are prone to affect drug performance due to excessive drying of the outer layer during drying, and drugs that are humid and undry inside affect the quality and use effect of the drug.
A preparation device including a centrifuge and a drying mechanism is designed. The drying mechanism includes a rotatable rotating shaft, an electric heating plate, an agitating rod and a circular plate. By controlling the motor to drive the rotation of the rotating shaft, the circular plate and the agitating rod are driven to rotate. The raw materials are swinged and dispersed on the circular plate to avoid accumulation. The electric heating plate provides heating to ensure that the raw materials are dried evenly.
Through the design of this device, the drying effect of the drug can be effectively improved, the performance and quality of the drug can be ensured, and the normal use of the drug can be reduced. At the same time, the quality problems caused by excessive drying or moisture during the drug drying process can be reduced.
Smart Images
Figure CN222678054U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of chemical production, and in particular to a device for preparing o-chlorophenylglycine. Background Art
[0002] Clopidogrel is a new and highly effective antiplatelet drug, which is clinically used to treat atherosclerotic diseases, acute coronary syndrome, and prevent restenosis and thrombotic complications after coronary stent implantation. Compared with other antiplatelet drugs, it has the advantages of strong efficacy, low cost, and few side effects. As an important intermediate for the synthesis of clopidogrel, the synthesis method and synthesis device of o-chlorophenylglycine are now widely studied by researchers.
[0003] At present, the method for making medicines is to process the medicines to make them into powders, then place multiple medicines into a reactor for reaction, transport the reacted medicines to a centrifugal device for centrifugation, and finally dry them to obtain mixed medicines. For drug drying, most of the existing drying methods place the medicines inside a drying box. Since the medicines are gathered together, the outer layer of the medicines is already dry and the inside is wet. Continuing to dry the inside of the medicines will cause the outer layer of the medicines to be over-dried, which will affect the performance of the medicines and the use of the medicines. Therefore, a preparation device for o-chlorophenylglycine is proposed to solve the above problems. Utility Model Content
[0004] In order to make up for the above deficiencies, the utility model provides a device for preparing o-chlorophenylglycine which overcomes the above technical problems or at least partially solves the above problems.
[0005] The utility model is achieved in this way:
[0006] The utility model provides a preparation device for o-chlorophenylglycine, comprising a centrifuge, and a feed line is installed on the centrifuge;
[0007] A drying mechanism, the drying mechanism comprising:
[0008] A drying tank, the drying tank is arranged at one side of the centrifuge, a control motor is fixedly installed on the top of the drying tank, and a rotating shaft is fixed at the output end of the control motor;
[0009] An inner cylinder, wherein the inner cylinder is fixedly installed inside the drying tank, and an electric heating plate is fixedly installed outside the inner cylinder;
[0010] A stirring rod is fixedly mounted at the bottom end of the rotating shaft. A circular plate is fixedly mounted on the outer surface of the rotating shaft, and a circular hole is provided on the upper surface of the circular plate.
[0011] In a preferred solution, a circular disc is fixedly mounted on the outer surface of the rotating shaft, the diameter of the circular disc is smaller than the diameter of the circular plate, and the circular disc is arranged above the circular plate.
[0012] In a preferred solution, a water recovery tank is provided on one side of the centrifuge, and one end of the feed line is fixedly connected to the water recovery tank and communicated with the interior of the water recovery tank.
[0013] In a preferred embodiment, a normal-pressure hydrolysis kettle is further provided outside the centrifuge, and a thermometer and a manhole are installed on the normal-pressure hydrolysis kettle, and the manhole is used for workers to enter the normal-pressure hydrolysis kettle for cleaning and maintenance operations.
[0014] In a preferred embodiment, a high-pressure hydrolysis kettle is arranged on one side of the atmospheric-pressure hydrolysis kettle, the high-pressure hydrolysis kettle is connected to the atmospheric-pressure hydrolysis kettle through another feed line, and another thermometer and pressure gauge are installed on the high-pressure hydrolysis kettle.
[0015] A heat transfer oil heater is also installed outside the high-pressure hydrolysis kettle, and the heat transfer oil heater is connected to the high-pressure hydrolysis kettle through a connecting pipe to achieve transportation and reflux. A jacket is arranged outside the high-pressure hydrolysis kettle, and the heat transfer oil is input into the jacket to heat the high-pressure hydrolysis kettle.
[0016] An acid conditioning kettle is arranged outside the high-pressure hydrolysis kettle, and the two are connected by a material transfer pipeline. The material transfer pipeline is arranged in two sections, and a material transfer pump is installed on the material transfer pipeline to transport the raw materials.
[0017] The acid regulating kettle is equipped with a pH meter and a feed pipeline, and a switch valve is installed on the feed pipeline. A jacket is also provided on the outside of the acid regulating kettle. Another feed pipeline is installed on the acid regulating kettle, and the raw materials are transported to the centrifuge through the feed pipeline. A flow meter is installed on the feed pipeline.
[0018] The utility model provides a device for preparing o-chlorophenylglycine, and its beneficial effects include:
[0019] 1. A rotatable shaft is installed inside the drying tank, and an electric heating plate is installed inside the drying tank. The motor is controlled to drive the shaft to rotate, so that the raw materials can be dried. A circular plate and a stirring rod are fixed on the outside of the shaft to swing the raw materials on the circular plate and disperse them into the drying tank to avoid accumulation. This improves the drying effect of the raw materials, ensures the performance of the medicine, and enables the medicine to be used normally.
[0020] 2. Aiming at the special process conditions in the synthesis of o-chlorophenylglycine, this device adopts a high-pressure hydrolysis kettle for hydrolysis reaction, and introduces high-temperature resistant heat transfer oil into the jacket of the high-pressure hydrolysis kettle for heating and insulation, which can make the hydrolysis reaction proceed smoothly; and a safety valve and a pressure gauge are installed on the upper end of the high-pressure hydrolysis kettle to prevent the pressure in the kettle from being too high and causing danger. A large amount of process water needs to be added during the centrifugation process to wash the product. The design of the recovery water tank can recycle this process water, which can be recycled after treatment, saving production costs. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present utility model, and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without creative work.
[0022] Figure 1 It is a flow chart of the utility model;
[0023] Figure 2 This is a schematic diagram of the structure of the drying tank of the utility model;
[0024] Figure 3 This is a schematic diagram of the internal structure of the drying tank of the utility model;
[0025] Figure 4 This is a schematic diagram of the position of the electric heating plate of the utility model;
[0026] In the figure: 1. normal pressure hydrolysis kettle; 2. high pressure hydrolysis kettle; 3. thermal oil heater; 30. drying mechanism; 31. drying tank; 311. control motor; 312. rotating shaft; 32. inner cylinder; 321. electric heating plate; 33. stirring rod; 331. round hole; 332. round plate; 4. disc; 5. centrifuge; 6. acid adjustment kettle; 7. recovery water tank; 8. unloading pipeline; 9. transfer pipeline; 10. transfer pump; 11. jacket; 12. thermometer; 13. feed pipeline; 14. flow meter; 15. manhole; 16. pressure gauge; 17. safety valve; 18. pH meter; 19. switch valve. DETAILED DESCRIPTION
[0027] In order to make the purpose, technical solution and advantages of the implementation of the utility model clearer, the technical solution in the implementation of the utility model will be clearly and completely described below in conjunction with the drawings in the implementation of the utility model. Obviously, the described implementation is a part of the implementation of the utility model, not all of the implementations. Based on the implementation of the utility model, all other implementations obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model. Example
[0028] Reference Figure 1-Figure 4 The utility model provides a technical solution: a preparation device of o-chlorophenylglycine, comprising a centrifuge 5 and a drying mechanism 30, and a feed line 8 is installed on the centrifuge 5, the drying mechanism 30 comprises a drying tank 31, the drying tank 31 is arranged at a position on one side of the centrifuge 5, a control motor 311 is fixedly installed on the top of the drying tank 31, a rotating shaft 312 is fixed at the output end of the control motor 311, an inner cylinder 32 is fixedly installed inside the drying tank 31, and an electric heating plate 321 is fixedly installed outside the inner cylinder 32, a stirring rod 33 is fixedly installed at the bottom end of the rotating shaft 312, a circular plate 332 is fixedly installed on the outer surface of the rotating shaft 312, and a circular hole 331 is provided on the upper surface of the circular plate 332.
[0029] In a preferred embodiment, a disc 4 is fixedly installed on the outer surface of the rotating shaft 312, the diameter of the disc 4 is smaller than the diameter of the circular plate 332, and the disc 4 is arranged above the circular plate 332. In order to improve the drying effect of the raw materials, the device has a disc 4 installed on the outside of the rotating shaft 312. When the raw materials are added to the interior of the drying tank 31, they will first fall onto the disc 4, and the disc 4 will rotate with the rotating shaft 312, which can drive the disc 4 to rotate, thereby throwing out the raw materials on the disc 4 and scattering them inside the drying tank 31, so that they will not pile up together, thereby improving the drying effect.
[0030] In a preferred embodiment, a recovery water tank 7 is provided on one side of the centrifuge 5, one end of the discharge pipeline 8 is fixedly connected to the recovery water tank 7 and communicated with the interior of the recovery water tank 7, and a normal pressure hydrolysis kettle 1 is also provided outside the centrifuge 5, and a thermometer 12 and a manhole 15 are installed on the normal pressure hydrolysis kettle 1, and the manhole 15 is used for staff to enter the normal pressure hydrolysis kettle 1 for cleaning and maintenance operations.
[0031] A high-pressure hydrolysis kettle 2 is arranged on one side of the normal-pressure hydrolysis kettle 1. The high-pressure hydrolysis kettle 2 is connected to the normal-pressure hydrolysis kettle 1 through another unloading pipeline 8. Another thermometer 12 and a pressure gauge 16 are installed on the high-pressure hydrolysis kettle 2 to prevent the pressure in the kettle from being too high and causing danger.
[0032] A heat transfer oil heater 3 is also installed outside the high-pressure hydrolysis kettle 2. The heat transfer oil heater 3 is connected to the high-pressure hydrolysis kettle 2 through a connecting pipe to achieve transportation and reflux. A jacket 11 is provided outside the high-pressure hydrolysis kettle 2. The heat transfer oil is input into the jacket 11 to heat the high-pressure hydrolysis kettle 2, so that the hydrolysis reaction can proceed smoothly.
[0033] An acid conditioning kettle 6 is arranged outside the high-pressure hydrolysis kettle 2, and the two are connected by a material transfer pipeline 9. The material transfer pipeline 9 is arranged in two sections. A material transfer pump 10 is installed on the material transfer pipeline 9, and the raw materials are transported by the material transfer pump 10.
[0034] A pH meter 18 and a feed pipeline 13 are installed on the acid regulating kettle 6, and a switch valve 19 is installed on the feed pipeline 13. A jacket 11 is also provided on the outside of the acid regulating kettle 6. Another discharge pipeline 8 is installed on the acid regulating kettle 6. The raw materials are transported to the centrifuge 5 through the discharge pipeline 8. A flow meter 14 is installed on the discharge pipeline 8.
[0035] Specifically, the working process or working principle of a preparation device for o-chlorophenylglycine is as follows: the current method for making medicines is to process the medicines to make them into powders, then place multiple medicines into a reactor for reaction, transport the reacted medicines to a centrifugal device for centrifugation, and finally dry them to obtain mixed medicines. For drug drying, the existing drying methods mostly place the medicines inside a drying box. Since the medicines are gathered together, the outer layer of the medicines is already dry and the inside is wet. Continuing to dry the inside of the medicines will cause the outer layer of the medicines to dry quickly, but this will cause the outer layer of the medicines to be over-dried, affecting the performance of the medicines and affecting the use of the medicines. Therefore, the present device is designed to solve this problem.
[0036] The device is provided with an assembly line to facilitate the preparation of drugs, and a rotatable rotating shaft 312 is provided inside the drying tank 31, and a stirring rod 33, a circular plate 332 and a disc 4 are installed outside the rotating shaft 312 to facilitate the drying of raw materials and improve the drying effect. The specific operation is to connect an external power supply, first add the drug and the reaction liquid to the inside of the normal pressure hydrolysis kettle 1, and the device is equipped with a stirrer on the normal pressure hydrolysis kettle 1, the high pressure hydrolysis kettle 2 and the acid adjustment kettle 6 to stir the raw materials, so the raw materials are added to the normal pressure hydrolysis kettle 1 for reaction, and then the raw materials are transported to the inside of the high pressure hydrolysis kettle 2, and the raw materials are also stirred. At the same time, the high pressure hydrolysis kettle 2 is used for hydrolysis reaction, and high temperature resistant heat transfer oil is introduced into the jacket 11 outside the high pressure hydrolysis kettle 2 for heating and heat preservation, so that the hydrolysis reaction can proceed smoothly, and a safety valve 17 and a pressure gauge 16 are installed at the upper end of the high pressure hydrolysis kettle 2 to prevent the pressure in the kettle from being too high and causing danger.
[0037] The hot oil is conveyed to the inside of the jacket 11 outside the high-pressure hydrolysis kettle 2 through the thermal oil heater 3, and refluxed through the connecting pipe, so that the hot oil is circulated and used to avoid waste.
[0038] Subsequently, the raw materials are transported to the interior of the acid regulating kettle 6 under the action of the material transfer pump 10, and the pH value of the raw materials is adjusted by the acid regulating kettle 6. To prevent the acidity from being too strong, the pH value of the raw materials is tested by the pH meter 18 to ensure that the pH value of the raw materials meets the requirements. After the acidity of the raw materials is adjusted, the raw materials are transported to the interior of the centrifuge 5, and the centrifuge 5 is turned on to throw out the water in the raw materials. The thrown out water will enter the interior of the recovery water tank 7 for collection so that the collected water can be reused.
[0039] The raw materials after the centrifugal operation need to be placed inside the drying tank 31 for drying in order to obtain raw materials that meet the needs of use. The rotating shaft 312 is driven to rotate by controlling the motor 311. The rotating shaft 312 will drive the disc 4 and the circular plate 332 to rotate. The raw materials entering the drying tank 31 will first fall on the disc 4. Under the rotation of the disc 4, the raw materials will be thrown off, and the raw materials will fall onto the upper surface of the circular plate 332. A circular hole 331 is provided on the circular plate 332, and part of the raw materials will fall from the inside of the circular hole 331. During the preparation of the medicine, the electric heating plate 321 of the device is turned on to heat up the inside of the drying tank 31 so as to dry the moist raw materials.
[0040] The raw materials are continuously swung around so that they cannot pile up together, thereby improving the drying effect of the raw materials. In this device, the side of the circular plate 332 does not contact the inner wall of the drying tank 31, so the raw materials will continue to be swung off under the rotation of the circular plate 332, so that the raw materials are dispersed and dropped to the bottom of the drying tank 31. As the amount of raw materials at the bottom increases, the stirring rod 33 continues to stir the raw materials and turn them over so as to thoroughly dry the raw materials and improve the drying effect. After the drying is completed, the raw materials are discharged through the discharge pipe at the bottom of the drying tank 31, and the raw materials can be unloaded to complete the operation.
[0041] The device can stably and efficiently realize the industrial production of o-chlorophenylglycine by arranging a combination of a normal pressure hydrolysis kettle 1, a high pressure hydrolysis kettle 2 and a centrifuge 5, and adopts the high pressure hydrolysis kettle 2 to carry out the hydrolysis reaction, and introduces high temperature resistant heat transfer oil into the jacket 11 on the high pressure hydrolysis kettle 2 for heating and heat preservation, so that the hydrolysis reaction can proceed smoothly.
[0042] During the centrifugal process, a large amount of process water needs to be added to wash the product. The design of the recovery water tank 7 can recover the process water, which can be recycled after treatment, thus saving production costs.
[0043] It should be noted that the electric heating plate 321 and the material transfer pump 10 are devices or equipment existing in the prior art, or are devices or equipment that can be realized in the prior art. Their power supply, specific composition and principles are clear to those skilled in the art, so they are not described in detail.
Claims
1. A device for preparing o-chlorophenylglycine, characterized in that: It comprises a centrifuge (5), and a discharge pipeline (8) is installed on the centrifuge (5); A drying mechanism (30), the drying mechanism (30) comprising: A drying tank (31), the drying tank (31) being arranged at a position on one side of the centrifuge (5), a control motor (311) being fixedly mounted on the top of the drying tank (31), and a rotating shaft (312) being fixed to the output end of the control motor (311); An inner cylinder (32), wherein the inner cylinder (32) is fixedly mounted inside the drying tank (31), and an electric heating plate (321) is fixedly mounted outside the inner cylinder (32); A stirring rod (33), the stirring rod (33) being fixedly mounted at the bottom end of the rotating shaft (312), a circular plate (332) being fixedly mounted on the outer surface of the rotating shaft (312), and a circular hole (331) being provided on the upper surface of the circular plate (332).
2. The preparation device of o-chlorophenylglycine according to claim 1, characterized in that: A circular disc (4) is fixedly mounted on the outer surface of the rotating shaft (312); the diameter of the circular disc (4) is smaller than the diameter of the circular plate (332), and the circular disc (4) is arranged above the circular plate (332).
3. The preparation device of o-chlorophenylglycine according to claim 2, characterized in that: A water recovery tank (7) is provided on one side of the centrifuge (5), and one end of the feed line (8) is fixedly connected to the water recovery tank (7) and communicates with the interior of the water recovery tank (7).
4. The preparation device of o-chlorophenylglycine according to claim 3, characterized in that: A normal-pressure hydrolysis kettle (1) is also provided outside the centrifuge (5). A thermometer (12) and a manhole (15) are installed on the normal-pressure hydrolysis kettle (1). The manhole (15) is used for workers to enter the normal-pressure hydrolysis kettle (1) to perform cleaning and maintenance operations.
5. The preparation device of o-chlorophenylglycine according to claim 4, characterized in that: A high-pressure hydrolysis kettle (2) is arranged on one side of the normal-pressure hydrolysis kettle (1). The high-pressure hydrolysis kettle (2) is connected to the normal-pressure hydrolysis kettle (1) via another feed discharge pipeline (8). Another thermometer (12) and a pressure gauge (16) are installed on the high-pressure hydrolysis kettle (2).
6. The device for preparing o-chlorophenylglycine according to claim 5, characterized in that: A heat transfer oil heater (3) is also installed outside the high-pressure hydrolysis kettle (2). The heat transfer oil heater (3) is connected to the high-pressure hydrolysis kettle (2) via a connecting pipe to achieve transportation and reflux. A jacket (11) is arranged outside the high-pressure hydrolysis kettle (2). Heat transfer oil is input into the jacket (11) to heat the high-pressure hydrolysis kettle (2).
7. The device for preparing o-chlorophenylglycine according to claim 6, characterized in that: An acid conditioning kettle (6) is arranged outside the high-pressure hydrolysis kettle (2), and the two are connected via a material transfer pipeline (9). The material transfer pipeline (9) is arranged in two sections, and a material transfer pump (10) is installed on the material transfer pipeline (9), and the raw materials are transported via the material transfer pump (10).
8. The device for preparing o-chlorophenylglycine according to claim 7, characterized in that: The acid regulating kettle (6) is equipped with a pH meter (18) and a feed pipeline (13), and an on-off valve (19) is installed on the feed pipeline (13). The outside of the acid regulating kettle (6) is also provided with a jacket (11). Another feed pipeline (8) is installed on the acid regulating kettle (6), and the raw materials are transported to the centrifuge (5) through the feed pipeline (8). The feed pipeline (8) is equipped with a flow meter (14).