A small animal drug delivery device for glioma research
By designing a drug delivery device including a catheter, a connecting plug and a rope tie, the limitations of the prior art small and medium-sized animal delivery devices in the accuracy of the drug delivery position and preventing animal bites are solved, and precise drug delivery and long-term use of small animals are achieved.
Patent Information
- Application Number
- CN202420454941.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-08
- Publication Date
- 2025-04-01
- Estimated Expiration
- 2034-03-08
AI Technical Summary
Existing small animal dosing devices have limitations in the accuracy of the dosing position and preventing animal bites, especially when it is necessary to administer the drug to areas under hard tissue structures, which are difficult to achieve precise control and long-term use.
A drug delivery device including a catheter, a connecting plug and a tie rope is designed. The catheter is arranged under the skin of a small animal, and the connecting plug is connected to the catheter. The fixing part is fixed by a tie rope so that the delivery end corresponds to the target area. The device catheter is buried under the skin, the connecting plug is in a conical structure, the outer wall is equipped with an annular groove to limit the position, and the fixing part is a limit bump or a T-shaped winding rod and stop to ensure the accuracy and stability of the drug delivery.
It has achieved accurate drug administration to small animals, especially in areas under hard tissue structures such as skulls, and is not easily gnawed by animals, and can be used for a long time, reducing human and material consumption.
Smart Images
Figure CN222693599U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the medical field, in particular to a small animal drug delivery device used for glioma research. Background Art
[0002] Traditionally, drug administration to small animals is mainly carried out by injection with a syringe. However, this method of administration is only suitable for situations where precise injection is not required, and it can only be administered to soft tissue parts such as the animal's abdominal cavity and subcutaneous tissue, which has great limitations. Currently, there is also a method of administering drugs through an intravenous catheter, but it is only suitable for animals under anesthesia, and the intravenous catheter must be removed in time after the animal wakes up, otherwise the animal will scratch or bite. In addition, there is also a method of administering drugs through a microinjection pump, which can continuously administer drugs to animals, but the dosage cannot be adjusted, and it is not easy to detect when the catheter is blocked, which still cannot meet actual needs. Utility Model Content
[0003] Based on this, the purpose of the utility model is to provide a small animal drug delivery device for glioma research, which has the advantages of accurate drug delivery position and preventing animals from gnawing.
[0004] A small animal drug delivery device for glioma research comprises a catheter, a connecting plug and a binding rope. The catheter is inserted under the skin of the small animal, and its connecting end is communicated with the inner cavity of the connecting plug. A fixing part is arranged on the catheter, and the fixing part is fixed by the binding rope so that the drug delivery end of the catheter corresponds to the target area.
[0005] The small animal drug delivery device for glioma research described in the utility model can accurately control the drug delivery area and can deliver drugs to areas under hard tissue structures such as the skull. The drug delivery device catheter is buried under the skin and is not easily gnawed by animals. After the animal wakes up, the drug delivery device does not need to be removed and can continue to be retained in the animal's body and used for a long time, greatly reducing manpower and material resources.
[0006] Furthermore, the connecting plug is in a conical structure, and the small end of the connecting plug is connected to and fixed to the conduit. This structure can improve the comfort of the animal.
[0007] Furthermore, an annular groove is provided on one side of the outer wall of the connecting plug close to the large end. This structure allows the sutured and gathered animal skin to be clamped in the annular groove, thereby limiting the position of the connecting plug.
[0008] Furthermore, the fixing part is two limiting protrusions with a spacing of less than 1 mm, and the limiting protrusions are integrally formed with the catheter. This structure can limit the binding rope to ensure the accuracy of drug administration.
[0009] Furthermore, the fixing part includes a winding rod connected to the outer wall of the catheter and a stopper arranged at the free end of the winding rod, and the winding rod and the stopper are arranged in a T-shape. This structure can limit the binding rope to ensure the accuracy of drug administration.
[0010] Furthermore, the fixing portion is 3-5 mm away from the drug delivery end, so that in actual use, the catheter can be reasonably cut according to the distance between the fixing position and the target area, thereby improving flexibility.
[0011] Furthermore, the outer diameter of the catheter is less than 0.5 mm. This structure can reduce the discomfort of the animal.
[0012] Furthermore, the connecting plug is made of a hard material, and the catheter is made of a flexible material. The hard material ensures the stability of the connecting plug structure and can cooperate with the syringe to achieve the injection of the liquid medicine. The flexible material can reduce the discomfort of the animal.
[0013] Furthermore, the catheter includes a main pipe and branch pipes, the main pipe is connected to at least two branch pipes through a joint, one end of the main pipe is fixed to the connection plug, and the other end is connected to the branch pipe through the joint, the other end of the branch pipe is a drug delivery end, and the fixing part is arranged on the branch pipe. This structure can realize multi-point drug delivery and meet actual needs.
[0014] Furthermore, a sealing plug is detachably inserted into the connecting plug, and the sealing plug is fixed to the outside of the connecting plug by a flexible connecting belt. This structure can prevent external dirt from entering the device and polluting the target area, affecting the health of small animals.
[0015] In order to better understand and implement the present invention, the present invention is described in detail below with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] Figure 1 This is a schematic diagram of the drug delivery device described in Example 1 of the utility model being placed in a small animal;
[0017] Figure 2 This is a structural diagram of an embodiment of the drug delivery device described in Embodiment 1 of the present utility model;
[0018] Figure 3 This is a structural diagram of another embodiment of the drug delivery device described in Embodiment 1 of the utility model;
[0019] Figure 4 is a partial enlarged view of the catheter;
[0020] Figure 5 It is a connection diagram of the syringe of the utility model and the drug delivery device;
[0021] Figure 6 is a structural diagram of the sealing plug;
[0022] Figure 7 This is a schematic diagram of the drug delivery device described in Example 2 of the utility model being placed in a small animal;
[0023] Explanation of the reference numerals in the accompanying drawings: 1. catheter; 11. connecting end; 12. drug administration end; 13. fixing portion; 131. limiting protrusion; 132. winding rod; 133. block; 14. drug outlet hole; 15. main pipe; 16. branch pipe; 17. joint; 2. connecting plug; 21. small end; 22. large end; 23. annular groove; 24. snap-on groove; 25. sealing plug; 26. connecting belt; 3. binding rope; 4. injection head; 41. snap-on joint; 5. target area. DETAILED DESCRIPTION
[0024] Example 1
[0025] See also Figure 1-6 , Figure 1 This is a schematic diagram of the drug delivery device of the utility model being placed in a small animal; Figure 2 This is a structural diagram of an embodiment of the drug delivery device of the utility model; Figure 3 This is a structural diagram of another embodiment of the drug delivery device of the utility model; Figure 4 is a partial enlarged view of the catheter; Figure 5 It is a connection diagram of the syringe of the utility model and the drug delivery device; Figure 6 This is a structural diagram of the sealing plug.
[0026] The utility model discloses a drug delivery device for small animals used for glioma research, comprising a catheter 1, a connecting plug 2 and a binding rope 3. The catheter 1 is a hollow pipeline, and is inserted under the skin of the small animal. Its connecting end 11 is connected to the inner cavity of the connecting plug 2, and its drug delivery end 12 corresponds to the target area 5 in the small animal. The inner cavity shape of the connecting plug 2 is adapted to the syringe 4. When in use, the drug enters the connecting plug 2 through the syringe and other structures, flows out from the drug delivery end 12 after passing through the catheter 1 and acts on the target area 5, thereby achieving drug delivery.
[0027] The connecting plug 2 is made of a hard material, such as plastic. The connecting plug 2 is a conical structure, and its small end 21 is connected to the catheter 1 and is connected and fixed by glue bonding or other means. A coaxial annular groove 23 is provided on the side of the outer wall of the connecting plug 2 close to the large end 22. The inner wall of the connecting plug 2 is provided with an anti-drop structure corresponding to the injection head 4 of the syringe (the metal needle needs to be removed when in use). The existing syringes are usually provided with a raised clamping joint 41 on the injection head 4, so a corresponding clamping groove 24 can be provided on the inner wall of the connecting plug 2. When the injection head 4 is inserted into the connecting plug 2, the clamping joint 41 is engaged with the clamping groove 24 to prevent it from falling off during the injection of the drug.
[0028] The catheter 1 is made of a flexible material, such as PU, and the outer diameter of the catheter 1 is less than 0.5 mm, thereby improving the comfort of small animals, and this material can prevent the formation of thrombus by reducing the adhesion of blood sediments. The catheter 1 is also provided with a fixing portion 13, and the position where the fixing portion 13 is set needs to be 3-5 mm away from the drug delivery end 12, so that there is enough margin, so that in actual use, the catheter 1 can be reasonably cut according to the distance between the fixing position and the target area 5.
[0029] Preferably, a plurality of drug outlet holes 14 are provided on the tube wall of the drug delivery end 12. When drug delivery is performed, the drug solution can not only flow out from the opening of the catheter drug delivery end 12, but also flow out from the drug outlet holes 14, which makes the drug solution more evenly distributed.
[0030] The binding rope 3 is tied to the fixing portion 13, and the binding rope 3 can be a suture commonly used in clinical practice. The fixing portion 13 can have a variety of structural forms. In one embodiment, please refer to Figure 2 The fixing portion 13 is two limiting protrusions 131 with a spacing of less than 1 mm, and the limiting protrusions 131 are an integrally formed structure with the catheter 1. The limiting protrusions 131 can be designed in various structural forms. In this embodiment, the limiting protrusions 131 are in a pointed cone shape, that is, they are narrowed at their free ends, so that a winding groove narrowing toward the catheter 1 is formed between the limiting protrusions 131, which is convenient for winding and limiting the binding rope 3.
[0031] In another embodiment, see Figure 3 The fixing part 13 includes a winding rod 132 connected to the outer wall of the catheter 1 and a stopper 133 arranged at the free end of the winding rod 132. Preferably, the winding rod 132 and the stopper 133 are arranged in a T-shape. When in use, the binding rope 3 is wound around the winding rod 132 and tied and fixed, and the stopper 133 can prevent the binding rope 3 from detaching, so that the catheter 1 can be stably fixed on the animal.
[0032] Preferably, when the arrangement path of the catheter 1 is more complicated or longer, a plurality of fixing parts 13 may be arranged at intervals along the catheter 1, so that they are sutured and fixed to the animal body through the binding ropes 3 respectively, to avoid displacement of the catheter 1 when the animal is moving and causing discomfort to the animal.
[0033] In order to prevent external dirt from entering the device and contaminating the target area 5, thereby affecting the health of the small animal, a sealing plug 25 can be inserted at the connection plug 2. The shape of the sealing plug 25 can be similar to the injection head 4, so that the sealing plug 25 and the connection plug 2 are clamped together while sealing the inside of the connection plug 2, thereby preventing the sealing plug 25 from falling off when the small animal moves. The sealing plug 25 can also be fixed to the outside of the connection plug 2 by a flexible connecting belt 26, thereby preventing the sealing plug 25 from being lost.
[0034] Example 2
[0035] See also Figure 7 , Figure 7 This is a schematic diagram of the drug delivery device in Example 2 of the utility model being placed in a small animal. This embodiment is basically the same as Example 1, with the only difference being that the catheter 1 includes a main pipe 15 and branch pipes 16, the main pipe 15 is connected to at least two branch pipes 16 via a connector 17, one end of the main pipe 15 is a connecting end fixed to the connecting plug 2, and the other end is connected to the branch pipes 16 via the connector 17, the other ends of the branch pipes 16 are drug delivery ends for outputting drug solution to the target area 5, and the fixing portion 13 is disposed on the branch pipes 16.
[0036] The sizes of the main pipe 15, branch pipes 16 and connectors 17 can be selected according to the amount of medication to be distributed and other actual conditions. The sizes should be as small as possible to improve the comfort of small animals while ensuring that the pipelines are not blocked.
[0037] The number of branch tubes 16 can be selected according to the number and location of the target areas. In this embodiment, since the brain of a small animal is divided into two hemispheres, the drugs need to be administered separately, so two branch tubes 16 are needed to administer the drugs to the two hemispheres respectively. Preferably, the connector 17 is in a Y-shaped structure.
[0038] The drug delivery device described in Examples 1 and 2 is used to deliver the drug to small animals (e.g., small animals such as mice), and the method comprises the following steps:
[0039] S1: Openings were made in the skin of the back of small animals, the skin of target area 5, and related tissues;
[0040] S2: Bluntly separate the skin and subcutaneous tissue along the back opening to the opening position of the target area 5 to form a cannulation channel;
[0041] S3: Clamp the connection plug 2 with a clamp, and pass the catheter 1 through the back opening along the subcutaneous tube passage to the target area 5;
[0042] S4: adjusting the length between the administration end 12 and the fixing portion 13 of the catheter 1 by cutting, tying the binding wire to the fixing portion 13 at the opening position of the target area 5, and fixing the free end of the binding wire at or near the target area 5, thereby fixing the catheter 1;
[0043] S5: The skin of the small animal is sutured at the opening on the back by purse-string suture. After the skin is sutured, it is gathered in the annular groove 23 of the connecting plug 2, thereby fixing the connecting plug 2 to the skin and preventing the connecting plug 2 from being separated from the animal body or being sunken into the animal body, which would affect the injection of the drug solution.
[0044] S6: Pull out the metal needle of the syringe, insert the injection head 4 into the connecting plug 2, and inject the drug solution into the drug delivery device through the syringe;
[0045] S7: After the drug injection is completed, heparin is injected to block the catheter 1 to prevent blood from entering the catheter 1 and causing the catheter 1 to be blocked, and then the sealing plug 25 is inserted into the connecting plug 2.
[0046] The drug delivery device is placed in the body of a small animal. When the drug solution needs to be injected again, the sealing plug 25 only needs to be pulled out and the drug solution can be injected again through the syringe.
[0047] The utility model provides a drug delivery device and method for small animals, which can accurately control the drug delivery area and can deliver drugs to areas under hard tissue structures such as the skull. The catheter of the drug delivery device is buried under the skin and is not easily gnawed by the animal. After the animal wakes up, the drug delivery device does not need to be removed and can continue to be retained in the animal's body and used for a long time, greatly reducing manpower and material resources.
[0048] It should be understood that in the description of the present application, the terms "center", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application. Unless otherwise specified, "plurality" means two or more.
[0049] It should be noted that, in the description of this application, unless otherwise clearly specified and limited, the terms "disposed", "connected", "connected", and "hollow" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.
[0050] The above-mentioned embodiments only express several implementation methods of the utility model, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the utility model patent. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the utility model, and the utility model is also intended to include these modifications and modifications.
Claims
1. A small animal drug delivery device for glioma research, characterized in that: The invention comprises a catheter, a connecting plug and a binding rope. The catheter is inserted under the skin of the small animal, and its connecting end is communicated with the inner cavity of the connecting plug. A fixing part is arranged on the catheter, and the fixing part is fixed by the binding rope so that the drug delivery end of the catheter corresponds to the target area.
2. A small animal drug delivery device for glioma research according to claim 1, characterized in that: The connecting plug is in a conical structure, and the small end of the connecting plug is connected to and fixed to the conduit.
3. A small animal drug delivery device for glioma research according to claim 2, characterized in that: An annular groove is provided on one side of the outer wall of the connecting plug close to the large end.
4. A small animal drug delivery device for glioma research according to claim 3, characterized in that: The fixing portion is two limiting protrusions with a spacing less than 1 mm, and the limiting protrusions and the catheter are integrally formed.
5. The small animal drug delivery device for glioma research according to claim 3, characterized in that: The fixing part includes a winding rod connected to the outer wall of the catheter and a stopper arranged at the free end of the winding rod, and the winding rod and the stopper are arranged in a T shape.
6. A drug delivery device for small animals used for glioma research according to claim 4 or 5, characterized in that: The fixing portion is 3-5 mm away from the administration end.
7. A small animal drug delivery device for glioma research according to claim 6, characterized in that: The outer diameter of the catheter is less than 0.5 mm.
8. A small animal drug delivery device for glioma research according to claim 7, characterized in that: The connecting plug is made of a hard material, and the conduit is made of a flexible material.
9. A drug delivery device for small animals used for glioma research according to claim 6, characterized in that: The catheter includes a main pipe and branch pipes, the main pipe is connected to at least two branch pipes through a joint, one end of the main pipe is fixed to the connecting plug, and the other end is connected to the branch pipes through the joint, the other ends of the branch pipes are respectively drug delivery ends, and the fixing part is arranged on the branch pipes.
10. The small animal drug delivery device for glioma research according to claim 1, characterized in that: A sealing plug is detachably inserted in the connecting plug, and the sealing plug is fixed to the outer side of the connecting plug through a flexible connecting belt.