A microreactor-assisted peptide synthesis device

Abstract

The utility model relates to the technical field of peptide synthesis equipment, and discloses a microreactor-assisted peptide synthesis device, including a cleaning device, wherein a mixing device is arranged inside the cleaning device, wherein the cleaning device includes a box, wherein the upper end of the box is fixedly connected with a motor, the lower end of the motor is fixedly connected with a frame, the inner top wall of the frame is fixedly connected with an electric push rod, the lower end of the electric push rod is fixedly connected with a slider, and the two ends of the slider are fixedly connected with connecting rods. The microreactor-assisted peptide synthesis device is driven by a motor, and the motor drives the frame to rotate, and the frame drives a scraper to rotate through a slider and a connecting rod, and the scraper scrapes the solution adhered to the inner wall of the box, and by starting the electric push rod, the electric push rod pushes the slider to move downward, and the slider drives the scraper to descend through the connecting rod, so that the scraper rotates and descends, and scrapes the inner wall of the box, thereby achieving the effect of facilitating the scraping of the adhered solution and reducing the waste of raw materials.

Description

Technical Field

[0001] The utility model relates to the technical field of polypeptide synthesis equipment, in particular to a polypeptide synthesis device assisted by a microreactor. Background Art

[0002] During the peptide synthesis process, the reaction solvent usually needs to be stirred and fused. Since stirring will produce vortices, the fusion effect of the reaction solvent will be reduced.

[0003] According to a microreactor-assisted peptide synthesis device disclosed in Chinese patent publication number CN 218573337 U, it is proposed that the peptide raw material is relatively viscous during the reaction process, and the vortex generated by stirring will gradually rise the peptide raw material, and will also cause the peptide raw material to stick to a higher position in the device, causing a problem of raw material waste. The patent sets a lifting piece in the middle area of ​​the rotating shaft, starts the motor, and the motor drives the rotating shaft to rotate, and the rotating shaft drives the stirring blade to rotate, stirs the reaction solvent, and at the same time, the rotating shaft drives the lifting groove to rotate, so that the end of the guide column moves along the path opened by the lifting groove. When the guide column moves to the top of the lifting groove, it moves down along the path opened by the lifting groove. Similarly, when the lifting groove moves to the bottom of the lifting groove, it starts to move up, and the guide column drives the lifting piece to move up and down through the installation sleeve. The lifting piece that moves up and down moves in the body of the peptide synthesis device, which can weaken the vortex generated by the rotation of the reaction solvent and improve the mixing effect of the reaction solvent. It can also prevent the reaction solvent from gradually rising under the action of centrifugal force and adhering to the inner wall of the higher body of the peptide synthesis device, reducing the waste of reaction solvent and improving the product output rate. However, the device drives the solution upward, causing the solution to adhere to the inside of the box, and the closed box cannot be scraped off, resulting in a waste of raw materials.

[0004] To this end, we proposed a microreactor-assisted peptide synthesis device to solve the problem that the raw materials still rise and adhere to the inner wall of the box, resulting in a waste of raw materials. Utility Model Content

[0005] The utility model aims to provide a microreactor-assisted polypeptide synthesis device to solve the problem that the above device proposed in the background technology still has the problem that raw materials rise and adhere to the inner wall of the box, resulting in waste of raw materials.

[0006] In order to solve the above technical problems, the utility model provides the following technical solutions: a microreactor-assisted polypeptide synthesis device, comprising a cleaning device, wherein a mixing device is provided inside the cleaning device;

[0007] The cleaning device includes a box body, the upper end of the box body is fixedly connected to a motor, the lower end of the motor is fixedly connected to a frame body, the inner top wall of the frame body is fixedly connected to an electric push rod, the lower end of the electric push rod is fixedly connected to a slider, the two ends of the slider are fixedly connected to connecting rods, and the other end of the connecting rod is fixedly connected to a scraper.

[0008] Preferably, the mixing device comprises a measuring cup, a conduit is provided at the lower end of the measuring cup, a pump body is provided at the lower end of the conduit, a delivery pipe is provided at the output end of the pump body, an annular sleeve is fixedly connected to the outer surface of the delivery pipe, and a nozzle is provided at the lower end of the annular sleeve.

[0009] Preferably, a feed inlet and a discharge outlet are respectively provided at the upper and lower ends of the box body, and a stirring blade is fixedly connected to the outer surface of the frame body.

[0010] Preferably, the sliding block is slidably connected to the frame, and the scraper is in contact with the inner wall of the box and is arranged in an inclined shape.

[0011] Preferably, the measuring cup is located at the upper end of the box body, and the pump body is located on the inner top wall of the box body and is fixedly connected to the box body.

[0012] Preferably, the annular sleeve is configured as a plurality of annular through pipes with the same center, and a pull rod is provided between the upper end of the annular sleeve and the box body.

[0013] Preferably, a plurality of water pumps are fixedly connected to the outer surface of the box body, and a water inlet pipe and a water outlet pipe are respectively provided at both ends of the water pump.

[0014] Compared with the prior art, the beneficial effects achieved by the utility model are:

[0015] First, the utility model uses a motor to drive the frame to rotate, and the frame drives the scraper to rotate through a slider and a connecting rod. The scraper scrapes the solution adhered to the inner wall of the box. By starting the electric push rod, the electric push rod pushes the slider to move downward, and the slider drives the scraper to descend through the connecting rod, so that the scraper rotates and descends to scrape the inner wall of the box, thereby achieving the effect of facilitating the scraping of the adhered solution and reducing the waste of raw materials.

[0016] Second, the utility model measures the added reaction solvent by means of a measuring cup, and according to the actual amount of reaction solvent added, draws the reaction solvent in the measuring cup through a pump body, transports it along a guide tube into a delivery pipe, and then enters an annular sleeve and is sprayed out by a nozzle, thereby increasing the spraying area, thereby achieving the effect of facilitating the rapid addition of a corresponding amount of reaction solvent, increasing the spraying area, and improving the mixing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a three-dimensional schematic diagram of the structure of the utility model;

[0018] Figure 2 It is a schematic cross-sectional view of the structure of the utility model;

[0019] Figure 3 It is a three-dimensional schematic diagram of the structural frame connection structure of the utility model;

[0020] Figure 4 It is a three-dimensional schematic diagram of the structural annular sleeve of the utility model.

[0021] Wherein: 1. cleaning device; 101. box body; 102. motor; 103. frame body; 104. electric push rod; 105. slider; 106. connecting rod; 107. scraper; 2. mixing device; 201. measuring cup; 202. conduit; 203. pump body; 204. delivery pipe; 205. annular sleeve; 206. nozzle; 207. water pump. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] The utility model provides the following technical solutions:

[0024] Embodiment 1

[0025] See also Figure 1-3 , a microreactor-assisted peptide synthesis device, comprising a cleaning device 1, wherein a mixing device 2 is provided inside the cleaning device 1;

[0026] The cleaning device 1 includes a box body 101, the upper end of the box body 101 is fixedly connected to a motor 102, the lower end of the motor 102 is fixedly connected to a frame body 103, the inner top wall of the frame body 103 is fixedly connected to an electric push rod 104, the lower end of the electric push rod 104 is fixedly connected to a slider 105, both ends of the slider 105 are fixedly connected to a connecting rod 106, and the other end of the connecting rod 106 is fixedly connected to a scraper 107.

[0027] Through the above technical solution, the motor 102 drives the frame 103 to rotate, and the frame 103 drives the scraper 107 to rotate through the slider 105 and the connecting rod 106. The scraper 107 scrapes the solution adhered to the inner wall of the box 101. By starting the electric push rod 104, the electric push rod 104 pushes the slider 105 to move downward, and the slider 105 drives the scraper 107 to descend through the connecting rod 106, so that the scraper 107 rotates and descends to scrape the inner wall of the box 101, thereby achieving the effect of facilitating the scraping of the adhered solution and reducing the waste of raw materials.

[0028] Specifically, a feed inlet and a discharge outlet are respectively provided at the upper and lower ends of the box body 101 , and a stirring blade is fixedly connected to the outer surface of the frame body 103 .

[0029] Through the above technical solution, the outer surface of the frame 103 is fixedly connected with a stirring blade, and when the motor 102 drives the frame 103 to rotate, the stirring blade is driven to rotate to mix and stir the mixed solution inside the box 101.

[0030] Specifically, the slider 105 is slidably connected to the frame 103 , and the scraper 107 is attached to the inner wall of the box 101 and is arranged in an inclined shape.

[0031] Through the above technical solution, the frame 103 limits the slider 105, and the scraper 107 is arranged in an inclined shape to guide the adhered solution to fall.

[0032] Embodiment 2

[0033] See also Figure 1 , Figure 4 , and on the basis of Example 1, it is further obtained that: the mixing device 2 includes a measuring cup 201, a conduit 202 is provided at the lower end of the measuring cup 201, a pump body 203 is provided at the lower end of the conduit 202, a delivery pipe 204 is provided at the output end of the pump body 203, an annular sleeve 205 is fixedly connected to the outer surface of the delivery pipe 204, and a nozzle 206 is provided at the lower end of the annular sleeve 205.

[0034] Through the above technical solution, the added reaction solvent is measured by the measuring cup 201, and according to the actual amount of reaction solvent added, the reaction solvent in the measuring cup 201 is extracted by the pump body 203 and transported along the conduit 202 into the delivery pipe 204, and then enters the annular sleeve 205 and is sprayed out by the nozzle 206 to increase the spraying area, thereby achieving the effect of facilitating the rapid addition of the corresponding amount of reaction solvent, increasing the spraying area, and improving the mixing efficiency.

[0035] The measuring cup 201 is located at the upper end of the box body 101 , and the pump body 203 is located at the inner top wall of the box body 101 and is fixedly connected to the box body 101 .

[0036] Specifically, the annular sleeve 205 is configured as a plurality of annular through pipes with the same center, and a pull rod is provided between the upper end of the annular sleeve 205 and the box body 101 .

[0037] Through the above technical solution, the annular sleeve 205 is configured as a plurality of annular through pipes with the same center, which facilitates increasing the spraying area, thereby accelerating mixing. The pull rod is used to support the annular sleeve 205 to enhance stability.

[0038] Specifically, a plurality of water pumps 207 are fixedly connected to the outer surface of the box body 101 , and a water inlet pipe and a water outlet pipe are respectively disposed at both ends of the water pump 207 .

[0039] Through the above technical solution, the solution at the bottom of the box 101 is extracted by the water pump 207, transmitted from the water inlet pipe to the water outlet pipe, and transported to the upper end of the box 101, thereby strengthening the liquid flow inside the box 101 and improving the mixing efficiency.

[0040] Although specific embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these specific embodiments without departing from the principles and spirit thereof, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A microreactor-assisted peptide synthesis device, comprising a cleaning device (1), characterized in that: The cleaning device (1) is provided with a mixing device (2) inside; The cleaning device (1) comprises a box body (101), the upper end of the box body (101) is fixedly connected to a motor (102), the lower end of the motor (102) is fixedly connected to a frame body (103), the inner top wall of the frame body (103) is fixedly connected to an electric push rod (104), the lower end of the electric push rod (104) is fixedly connected to a slider (105), both ends of the slider (105) are fixedly connected to a connecting rod (106), and the other end of the connecting rod (106) is fixedly connected to a scraper (107).

2. A microreactor-assisted peptide synthesis device according to claim 1, characterized in that: The mixing device (2) comprises a measuring cup (201), a conduit (202) is provided at the lower end of the measuring cup (201), a pump body (203) is provided at the lower end of the conduit (202), a delivery pipe (204) is provided at the output end of the pump body (203), an annular sleeve (205) is fixedly connected to the outer surface of the delivery pipe (204), and a nozzle (206) is provided at the lower end of the annular sleeve (205).

3. A microreactor-assisted peptide synthesis device according to claim 1, characterized in that: The upper and lower ends of the box body (101) are respectively provided with a feed inlet and a discharge outlet, and the outer surface of the frame body (103) is fixedly connected with a stirring blade.

4. A microreactor-assisted peptide synthesis device according to claim 1, characterized in that: The sliding block (105) is slidably connected to the frame (103), and the scraper (107) is in contact with the inner wall of the box (101) and is arranged in an inclined shape.

5. A microreactor-assisted peptide synthesis device according to claim 2, characterized in that: The measuring cup (201) is located at the upper end of the box body (101), and the pump body (203) is located on the inner top wall of the box body (101) and is fixedly connected to the box body (101).

6. A microreactor-assisted peptide synthesis device according to claim 2, characterized in that: The annular sleeve (205) is configured as a plurality of annular through pipes with the same center, and a pull rod is provided between the upper end of the annular sleeve (205) and the box body (101).

7. A microreactor-assisted peptide synthesis device according to claim 1, characterized in that: A plurality of water pumps (207) are fixedly connected to the outer surface of the box body (101), and a water inlet pipe and a water outlet pipe are respectively provided at two ends of the water pump (207).

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