A switching four-way valve for changing the flow direction of a perfusion bag and a flow direction switching system

Abstract

The utility model discloses a switching four-way valve for changing the flow direction of a perfusion bag and a flow direction switching system. The switching four-way valve for changing the flow direction of a perfusion bag comprises a valve body component, a valve core component and a drive component. The valve core component is arranged in the valve body component and is movably connected. The drive component is arranged at the upper end of the valve core component. The valve body component comprises an upper sealing plate, a valve body shell and a sealing cover. The top of the valve body shell is provided with a receiving groove extending inwardly, and the receiving groove is used to accommodate the valve core component. The valve core component comprises a valve core, a lower magnet, a magnet gasket and a lower sealing plate. The valve core is movably connected to the bottom of the valve body shell. The drive component comprises an upper magnet cover plate, an upper magnet, a magnet fixing plate and a motor. The utility model is easy to use and can realize rapid switching of the flow direction of a pipeline while keeping the pipeline isolated from the outside, realizing modularization and unitization of a switching structure and meeting the aseptic environment required for biopharmaceutical production.

Description

Technical Field

[0001] The utility model relates to the technical field of biomedicine, in particular to a switching four-way valve for changing the flow direction of a perfusion bag. Background Art

[0002] In traditional cell culture, as the culture process continues, the concentration of metabolites in the reactor continues to increase, and the cells will die. How to achieve continuous processing and use a small-volume reactor to produce the same output as a large-volume reactor has become a research trend.

[0003] At present, biopharmaceutical manufacturers and pharmaceutical equipment manufacturers believe that cell perfusion culture technology has the potential to solve the above problems. The solution is to filter out the cell culture medium in the reactor during the reaction process and add new culture medium at the same time, so as to achieve a dynamic balance of metabolites and realize continuous production.

[0004] Filtering the cell culture solution in the reactor is an important part of the cell perfusion culture technology. Among them, filtration is the key, and hollow fibers are usually used to complete the filtration. However, during long-term filtration, the filtration gap of the hollow fiber will be blocked. The existing solution is to reversely flush the blockage in the filtration gap by rotating the reciprocating diaphragm pump forward and backward to cause it to fall off. In the prior art CN219603595U, the flow direction of the cell solution flowing through the filter membrane is switched by switching the flow path of the pipeline on and off.

[0005] However, the reciprocating frequency of the reciprocating diaphragm pump is difficult to match the steering frequency required by the filter membrane, and it is costly and difficult to maintain. Using the pipeline on-off method to achieve flow direction switching requires too many pinch valves, making the overall equipment messy and not intensive, and is not suitable for frequent flow direction switching. Utility Model Content

[0006] In view of the above situation, it is necessary to provide a switching four-way valve and a flow direction switching system for changing the flow direction of the perfusion bag in order to solve the problem of low concentration of flow direction switching in the prior art.

[0007] A switching four-way valve for changing the flow direction of a perfusion bag comprises a valve body assembly, a valve core assembly and a drive assembly, wherein the valve core assembly is movably arranged in the valve body assembly, and the drive assembly is arranged at the upper end of the valve core assembly;

[0008] The valve body assembly comprises an upper sealing plate, a valve body shell and a sealing cover. The top of the valve body shell is provided with an inwardly extending accommodating groove, the accommodating groove is used to accommodate the valve core assembly, the sealing cover is provided above the valve body shell, the upper sealing plate is provided between the sealing cover and the valve body shell, the upper and lower surfaces of the upper sealing plate are respectively in contact with the sealing cover and the valve body shell, four fluid channels are evenly provided in the circumference of the valve body shell, and the ends of the four fluid channels away from the valve body shell are provided with pipeline interfaces, the pipeline interfaces are used to connect external pipelines;

[0009] The valve core assembly includes a valve core, a lower magnet, a magnet gasket and a lower sealing plate. The valve core is movably connected to the bottom of the valve body shell. A number of magnet gaskets are evenly distributed in the valve core. The lower magnet is fixed on the magnet gasket, and the magnet gasket is fixed on the valve core. The lower sealing plate is provided between the valve core and the valve body shell, and the lower sealing plate abuts against the valve body shell. The two opposite outer edges of the valve core are provided with arc grooves, and the arc grooves communicate with two adjacent fluid channels.

[0010] The driving assembly includes an upper magnet cover plate, an upper magnet, a magnet fixing plate and a motor. The magnet fixing plate is arranged on the upper sealing plate. A plurality of magnet placement holes are evenly distributed on the magnet fixing plate. A plurality of upper magnets are arranged in the plurality of magnet placement holes. A plurality of the upper magnets are adapted to a plurality of the lower magnets. The magnet fixing plate is fixed to the upper magnet cover plate by bolts. The upper magnet cover plate is vertically connected to the output shaft of the motor. The motor is fixed to the valve body housing through a bracket.

[0011] The utility model provides a switching four-way valve between the circuit formed by the reaction container and the filter, the valve core of the switching four-way valve is provided with an arc groove, and the upper magnet and the lower magnet of the magnetic coupling are driven by the control motor, thereby driving the rotation of the valve core assembly in the valve body shell to realize the switching of the arc groove and the pipeline interface, that is, the direction of the pipeline cell solution is switched, and an O-ring is provided between the upper sealing plate and the lower sealing plate and the valve body shell, and the upper sealing plate and the lower sealing plate are fastened to the valve body shell by bolts to improve the sealing performance, so that the cell solution flowing in the valve body assembly and the valve core assembly is isolated from the outside world, and the internal environment is maintained; the motor is controlled to realize The valve core assembly is now rotated 90° in the valve body shell, and the pipeline interface remains connected to the output and input ends of the centrifugal pump in the same flow direction, and the pipeline connection sequence between the pipeline interface and the reaction container and the filter remains unchanged, but the inlet and outlet directions of the pipeline interface and the reaction container and the filter are swapped to achieve the function of switching the flow direction of the cell solution; the utility model is easy to use, can achieve rapid switching of the pipeline flow direction, and at the same time keep the pipeline isolated from the outside world, realizes the modularization and unitization of the switching structure, and the power connection mode is closed and magnetically coupled, which improves the sealing of the switching four-way valve and meets the sterile environment required for biopharmaceutical production.

[0012] Furthermore, a first O-ring is provided between the upper sealing plate and the top of the valve body shell, the valve body shell is provided with a first threaded hole, the upper sealing plate is provided with a second threaded hole, and the cover is provided with a third threaded hole, the first threaded hole is respectively adapted to the second threaded hole and the third threaded hole, and the valve body shell and the cover are fixed by bolts.

[0013] Furthermore, a second O-ring is provided between the valve core and the lower sealing plate, the valve core is provided with a fourth threaded hole, the lower seal is provided with a fifth threaded hole, the fourth threaded hole and the fifth threaded hole are adapted to each other, and the lower sealing plate and the valve core are fixed by bolts.

[0014] Furthermore, the height of the arc groove along the axial direction of the valve core is consistent with the height of the fluid channel.

[0015] Furthermore, the magnetic poles of the plurality of upper magnets are distributed alternately, and the magnetic poles of the plurality of lower magnets are distributed alternately, and the magnetic poles of the plurality of upper magnets and the magnetic poles of the plurality of lower magnets are magnetically attracted to each other in the vertical direction.

[0016] The utility model also provides a flow direction switching system, comprising the switching four-way valve for changing the flow direction of the perfusion bag.

[0017] Furthermore, the flow direction switching system also includes a centrifugal pump, a reaction container and a filter. The centrifugal pump is arranged on one side of the switching four-way valve for changing the flow direction of the perfusion bag, the reaction container is arranged on the side of the centrifugal pump away from the switching four-way valve for changing the flow direction of the perfusion bag, and the filter is arranged on the side of the reaction container away from the centrifugal pump.

[0018] Furthermore, the input end and the output end of the centrifugal pump are respectively connected to any two oppositely arranged pipeline interfaces through a first pipeline, and the reaction container is respectively connected to the other two oppositely arranged pipeline interfaces through a second pipeline. The filter is provided in any of the second pipelines, and the filter is provided with a harvesting port, which is connected to an external container. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the structure of a switching four-way valve for changing the flow direction of a perfusion bag according to the first embodiment of the utility model;

[0020] Figure 2 It is a side cross-sectional view of a switching four-way valve for changing the flow direction of a perfusion bag according to the first embodiment of the utility model;

[0021] Figure 3 It is a top view of a cross-sectional view of a switching four-way valve part structure for changing the flow direction of the perfusion bag according to the first embodiment of the utility model;

[0022] Figure 4 The flow direction switching system of the first embodiment of the utility model is used in a schematic diagram Figure 1 ;

[0023] Figure 5 The flow direction switching system of the first embodiment of the utility model is used in a schematic diagram Figure 2 .

[0024] Figure numerals: 1. a switching four-way valve for changing the flow direction of the perfusion bag; 10. a valve body assembly; 11. an upper sealing plate; 12. a valve body shell; 13. a sealing cover; 14. a pipeline interface; 15. a first O-ring; 16. a receiving groove; 20. a valve core assembly; 21. a valve core; 22. a lower magnet; 23. a magnet gasket; 24. a lower sealing plate; 25. an arc groove; 26. a second O-ring; 30. a driving assembly; 31. an upper magnet cover plate; 32. an upper magnet; 33. a magnet fixing plate; 34. a motor; 35. a bracket; 2. a centrifugal pump; 3. a reaction vessel; 4. a filter; 41. a harvesting port; 5. a first pipeline; 6. a second pipeline. DETAILED DESCRIPTION

[0025] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. The drawings provide embodiments of the present invention. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing this embodiment is to make the disclosure of the present invention more thorough and comprehensive.

[0026] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by technicians in the technical field of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items. In addition, the various embodiments of the present invention, the features in the embodiments, and the features of the embodiments can be freely combined without obvious conflicts or contradictions.

[0028] like Figures 1 to 3As shown, a switching four-way valve 1 for changing the flow direction of a perfusion bag includes a valve body assembly 10, a valve core assembly 20, and a drive assembly 30. The valve core assembly 20 is arranged in the valve body assembly 10 and is movably connected, and the drive assembly 30 is arranged at the upper end of the valve core assembly 20.

[0029] Specifically, the valve body assembly 10 includes an upper sealing plate 11, a valve body shell 12 and a cover 13. The top of the valve body shell 12 is provided with an inwardly extending accommodating groove 16, and the accommodating groove 16 is used to accommodate the valve core assembly 20. The cover 13 is arranged above the valve body shell 12. The upper sealing plate 11 is arranged between the cover 13 and the valve body shell 12. The upper and lower surfaces of the upper sealing plate 11 are respectively in contact with the cover 13 and the valve body shell 12. A first O The valve body shell 12 is provided with a first threaded hole, the cover 13 is provided above the upper sealing plate 11, the upper sealing plate 11 is provided with a second threaded hole, the cover 13 is provided with a third threaded hole, the first threaded hole is respectively adapted to the second threaded hole and the third threaded hole, the valve body shell 12 and the cover 13 are fixed by bolts, the valve body shell 12 is evenly provided with four fluid channels in the circumference, the four fluid channels are away from the valve body shell 12 and are provided with pipeline interfaces 14, and the pipeline interfaces 14 are used to connect external pipelines.

[0030] Specifically, the valve core assembly 20 includes a valve core 21, a lower magnet 22, a magnet gasket 23 and a lower sealing plate 24. The valve core 21 is movably connected to the bottom of the valve body shell 12. A plurality of magnet gaskets 23 are evenly distributed in the valve core 21. A plurality of lower magnets 22 are fixed on the magnet gaskets 23. The magnetic poles of the plurality of lower magnets 22 are alternately distributed. The magnet gaskets 23 are fixed on the valve core 21. The lower sealing plate 24 is provided between the valve core 21 and the valve body shell 12. A second O-ring 26 is provided between the sealing plates 24, the valve core 21 is provided with a fourth threaded hole, the lower seal 24 is provided with a fifth threaded hole, the fourth threaded hole and the fifth threaded hole are adapted to each other, the lower sealing plate 24 is fixed to the valve core 21 by bolts, the lower sealing plate 24 is tightly fitted to the valve body shell 12, and arc grooves 25 are provided on opposite sides of the edge of the valve core 21, the arc grooves 25 connect the two adjacent fluid channels, and the height of the arc groove 25 along the axial direction of the valve core 21 is consistent with the height of the fluid channel.

[0031] Specifically, the drive assembly 30 includes an upper magnet cover plate 31, an upper magnet 32, a magnet fixing plate 33 and a motor 34. The magnet fixing plate 33 is arranged on the upper sealing plate 11. The magnet fixing plate 33 is evenly distributed with a plurality of magnet placement holes. A plurality of upper magnets 32 are arranged in the plurality of magnet placement holes. The magnetic poles of the plurality of upper magnets 32 are alternately distributed. The magnetic poles of the plurality of upper magnets 32 and the magnetic poles of the plurality of lower magnets 22 are magnetically attracted to each other in the vertical direction. The magnet fixing plate 33 is fixed to the upper magnet cover plate 31 by bolts. The upper magnet cover plate 31 is vertically connected to the output shaft of the motor 34. The motor is fixed to the valve body housing 12 through a bracket 35.

[0032] like Figure 4 and Figure 5 As shown, the utility model also provides a flow direction switching system, including the switching four-way valve 1 for changing the flow direction of the perfusion bag.

[0033] Specifically, the flow direction switching system also includes a centrifugal pump 2, a reaction container 3 and a filter 4. The centrifugal pump 2 is arranged on one side of the switching four-way valve 1 for changing the flow direction of the perfusion bag, the reaction container 3 is arranged on one side of the centrifugal pump 2, and the filter 4 is arranged on the side of the reaction container 3 away from the centrifugal pump 2.

[0034] Specifically, the input end and the output end of the centrifugal pump 2 are respectively connected to any two oppositely arranged pipeline interfaces 14 through the first pipeline 5, and the reaction container 3 is respectively connected to two oppositely arranged pipeline interfaces 14 through the second pipeline 6. The filter 4 is provided in any second pipeline 6 connecting the reaction container 3 and the pipeline interface 14, and the filter 4 is provided with a harvesting port 41, and the harvesting port 41 is connected to an external container.

[0035] The specific implementation process is:

[0036] The cells are cultured in the reaction vessel 3, and the culture medium is sent to the filter 4 by the centrifugal pump 2 for filtration. The contents smaller than the filtration gap are filtered out, while the contents larger than the gap are retained. Since the filter membrane is easily blocked during the filtration process, a flow direction diversion is specially set.

[0037] Forward filtration: after the centrifugal pump 2 is turned on, the cell solution flows out from the left port of the reaction container 3, is connected to the upper pipe interface of the switching four-way valve 1 for changing the flow direction of the perfusion bag through the second pipe 6, and then is output to the left lateral fluid channel through the internal arc groove 25 through the upper lateral fluid channel, and is connected to the input end of the centrifugal pump 2 by the first pipe 5 connected to the left pipe interface 14 of the switching four-way valve 1 for changing the flow direction of the perfusion bag, and then is connected to the first pipe 5 through the output end of the centrifugal pump 2 to the right pipe interface 14 of the switching four-way valve 1 for changing the flow direction of the perfusion bag, and then through the right lateral fluid channel and another internal arc groove 25, it is finally output from the lower lateral fluid channel to the lower pipe interface 14 of the switching four-way valve 1 for changing the flow direction of the perfusion bag, and the lower pipe interface 14 is connected to the second pipe 6 to the filter 4. After being filtered, the cell solution flows back into the right port of the reaction container 3.

[0038] Turning direction: after the filter membrane is clogged and the filtering effect is affected, the motor 34 is started, the motor 34 drives the upper magnet 32 ​​to rotate, and the upper magnet 32 ​​is coupled and driven with the lower magnet 22 through the upper sealing plate 31. After the motor 34 drives the upper magnet 32 ​​to rotate ninety degrees, the lower magnet 22 also drives the valve core 21 to rotate ninety degrees; the connection sequence in the switching four-way valve 1 that changes the flow direction of the perfusion bag is changed from the upper lateral fluid channel and the left lateral fluid channel, and the right lateral fluid channel and the lower lateral fluid channel to the upper lateral fluid channel and the right lateral fluid channel, and the left lateral fluid channel and the lower lateral fluid channel.

[0039] Reverse filtration: After the centrifugal pump 2 is turned on, the cell solution flows out of the right mouth of the reaction container 3 and is connected to the filter 4 through the second pipeline 6. The filtered cell solution is connected to the pipeline interface 14 on the lower side of the switching four-way valve 1 for changing the flow direction of the perfusion bag through the second pipeline 6, passes through the internal arc groove 25 after entering, and then flows out from the pipeline interface 14 on the left side of the switching four-way valve 1 for changing the flow direction of the perfusion bag, is connected to the input end of the centrifugal pump 2 through the first pipeline 5, and then connected to the first pipeline 5 through the output end of the centrifugal pump 2 to the right side pipeline interface 14 of the switching four-way valve 1 for changing the flow direction of the perfusion bag, after passing through the internal arc groove 25, flows out from the upper side pipeline interface 14 of the switching four-way valve 1 for changing the flow direction of the perfusion bag, and flows into the left mouth of the reaction container 3 through the second pipeline 6.

[0040] Thus, a forward and reverse filtration cycle is completed, the direction of the cell solution flowing into the filter 4 is reversed, and the blockage on the filter membrane is reversely washed down and is no longer retained and enters the cycle again.

[0041] Figure 4 and Figure 5 There are two filtering flow direction states. Centrifugal pump 2 is the power source of the cell solution. The flow direction is fixed. The left interface is the input end of centrifugal pump 2, and the right interface is the output end of centrifugal pump 2. Figure 4 In the figure, the upper interface of the switching four-way valve 1 for changing the flow direction of the perfusion bag is communicated with the left interface through the first pipeline 5, and the lower interface of the switching four-way valve 1 for changing the flow direction of the perfusion bag is communicated with the right interface through the first pipeline 5. In this state, the upper interface is the inlet of the switching four-way valve 1 for changing the flow direction of the perfusion bag, and the lower interface is the outlet of the switching four-way valve 1 for changing the flow direction of the perfusion bag. Figure 5 In the figure, the upper interface of the switching four-way valve 1 for changing the flow direction of the perfusion bag is communicated with the right interface through the first pipeline 5, and the lower interface is communicated with the left interface through the first pipeline 5. In this state, the upper interface is the outlet of the switching four-way valve 1 for changing the flow direction of the perfusion bag, and the lower interface is the inlet of the switching four-way valve 1 for changing the flow direction of the perfusion bag.

[0042] The utility model provides a switching four-way valve 1 for changing the flow direction of the perfusion bag between the pipelines connected to the reaction container 3 and the filter 4. The valve core 21 of the switching four-way valve 1 for changing the flow direction of the perfusion bag is provided with an arc groove 25. The upper magnet 32 ​​and the lower magnet 22 of the magnetic coupling are driven by the control motor 34, thereby driving the valve core assembly 20 to rotate in the valve body shell 10, so as to realize the switching of the connecting arc groove 25 and the pipeline interface 14, that is, the switching of the cell solution direction of the pipeline. An O-ring 15 is provided between the upper sealing plate 11 and the lower sealing plate 24 and the valve body shell 12. At the same time, the upper sealing plate 11 and the lower sealing plate 24 are connected to the valve body shell 12 by bolts. The valve body shell 12 is tightened to improve the sealing performance, so that the cell solution flowing in the valve body assembly 10 and the valve core assembly 20 is isolated from the outside world and the internal environment is maintained; by controlling the motor 34, the valve core assembly 20 is rotated 90° in the valve body shell 12, and the pipeline interface 14 remains connected to the output and input ends of the centrifugal pump 2. The pipeline connection sequence between the pipeline interface 14 and the reaction container 2 and the filter 4 remains unchanged, but the inlet and outlet directions of the pipeline interface 14 and the reaction container 3 and the filter 4 are swapped to achieve the effect of switching the flow direction of the cell solution. It can be connected to an external container through the harvesting port 41 to collect the filtered cell solution.

[0043] The utility model is easy to use and can realize rapid switching of pipeline flow direction while keeping the pipeline isolated from the outside world, realizes modularization and unitization of the switching structure, and the power connection mode is closed and magnetically coupled, thereby improving the sealing performance of the switching four-way valve 1 for changing the flow direction of the perfusion bag and meeting the aseptic environment required for biopharmaceutical production.

[0044] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0045] The above-mentioned embodiments only express the implementation methods of the utility model, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the patent of the utility model. It should be pointed out that, for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the utility model, and these all belong to the protection scope of the utility model. Therefore, the protection scope of the utility model patent shall be based on the attached claims.

Claims

1. A switching four-way valve for changing the flow direction of a perfusion bag, characterized in that: It includes a valve body assembly, a valve core assembly, and a drive assembly, wherein the valve core assembly is movably arranged in the valve body assembly, and the drive assembly is arranged at the upper end of the valve core assembly; The valve body assembly comprises an upper sealing plate, a valve body shell and a sealing cover. The top of the valve body shell is provided with an inwardly extending accommodating groove, the accommodating groove is used to accommodate the valve core assembly, the sealing cover is provided above the valve body shell, the upper sealing plate is provided between the sealing cover and the valve body shell, the upper and lower surfaces of the upper sealing plate are respectively in contact with the sealing cover and the valve body shell, four fluid channels are evenly provided in the circumference of the valve body shell, and the ends of the four fluid channels away from the valve body shell are provided with pipeline interfaces, the pipeline interfaces are used to connect external pipelines; The valve core assembly includes a valve core, a lower magnet, a magnet gasket and a lower sealing plate. The valve core is movably connected to the bottom of the valve body shell. A number of magnet gaskets are evenly distributed in the valve core. The lower magnet is fixed on the magnet gasket, and the magnet gasket is fixed on the valve core. The lower sealing plate is provided between the valve core and the valve body shell, and the lower sealing plate abuts against the valve body shell. The two opposite outer edges of the valve core are provided with arc grooves, and the arc grooves communicate with two adjacent fluid channels. The driving assembly includes an upper magnet cover plate, an upper magnet, a magnet fixing plate and a motor. The magnet fixing plate is arranged on the upper sealing plate. A plurality of magnet placement holes are evenly distributed on the magnet fixing plate. A plurality of upper magnets are arranged in the plurality of magnet placement holes. A plurality of the upper magnets are adapted to a plurality of the lower magnets. The magnet fixing plate is fixed to the upper magnet cover plate by bolts. The upper magnet cover plate is vertically connected to the output shaft of the motor. The motor is fixed to the valve body housing through a bracket.

2. The switching four-way valve for changing the flow direction of the perfusion bag according to claim 1, characterized in that: A first O-ring is provided between the upper sealing plate and the top of the valve body shell, the valve body shell is provided with a first threaded hole, the upper sealing plate is provided with a second threaded hole, and the cover is provided with a third threaded hole, the first threaded hole is respectively matched with the second threaded hole and the third threaded hole, and the valve body shell and the cover are fixed by bolts.

3. The switching four-way valve for changing the flow direction of the perfusion bag according to claim 1, characterized in that: A second O-ring is provided between the valve core and the lower sealing plate, the valve core is provided with a fourth threaded hole, the lower seal is provided with a fifth threaded hole, the fourth threaded hole and the fifth threaded hole are adapted, and the lower sealing plate and the valve core are fixed by bolts.

4. The switching four-way valve for changing the flow direction of the perfusion bag according to claim 1, characterized in that: The height of the arc groove along the axial direction of the valve core is consistent with the height of the fluid channel.

5. The switching four-way valve for changing the flow direction of the perfusion bag according to claim 1, characterized in that: The magnetic poles of the plurality of upper magnets are distributed alternately, and the magnetic poles of the plurality of lower magnets are distributed alternately. The magnetic poles of the plurality of upper magnets and the magnetic poles of the plurality of lower magnets are magnetically attracted to each other in a vertical direction.

6. A flow direction switching system, characterized in that: The invention comprises a switching four-way valve for changing the flow direction of the perfusion bag as described in any one of claims 1 to 5.

7. The flow direction switching system according to claim 6, characterized in that: The flow direction switching system also includes a centrifugal pump, a reaction container and a filter. The centrifugal pump is arranged on one side of the switching four-way valve for changing the flow direction of the perfusion bag, the reaction container is arranged on a side of the centrifugal pump away from the switching four-way valve for changing the flow direction of the perfusion bag, and the filter is arranged on a side of the reaction container away from the centrifugal pump.

8. The flow direction switching system according to claim 7, characterized in that: The input end and the output end of the centrifugal pump are respectively connected to any two oppositely arranged pipeline interfaces through the first pipeline, and the reaction container is respectively connected to the other two oppositely arranged pipeline interfaces through the second pipeline. The filter is provided in any of the second pipelines, and the filter is provided with a harvesting port, which is connected to an external container.

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