Perfusator adsorbent leaching device

Abstract

The utility model relates to the technical field of adsorbent elution devices, in particular to a perfusion device adsorbent leaching device which comprises a PLC (programmable logic controller), a solvent storage tank, a purification washing agent recovery tank, a leaching agent preparation tank, a leaching agent storage tank, a plate heat exchanger, a leaching column, a leaching solution collection tank, a leaching solution purification mechanism and a plurality of water pumps. The eluant preparation tank is provided with a concentration sensor, the concentration sensor transmits a first signal, the purification lotion recovery tank, the eluant preparation tank, the eluant storage tank, the elution column and the eluant collection tank are all provided with liquid level sensors, the liquid level sensors transmit a second signal, and the concentration sensor and the liquid level sensors are electrically connected with the PLC. The PLC receives the first signal and the second signal and sends out a third signal, the PLC is electrically connected with the water pump, and the water pump receives the third signal and makes a response to opening or closing. The method has the advantages that the productivity is improved, and energy and labor cost are saved.

Description

Technical Field

[0001] The present application relates to the technical field of adsorbent eluting devices, and in particular to a perfusion adsorbent eluting device. Background Art

[0002] The adsorbent of the perfusion device is a macroporous neutral resin, which is divided into 80 / 100 / 130 / 150 / 200 / 230 / 250 / 280 / 330 / 350 according to the different loading amounts. It is used in the same way as the activated carbon perfusion device. The small model 80-130 is mainly used for dialysis series perfusion for molecular adsorption of uremia. 150-280 is used for the adsorption of poisoning toxins, and 280-330 is used in the field of immunoadsorption and liver disease.

[0003] Some organic substances will be introduced into the production and synthesis process of the perfusion adsorbent. This equipment realizes the fully automatic elution operation of the introduced organic solvent. Since the reaction process of the existing elution device is long and there are many instruments, it requires multiple staff to monitor and the production efficiency is low. Utility Model Content

[0004] In order to improve production capacity and save energy and labor costs, the present application provides a perfusion device adsorbent elution device.

[0005] The present application provides a perfusion device for sorbent washing, which adopts the following technical solution:

[0006] A perfusion device adsorbent elution device comprises a PLC controller, a solvent storage tank, a purification lotion recovery tank connected to the solvent storage tank, an eluent preparation tank connected to the solvent storage tank, an eluent storage tank connected to the eluent preparation tank, a plate heat exchanger connected to the eluent storage tank, an eluent column connected to the plate heat exchanger, an eluent collection tank connected to the eluent column, and an eluent purification mechanism connected to the eluent collection tank, wherein the eluent purification mechanism is connected to the purification lotion recovery tank, the eluent preparation tank is provided with a concentration sensor, and the concentration sensor emits a first signal, the purification lotion recovery tank, the eluent preparation tank, the eluent storage tank, The elution column and the elution liquid collecting tank are both provided with a liquid level sensor, and the liquid level sensor transmits a second signal. The concentration sensor and the liquid level sensor are both electrically connected to the PLC controller, and the PLC controller receives the first signal and the second signal, and sends a third signal. A water pump is connected between the purification detergent recovery tank, the solvent storage tank and the elution agent preparation tank, a water pump is provided between the eluent preparation tank and the eluent storage tank, a water pump is provided between the eluent storage tank and the plate heat exchanger, and a water pump is provided between the elution liquid collecting tank and the elution liquid purification mechanism. The PLC controller is electrically connected to the water pump, and the water pump receives the third signal and responds to opening or closing.

[0007] By adopting the above technical solution, when the user uses this application, the eluent is taken from the eluent storage tank and. Some organic substances will be introduced into the perfusion device adsorbent during the production and synthesis process. This equipment realizes the fully automatic elution operation of the introduced organic solvent, including the recovery of the eluent in the eluent, the configuration integration with the eluent and the fully automated production equipment, which improves the efficiency of the cleaning process of the organic substances contained in the perfusion device adsorbent, and achieves the purpose of increasing production capacity, saving energy and labor in this process.

[0008] Optionally, the elution column is provided with an outlet, a feed port, a vent port, and an ethanol inlet, the outlet is located at the bottom of the elution column, the feed port, the vent port and the ethanol inlet are all located at the top of the elution column, the elution column is provided with a head, and the liquid level inside the elution column is located below the head.

[0009] By adopting the above technical solution, the basic function of the elution column is realized and the elution purpose is achieved.

[0010] Optionally, a slat mirror is provided on the side of the elution column, and the number of the slat mirrors is two, the two slat mirrors are respectively located at the top and bottom of the side of the elution column, the length directions of the two slat mirrors overlap, and the head is located between the two slat mirrors.

[0011] By adopting the above technical solution, the user can observe the amount and state of the solution inside the elution column through the slatted sight glass.

[0012] Optionally, the ratio between the height of the elution column volume and the inner diameter of the elution column volume is 4:1.

[0013] By adopting the above technical solution, the elution efficiency is better when the aspect ratio is 4:1.

[0014] Optionally, the number of the elution columns is two, and both of the two elution columns are connected to the elution liquid collection tank.

[0015] By adopting the above technical solution, the production output value of each production is increased and the production efficiency is improved.

[0016] Optionally, the working volume of the elution column is 350 L, the height of the elution column is 2 meters, and the inner diameter of the elution column is 0.5 meters.

[0017] By adopting the above technical solution, the initial liquid level of the solution is located between the two slat sight glasses, which is convenient for users to observe the product status.

[0018] In summary, the present application includes at least one of the following beneficial technical effects:

[0019] The PLC controller, concentration sensor, liquid level sensor and water pump in the present application enable the device to adjust according to the solution content and solution concentration in multiple reaction containers through positive and negative feedback between the components, without excessive manual intervention, thus reducing costs and improving production efficiency;

[0020] The aspect ratio of the elution column in the present application is 4:1, which improves the elution efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a control logic diagram of a perfusion device adsorbent elution device disclosed in Example 1 of the present application;

[0022] Figure 2 This is a schematic diagram of the production process of a perfusion device adsorbent elution device in Example 1 of the present application;

[0023] Figure 3 yes Figure 2 A partial enlarged view of the middle A;

[0024] Figure 4 yes Figure 2 A partial enlarged view of point B in the middle;

[0025] Figure 5 yes Figure 2 A partial enlarged view of point C in the middle;

[0026] Figure 6 yes Figure 2 A partial enlarged view of point D in the middle;

[0027] Figure 7 yes Figure 2 A partial enlarged view of point E in the middle;

[0028] Figure 8 is a schematic diagram of the structure of the elution column in Example 2;

[0029] Fig. 9 is a top view of the elution column in Example 2;

[0030] Fig.10 yes Figure 8 A partial enlarged view of point F in the middle.

[0031] Explanation of the reference numerals: 1. solvent storage tank; 2. purification detergent recovery tank; 3. eluent preparation tank; 4. eluent storage tank; 5. plate heat exchanger; 6. eluent column; 61. outlet; 62. feed port; 63. vent port; 64. ethanol inlet; 65. slat sight glass; 7. eluent collection tank; 8. eluent purification mechanism; 9. control valve; 10. concentration sensor; 20. liquid level sensor; 30. water pump. DETAILED DESCRIPTION

[0032] The following is combined with Figure 1 -Attached Figure 8 This application is described in further detail.

[0033] At present, in order to improve production capacity and save energy and labor costs, the embodiment of the present application proposes a perfusion device adsorbent elution device.

[0034] The present application discloses a perfusion device for rinsing adsorbent. Figure 1-7 A perfusion device adsorbent elution device comprises a PLC controller, a solvent storage tank 1, a purification lotion recovery tank 2 connected to the solvent storage tank 1, an eluent preparation tank 3 connected to the solvent storage tank 1, an eluent storage tank 4 connected to the eluent preparation tank 3, a plate heat exchanger 5 connected to the eluent storage tank 4, an eluent column 6 connected to the plate heat exchanger 5, an eluent collection tank 7 connected to the eluent column 6, and an eluent purification mechanism 8 connected to the eluent collection tank 7, the eluent purification mechanism 8 is connected to the purification lotion recovery tank 2, the eluent preparation tank 3 is provided with a concentration sensor 10, the concentration sensor 10 emits a first signal, the purification lotion recovery tank 2, the eluent preparation tank 3, the eluent storage tank 4, the eluent column 6 and the eluent The collecting tanks 7 are each provided with a liquid level sensor 20, which transmits a second signal. The concentration sensor 10 and the liquid level sensor 20 are both electrically connected to the PLC controller, and the PLC controller receives the first signal and the second signal, and sends a third signal. A water pump 30 is connected between the purification detergent recovery tank 2, the solvent storage tank 1 and the eluent preparation tank 3, a water pump 30 is provided between the eluent preparation tank 3 and the eluent storage tank 4, a water pump 30 is provided between the eluent storage tank 4 and the plate heat exchanger 5, a water pump 30 is provided between the eluent collection tank 7 and the eluent purification mechanism 8, the PLC controller and the water pump 30 are electrically connected, and the water pump 30 receives the third signal and responds to opening or closing.

[0035] When the user uses the present application, the PLC controller, the concentration sensor 10, the liquid level sensor 20 and the water pump 30 form a closed loop of the control system, the water pump 30 between the purification lotion recovery tank 2, the solvent storage tank 1 and the eluent preparation tank 3 is turned on, the external water source is connected to the top of the eluent preparation tank 3, the solvent inside the purification lotion recovery tank 2 and the solvent storage tank 1 enters the inside of the eluent preparation tank 3, the concentration sensor 10 is used to monitor the solution concentration inside the eluent preparation tank 3, at this time, the first signal emitted by the concentration sensor 10 is received by the PLC controller, and the concentration inside the eluent preparation tank 3 is monitored in real time, and the PLC controller emits a third signal to control the opening and closing of the water pump 30 to achieve the purpose of adjusting the solution concentration inside the eluent preparation tank 3, when the liquid level inside the eluent preparation tank 3 reaches the preset value of the liquid level sensor 20, the liquid level sensor 20 emits a second signal, after receiving the second signal, the PLC controller emits a third signal to control the water pump 30 to close, control the upper limit of the solution inside the eluent preparation tank 3, and improve production safety.

[0036] The water pump 30 between the eluent preparation tank 3 and the eluent storage tank 4 is controlled to transport the prepared eluent from the eluent preparation tank 3 to the inside of the eluent storage tank 4. The liquid level sensor 20 inside the eluent storage tank 4 monitors the amount of solution inside the eluent storage tank 4. When the amount of solution inside the eluent storage tank 4 reaches a preset value, the liquid level sensor 20 sends a second signal, the PLC controller receives the second signal, and sends a third signal to control the water pump 30 between the eluent storage tank 4 and the eluent preparation tank 3 to close, thereby achieving the purpose of controlling the amount of solution inside the eluent storage tank 4.

[0037] The water pump 30 between the eluent storage tank 4 and the plate heat exchanger 5 transfers the eluent in the eluent storage tank 4 through the plate heat exchanger 5 and into the interior of the eluent column 6. When the liquid level sensor 20 of the eluent column 6 detects that the solution volume has reached a preset value, it transmits a second signal. The PLC controller receives the second signal and sends a third signal to control the closure of the water pump 30 between the eluent storage tank 4 and the plate heat exchanger 5. After the elution work in the eluent column 6 is completed, the eluent flows into the eluent collecting tank 7, and then enters the eluent purification mechanism 8 through the water pump 30 between the eluent collecting tank 7 and the eluent purification mechanism 8. After purification by the eluent purification mechanism 8, it is sent to the purified detergent recovery tank 2 to complete recovery, thereby reducing raw material waste. Example

[0038] The difference between the second embodiment of the present application and the first embodiment is that the first embodiment is the control system of the present application, and the second embodiment is the specific structure of the elution column 6. When the elution column 6 is working, the adsorbent matrix is ​​filled into the elution column 6 to form a stationary phase, and a specific solvent is used for elution, and these solvents constitute the mobile phase. In the elution process, the components in the adsorbent are separated in the stationary phase and the mobile phase according to their different distribution adsorption coefficients, and the components are separated through repeated adsorption and desorption processes.

[0039] When solvent elution is adopted, a series of processes of adsorption → desorption → re-adsorption → re-desorption occur, and components are precipitated out of the elution column 6 in order according to the strength of the adsorption force. Components with stronger adsorption force move a smaller distance and flow out of the elution column 6 later; components with weaker adsorption force move a larger distance and flow out of the elution column 6 earlier.

[0040] In the present application, there are two eluent columns 6, and both eluent columns 6 are connected to the eluent collection tank 7 to achieve the purpose of increasing the yield. Figure 8 and Fig. 9 The elution column 6 is provided with an outlet 61, a feed port 62, a vent port 63, and an ethanol inlet 64. The outlet 61 is located at the bottom of the elution column 6. The feed port 62, the vent port 63, and the ethanol inlet 64 are all located at the top of the elution column 6. The elution column 6 is provided with a head to realize the basic functions of the elution column 6. The side of the elution column 6 is provided with a slat mirror 65. There are two slat mirrors 65. The two slat mirrors 65 are respectively located at the top and bottom of the side of the elution column 6. The length directions of the two slat mirrors 65 overlap. The head is located between the two slat mirrors 65. At the same time, the liquid level inside the elution column 6 is located below the head. The user can observe the solution content inside the elution tower between the two slat mirrors 65, which is convenient for the user to observe.

[0041] At the same time, the ratio between the height of the volume of the elution column 6 and the inner diameter of the volume of the elution column 6 is 4:1, the height of the elution column 6 is 2 meters, the inner diameter of the elution column 6 is 0.5 meters, and the working volume of the elution column 6 is 350L. The reason for using the aspect ratio of 4:1 is that when the aspect ratio is small, due to the difference of the mobile phase in the elution process from top to bottom, a part of the stationary phase will be eluted and penetrated earlier, thereby forming a component with smaller adsorption force, which will produce a large difference in diversion. If the aspect ratio is too large, the eluent will reach the saturation coefficient earlier in the process of a series of adsorption→desorption→re-adsorption→re-desorption, resulting in the bottom stationary phase being unable to precipitate in the process of re-desorption.

[0042] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A perfusion device for rinsing an adsorbent, characterized in that: The invention comprises a PLC controller, a solvent storage tank (1), a purification detergent recovery tank (2) connected to the solvent storage tank (1), an eluent preparation tank (3) connected to the solvent storage tank (1), an eluent storage tank (4) connected to the eluent preparation tank (3), a plate heat exchanger (5) connected to the eluent storage tank (4), an eluent column (6) connected to the plate heat exchanger (5), an eluent collection tank (7) connected to the eluent column (6), and an eluent purification mechanism (8) connected to the eluent collection tank (7), wherein the eluent purification mechanism (8) is connected to the purification detergent recovery tank (2), the eluent preparation tank (3) is provided with a concentration sensor (10), and the concentration sensor (10) emits a first signal, wherein the purification detergent recovery tank (2), the eluent preparation tank (3), the eluent storage tank (4), the eluent column (6) ) and the eluent collecting tank (7) are both provided with a liquid level sensor (20), the liquid level sensor (20) emits a second signal, the concentration sensor (10) and the liquid level sensor (20) are both electrically connected to the PLC controller, and the PLC controller receives the first signal and the second signal and emits a third signal, a water pump (30) is connected between the purification detergent recovery tank (2), the solvent storage tank (1) and the eluent preparation tank (3), a water pump (30) is provided between the eluent preparation tank (3) and the eluent storage tank (4), a water pump (30) is provided between the eluent storage tank (4) and the plate heat exchanger (5), a water pump (30) is provided between the eluent collecting tank (7) and the eluent purification mechanism (8), the PLC controller and the water pump (30) are electrically connected, and the water pump (30) receives the third signal and responds to opening or closing.

2. A perfusion device for rinsing an adsorbent according to claim 1, characterized in that: The elution column (6) is provided with an outlet (61), a feed port (62), a vent port (63), and an ethanol inlet (64); the outlet (61) is located at the bottom of the elution column (6); the feed port (62), the vent port (63), and the ethanol inlet (64) are all located at the top of the elution column (6); the elution column (6) is provided with a head, and the liquid level inside the elution column (6) is located below the head.

3. A perfusion device for rinsing an adsorbent according to claim 2, characterized in that: The side of the elution column (6) is provided with a slat sight glass (65), and the number of the slat sight glass (65) is two. The two slat sight glasses (65) are respectively located at the top and bottom of the side of the elution column (6), the length directions of the two slat sight glasses (65) overlap, and the head is located between the two slat sight glasses (65).

4. The perfusion device according to claim 1, characterized in that: The ratio between the height of the volume of the elution column (6) and the inner diameter of the volume of the elution column (6) is 4:

1.

5. The perfusion device for rinsing an adsorbent according to claim 1, characterized in that: The number of the elution columns (6) is two, and the two elution columns (6) are both connected to the elution liquid collection tank (7).

6. The perfusion device for rinsing an adsorbent according to claim 4, characterized in that: The working volume of the elution column (6) is 350 L, the volume height of the elution column (6) is 2 meters, and the volume inner diameter of the elution column (6) is 0.5 meters.

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