Device for preparing wound surface of pressure sore mouse model

Abstract

The utility model discloses a wound surface preparation device for a pressure sore mouse model, which particularly belongs to the technical field of magnetic sheet method pressure sore mouse model construction and comprises a wound surface dehairing mechanism and a wound area measuring frame. The wound surface dehairing mechanism comprises a dehairing blade, a fixed disc, a dehairing net, a rotating rod and a driving motor; the output end of the driving motor is fixed with the rotating rod; the dehairing blade is fixedly arranged at the side end of the fixed disc; the dehairing net is provided with holes for mouse hair to penetrate through, and the fixing disc is located in the dehairing net. And the motion range of the dehairing net is within the wound area measuring frame. The dehairing area of 1 cm < 2 > can be rapidly prepared through the pressure sore mouse model wound surface preparation device. Meanwhile, through isolation of the dehairing net, direct contact between the blade and the mouse skin is avoided, and damage to the mouse skin caused by the blade is prevented.

Description

Technical Field

[0001] The utility model belongs to the technical field of constructing a pressure sore mouse model using a magnetic sheet method, and in particular relates to a device for preparing a wound surface of a pressure sore mouse model. Background Art

[0002] In the research project of the new thermosensitive poloxamer gel-encapsulated artificial musk borneol on the wound repair effect of the pressure sore mouse model, the utility model first needs to construct a mouse model. The specific operation is: 24 3-month-old, 20-25g, male ICR mice are adaptively raised in a single cage for 1 week. After anesthesia by intraperitoneal injection of 1% sodium pentobarbital 50mg / kg, the gracilis muscles on both sides of the hind limbs of the mice are depilated, and a permanent circular magnet with a magnetic force of 0.35T is used to apply pressure. After 3 cycles of pressure, a sterile blade is used to uniformly cut the compressed skin to a depth of 10mm to the lower dermis, and the pressure is continued for 1 cycle, and the pressure sore model is established.

[0003] In the above process, the staff needs to remove the hair from the gracilis muscles on both sides of the mouse's hind limbs. In the laboratory, the staff generally use a razor to remove the mouse's hair from the gracilis muscles on both sides of the mouse's hind limbs (the mouse's hair is about 1 cm).

[0004] The laboratory had the following defects in the above operation process: 1. When shaving, the blade came into direct contact with the mouse skin, which would damage the mouse epidermis, making it difficult to control the single variable factor of pressure sore injury in the future. 2. Since the area of ​​pressure sores is generally 1cm 2 Therefore, it is difficult to control the area of ​​the experimental area when shaving with a razor. Utility Model Content

[0005] The utility model aims to provide a device for preparing wounds of pressure sores in mice models. The device can quickly prepare wounds of 1 cm 2 At the same time, the shaving net is used to isolate the mouse from direct contact with the blade and prevent the blade from causing damage to the mouse skin.

[0006] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0007] The invention discloses a wound preparation device for a pressure sore mouse model, comprising a wound scraping mechanism and a wound area measuring frame; the wound scraping mechanism comprises a scraping blade, a fixed disk, a scraping net, a rotating rod and a driving motor; the output end of the driving motor is fixed to the rotating rod; the scraping blade is fixedly arranged at the side end of the fixed disk; the scraping net is provided with holes for mouse hair to pass through, and the fixed disk is located in the scraping net; the movement range of the scraping net is within the wound area measuring frame.

[0008] The wound area measurement frame can be adjusted according to actual needs. For example, in this experiment, 1 cm2 is sufficient. The wound surface scraping mechanism can move within the wound area measurement frame to achieve scraping in a specific area.

[0009] Since the shaving blade and the mouse skin are separated by the shaving net, the blade can be prevented from directly contacting the skin, thereby scratching or damaging the skin.

[0010] Preferably, the wound area measuring frame and the shaving net are fixed by an elastic band.

[0011] For the complete set of equipment, in order to avoid the loss of the wound area measurement frame, the wound area measurement frame can be placed on the mouse first, and a specific area can be circled, and then the circled area can be shaved by the wound surface shaving mechanism.

[0012] Preferably, a limiting rod is provided on the inner side wall of the shaving net, and the wound scraping mechanism further comprises a limiting bracket, which is sleeved on the rotating rod, and the limiting bracket and the limiting rod are plugged and fixed.

[0013] Preferably, the limit bracket includes a limit leg and a hollow bearing seat. A groove is provided at one end of the limit rod facing the rotating rod. The bearing seat is sleeved on the outer end of the rotating rod. One end of the limit leg is fixed to the bearing seat, and the other end is plugged and fixed to the groove.

[0014] The limit bracket includes a limit foot and a bearing seat. The bearing seat is sleeved on the rotating rod, which is equivalent to the inner side of the bearing seat being relatively fixed to the rotating rod, and the outer side of the bearing seat is fixed to the limit foot. Since multiple rotors are installed in the middle of the bearing seat. When the rotating rod drives the fixed disk to rotate, the horizontal position of the rotating rod is fixed and will not shift while rotating. It is also very convenient to install. The free end of the limit foot will be embedded in the groove on the free end of the limit rod, which is equivalent to limiting it in the horizontal direction. This design is conducive to the rapid installation and disassembly of the internal structure of the scraping net.

[0015] Preferably, a fixing ring is provided at the bottom end of the scraping net, and correspondingly, a columnar protrusion adapted to the fixing ring is provided at the bottom end of the fixing plate.

[0016] The fixing ring and the columnar projection are plug-fitted, which is conducive to positioning the rotating rod and preventing the rotating rod from deviating from the center of the scraping net when rotating.

[0017] Preferably, the inner area of ​​the wound area measurement frame is 1 cm 2 .

[0018] Preferably, the inner side wall of the fixing ring is provided with a shallow groove, and correspondingly, the outer side wall of the columnar protrusion is provided with an annular convex portion corresponding to the shallow groove. The cooperation between the shallow groove and the annular convex portion can prevent the rotating rod from accidentally falling off during rotation.

[0019] The beneficial effects of this program are:

[0020] 1. By setting a wound area measurement frame with a predicted area, local shaving can be achieved to avoid adding irrelevant variables to the experiment.

[0021] 2. The shaving blade is isolated from the mouse skin by a shaving net, which prevents the blade from directly contacting the skin and causing scratches or cuts. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the structure of the device for preparing the wound surface of the pressure sore mouse model;

[0023] Figure 2 This is a schematic diagram of the cross-sectional structure of the device for preparing the wound surface of a pressure ulcer mouse model.

[0024] In the figure: 1, rotating rod, 2, bearing seat, 3, limiting support foot, 4, limiting rod, 5, wound area measurement frame, 6, elastic band, 8, shaving blade, 9, fixing plate, 10, shaving net, 11, fixing ring, 12, columnar protrusion. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] Based on the above content, this embodiment is described as follows from the perspective of application:

[0027] The main parts of the pressure sore mouse model wound preparation device include:

[0028] Wound shaving mechanism;

[0029] The wound scraping mechanism includes a scraping blade 8, a fixing plate 9, a scraping net 10, a rotating rod 1, a driving motor, and a limit bracket;

[0030] The limiting bracket includes: a limiting support foot and a hollow bearing seat 2;

[0031] Wound area determination box 5.

[0032] In this mouse model establishment experiment, the size of the magnet used to treat the pressure sores in the experimental area is: 4mm in diameter, 2mm in thickness, and 1.2g in weight. Therefore, the area within the wound area measurement frame 5 is 1cm 2 The hair of mice is about 1 cm. When shaving, the wound area measuring frame 5 can be placed on the gracilis muscles of the hind limbs of the mice, and then the wound shaving mechanism can be moved so that the hair of the mice passes through the hole 7 and contacts the rotating shaving blade 8, thereby achieving shaving in the area.

[0033] Since the shaving area is relatively small and mouse hair has a length of 1 cm, it is often necessary to remove the shaving blade 8 to clean the hair. The innovative part of the present application is in the shaving area (i.e. the head), and the body of the whole machine can use the structure of a traditional razor.

Claims

1. A device for preparing wounds of pressure sores in mice models, characterized in that: It includes a wound surface scraping mechanism and a wound area measuring frame (5); The wound surface scraping mechanism comprises a scraping blade (8), a fixed disk (9), a scraping net (10), a rotating rod (1) and a driving motor; The output end of the driving motor is fixed to the rotating rod (1); The shaving blade (8) is fixedly arranged on the side end of the fixed plate (9); The hair scraping net (10) is provided with holes (7) for mouse hair to pass through, and the fixing plate (9) is located inside the hair scraping net (10); The movement range of the shaving net (10) is within the wound area measurement frame (5).

2. The device for preparing wounds of a pressure sore mouse model according to claim 1, characterized in that: The wound area measuring frame (5) and the hair-shaving net (10) are fixed to each other via an elastic band (6).

3. The device for preparing wound surface of pressure sore mouse model according to claim 1, characterized in that: The inner side wall of the scraping net (10) is provided with a limiting rod (4), and the wound scraping mechanism further comprises a limiting bracket, which is sleeved on the rotating rod (1), and the limiting bracket and the limiting rod (4) are plugged and fixed.

4. The device for preparing wound surface of pressure sore mouse model according to claim 3, characterized in that: The limiting bracket comprises a limiting support leg (3) and a hollow bearing seat (2); a groove is provided at one end of the limiting rod (4) facing the rotating rod (1); the bearing seat (2) is sleeved on the outer end of the rotating rod (1); one end of the limiting support leg (3) is fixed to the bearing seat (2), and the other end is plugged and fixed to the groove.

5. The device for preparing wound surface of pressure sore mouse model according to claim 1, characterized in that: The bottom end of the scraping net (10) is provided with a fixing ring (11), and correspondingly, the bottom end of the fixing plate (9) is provided with a columnar protrusion (12) adapted to the fixing ring (11).

6. The device for preparing wound surface of pressure sore mouse model according to claim 1, characterized in that: The internal area of ​​the wound area measurement frame (5) is 1 cm 2 .

7. The device for preparing wound surface of pressure sore mouse model according to claim 5, characterized in that: The inner wall of the fixing ring (11) is provided with a shallow groove, and correspondingly, the outer wall of the columnar protrusion (12) is provided with an annular protrusion corresponding to the shallow groove.

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