Special linear supercharged gas-liquid-solid three-phase mixer for fermentation tank

Abstract

The utility model discloses a special linear supercharged gas-liquid-solid three-phase mixer for a fermentation tank, and relates to the technical field of mixers. The device comprises a necking-down type liquid inlet, a throat pipe, a diffuser pipe and a distributor, air enters from an air inlet pipe of the mixer and flows at a high speed through a conical nozzle, static pressure energy is converted into kinetic energy, a negative pressure area is formed, fermentation liquor is pressed from a large-diameter end to a small-diameter end from a liquid inlet of the mixer through pressure difference, enters the mixer and enters a diffuser pipe through a throat pipe, linear diffusion is achieved, bubbles are broken, and the fermentation liquor is purified. Gas-liquid-solid three phases are mixed and then flow out of the diffuser pipe, distribution of an affected area is completed through the distributor, and the transmission efficiency is improved; compressed air passes through a nozzle high-speed flow to convert static pressure energy into kinetic energy, so that collision crushing is realized; the kinetic energy of the three-phase flow is maximized under the constraint of the throat pipe; an influence area is increased through the distributor, and transmission efficiency is improved; according to the invention, de-stirring of the fermentation reaction kettle can be realized, and the required shear stress is provided according to the requirements of fermentation products.

Description

Technical Field

[0001] The utility model belongs to the technical field of mixers, in particular to a linear pressurized gas-liquid-solid three-phase mixer special for a fermentation tank. Background Art

[0002] Almost all domestic fermentation industries such as antibiotics, vitamins, amino acids, and organic acids use ventilated stirred reactors for industrial production. Fermentation equipment has always had the problem of large energy waste in the fermentation process, high energy consumption, and low ventilation utilization rate.

[0003] Restricted by engineering level, traditional stirred aeration fermentation reactors have significantly restricted the progress of fermentation. With the development of engineered bacteria and the advancement of synthetic biology, aeration fermentation characterized by high-density fermentation of Escherichia coli, Bacillus subtilis and yeast has higher and higher requirements for engineering level, and traditional stirred aeration reactors are becoming more and more constrained.

[0004] In the practical promotion of various products of fermentation tanks, the key technology is to control ventilation, among which the mixer is the key component to control ventilation. According to the differences in shear stress requirements of different fermentation products, different genera and the biological world, this technical solution has developed a new adaptability of a three-phase mixer with linear booster, which can realize the de-agitation of the fermentation reactor, form a series of standardization, and have mild shear mixing and mass transfer characteristics. Utility Model Content

[0005] The utility model provides a linear booster gas-liquid-solid three-phase mixer specially used for fermentation tanks. When in use, air enters from the air inlet pipe of the mixer, flows through the conical nozzle at high speed, realizes the conversion of static pressure energy into kinetic energy and forms a negative pressure zone, and the pressure difference presses the fermentation liquid from the large diameter end to the small diameter end of the mixer inlet and enters the mixer, enters the diffuser through the throat, realizes linear pressure expansion, breaks the bubbles, realizes the gas-liquid-solid three-phase mixing, and then flows out of the diffuser, and completes the distribution in the affected area through the distributor; the compressed air flows through the nozzle at high speed to convert the static pressure energy into kinetic energy, and realizes the collision The bubbles are crushed by collision; the three-phase flow maximizes its kinetic energy under the constraint of the throat; the three-phase flow enters the diffuser and begins to be linearly pressurized, the viscous shear of the velocity gradient of the flow field causes the bubbles to decelerate drastically and deform to achieve crushing; it is installed vertically upward, and the liquid near the wall of the diffuser is back-mixed, and is stretched, rotated and torn with the rising bubbles to achieve bubble crushing; the momentum is fully transferred at the outlet of the diffuser, and the affected area is increased through the distributor to improve the transfer efficiency; the fermentation reactor can be de-stirred and the required shear stress can be provided according to the needs of the fermentation products; in summary, the problems in the background technology are solved.

[0006] In order to solve the above technical problems, the utility model is realized by the following technical solutions:

[0007] The utility model discloses a linear pressurized gas-liquid-solid three-phase mixer specially used for a fermentation tank, comprising a contracted liquid inlet, a throat connected to the end of the liquid inlet with a smaller diameter, a diffuser connected to the end of the throat, an air inlet fixedly installed by a first fixed rib plate, and a distributor fixedly installed by a second fixed rib plate;

[0008] The first fixed rib is arranged around the liquid inlet, the air inlet pipe extends into the liquid inlet and a conical nozzle is arranged at the front end;

[0009] The second fixed rib is arranged around the periphery of the diffuser tube, and the distributor is located at the front end of the diffuser tube in the expanding direction.

[0010] Furthermore, the distributor, diffuser, throat, conical nozzle, liquid inlet and air inlet are coaxially arranged.

[0011] Furthermore, the throat pipe is a pipe of equal diameter; the small diameter end of the diffuser pipe and the small diameter end of the liquid inlet have the same diameter as the throat pipe;

[0012] Furthermore, the distributor adopts an outward-expanding conical structure.

[0013] Compared with the prior art, the utility model has the following beneficial effects:

[0014] (1) When in use, air enters from the air inlet pipe of the mixer, flows through the conical nozzle at high speed, realizes the conversion of static pressure energy into kinetic energy and forms a negative pressure zone. The pressure difference presses the fermentation liquid from the large diameter end of the mixer inlet to the small diameter end and enters the mixer, passes through the throat pipe and enters the diffuser, realizes linear pressure expansion, breaks the bubbles, realizes the three-phase mixing of gas, liquid and solid, and then flows out of the diffuser, and completes the distribution in the affected area through the distributor, thereby improving the transfer efficiency;

[0015] (2) The compressed air flows through the nozzle at high speed, converting static pressure energy into kinetic energy, achieving collision and crushing; the three-phase flow maximizes kinetic energy under the throat constraint;

[0016] (3) The three-phase flow enters the diffuser and begins to increase linear pressure. The viscous shear of the velocity gradient in the flow field causes the bubbles to decelerate and deform violently, leading to their breakage.

[0017] (4) The structure is installed vertically upward, and the liquid near the wall of the flow field diffuser is mixed, stretched, rotated and torn with the rising bubbles to achieve bubble breakage;

[0018] (5) It is possible to eliminate the stirring of the fermentation reactor and provide the required shear stress according to the needs of the fermentation product;

[0019] (6) For some clumping fermentation mycelium forms, in order to meet the oxygen supply demand and not to break up the clumping mycelium, a linear booster gas-liquid-solid three-phase mixer can be used to meet the stirring fermentation of the fermentation product; for example, avermectin clumping mycelium, S-antibiotic spherical fermentation, etc.

[0020] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0022] Figure 1 This is a schematic diagram of the structure of a linear pressurized gas-liquid-solid three-phase mixer dedicated to a fermentation tank of the utility model;

[0023] Figure 2 for Figure 1 A top view of the structure;

[0024] Figure 3 for Figure 1 Bottom view of the structure;

[0025] Figure 4 for Figure 1 A structural cross-sectional view of the middle distributor;

[0026] Figure 5 for Figure 1 A schematic diagram of the structure of the second fixed rib;

[0027] Figure 6 for Figure 1 A schematic diagram of the structure of the first fixed rib;

[0028] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0029] 1-air inlet pipe, 11-conical nozzle, 12-first fixed rib, 2-liquid inlet, 3-throat, 4-diffuser, 5-distributor, 51-second fixed rib. DETAILED DESCRIPTION

[0030] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0031] In the description of the present invention, it is necessary to understand that the terms "one end", "end", "circumferential side", "front end", "surrounding", "flared" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0032] Almost all domestic fermentation industries such as antibiotics, vitamins, amino acids, and organic acids use universal ventilation stirring reactor technology for industrial product production. The domestic large-scale fermentation industry has been in operation for more than 60 years, but there has been no major breakthrough in fermentation equipment. The fermentation process has always been characterized by large energy waste, high energy consumption, and low ventilation oxygen utilization.

[0033] In recent years, with the progress in the strains and processes of various fermentation products, the fermentation level has been greatly improved; there have been certain breakthroughs at the molecular and cellular levels, but due to the constraints of engineering level, the traditional stirred and ventilated fermentation reactor has obviously restricted the progress of fermentation; with the development of engineered bacteria and the progress of synthetic biology, the ventilation fermentation characterized by high-density fermentation of Escherichia coli, Bacillus subtilis and yeast has higher and higher requirements on the engineering level, and the traditional stirred and ventilated reactor is becoming more and more constrained.

[0034] The key technology of the fermentation tank is to control ventilation, among which the mixer is the key component of controlling ventilation. According to the differences in shear stress requirements of different bacterial genera of different fermentation products, we continuously develop three-phase mixers with new suitability to achieve the de-agitation of the fermentation reactor. We have developed a pressurized gas-liquid-solid three-phase mixer and completed series standardization. This series of three-phase mixers has the characteristics of mild shear mixing and mass transfer.

[0035] In the ventilated aerobic fermentation industry, the general ventilated fermentation tank stirring system has multiple layers of blades, and the bottom blades are turbine radial flow stirring. The bottom radial flow stirring energy consumption is generally designed to account for 60% of the total stirring power, and the middle and upper parts are multi-layer open axial flow mixed slurry; the high mass transfer circulation fermenter and self-mixing circulation fermenter used in this technical solution are both non-stirring energy-saving fermenters, and the gas-liquid-solid three-phase mixer replaces the bottom radial flow stirring to achieve a huge energy-saving effect.

[0036] See also Figure 1-6 As shown, according to the basic information parameters of the fermentation product, the three-phase mixer design calculation is completed, the quantity and specifications are determined, and the air inlet pipe network at the bottom of the fermentation tank is arranged;

[0037] The utility model is a linear booster gas-liquid-solid three-phase mixer for a fermentation tank, comprising a contracted liquid inlet 2, a throat 3 connected to the end of the liquid inlet 2 with a smaller diameter, a diffuser 4 connected to the end of the throat 3, an air inlet pipe 1 fixedly installed by a first fixed rib 12, and a distributor 5 fixedly installed by a second fixed rib 51;

[0038] The first fixed rib plate 12 is disposed around the liquid inlet 2, the air inlet pipe 1 extends into the liquid inlet 2 and a conical nozzle 11 is disposed at the front end;

[0039] The second fixed ribs 51 are disposed around the periphery of the diffuser tube 4 , and the distributor 5 is located at the front end of the diffuser tube 4 in the expanding direction.

[0040] The distributor 5, the diffuser pipe 4, the throat pipe 3, the conical nozzle 11, the liquid inlet 2 and the air inlet pipe 1 are arranged coaxially.

[0041] The throat pipe 3 is a pipe of equal diameter; the small diameter end of the diffuser pipe 4 and the small diameter end of the liquid inlet 2 have the same diameter as the throat pipe 3 .

[0042] Wherein, the distributor 5 adopts an outward-expanding conical structure;

[0043] The mixer air inlet pipe 1 is welded with a special conical nozzle 11, and the air inlet pipe 1 and the liquid inlet reducer, i.e., the liquid inlet port 2, are positioned by a special positioning mold and are welded and connected by a fixed-length rib plate, i.e., a first fixed rib plate 12. In this specific embodiment, there are three rib plates arranged around with equal spacing, and the liquid inlet reducer, i.e., the liquid inlet port 2, is connected to the throat 3, and the throat 3 is connected to the diffuser 4. The end of the diffuser 4 and the distributor 5 are positioned by a special positioning mold and are welded and connected by a fixed-length rib plate, i.e., a second fixed rib plate 51;

[0044] The mixer is placed at the bottom of the fermentation tank and immersed in the deep liquid and solid. Air enters from the air inlet pipe 1 of the mixer and flows at high speed through the conical nozzle 11 to realize the conversion of static pressure energy into kinetic energy, forming a negative pressure zone. The pressure difference presses the fermentation liquid from the liquid inlet reducer of the mixer, that is, the liquid inlet 2, into the mixer, and enters the diffuser 4 through the throat 3 to realize linear expansion, so that the bubbles are broken. The different angles of the diffuser can realize different bubble sizes. The three-phase gas-liquid-solid mixture flows out of the diffuser 4, and the distribution of the affected area is completed through the distributor 5. The different angles of the distributor can realize the size of the affected area. In this specific embodiment, the distributor 5 is specifically a flared structure with a cross-section of 120° outward expansion; the cross-sectional expansion angle of the diffuser 4 is 8°; the diameter of the air inlet pipe is 3mm and the length is 38mm; the height of the liquid inlet 2 is 89mm, the upper small diameter is 2.5mm, and the lower large diameter is 45mm; the thickness of the first fixed rib 12 and the second fixed rib 51 are both 5mm; the specific structure is as follows Figure 1-6 shown.

[0045] The general ventilation stirred fermenter used for filamentous bacteria fermentation has three shortcomings: rigid shear damage, nucleic acid leakage, and plasmid leakage. When frequency conversion is used to reduce shear, there is a mismatch between the stirring input work and the ventilation expansion work, resulting in serious gas flooding and a significant reduction in efficiency.

[0046] The fermentation-specific linear pressurized gas-liquid-solid three-phase mixer of the present technical solution can be designed to meet appropriate shear stress according to the requirements of different fermentation products.

[0047] Basic principle of mixer:

[0048] 1. Compressed air flows through the nozzle at high speed to convert static pressure energy into kinetic energy, achieving collision and crushing;

[0049] 2. The three-phase flow achieves maximum kinetic energy under throat constraints;

[0050] 3. The three-phase flow enters the diffuser and begins to increase linear pressure. The viscous shear of the velocity gradient of the flow field causes the bubbles to decelerate and deform violently to break up.

[0051] 4. Installed vertically upward, the liquid near the wall of the flow field diffuser tube is mixed, stretched, rotated and torn with the rising bubbles to achieve bubble breaking;

[0052] 5. The momentum is fully transferred at the outlet of the diffuser, and the impact area is enlarged through the distributor to improve the transfer efficiency.

[0053] From the perspective of bubble force balance, the bubble inertia force is balanced by the pressure gradient force, drag force, added mass force, history force, bubble gravity, and bubble buoyancy.

[0054] The forces that dominate bubble breakage are mainly pressure gradient force, drag force, and added mass force; different angles and lengths of the linear diffuser can achieve appropriate pressure gradient force to achieve the required scale of bubble breakage.

[0055] For some clumping fermentation mycelium forms, in order to meet the oxygen supply demand and not to break up the clumping mycelium, a linear pressurized gas-liquid-solid three-phase mixer can be used to meet the stirring fermentation of the fermentation product; such as avermectin clumping mycelium and S-antibiotic spherical clumping fermentation.

[0056] In the experimental tank device, under the conditions of constant air volume, constant temperature and constant pressure, the sodium sulfite solution oxidation experiment was carried out to determine the mixer performance; DO (dissolved oxygen) and tail gas oxygen concentration were continuously determined, and the continuous characteristic curve of the linear pressurized gas-liquid-solid three-phase mixer was drawn, as well as curves such as KLa, OTR (oxygen supply), DO, tail gas oxygen concentration, sodium sulfite consumption rate and oxygen utilization rate; in addition, the liquid-gas ratio detection was completed on a special liquid-gas ratio detection device, and the gas content detection was completed on a gas content experimental device. The biggest feature is the wide shear stress adjustment range, which further broadens the scope of use of fermentation products.

[0057] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A linear pressurized gas-liquid-solid three-phase mixer for a fermentation tank, characterized in that: It comprises a contracted liquid inlet (2), a throat (3) connected to the end of the liquid inlet (2) with a smaller diameter, a diffuser (4) connected to the end of the throat (3), an air inlet pipe (1) fixedly mounted via a first fixed rib (12), and a distributor (5) fixedly mounted via a second fixed rib (51); The first fixed rib plate (12) is arranged around the liquid inlet (2), the air inlet pipe (1) extends into the liquid inlet (2) and a conical nozzle (11) is provided at the front end; The second fixed rib plate (51) is arranged around the periphery of the diffuser tube (4), and the distributor (5) is located at the front end of the diffuser tube (4) in the expanding direction.

2. The linear pressurized gas-liquid-solid three-phase mixer for fermentation tank according to claim 1, characterized in that: The distributor (5), the diffuser (4), the throat (3), the conical nozzle (11), the liquid inlet (2) and the air inlet pipe (1) are arranged coaxially.

3. The linear pressurized gas-liquid-solid three-phase mixer for fermentation tank according to claim 1, characterized in that: The throat pipe (3) is a pipe of equal diameter; the small diameter end of the diffuser pipe (4) and the small diameter end of the liquid inlet (2) have the same diameter as the throat pipe (3).

4. The linear pressurized gas-liquid-solid three-phase mixer for a fermentation tank according to claim 1, characterized in that: The distributor (5) adopts an outward-expanding conical structure.

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