Auxiliary device for drying immunochromatography test paper semi-finished product

Abstract

The utility model relates to an auxiliary device for drying a semi-finished product of immunochromatography test paper, which comprises a supporting plate, and a first limiting column group and a second limiting column group are sequentially and alternately arranged on the supporting plate along the width extension direction of the supporting plate; the first limiting column set and the second limiting column set each comprise a plurality of limiting columns evenly distributed on the supporting plate in the length direction of the supporting plate in an extending mode, a first vent hole is formed in the portion, between the first limiting column set and the second limiting column set, of the supporting plate, and a limiting block is arranged on the portion, on one side of the first limiting column set, of the supporting plate. A first limiting groove is formed in the portion, on the other side of the first limiting column set, of the supporting plate, extends in the length direction of the supporting plate and is matched with the limiting block. The conjugate pad supporting the liquid loaded with the time-resolved fluorescent microsphere labeled anti-calcitonin monoclonal antibody can be conveniently dried, and pollution caused by interpenetration between the two conjugate pads to be dried is avoided. The utility model has the advantages of convenient use and wide market prospect.

Description

Technical Field

[0001] The utility model relates to the field of auxiliary equipment for drying semi-finished immunochromatographic test paper, in particular to an auxiliary device for drying semi-finished immunochromatographic test paper. Background Art

[0002] Procalcitonin (PCT) is an endogenous non-steroidal anti-inflammatory substance that is induced during bacterial infection. Bacterial endotoxin is the main stimulating factor that induces PCT production. Under physiological conditions, the PCT concentration in the blood of healthy people is less than 0.2μg / L and is usually not detected. During bacterial infection, in addition to the thyroid gland, macrophages and monocytes in the liver, lymphocytes and endocrine cells in the lung and intestinal tissues can synthesize and secrete PCT. At this time, the PCT level in the blood will increase significantly, and will continue to increase or gradually decrease as the infection progresses or is controlled. Common methods for detecting PCT include semi-quantitative and quantitative methods. The semi-quantitative method generally uses colloidal gold immunochromatography. By observing the color depth of the test line on the colloidal gold immunochromatography test strip, the PCT content in the serum can be divided into roughly 4 levels. Quantitative methods currently include immunofluorescence, immunochemiluminescence, etc. In comparison, immunofluorescence, immunochemiluminescence, etc. can quantitatively detect the content of PCT, but the detection equipment is complex and expensive to operate, the detection cost is high, and it takes a long time. Colloidal gold immunochromatography is still a very important choice in the initial qualitative analysis stage due to its advantages such as convenient detection and low cost.

[0003] The immunochromatographic test strip includes a sample pad, a filter pad, a conjugation pad, a chromatographic membrane and a water-absorbing pad, and these five parts are overlapped and pasted on the bottom plate in sequence. The sample pad is a glass cellulose membrane and a whole blood separation membrane, the conjugation pad is a glass cellulose membrane, the chromatographic membrane is a nitrocellulose membrane, and the water-absorbing pad is a water-absorbing glass cellulose membrane. The time-resolved fluorescent microspheres labeled anti-calcitonin monoclonal antibody are evenly sprayed on the conjugation pad; the anti-calcitonin polyclonal antibody is sprayed on the chromatographic membrane to form a detection line.

[0004] During the processing of the conjugate pad, according to the production requirements, the amount of liquid of the time-resolved fluorescent microsphere-labeled anti-calcitonin monoclonal antibody loaded on the conjugate pads of the same size should be approximately the same. Only after the conjugate pads are dried and solidified can the final immunochromatographic test paper inspection effect be approximately the same. During the drying and curing process of the conjugate pads, contact between the two conjugate pads should be avoided, especially stacking of the conjugate pads is not allowed. The reason is that since the conjugate pads use glass cellulose membranes, the liquid loaded in the upper conjugate pad will be impregnated into the conjugate pad placed below under the action of gravity; of course, contact between the two conjugate pads will also cause the liquid loaded on the two conjugate pads to be impregnated. The specific reason is that due to the difference in the placement angles of the two connected conjugate pads, there will be differences in liquid concentrations at the contact points of the two conjugate pads, which will also cause liquid penetration at the contact points of the two conjugate pads; the above-mentioned contact placement for drying will result in differences in the amount of time-resolved fluorescent microsphere-labeled anti-calcineurin monoclonal antibody loaded in the dried conjugate pads, thereby affecting the repeatability of the detection effect. Therefore, in the drying process of the conjugate pads, there is room for improvement, so as to realize the separate storage of the conjugate pads and avoid the technical problem of contact between the two conjugate pads to cause penetration of the liquid loaded on the conjugate pads with time-resolved fluorescent microsphere-labeled anti-calcineurin monoclonal antibody. Summary of the invention

[0005] In view of the deficiencies in the prior art, the utility model provides an auxiliary device for drying semi-finished immunochromatographic test paper, which is convenient for drying a conjugate pad supporting a liquid loaded with time-resolved fluorescent microspheres labeled with anti-calcitonin monoclonal antibodies and avoids mutual penetration and contamination between two conjugate pads to be dried, so as to overcome the defects in the prior art.

[0006] The technical solution adopted by the utility model is: an auxiliary device for drying semi-finished immunochromatographic test paper, including a support plate, on which a first limit column group and a second limit column group are alternately arranged in sequence along the width extension direction of the support plate, the first limit column group and the second limit column group both include a plurality of limit columns extending uniformly and distributed along the length direction of the support plate, a first vent hole is arranged on the support plate between the first limit column group and the second limit column group, a limit block is arranged on the support plate on one side of the first limit column group, a first limit groove is arranged on the support plate on the other side of the first limit column group, the first limit groove extends along the length direction of the support plate, and the first limit groove and the limit block cooperate with each other.

[0007] Preferably, a cover plate is arranged above the support plate, and the cover plate and the limiting column are movably connected. A second limiting groove is respectively arranged on the cover plate above each limiting column, and the cross-sectional shape of each limiting column and the cross-sectional shape of the inner cavity of each second limiting groove both adopt a circular structure.

[0008] Preferably, a label slot is provided on the cover plate, and a second through hole is provided on the cover plate above each first vent hole.

[0009] Preferably, the support plate and the cover plate both adopt a rectangular plate structure, and four first connecting rods are arranged on the outer support plates of several of the limit columns, and the four first connecting rods are evenly distributed in a star shape on the outer side of the central axis of the support plate, and a third through hole is arranged on the cover plate above each first connecting rod, and a second connecting rod is respectively arranged in each third through hole, and each second connecting rod is connected to the corresponding first connecting rod below, and a third connecting rod is respectively arranged on the top of each of the second connecting rods, and a fixed block is respectively arranged on the outer side of each second connecting rod, and the fixed block is located above the cover plate, and the partial shape of the fixed block matches the shape of the cross-section of the second connecting rod.

[0010] Preferably, the second connecting rod adopts a rectangular rod structure, the fixed block adopts an N-shaped block structure, the thickness of the open end of the fixed block gradually increases as the fixed block gradually moves away from the open end of the fixed block, and the maximum thickness of the fixed block is not less than the distance between the third connecting rod and the cover plate.

[0011] Preferably, the cross-section of the limit block adopts a trapezoidal structure.

[0012] The beneficial effects of the utility model are as follows: the utility model avoids mutual penetration and contamination between adjacent semi-finished products by satisfying the objective requirement of placing a binding pad supporting a load with a certain amount of time-resolved fluorescent microsphere-labeled anti-calcitonin monoclonal antibody liquid separately through the gap formed by the first limiting column group and the second limiting column group alternately arranged on the support plate; the semi-finished product is supported by a plurality of limiting columns of the first limiting column group or the plurality of limiting columns, so that the top surface and the bottom surface of the semi-finished product are more exposed to the drying environment, so that the vaporized solvent initially discharged from the top surface and the bottom surface of the semi-finished product evaporates to the adjacent drying environment, making the drying process more thorough and worthy of promotion.

[0013] The utility model has the advantages of simple structure, convenient operation, ingenious design, greatly improved working efficiency, good social and economic benefits, and is a product that is easy to promote and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a structural schematic diagram of the utility model.

[0015] Figure 2 It is a three-dimensional structural schematic diagram of the utility model. DETAILED DESCRIPTION

[0016] like Figure 1 and Figure 2As shown, an auxiliary device for drying semi-finished immunochromatographic test paper includes a support plate 1, on which a first limiting column group and a second limiting column group are alternately arranged in sequence along the width extension direction of the support plate 1, the first limiting column group and the second limiting column group both include a plurality of limiting columns 2 extending uniformly and distributed along the length direction of the support plate 1 on the support plate 1, a first vent 3 is arranged on the support plate 1 between the first limiting column group and the second limiting column group, a limiting block 4 is arranged on the support plate 1 on one side of the first limiting column group, and a first limiting groove 5 is arranged on the support plate 1 on the other side of the first limiting column group, the first limiting groove 5 extends along the length direction of the support plate 1, and the first limiting groove 5 and the limiting block 4 cooperate. A second through hole 9 is respectively arranged on the cover plate 6 above each first vent 3, so that the gaseous solvent released by the dried object can be more easily diffused into the adjacent dry air flow.

[0017] The conventional commercially available glass cellulose membrane used as the raw material of the binding pad is cut into a long strip sheet structure with a width of 20mm to 30mm according to production needs during use, and then loaded with time-resolved fluorescent microspheres labeled anti-calcineurin monoclonal antibody liquid. In order to better meet the parameter requirements of the glass cellulose membrane after cutting, the distance between the first limiting column group and the second limiting column group of this product is 13mm to 19.5mm, so that the binding pad loaded with time-resolved fluorescent microspheres labeled anti-calcineurin monoclonal antibody liquid can be tilted and placed in the gap between the first limiting column group and the second limiting column group, thereby facilitating the volatilization of the liquid components in the medium loaded on the binding pad.

[0018] Furthermore, a cover plate 6 is arranged above the support plate 1, so that foreign matter directly falls on the semi-finished product being dried to form direct contamination; the cover plate 6 is movably connected to the limiting column 2, and a second limiting groove 7 is arranged on the cover plate 6 above each limiting column 2, and the cross-sectional shape of each limiting column 2 and the cross-sectional shape of the inner cavity of each second limiting groove 7 are both circular structures, so that the position of the cover plate 6 is easy to fix.

[0019] To go further, the support plate 1 and the cover plate 6 both adopt a rectangular plate structure, and four first connecting rods 10 are arranged on the outer support plate 1 of several of the limit columns 2. The four first connecting rods 10 are evenly distributed in a star shape on the outside of the central axis of the support plate 1, and a third through hole 11 is arranged on the cover plate 6 above each first connecting rod 10. A second connecting rod 12 is respectively arranged in each third through hole 11, and each second connecting rod 12 is connected to the corresponding first connecting rod 10 below, and a third connecting rod 13 is respectively arranged on the top of each of the second connecting rods 12, and a fixed block 14 is respectively arranged on the outside of each second connecting rod 12, and the fixed block 14 is located above the cover plate 6, and the partial shape of the fixed block 14 matches the shape of the cross-section of the second connecting rod 12. The cross section of the third connecting rod 13 and the cross section of the inner cavity of the third through hole 11 are both circular structures, the diameter of the top of the third connecting rod 13 gradually decreases as the height of the third connecting rod 13 decreases, the diameter of the cross section of the third connecting rod 13 and the diameter of the circumscribed circle of the second connecting rod 12 are not greater than the diameter of the third through hole 11, and the diameter of the circumscribed circle of the first connecting rod 10 is not less than the diameter of the third through hole 11. Thus, the relative position of the cover plate 6 is fixed by using the first connecting rod 10, the second connecting rod 12, the third connecting rod 13 and the fixing block 14.

[0020] It is worth mentioning that the second connecting rod 12 adopts a rectangular rod structure, the fixed block 14 adopts an N-shaped block structure, the thickness of the open end of the fixed block 14 gradually increases as the fixed block 14 gradually moves away from the open end of the fixed block 14, and the maximum thickness of the fixed block 14 is not less than the distance between the third connecting rod 13 and the cover plate 6. Therefore, the thickness variation trend of the open end of the fixed block 14 is used to form a guide, so that the fixed block 14 is more convenient to install at the preset installation position.

[0021] If there are many objects to be dried in the same batch, the space for carrying the objects on a single support plate 1 cannot meet the carrying requirements of the objects in the same batch. In order to facilitate the staff to identify the objects in the same batch, the cross-section of the inner cavity of the first limiting groove 5 and the cross-section of the limiting block 4 described in this product are both trapezoidal structures, and a label card slot 8 is provided on the cover plate 6; thereby, by utilizing the structural relationship between the first limiting groove 5 and the limiting block 4, two adjacent support plates 1 are connected, so that a plurality of support plates 1 are connected to jointly carry the objects in the batch, and the objects to be dried are placed in sequence and then the corresponding cover plates 6 are installed and fixed. A label is inserted into the label card slot 8 on one of the cover plates 6 to indicate the state of the object to be dried and the placement time, so that the staff can more easily judge the duration of the drying process according to the placement state of the object to be dried and the time displayed on the label.

[0022] The usage of this product is as follows: Figure 1 and Figure 2 As shown, the following steps are included:

[0023] After the binding pad completes the loading of the liquid of the time-resolved fluorescent microsphere-labeled anti-calcitonin monoclonal antibody, the semi-finished immunochromatographic test paper is formed. According to the number of the semi-finished immunochromatographic test paper, several support plates 1 are selected to be combined by inserting the limit blocks 4 on the support plates 1 into the first limit grooves 5 on the adjacent limit blocks 4. Then, the semi-finished immunochromatographic test paper is placed one by one in the gap between the first limit column group and the second limit column group, so that one semi-finished immunochromatographic test paper is placed in the gap between the first limit column group and the second limit column group on each support plate 1; the semi-finished immunochromatographic test paper is in the shape of a long strip and is placed in the gap between the first limit column group and the second limit column group in an inclined manner; then, the corresponding cover plate 6 is installed on each support plate 1, and after the cover plate 6 is installed to the preset installation position, the relative position of the cover plate 6 is fixed by the corresponding fixing block 14. Finally, fill in the time and batch number of the label mark to start drying, and place this product in the drying equipment for drying.

[0024] The sample pad, filter pad, chromatographic membrane and absorbent pad are processed according to production requirements. Finally, the sample pad, binding pad, filter pad, chromatographic membrane and absorbent pad are overlapped and pasted on the bottom plate according to product requirements to complete the subsequent steps. After processing, they still need to be cut to an appropriate width and then further packaged to form a product.

[0025] Through this embodiment, the objective requirement of placing the binding pad supporting the anti-calcitonin monoclonal antibody liquid labeled with a certain amount of time-resolved fluorescent microspheres separately is met by the gap formed by the first limiting column group and the second limiting column group alternately arranged on the support plate 1, thereby avoiding the mutual penetration and contamination between adjacent semi-finished products; the semi-finished product is supported by a plurality of limiting columns 2 of the first limiting column group or the plurality of limiting columns 2, so that the top surface and the bottom surface of the semi-finished product are more exposed to the drying environment, so that the vaporized solvent initially discharged from the top surface and the bottom surface of the semi-finished product evaporates to the adjacent drying environment, making the drying process more thorough and worthy of promotion.

[0026] The embodiments described above are only preferred embodiments of the present invention and are not intended to limit the scope of implementation of the present invention. Therefore, any equivalent changes or modifications made based on the structures, features and principles described in the patent scope of the present invention should be included in the patent application scope of the present invention.

Claims

1. An auxiliary device for drying semi-finished immunochromatographic test paper, characterized in that: The invention comprises a support plate (1), wherein a first limiting column group and a second limiting column group are alternately arranged on the support plate (1) along the width extension direction of the support plate (1), the first limiting column group and the second limiting column group both comprise a plurality of limiting columns (2) extending along the length direction of the support plate (1) and evenly distributed, a first vent hole (3) is arranged on the support plate (1) between the first limiting column group and the second limiting column group, a limiting block (4) is arranged on the support plate (1) on one side of the first limiting column group, and a first limiting groove (5) is arranged on the support plate (1) on the other side of the first limiting column group, the first limiting groove (5) extending along the length direction of the support plate (1), and the first limiting groove (5) and the limiting block (4) cooperate with each other.

2. The auxiliary device for drying the semi-finished immunochromatographic test paper according to claim 1, characterized in that: A cover plate (6) is arranged above the support plate (1), the cover plate (6) and the limiting column (2) are movably connected, a second limiting groove (7) is arranged on the cover plate (6) above each limiting column (2), and the cross-sectional shape of each limiting column (2) and the cross-sectional shape of the inner cavity of each second limiting groove (7) are both circular structures.

3. The auxiliary device for drying the semi-finished immunochromatographic test paper according to claim 2, characterized in that: The cover plate (6) is provided with a label slot (8), and a second through hole (9) is provided on the cover plate (6) above each first vent hole (3).

4. The auxiliary device for drying the semi-finished immunochromatographic test paper according to claim 2, characterized in that: The support plate (1) and the cover plate (6) both adopt a rectangular plate structure. Four first connecting rods (10) are arranged on the outer support plate (1) of a plurality of the limiting columns (2). The four first connecting rods (10) are evenly distributed in a star shape on the outer side of the central axis of the support plate (1). A third through hole (11) is arranged on the cover plate (6) above each first connecting rod (10). A second connecting rod (12) is arranged in each third through hole (11). Each second connecting rod (12) is connected to the corresponding first connecting rod (10) below. A third connecting rod (13) is arranged on the top of each second connecting rod (12). A fixed block (14) is arranged on the outer side of each second connecting rod (12). The fixed block (14) is located above the cover plate (6). The partial shape of the fixed block (14) matches the shape of the cross section of the second connecting rod (12).

5. The auxiliary device for drying the semi-finished immunochromatographic test paper according to claim 4, characterized in that: The second connecting rod (12) adopts a rectangular rod-shaped structure, the fixed block (14) adopts an N-shaped block-shaped structure, the thickness of the open end of the fixed block (14) gradually increases as the fixed block (14) gradually moves away from the open end of the fixed block (14), and the maximum thickness of the fixed block (14) is not less than the distance between the third connecting rod (13) and the cover plate (6).

6. The auxiliary device for drying the semi-finished immunochromatographic test paper according to claim 1, characterized in that: The cross section of the limit block (4) adopts a trapezoidal structure.

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