Experimental device for detecting dissolution conditions of enteric polymer under different pH values

Abstract

The utility model discloses an experimental device for detecting the dissolution condition of an enteric polymer under different pH values, and relates to the technical field of experimental devices. Comprising a solution box and an experiment frame, the experiment frame is located on one side of the solution box and comprises a horizontal frame, a vertical frame and a lifting device, the top of the vertical frame is rotationally connected with the middle of the horizontal frame, the lifting device is rotationally connected with the end, away from the solution box, of the horizontal frame, a guide block is arranged at the end, close to the solution box, of the horizontal frame, and the end, away from the horizontal frame, of the guide block is arc-shaped; a rope is attached to the arc-shaped surface of the guide block, one end of the rope is fixedly connected with the top of the guide block, the other end of the rope is connected with a placement cage, and the placement cage is located above the solution box; the solution boxes and the placing cages are made of transparent materials, and a plurality of groups of solution boxes and experiment frames are arranged. According to the device, enteric polymers can be added into or taken out of a plurality of solution tanks at the same time, errors are small, and the situation that time differences exist when the enteric polymers are manually added one by one is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental devices, in particular to an experimental device for detecting the dissolution of enteric polymers at different pH values. Background Art

[0002] Enteric polymers refer to substances that can resist gastric acid erosion and quickly disintegrate after entering a certain part of the intestine. They are often used in oral targeted drug release systems.

[0003] The physiological conditions of different sections of the human intestine are different, and the absorption of drugs in different sections often varies greatly. The drugs need to be delivered to their optimal absorption site, so enteric-coated polymers with different positioning release are needed.

[0004] At present, the dissolution of enteric polymers in different environments is generally tested by operators manually adding the test substance into the solution, observing and recording it with the naked eye. This method is inefficient and has large errors. Utility Model Content

[0005] The main purpose of the utility model is to provide an experimental device for detecting the dissolution of enteric polymers at different pH values, so as to solve the above problems.

[0006] To achieve the above-mentioned purpose, the utility model provides an experimental device for detecting the dissolution of enteric polymers at different pH values, comprising a solution box and an experimental frame;

[0007] The experimental frame is located on one side of the solution tank, and includes a horizontal frame, a vertical frame and a lifting device. The top of the vertical frame is rotatably connected to the middle of the horizontal frame, the lifting device is rotatably connected to an end of the horizontal frame away from the solution tank, and an end of the horizontal frame close to the solution tank is rotatably connected to a placement cage, and the placement cage is located above the solution tank;

[0008] The solution box and the placement cage are made of transparent material, and multiple groups of the solution box and the experimental rack are provided.

[0009] Furthermore, the lifting device includes a hydraulic cylinder and a connecting rod, one end of the connecting rod is rotatably connected to an end of the horizontal frame away from the solution tank, and the other end of the connecting rod is rotatably connected to a piston rod of the hydraulic cylinder.

[0010] Furthermore, the lifting device includes a motor, a turntable and a rotating rod, the turntable is coaxially fixedly connected to the output shaft of the motor, one end of the rotating rod is rotatably connected to the eccentric shaft of the turntable, and the other end of the rotating rod is rotatably connected to an end of the horizontal frame away from the solution tank.

[0011] Furthermore, a visual observation device is also provided on the side of the solution tank, and the visual observation device is used to observe and record changes inside the solution tank.

[0012] Furthermore, a dynamometer is provided on the top of the placement cage, the top of the dynamometer is rotatably connected to the horizontal frame, and the bottom of the placement cage is filter paper, which is funnel-shaped.

[0013] Furthermore, a weighing device is provided at the bottom of the solution tank.

[0014] The utility model has the following beneficial effects:

[0015] The utility model can add or take out enteric-coated polymers into or out of a plurality of solution boxes at the same time, with a small error, and can record the dissolution situation through a visual observation device, and can also compare the weight change of the enteric-coated polymers or solutions before and after weighing, thereby avoiding the situation that naked-eye observation is greatly influenced by subjective factors and cannot achieve accurate quantification; at the same time, the design of the guide block makes the placement cage more stable during the descent and lifting process, thereby avoiding vibration caused by the change of the movement state of the placement cage and affecting the experimental results, and also avoiding the splashing of the solution caused by the unstable descent or lifting of the placement cage. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of an embodiment of an experimental device for detecting the dissolution of enteric polymers at different pH values ​​according to the utility model. Figure 1 ;

[0017] Figure 2 The present invention is a schematic diagram of an experimental device for detecting the dissolution of enteric polymers at different pH values. Figure 2 .

[0018] In the figure: 1-solution box; 2-horizontal frame; 3-vertical frame; 401-hydraulic cylinder; 402-connecting rod; 403-turntable; 404-turning rod; 5-placing cage; 6-tensile meter; 7-filter paper; 8-weighing device; 9-guide block. DETAILED DESCRIPTION

[0019] In order to achieve the above-mentioned purpose and effect, the technical means and structure adopted by the utility model are described in detail with reference to the accompanying drawings for the preferred embodiments of the utility model and their features and functions.

[0020] As attached Figure 1 As shown, the utility model provides an experimental device for detecting the dissolution of enteric polymers at different pH values, including a solution box 1 and an experimental frame;

[0021] The solution box 1 is made of transparent material. The experimental frame includes a horizontal frame 2, a vertical frame 3 and a lifting device. The vertical frame 3 is located on one side of the solution box 1. The top of the vertical frame 3 is rotatably connected to the middle of the horizontal frame 2. The lifting device includes a hydraulic cylinder 401 and a connecting rod 402. One end of the connecting rod 402 is rotatably connected to one end of the horizontal frame 2. The other end of the connecting rod 402 is rotatably connected to the piston rod of the hydraulic cylinder 401. The horizontal frame 2 is driven to rotate up and down by the extension and contraction of the piston rod. An arc-shaped guide block 9 is provided at one end of the horizontal frame 2 away from the hydraulic cylinder 401. A rope is fixed on the top of the guide block 9. The rope is attached to the arc surface of the guide block 9. The arc surface of the guide block 9 is provided with a groove adapted to the rope to make the rope more stable. The bottom of the rope is connected to a cage 5 for placing. When the horizontal frame 2 rotates up and down, the length of the fitting distance between the rope and the guide block 9 will change, so that the placement cage 5 will only move in the vertical direction, and the horizontal position of the placement cage 5 will not change, and the placement cage 5 is located above the solution box 1. When the horizontal frame 2 rotates, the placement cage 5 can enter the interior of the solution box 1, and the position of the placement cage 5 is affected by the change of the contact point between the rope and the guide block 9, which can make the process of lowering and lifting the placement cage 5 more stable, avoid the vibration of the placement cage 5 due to the sudden change of the movement state of the placement cage 5 in the initial stage and the end stage of the lowering or lifting process, and avoid the solution splashing when the placement cage 5 contacts the liquid surface when it is lowered into the liquid or lifted out of the liquid, affecting the experimental results; the solution box 1 and the experimental frame are provided with multiple groups.

[0022] During specific use, the operator first adds solutions of the same volume but different pH values ​​into each solution box 1, and then puts the same enteric polymer into each placement cage 5, and then simultaneously starts each hydraulic cylinder 401 to rotate the end of the horizontal frame 2 away from the solution box 1 upward, and the placement cage 5 moves downward accordingly and enters the solution box 1, so that the enteric polymer in the placement cage 5 is immersed in the solution. At this time, the operator can observe the dissolution of the enteric polymer and compare the dissolution of the enteric polymer in solutions of different pH values.

[0023] In this embodiment, a visual observation device is also provided on the side of the solution tank 1, and the visual observation device is used to observe and record the changes inside the solution tank 1. The operator can compare the dissolution of the enteric polymer in solutions of different pH values ​​in more detail by viewing the videos and photos recorded by the visual observation device, so as to avoid the situation where the naked eye cannot observe the changes in place.

[0024] In this embodiment, a tensiometer 6 is provided on the top of the placement cage 5, and the top of the tensiometer 6 is rotatably connected to the horizontal frame 2, and the bottom of the placement cage 5 is a filter paper 7, which is funnel-shaped. The operator can put the enteric polymer into the solution for a certain period of time and then lift the placement cage 5, and by comparing the change in the reading of the tensiometer 6 during the same period of time, determine the weight of the enteric polymer remaining on the filter paper 7, and then determine how much the enteric polymer dissolves in solutions with different pH values.

[0025] In this embodiment, a weighing device 8 is provided at the bottom of the solution box 1, and specifically an electronic scale can be selected; the operator can lift the placement cage 5 after the enteric polymer is placed in the solution for a certain period of time, and by comparing the changes in the electronic scale readings within the same period of time, determine the amount of enteric polymer dissolved in solutions with different pH values.

[0026] In this embodiment, the hydraulic cylinder 401 and the connecting rod 402 can be replaced by a turntable 403 and a rotating rod 404. The turntable 403 is coaxially fixedly connected to the output shaft of the motor. One end of the rotating rod 404 is rotatably connected to the eccentric shaft of the turntable 403, and the other end of the rotating rod 404 is rotatably connected to the end of the horizontal frame 2 away from the solution tank 1. When the turntable 403 is driven to rotate by the motor, the horizontal frame 2 is further driven to rotate up and down, so that the placement cage 5 can be moved closer to or away from the solution tank 1.

[0027] The above description is only the preferred embodiment of the utility model, not all embodiments. Anyone should be aware that structural changes made under the inspiration of the utility model, and all technical solutions that are the same or similar to the utility model, belong to the protection scope of the utility model.

Claims

1. An experimental device for detecting the dissolution of enteric polymers at different pH values, characterized in that: It comprises a solution box (1) and an experimental stand; The experimental frame is located on one side of the solution tank (1), and comprises a horizontal frame (2), a vertical frame (3) and a lifting device. The top of the vertical frame (3) is rotatably connected to the middle of the horizontal frame (2), and the lifting device is rotatably connected to an end of the horizontal frame (2) away from the solution tank (1). A guide block (9) is provided at one end of the horizontal frame (2) close to the solution tank (1). The end of the guide block (9) away from the horizontal frame (2) is arc-shaped. A rope is attached to the arc-shaped surface of the guide block (9). One end of the rope is fixedly connected to the top of the guide block (9), and the other end of the rope is connected to a placement cage (5). The placement cage (5) is located above the solution tank (1); The solution box (1) and the placement cage (5) are made of transparent materials, and multiple groups of the solution box (1) and the experimental rack are provided.

2. An experimental device for detecting the dissolution of enteric polymers at different pH values ​​as claimed in claim 1, characterized in that: The lifting device comprises a hydraulic cylinder (401) and a connecting rod (402), one end of the connecting rod (402) being rotatably connected to an end of the horizontal frame (2) away from the solution tank (1), and the other end of the connecting rod (402) being rotatably connected to a piston rod of the hydraulic cylinder.

3. The experimental device for detecting the dissolution of enteric polymers at different pH values ​​according to claim 1, characterized in that: The lifting device comprises a motor, a rotating disk (403) and a rotating rod (404); the rotating disk (403) is coaxially fixedly connected to the output shaft of the motor; one end of the rotating rod (404) is rotatably connected to the eccentric shaft of the rotating disk (403); and the other end of the rotating rod (404) is rotatably connected to an end of the horizontal frame (2) away from the solution tank (1).

4. The experimental device for detecting the dissolution of enteric polymers at different pH values ​​according to claim 1, characterized in that: A visual observation device is also provided on the side of the solution tank (1), and the visual observation device is used to observe and record changes inside the solution tank (1).

5. The experimental device for detecting the dissolution of enteric polymers at different pH values ​​according to claim 1, characterized in that: A tensiometer (6) is arranged on the top of the placement cage (5), and the top of the tensiometer (6) is rotatably connected to the horizontal frame (2). The bottom of the placement cage (5) is filter paper (7), and the filter paper (7) is funnel-shaped.

6. The experimental device for detecting the dissolution of enteric polymers at different pH values ​​according to claim 1, characterized in that: A weighing device (8) is provided at the bottom of the solution tank (1).

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