Embryo freezing operation box

By designing an embryo freezing operation box with adjustable height, the existing equipment is fragile, easy to contaminate, fast consumption of liquid krypton and inconvenient operation, and the effect of reducing pollution risks and liquid krypton consumption and improving operational convenience is achieved.

CN222815149UActive Publication Date: 2025-05-02上海翊尘生物技术有限公司
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Patent Information

Application Number
CN202421813674.9
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-07-29
Publication Date
2025-05-02
Estimated Expiration
2034-07-29

AI Technical Summary

Technical Problem

Existing embryo refrigeration equipment is fragile, easy to contaminate, fast liquid nitrogen consumption, inconvenient operation, and cannot adjust the height according to demand.

Method used

An embryo freezing operation box is designed, using a spliced ​​box and metal inner liner, with an open top cover design, a liquid level sensor and an adjustable lighting assembly, and the box can be adjusted by stacking intermediate modules.

Benefits of technology

It reduces the risk of pollution and liquid nitrogen consumption, reduces operational complexity, improves operational convenience and flexibility in regulating liquid nitrogen stocks.

✦ Generated by Eureka AI based on patent content.

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    Figure CN222815149U_ABST
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Abstract

The utility model provides an embryo freezing operation box which comprises a spliced box body, a metal inner container arranged in the box body and a top cover installed at the upper end of the box body, the box body comprises a bottom layer die holder and a top layer module, and a plurality of sets of middle modules are arranged between the bottom layer die holder and the top layer module in a stacked mode. The height of the box body is adjusted according to the metal liner; a plurality of magnetic connecting columns are distributed on the attaching end faces among the bottom-layer die base, the middle die block and the top-layer die block so that the stability of mutual connection can be improved. The top cover at the upper end of the box body adopts a partial opening design and can be covered during operation, so that the air contact area is greatly reduced, and the liquid nitrogen consumption speed is greatly reduced; and a liquid level sensor is mounted on the top cover. The lighting assembly is arranged at the top of the box body and detachably installed on the top layer module through the magnetic connecting column, a person can adjust the height and the angle of the lamp holder through the adjusting piece so that a light source can irradiate into the metal inner container, and observation and operation of the person are facilitated.
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Description

Technical Field

[0001] The utility model relates to the technical field of embryo freezing equipment, in particular to an embryo freezing operation box. Background Art

[0002] Ultra-low temperature rapid freezing technology, vitrification freezing is the latest technology for freezing embryos during the IVF process. By quickly immersing the prepared embryos in liquid nitrogen, the temperature of the embryos can be reduced to minus 196°C within a few seconds. Due to the fast freezing speed, the water in the embryos does not have time to form ice crystals, and will not cause any damage to the embryo cells and activity. The embryos can then be stored in liquid nitrogen for a long time.

[0003] At present, IVF laboratories usually purchase ordinary polystyrene plastic foam boxes to hold liquid nitrogen. This foam box is low-cost and easy to obtain. But the disadvantages are also obvious:

[0004] Fragile and easy to break, it is difficult to reuse multiple times, and the cost is increased;

[0005] Easy to get dusty, thus introducing the risk of contamination;

[0006] Lightweight foam particles often fall off and stick to various places through static electricity, making them difficult to clean and introducing unknown risks;

[0007] The operation needs to be open, the open area is large, the liquid nitrogen is lost quickly, and liquid nitrogen needs to be added frequently to maintain the experiment;

[0008] The conventional foam box itself has a thermal conductivity that determines the rapid loss of liquid nitrogen;

[0009] Liquid nitrogen vaporizes and covers the top of the foam box, making it impossible to see the internal liquid nitrogen loss and determine when to add liquid nitrogen;

[0010] It is impossible to quantify, miss the time to add liquid nitrogen, resulting in some samples not being fully immersed, affecting the freezing effect. In addition, the existing operating box cannot adjust the height according to needs, affecting personnel use. Utility Model Content

[0011] The technical problem solved by the utility model is to provide an embryo freezing operation box, which can reduce the risk of contamination, reduce liquid nitrogen consumption, reduce operations, replenish liquid nitrogen in time, and the like, and the height can be adjusted according to needs to facilitate personnel operation and increase or decrease the liquid nitrogen inventory.

[0012] The technical problem solved by the utility model is achieved by adopting the following technical scheme: an embryo freezing operation box, comprising a box body that is spliced ​​and arranged, a metal liner arranged in the box body, and a top cover installed on the upper end of the box body, the box body comprising a bottom mold base and a top module, and a plurality of groups of intermediate modules can be stacked between the bottom mold base and the top module to adjust the height of the box body according to the metal liner; a plurality of magnetic connection columns are distributed on the fitting end surfaces between the bottom mold base, the intermediate module and the top module to improve the stability of the mutual connection; the top cover is set on one side of the upper end of the box body, used to cover one end of the upper end opening of the box body, and the other end of the box body is still designed to be open, so as to facilitate personnel operation, reduce the air contact area, and thus slow down the consumption rate of liquid nitrogen, a guide cylinder is installed at the corresponding position of the top cover, and a liquid level sensor is inserted and installed on the guide cylinder to detect the liquid level height in the metal liner; an adjustable lighting component is also installed on the side of the box body away from the top cover, so as to facilitate personnel to see the situation in the metal liner clearly and facilitate personnel operation.

[0013] As a further solution of the utility model:

[0014] The bottom mold base is provided with a groove to accommodate the bottom of the metal liner. The middle module and the top module are hollow structures and are stacked in sequence. The upper ends of the bottom mold base, the middle module and the top module are respectively provided with card slots, and the lower ends of the middle module and the top module are provided with card bodies that are arranged in cooperation with the card slots. The card body is an annular structure and can be inserted into the card slot for sealing.

[0015] As a further solution of the utility model:

[0016] The upper end of the metal liner is provided with an outwardly bent side plate, which is abutted in the card slot at the upper end of the top module to make the upper end surface of the metal liner flush with the upper end surface of the top module, thereby improving the stability of the metal liner installation.

[0017] As a further solution of the utility model:

[0018] The top cover is mounted on the upper ends of the side plates and the top module, and the lower end of the top cover is provided with a convex body inserted into the inner cavity of the metal liner to improve the stability of the top cover installation.

[0019] As a further solution of the utility model:

[0020] The top cover is provided with a guide hole corresponding to the guide cylinder, the guide cylinder is fixedly installed in the guide hole, and the liquid level sensor is inserted and installed on the guide cylinder.

[0021] As a further solution of the utility model:

[0022] The bottom mold base, the middle module and the top module are arranged on one side thereof, and correspondingly, connection holes are arranged. The magnetic connection columns are inserted and installed in the connection holes to enhance the stability of the connection.

[0023] As a further solution of the utility model:

[0024] The bottom mold base, the middle module and the top module are made of composite polyethylene-vinyl ester copolymer foam material, and the metal liner is made of 304 stainless steel material.

[0025] As a further solution of the utility model:

[0026] The lighting assembly includes a plate installed on the upper end of the top module, a lamp holder adjustably installed on the upper end of the plate, and a lampshade arranged on one side of the lamp holder. Magnetic connecting columns are installed on both sides of the plate, and are inserted into corresponding connecting holes of the top module through the magnetic connecting columns to improve the stability of the installation of the lighting assembly.

[0027] As a further solution of the utility model:

[0028] The lamp holder is rotatably connected to the mounting plate through an adjusting member, which includes an adjusting plate, the lower end of which is rotatably mounted on a first clamping seat on the mounting plate, and the upper end of which is rotatably mounted on a second clamping seat at the bottom of the lamp holder to adjust the height and illumination angle of the lamp holder so that the light source can illuminate the metal inner tank, making it convenient for personnel to check the situation.

[0029] As a further solution of the utility model:

[0030] The outer end of the first clamping seat is provided with a first knob for adjusting the tightness of the adjustment plate, and the first knob is threadedly connected to the first screw that penetrates the adjustment plate so as to clamp and fix the adjustment plate through the first clamping seats on both sides. The second clamping seat is provided with a second screw, one end of the second screw is abutted on the second clamping seat, and the other end is threadedly connected to the second knob at the outer end of the lamp holder so as to be tightened by the second knob, so that the adjustment plate is abutted against the inner side of the second clamping seat, thereby fixing the lamp holder, which is convenient for adjusting the rotation angle of the lamp holder.

[0031] As a further solution of the utility model:

[0032] The lamp holder is provided with corresponding grooves corresponding to the mounting plate and the adjusting member, so that the mounting plate and the adjusting member can be built into the grooves in a folded state, thereby improving the aesthetics.

[0033] Compared with the prior art, the beneficial effects of the utility model are:

[0034] The top cover on the upper end of the box adopts a partially open design, which can be covered during operation, greatly reducing the air contact area and greatly reducing the liquid nitrogen consumption rate; a liquid level sensor is installed on the top cover, which can directly read the remaining liquid nitrogen height / volume on the top of the box.

[0035] A lighting assembly is provided on the top of the box, which can be detachably mounted on the top module via a magnetic connecting column. Personnel can adjust the height and angle of the lamp holder through the adjustment piece so that the light source can shine into the metal inner tank, making it easier for personnel to observe and operate.

[0036] The cabinet adopts a split design. The height of the cabinet can be adjusted by adding or removing middle modules to meet the requirements of different operating systems. The overall liquid nitrogen storage capacity can be increased by raising the cabinet.

[0037] The bottom mold base, the middle module and the top module are spliced ​​together, and the stability of the connection is enhanced by magnetic connection columns, so that the end faces fit more closely and the sealing performance of the box is improved.

[0038] The box is made of high-density, high-hardness composite polyethylene-vinyl ester copolymer foam material, and the metal liner is made of 304 stainless steel structure; the external material is durable, corrosion-resistant, high-strength, and not easy to damage; the metal liner is more stable, has better support and better thermal conductivity; it is resistant to high and low temperatures and can be used repeatedly for a long time; the structure is dense and non-porous, not easy to get dusty; and it is easy to wipe and disinfect with ordinary disinfectants. The material has a low thermal conductivity coefficient, better insulation performance, and the thickness has increased by more than 50%, further reducing the rate of liquid nitrogen loss.

[0039] Vitrification needs to be performed in a sterile environment, usually in a human in vitro fertilization (IVF) laboratory. The liquid nitrogen container needs to be placed in a biosafety cabinet for operation. This product is used as a liquid nitrogen container to replace ordinary foam boxes. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0041] Figure 2 This is a schematic diagram of the metal liner structure of the utility model;

[0042] Figure 3 This is a schematic diagram of the top cover structure of the utility model;

[0043] Figure 4 This is a schematic diagram of the top module structure of the utility model;

[0044] Figure 5 This is a schematic diagram of the structure of the intermediate module of the utility model;

[0045] Figure 6 This is a schematic diagram of the bottom mold base structure of the utility model;

[0046] Figure 7 This is a schematic diagram of the lighting assembly structure of the utility model;

[0047] Markings in the figure: 1. Box body; 2. Metal liner; 3. Top cover; 4. Lighting component; 11. Bottom mold base; 12. Middle module; 13. Top module; 14. Magnetic connecting column; 15. Card slot; 16. Card body; 17. Connecting hole; 21. Side plate; 31. Guide cylinder; 32. Liquid level sensor; 33. Protrusion; 41. Paste plate; 42. Lamp holder; 43. Lamp cover; 44. Adjustment plate; 45. First clamp seat; 46. Second clamp seat; 47. First knob; 48. Second knob. DETAILED DESCRIPTION

[0048] In order to make the technical means for realizing the utility model, creative features, objectives and effects easy to understand, the utility model is further explained below with reference to specific illustrations.

[0049] like Figures 1 to 7 As shown,

[0050] The present embodiment provides an embryo freezing operation box, comprising a box body 1 which is spliced ​​and arranged, a metal liner 2 arranged in the box body 1, and a top cover 3 installed on the upper end of the box body 1. The box body 1 comprises a bottom mold base 11 and a top module 13. A plurality of groups of middle modules 12 can be stacked between the bottom mold base 11 and the top module 13 to adjust the height of the box body 1 according to the metal liner 2. A plurality of magnetic connection columns 14 are distributed on the fitting end surfaces between the bottom mold base 11, the middle module 12 and the top module 13 to improve the stability of the mutual connection. The top cover 3 is set on one side of the upper end of the box body 1 to cover one end of the upper opening of the box body 1. The other end of the box body 1 is still designed to be open, which is convenient for personnel to operate and reduce the air contact area, thereby slowing down the consumption rate of liquid nitrogen. A guide cylinder 31 is installed at the corresponding position of the top cover 3, and a liquid level sensor 32 is installed on the guide cylinder 31 to detect the liquid level height in the metal liner 2; an adjustable lighting component 4 is also installed on the side of the box body 1 away from the top cover 3, so that personnel can see the situation inside the metal liner 2 and facilitate personnel operation.

[0051] In this embodiment, the bottom mold base 11 is provided with a groove to accommodate the bottom of the metal liner 2, the middle module 12 and the top module 13 are hollow structures, and are stacked in sequence, and the upper ends of the bottom mold base 11, the middle module 12 and the top module 13 are respectively provided with a card slot 15, and the lower ends of the middle module 12 and the top module 13 are provided with a card body 16 that is arranged in cooperation with the card slot 15, and the card body 16 is an annular structure, so as to be inserted into the card slot 15 for sealing. Specifically, the card body 16 at the lower end of the middle module 12 can be inserted into the card slot 15 at the upper end of the bottom mold base 11, so that the middle module 12 and the bottom mold base 11 are sealed, and the card body 16 at the lower end of the top module 13 can be inserted into the card slot 15 at the upper end of the middle module 12 or the card slot 15 at the upper end of the bottom mold base 11 for sealing.

[0052] In this embodiment, an outwardly bent side plate 21 is provided at the upper end of the metal liner 2, and the side plate 21 is abutted against the slot 15 at the upper end of the top module 13 so that the upper end surface of the metal liner 2 is flush with the upper end surface of the top module 13, thereby improving the installation stability of the metal liner 2.

[0053] In this embodiment, the top cover 3 is mounted on the upper ends of the side panels 21 and the top module 13 , and the lower end of the top cover 3 is provided with a protrusion 33 inserted into the inner cavity of the metal liner 2 to improve the stability of the installation of the top cover 3 .

[0054] The top cover 3 is provided with a guide hole corresponding to the guide cylinder 31 , the guide cylinder 31 is fixedly installed in the guide hole, and the liquid level sensor 32 is inserted and installed on the guide cylinder 31 .

[0055] In this embodiment, connection holes 17 are correspondingly distributed on one side where the bottom mold base 11, the middle module 12 and the top module 13 are attached to each other, and the magnetic connection column 14 is inserted and installed in the connection hole 17 to enhance the stability of the connection.

[0056] In this embodiment, the bottom mold base 11, the middle module 12 and the top module 13 are made of composite polyethylene-vinyl ester copolymer foam material, and the metal liner 2 is made of 304 stainless steel material.

[0057] In this embodiment, the lighting assembly 4 includes a plate 41 installed on the upper end of the top-level module 13, a lamp holder 42 adjustably installed on the upper end of the plate 41, and a lampshade 43 arranged on one side of the lamp holder 42. Magnetic connecting columns 14 are installed on both sides of the plate 41, and the magnetic connecting columns 14 are inserted and installed in the corresponding connecting holes 17 of the top-level module 13 to improve the installation stability of the lighting assembly 4.

[0058] The lamp holder 42 is rotatably connected to the mounting plate 41 through an adjusting member, and the adjusting member includes an adjusting plate 44, the lower end of the adjusting plate 44 is rotatably mounted on a first clamping seat 45 on the mounting plate 41, and the upper end of the adjusting plate 44 is rotatably mounted on a second clamping seat 46 at the bottom of the lamp holder 42, so as to adjust the height and illumination angle of the lamp holder 42 so that the light source can illuminate the metal inner liner 2, making it convenient for personnel to check the situation.

[0059] The outer end of the first clamp seat 45 is provided with a first knob 47 for adjusting the tightness of the adjustment plate 44. The first knob 47 is threadedly connected to the first screw that penetrates the adjustment plate 44 so as to clamp and fix the adjustment plate 44 through the first clamp seats 45 on both sides. The second clamp seat 46 is provided with a second screw. One end of the second screw is abutted on the second clamp seat 46, and the other end is threadedly connected to the second knob 48 at the outer end of the lamp holder 42 so as to be tightened by the second knob 48, so that the adjustment plate 44 is abutted against the inner side of the second clamp seat 46, thereby fixing the lamp holder 42 and facilitating the adjustment of the rotation angle of the lamp holder 42.

[0060] The lamp holder 42 is provided with corresponding grooves corresponding to the plate 41 and the adjusting member, so that the plate 41 and the adjusting member can be built into the grooves in a folded state, thereby improving the aesthetics.

[0061] The above shows and describes the basic principle and main features of the utility model and the advantages of the utility model. The technicians in this industry should understand that the utility model is not limited by the above embodiments. The above embodiments and the description only illustrate the principle of the utility model. Without departing from the spirit and scope of the utility model, the utility model will also have various changes and improvements, and these changes and improvements fall within the scope of the utility model to be protected. The scope of protection of the utility model is defined by the attached claims and their equivalents. It should be noted that in this article, if there are first and second relationship terms such as only used to distinguish one entity or operation from another entity or operation, it does not necessarily require or imply that there is any such actual relationship or order between these entities or operations. Moreover, the term "include", "comprise" or any other variant thereof is intended to cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements includes not only those elements, but also includes other elements that are not explicitly listed, or also includes elements inherent to such process, method, article or equipment. Without more constraints, an element defined by the phrase "comprising a..." does not exclude the existence of other identical elements in the process, method, article or apparatus comprising the element.

Claims

1. An embryo freezing operation box, characterized in that: It includes a spliced ​​box body, a metal liner arranged in the box body, and a top cover installed on the upper end of the box body, the box body includes a bottom mold base and a top module, and a plurality of groups of intermediate modules can be stacked between the bottom mold base and the top module to adjust the height of the box body according to the metal liner; a plurality of magnetic connection columns are distributed on the fitting end surfaces between the bottom mold base, the intermediate module and the top module; the top cover is erected on one side of the upper end of the box body to cover one end of the opening at the upper end of the box body, and the other end of the box body is still designed to be open, and a guide cylinder is installed at the corresponding position of the top cover, and a liquid level sensor is inserted and installed on the guide cylinder to detect the liquid level height in the metal liner; an adjustable lighting component is also installed on the side of the box body away from the top cover.

2. An embryo freezing operation box according to claim 1, characterized in that: The bottom mold base is provided with a groove to accommodate the bottom of the metal liner. The middle module and the top module are hollow structures and are stacked in sequence. The upper ends of the bottom mold base, the middle module and the top module are respectively provided with card slots, and the lower ends of the middle module and the top module are provided with card bodies that are arranged in cooperation with the card slots. The card body is an annular structure and can be inserted into the card slot for sealing.

3. An embryo freezing operation box according to claim 2, characterized in that: The upper end of the metal liner is provided with a side plate bent outwards, and the side plate is abutted in the slot at the upper end of the top module so that the upper end surface of the metal liner is flush with the upper end surface of the top module.

4. An embryo freezing operation box according to claim 3, characterized in that: The top cover is erected on the upper ends of the side plates and the top module, and the lower end of the top cover is provided with a convex body inserted in the inner cavity of the metal liner; the top cover is provided with a guide hole corresponding to the guide cylinder, the guide cylinder is fixedly installed in the guide hole, and the liquid level sensor is inserted and installed on the guide cylinder.

5. The embryo freezing operation box according to claim 3, characterized in that: The bottom mold base, the middle module and the top module are arranged on one side thereof, and correspondingly, connection holes are arranged, and the magnetic connection columns are inserted and installed in the connection holes.

6. The embryo freezing operation box according to claim 1, characterized in that: The bottom mold base, the middle module and the top module are made of composite polyethylene-vinyl ester copolymer foam material, and the metal liner is made of 304 stainless steel material.

7. The embryo freezing operation box according to claim 5, characterized in that: The lighting assembly includes a plate installed on the upper end of the top module, a lamp holder adjustably installed on the upper end of the plate, and a lampshade arranged on one side of the lamp holder. Magnetic connecting columns are installed on both sides of the plate and are inserted into corresponding connecting holes of the top module through the magnetic connecting columns.

8. An embryo freezing operation box according to claim 7, characterized in that: The lamp holder is rotatably connected to the mounting plate through an adjusting member, which includes an adjusting plate, the lower end of which is rotatably mounted on a first clamping seat on the mounting plate, and the upper end of which is rotatably mounted on a second clamping seat at the bottom of the lamp holder to adjust the height and illumination angle of the lamp holder.

9. An embryo freezing operation box according to claim 8, characterized in that: The outer end of the first clamping seat is provided with a first knob for adjusting the tightness of the adjustment plate, and the first knob is threadedly connected to the first screw that penetrates the adjustment plate so as to clamp and fix the adjustment plate through the first clamping seats on both sides. The second clamping seat is provided with a second screw, one end of the second screw is abutted on the second clamping seat, and the other end is threadedly connected to the second knob at the outer end of the lamp holder so as to be tightened by the second knob, so that the adjustment plate is abutted against the inner side of the second clamping seat.

10. The embryo freezing operation box according to claim 9, characterized in that: The lamp holder is provided with corresponding grooves corresponding to the mounting plate and the adjusting member, so that the mounting plate and the adjusting member can be built into the grooves in a folded state.

Citation Information

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