Stirring shaft sealing device of biological reaction bag and biological reaction bag

Abstract

The utility model provides a biological reaction bag stirring shaft sealing device and a biological reaction bag, the biological reaction bag stirring shaft sealing device comprises a stirring shaft, the periphery of the stirring shaft is sleeved with a shaft sleeve, the inner bottom end of the shaft sleeve is provided with a first bearing, the inner top end of the shaft sleeve is provided with a mechanical sealing assembly, and a second bearing is arranged below the mechanical sealing assembly; the second bearing is positioned above the first bearing; the stirring shaft sequentially penetrates through the mechanical sealing assembly, the second bearing and the first bearing from top to bottom. The biological reaction bag can achieve a more efficient sealing effect by adopting the mechanical sealing assembly, so that the safety and the stability in the biological reaction process are ensured; due to the design of the two bearings, the weight and the rotating force of the reaction bag can be uniformly borne, vibration and friction are reduced, the stirring paddle of the biological reaction bag rotates more stably, the higher rotating speed can be achieved, and therefore the operation effect of the whole system is improved.

Description

Technical Field

[0001] The utility model relates to the field of bioreactor bags, in particular to a stirring shaft sealing device of a bioreactor bag and a bioreactor bag. Background Art

[0002] Bioreactor bags are widely used in the biopharmaceutical field. Traditional reaction bags are mainly driven by mechanical drive, magnetic levitation technology or magnetic coupling.

[0003] Mechanical drive is to mechanically connect the agitator to a drive shaft or column, which is lowered into the fluid through an opening in the top of the reaction bag, and then an external motor is used to rotate the drive shaft or column. In a closed system, the agitator is usually connected to the external motor through a hydraulically sealed drive shaft. However, these types of stirring devices are generally uncommon for mixers and bioreactors used to manufacture pharmaceuticals or biomaterials because the fluid in the vessel may be contaminated and may leak.

[0004] Magnetic levitation technology is a device that uses the power of magnetic field polarity and magnetic rotor repulsion to drive rotation. This form has many defects. First, the stirring component can only stir at the bottom area of ​​the reaction bag. Once the reaction bag becomes larger or higher, it is likely to cause uneven stirring and insufficient mixing. Secondly, because the stirring component is fixed in the axial direction, there is a risk of dislocation and falling off in actual use.

[0005] The magnetic coupling agitator system usually includes a rotating magnetic drive head outside the reaction bag and a magnetic agitator inside the reaction bag. The movement of the magnetic drive head enables the transmission of torque, and thus enables the magnetic agitator to rotate, allowing the agitator to mix the substances in the vessel. This form is the most widely used in bioreactor bags. However, it has many disadvantages. First, the drive is installed on the reactor support container, and the installation of the matching bioreactor bag is very inconvenient; secondly, the magnetic coupling transmission mode has a limited rotation speed, and excessive rotation speed is prone to demagnetization and other phenomena; the stirring component of the magnetic coupling transmission cannot be scaled proportionally with the change in the volume of the reaction bag, and there are some limitations to some extent, and the processing cost is relatively high. Utility Model Content

[0006] The first purpose of the utility model is to provide a stirring shaft sealing device for a bioreactor bag, which is used to solve the problems of limited rotation speed and poor sealing of the stirring system of the existing bioreactor bag.

[0007] The second object of the utility model is to provide a bioreactor bag, including the stirring shaft sealing device of the bioreactor bag.

[0008] In order to achieve the above-mentioned first purpose, the utility model provides a stirring shaft sealing device for a bioreactor bag, including a stirring shaft, a shaft sleeve is provided on the outer peripheral sleeve of the stirring shaft, a first bearing is provided at the inner bottom end of the shaft sleeve, a mechanical sealing assembly is provided at the inner top end of the shaft sleeve, a second bearing is provided below the mechanical sealing assembly, and the second bearing is located above the first bearing; the stirring shaft passes through the mechanical sealing assembly, the second bearing and the first bearing in sequence from top to bottom.

[0009] As can be seen from the above scheme, the use of mechanical seal components enables the bioreactor bag to achieve a more efficient sealing effect. This sealing method can effectively prevent liquid or gas leakage, thereby ensuring safety and stability during the bioreactor process; the design of two bearings makes the rotation of the bioreactor bag more stable, and the bearings can evenly bear the weight and rotational force of the reaction bag, reduce vibration and friction, and thus improve the operating efficiency of the entire system. A higher rotation speed can be achieved, which can meet the high speed of 400rpm / min; at the same time, the structural design of the mechanical seal component and the bearing is simple, which makes the cleaning and maintenance of the bioreactor bag more convenient, and also helps to reduce the risk of contamination and cross infection.

[0010] A further solution is that the mechanical seal assembly includes a stationary ring, a dynamic ring, a spring and a spring seat, the stationary ring is located above the dynamic ring, and the top of the dynamic ring contacts the bottom of the stationary ring, the dynamic ring is located above the spring, the stationary ring is arranged at the inner top of the sleeve, and the spring is arranged in the spring seat.

[0011] It can be seen from the above scheme that the static ring is located above the dynamic ring. This design helps to form a tighter sealing interface. When the dynamic ring rotates, the contact between it and the static ring is more stable, reducing the possibility of leakage, thereby improving the overall sealing performance; the spring is arranged inside the spring seat, and the dynamic ring is located above the spring seat, which can effectively fine-tune the position of the dynamic ring to ensure that the contact between the dynamic ring and the static ring is more uniform. At the same time, the elastic characteristics of the spring can also play a buffering role, reducing the damage to the seal caused by vibration or impact, and further enhancing the reliability and stability of the seal.

[0012] A further solution is that a first sealing ring is provided on a side of the moving ring close to the spring.

[0013] It can be seen from the above solution that the provision of the first sealing ring can prevent leakage of the medium and entry of external dust and particles, while enhancing the stability of the mechanical sealing structure.

[0014] A further solution is that a second sealing ring is arranged between the stationary ring and the shaft sleeve.

[0015] It can be seen from the above solution that the provision of the second sealing ring further improves the sealing stability of the sealing device.

[0016] A further solution is that the shaft sleeve includes a fixed plate, a sleeve body and a shaft cover, the fixed plate is fixedly arranged on the upper surface of the sleeve body, the shaft cover is installed on the bottom of the sleeve body, the fixed plate, the sleeve body and the shaft cover are all sleeved outside the stirring shaft, and the mechanical seal assembly, the second bearing and the first bearing are all arranged in the sleeve body.

[0017] It can be seen from the above scheme that the provision of the fixed disk improves the sealing performance between the stirring shaft sealing device and the reaction bag body, and the provision of the shaft cover facilitates the installation, cleaning and maintenance of the sealing device.

[0018] A further solution is that a third sealing ring is provided between the shaft cover and the sleeve body.

[0019] It can be seen from the above scheme that such an arrangement makes the sealing performance of the stirring shaft sealing device better.

[0020] A further solution is that a shaft sleeve limiting piece is arranged on the peripheral wall of the sleeve body.

[0021] It can be seen from the above scheme that the provision of the shaft sleeve limiter makes the operation of the sealing device more stable.

[0022] A further solution is that at least one stirring paddle is arranged on the mixing shaft, and the stirring paddle is arranged outside the shaft sleeve.

[0023] It can be seen from the above scheme that the stirring paddle is used to mix and stir the fluid in the bioreactor bag.

[0024] A further solution is that a stirring paddle includes a mounting plate and at least one blade, the mounting plate is sleeved on the stirring shaft, the blade is mounted on the mounting plate, and an angle exists between the cross section of the blade and the mounting plate.

[0025] It can be seen from the above scheme that the setting of such a stirring paddle makes the stirring more uniform, has better heat transfer, mass transfer and mixing effects, solves the problem of dead corners in existing stirring, and has a stronger load capacity.

[0026] In order to achieve the above-mentioned second purpose, the utility model provides a bioreactor bag, which includes a stirring shaft sealing device of a bioreactor bag as in any of the above-mentioned schemes, wherein the mechanical sealing assembly, the second bearing and the first bearing are all arranged outside the bag body of the bioreactor bag, and the stirring shaft extends into the bag body.

[0027] As can be seen from the above scheme, the stirring shaft sealing device including the utility model has a better sealing effect, and during use, the stirring speed may be better and the load capacity is stronger. Setting stirring shafts of different lengths can make the sealing device suitable for bioreactor bags of different sizes. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1The utility model is a structural schematic diagram of a biological reaction bag.

[0029] Figure 2 The utility model is a structural schematic diagram of a stirring shaft sealing device of a bioreactor bag.

[0030] Figure 3 The utility model is a cross-sectional view of a stirring shaft sealing device of a bioreactor bag without the stirring shaft.

[0031] The present invention will be further described below with reference to the accompanying drawings and embodiments. DETAILED DESCRIPTION

[0032] See also Figures 1 to 3 The bioreactor bag 1 provided in this embodiment includes a stirring shaft sealing device 2 .

[0033] See also Figure 2 and Figure 3 The stirring shaft sealing device 2 comprises a stirring shaft 21, and a shaft sleeve 23 is provided on the outer periphery of the stirring shaft. A first bearing 26 is provided at the inner bottom end of the shaft sleeve 23, a mechanical seal assembly is provided at the inner top end of the shaft sleeve 23, a second bearing 25 is provided below the mechanical seal assembly, and the second bearing 25 is located above the first bearing 26; the stirring shaft 21 passes through the mechanical seal assembly, the second bearing 25 and the first bearing 26 in sequence from top to bottom.

[0034] The mechanical seal assembly includes a stationary ring 241, a dynamic ring 242, a spring 243 and a spring seat 244. The stationary ring 241 is located above the dynamic ring 242 and the top of the dynamic ring 242 contacts the bottom of the stationary ring 241. The dynamic ring 242 is located above the spring 243. The stationary ring 241 is arranged at the inner top of the sleeve 23, and the spring 243 is arranged in the spring seat 244. A first sealing ring 246 is arranged on the side of the dynamic ring 242 close to the spring 243. A second sealing ring 245 is arranged between the stationary ring 241 and the sleeve 23.

[0035] The static ring 241 is located above the dynamic ring 242. This design helps to form a tighter sealing interface. When the dynamic ring 242 rotates, the contact between it and the static ring 241 is more stable, reducing the possibility of leakage, thereby improving the overall sealing performance; the spring 243 is set inside the spring seat 244, and the dynamic ring 242 is located above the spring 243, which can effectively fine-tune the position of the dynamic ring 242 to ensure that the contact between the dynamic ring 242 and the static ring 241 is more uniform and airtight. At the same time, the elastic characteristics of the spring 243 can also play a buffering role, reducing the damage to the seal caused by vibration or impact, and further enhancing the reliability and stability of the seal. The setting of the first sealing ring 245 and the second sealing ring 246 can prevent the leakage of the medium and the entry of external dust and particles, while enhancing the stability of the mechanical sealing structure.

[0036] In this embodiment, the sleeve 23 includes a fixed disk 231, a sleeve body 232 and a shaft cover 233. The fixed disk 231 is fixedly arranged on the upper surface of the sleeve body 232. The fixed disk 231 and the sleeve body 232 can also be the same part. The shaft cover 233 is installed at the bottom of the sleeve body 232. The fixed disk 231, the sleeve body 232 and the shaft cover 233 are all sleeved outside the stirring shaft 21. The mechanical seal assembly, the second bearing 25 and the first bearing 26 are all arranged in the sleeve body 232. The fixed disk 231 and the sleeve body 232 are fixedly connected together, and the shaft cover 233 is locked together with the sleeve body 232 by screws 234. A third sealing ring 236 is arranged between the shaft cover 233 and the sleeve body 232. A sleeve stopper 235 is arranged on the peripheral wall of the sleeve body 232.

[0037] The setting of the fixed plate 231 improves the sealing performance between the stirring shaft sealing device 2 and the bioreactor bag body 1, and the setting of the shaft cover 233 facilitates the installation, cleaning and maintenance of the stirring shaft sealing device 2. The third sealing ring 236 improves the sealing performance of the stirring shaft sealing device 2. The setting of the shaft sleeve limiter 235 makes the operation of the stirring shaft sealing device 2 more stable.

[0038] See also Figure 2 The stirring shaft 21 is provided with stirring paddles. In the present embodiment, three stirring paddles are provided in total, and the stirring paddles are arranged along the axial direction of the stirring shaft 21 .

[0039] A stirring paddle includes a mounting plate 22 and a blade 221. The mounting plate 22 is sleeved on the stirring shaft 21. The blade 221 is mounted on the mounting plate 22. There is an angle between the blade 221 and the cross section of the mounting plate 22. In this embodiment, six blades 221 are arranged on one mounting plate 22, and the blades 221 are arranged along the circumference of the mounting plate 22.

[0040] The arrangement of multiple stirring paddles enables the fluid in the bioreactor bag 1 to be stirred more evenly, with better heat transfer, mass transfer and mixing effects, solves the problem of dead corners in existing stirring, and has a stronger load capacity.

[0041] The stirring shaft 21 extends into the bioreactor bag 1, and the stirring paddle is located in the bag body of the bioreactor bag 1. The fixing plate 231 is connected to the bottom surface of the bioreactor bag 1 to achieve effective fixing and sealing. The mechanical seal assembly, the second bearing 25, the first bearing 26, the sleeve 232 and the shaft cover 233 are all arranged outside the bag body of the bioreactor bag 1.

[0042] This embodiment uses a mechanical seal assembly to enable the bioreactor bag 1 to achieve a more efficient sealing effect. This sealing method can effectively prevent liquid or gas leakage, thereby ensuring safety and stability during the bioreactor process; the design of the two bearings makes the rotation of the bioreactor bag 1 more stable, and the bearings can evenly bear the weight and rotational force of the bioreactor bag 1, reduce vibration and friction, and thus improve the operating efficiency of the entire system. A higher rotation speed can be achieved, which can meet the high speed of 400rpm / min and has a stronger load capacity. At the same time, the structural design of the mechanical seal assembly and the bearing is simple, which makes the cleaning and maintenance of the bioreactor bag 1 more convenient, and also helps to reduce the risk of contamination and cross infection.

[0043] The above embodiments are only preferred examples of the present invention and are not intended to limit the scope of implementation of the present invention. Therefore, any equivalent changes or modifications made based on the structure, features and principles of the present invention should be included in the scope of the present invention patent application.

Claims

1. A stirring shaft sealing device for a bioreactor bag, comprising a stirring shaft, characterized in that: The outer peripheral sleeve of the stirring shaft is provided with a shaft sleeve, the inner bottom end of the shaft sleeve is provided with a first bearing, the inner top end of the shaft sleeve is provided with a mechanical seal assembly, a second bearing is provided below the mechanical seal assembly, and the second bearing is located above the first bearing; The stirring shaft passes through the mechanical seal assembly, the second bearing and the first bearing in sequence from top to bottom.

2. The stirring shaft sealing device of a bioreactor bag according to claim 1, characterized in that: The mechanical seal assembly includes a stationary ring, a dynamic ring, a spring and a spring seat, wherein the stationary ring is located above the dynamic ring, and the top end of the dynamic ring contacts the bottom end of the stationary ring, the dynamic ring is located above the spring, the stationary ring is arranged at the inner top end of the sleeve, and the spring is arranged in the spring seat.

3. The stirring shaft sealing device of a bioreactor bag according to claim 2, characterized in that: A first sealing ring is arranged on one side of the dynamic ring close to the spring.

4. The stirring shaft sealing device of a bioreactor bag according to claim 2, characterized in that: A second sealing ring is arranged between the stationary ring and the shaft sleeve.

5. A stirring shaft sealing device for a bioreactor bag according to any one of claims 1 to 4, characterized in that: The shaft sleeve includes a fixed disk, a sleeve body and a shaft cover, the fixed disk is fixedly arranged on the upper surface of the sleeve body, the shaft cover is installed on the bottom of the sleeve body, the fixed disk, the sleeve body and the shaft cover are all sleeved outside the stirring shaft, and the mechanical seal assembly, the second bearing and the first bearing are all arranged in the sleeve body.

6. The stirring shaft sealing device of a bioreactor bag according to claim 5, characterized in that: A third sealing ring is arranged between the shaft cover and the sleeve body.

7. The stirring shaft sealing device of a bioreactor bag according to claim 5, characterized in that: A shaft sleeve limiting piece is arranged on the peripheral wall of the sleeve body.

8. The stirring shaft sealing device of a bioreactor bag according to any one of claims 1 to 4, characterized in that: The stirring shaft is provided with at least one stirring paddle, and the stirring paddle is arranged outside the shaft sleeve.

9. The stirring shaft sealing device of a bioreactor bag according to claim 8, characterized in that: One of the stirring paddles comprises a mounting plate and at least one blade, wherein the mounting plate is sleeved on the stirring shaft, and the blade is mounted on the mounting plate, and an angle exists between the blade and the cross section of the mounting plate.

10. A bioreactor bag, characterized in that: The bioreactor bag comprises a stirring shaft sealing device for a bioreactor bag as claimed in any one of claims 1 to 9, the mechanical sealing assembly, the second bearing and the first bearing are all arranged outside the bag body of the bioreactor bag, and the stirring shaft extends into the bag body.

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