Purification equipment for compound production
By designing a purification equipment for the production of compounds including centrifugal shells, connecting pipes, reflux pipes and other components, the problem that existing equipment cannot efficiently separate the solid-liquid mixture of pharmaceutical intermediates, and efficient separation and purification are achieved, reducing loss costs.
Patent Information
- Application Number
- CN202421485731.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-27
- Publication Date
- 2025-05-02
- Estimated Expiration
- 2034-06-27
AI Technical Summary
The existing centrifugal purification equipment cannot achieve efficient separation of solid-liquid mixtures of pharmaceutical intermediates, especially the inability to separate solid precipitates, heavy liquids and light liquids at the same time, resulting in poor separation effect.
A purification equipment for the production of compounds is designed, including centrifugal shells, connecting pipes, reflux tubes and other components. The separation mechanism of heavy liquid and light liquid and a solid-liquid separator is achieved to separate the solid-liquid mixture, and the heavy liquid is re-entered into the liquid inlet pipe through the reflux tube to improve the separation and purification effect.
It realizes efficient separation of solid-liquid mixtures of pharmaceutical intermediates, improves separation and purification efficiency, avoids waste of heavy liquids, and reduces the loss cost during the purification of pharmaceutical intermediates.
Smart Images
Figure CN222817041U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of compound purification equipment, in particular to a purification equipment for compound production. Background Art
[0002] Pharmaceutical intermediates refer to intermediate chemicals or compounds used to synthesize final products during the drug manufacturing process. They are usually intermediate products in chemical synthesis or key intermediates in biosynthesis.
[0003] The main function of pharmaceutical intermediates is to convert chemical raw materials into final drug molecules, so they play a vital role in drug manufacturing. Since the quality and safety of drugs are crucial to human health, the production and quality control of pharmaceutical intermediates are also very strict.
[0004] There are many types of pharmaceutical intermediates, which can be divided into many types according to their structures and functions, such as amino acids, sugars, nucleotides, lipids, peptides, proteins, enzymes, vitamins, etc.
[0005] Currently, the global pharmaceutical intermediates market is growing rapidly, especially in emerging economies and developing countries, mainly due to the increasing demand for drugs caused by the aging population and the increasing incidence of chronic diseases and cancer.
[0006] Centrifugal purification equipment is a commonly used equipment for purifying pharmaceutical intermediates. However, laboratory centrifugal equipment requires liquid to be placed in the centrifuge for centrifugation before being taken out. It does not have a continuous centrifugal separation effect and is not suitable for large-scale purification of pharmaceutical intermediates. Existing centrifugal equipment has a good separation effect on liquid mixtures, but a poor separation effect on liquid mixtures and solid mixtures. It cannot separate solid precipitates, heavy liquids and light liquids at the same time. Therefore, a high-efficiency separation and purification equipment is needed for the purification of pharmaceutical intermediates. Utility Model Content
[0007] In order to solve the above technical problems, the utility model provides a purification device for compound production.
[0008] The technical solution of the utility model is: a purification device for compound production, comprising a centrifugal shell, a connecting pipe, and a reflux pipe, the top of the centrifugal shell is rotatably connected with a stirring rod, the bottom of the centrifugal shell is provided with a liquid inlet pipeline, the top of the centrifugal shell is provided with a heavy liquid separation mechanism and a light liquid separation mechanism, the top of the light liquid separation mechanism is fixedly connected with a stirring motor for driving the stirring rod to rotate, and the bottom side of the centrifugal shell is fixedly connected with a solid-liquid separator through the connecting pipe.
[0009] Furthermore, the heavy liquid separation mechanism comprises a heavy liquid collecting shell, the heavy liquid collecting shell is fixedly connected to the outer wall of the centrifugal shell, and a heavy liquid outlet is provided on the side of the heavy liquid collecting shell.
[0010] Description: The outer heavy liquid is collected by the heavy liquid collection shell to separate the heavy liquid.
[0011] Furthermore, the light liquid separation mechanism includes a separation sleeve, which is located on the inner side of the heavy liquid collecting shell, the top of the separation sleeve is fixedly connected to the light liquid collecting shell, the bottom of the light liquid collecting shell is fixedly connected to the heavy liquid collecting shell, and a light liquid outlet is provided on the left side of the light liquid collecting shell.
[0012] Description: The light liquid is guided to the light liquid separation shell through the separation sleeve and collected, and then discharged through the light liquid outlet to obtain light liquid.
[0013] Furthermore, the solid-liquid separator includes a shell, the interior of the shell is rotatably connected to a screw barrel, the left end of the shell is fixedly connected to a separation motor for driving the screw barrel to rotate, the right end of the screw barrel is fixedly connected to the connecting pipe, a material discharge port is provided in the middle of the screw barrel, a liquid discharge port is provided on the left side of the shell, the liquid discharge port is fixedly connected to the reflux pipe, and a solid discharge port is provided at the lower right side of the shell.
[0014] Description: The mixture of solid material slag and heavy liquid enters the screw barrel of the solid-liquid separator and is discharged from the material discharge port of the screw barrel. Under the action of the screw rod, the solid is driven by the screw rod to be discharged from the right end, and the heavy liquid flows out from the left end of the solid-liquid separator.
[0015] Furthermore, the lower left end of the solid-liquid separator is fixedly connected to the liquid inlet pipeline through the reflux pipe.
[0016] Note: The separated heavy liquid is re-entered into the liquid inlet pipe through the reflux pipe to improve the quality of the separated heavy liquid.
[0017] The beneficial effects of the utility model are:
[0018] The utility model can purify and separate the solid-liquid mixture of the pharmaceutical intermediate, and can not only separate the solid and the liquid, but also centrifugally separate the mixed components in the liquid at the same time. The centrifugal separation of the device is continuous, which greatly improves the separation and purification efficiency of the pharmaceutical intermediate. After the mixture of solid and heavy liquid is secondary separated by the solid-liquid separator, the heavy liquid re-enters the liquid inlet pipeline for separation and purification, avoiding the waste of heavy liquid, improving the purification effect of the pharmaceutical intermediate, and reducing the loss cost in the purification process of the pharmaceutical intermediate. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 It is a structural schematic diagram of the utility model.
[0020] Among them, 1-centrifugal shell, 2-stirring rod, 3-liquid inlet pipe, 4-heavy liquid separation mechanism, 5-light liquid separation mechanism, 6-stirring motor, 7-connecting pipe, 8-solid-liquid separator, 9-reflux pipe, 61-gear one, 21-gear two, 41-heavy liquid collecting shell, 42-heavy liquid outlet, 51-separation sleeve, 52-light liquid collecting shell, 53-light liquid outlet, 81-shell, 82-screw barrel, 83-separation motor, 84-material discharge outlet, 85-liquid discharge outlet, 86-solid discharge outlet, 91-reflux pump. DETAILED DESCRIPTION
[0021] Embodiment 1:
[0022] like Figure 1 As shown, a purification device for compound production includes a centrifugal shell 1, a connecting pipe 7, and a reflux pipe 9. The top of the centrifugal shell 1 is rotatably connected to a stirring rod 2, the bottom of the centrifugal shell 1 is provided with a liquid inlet pipe 3, the top of the centrifugal shell 1 is provided with a heavy liquid separation mechanism 4 and a light liquid separation mechanism 5, the top of the light liquid separation mechanism 5 is fixedly connected to a stirring motor 6 for driving the stirring rod 2 to rotate, and the bottom side of the centrifugal shell 1 is fixedly connected to a solid-liquid separator 8 through a connecting pipe 7.
[0023] A gear 1 61 is fixedly connected to the output shaft of the stirring motor 6 , and a gear 2 21 is fixedly connected to the output shaft of the stirring rod 2 . The gear 1 61 is meshed and transmission-connected with the gear 2 21 .
[0024] The heavy liquid separation mechanism 4 comprises a heavy liquid collecting shell 41 , which is fixedly connected to the outer wall of the centrifugal shell 1 , and a heavy liquid outlet 42 is provided on the side of the heavy liquid collecting shell 41 .
[0025] The light liquid separation mechanism 5 includes a separation sleeve 51, which is located on the inner side of the heavy liquid collecting shell 41. The top of the separation sleeve 51 is fixedly connected to the light liquid collecting shell 52, the bottom of the light liquid collecting shell 52 is fixedly connected to the heavy liquid collecting shell 41, and a light liquid outlet 53 is provided on the left side of the light liquid collecting shell 52.
[0026] The solid-liquid separator 8 includes a shell 81, and a screw barrel 82 is rotatably connected inside the shell 81. A separation motor 83 for driving the screw barrel 82 to rotate is fixedly connected to the left end of the shell 81. The right end of the screw barrel 82 is fixedly connected to the connecting pipe 7. A material discharge port 84 is provided in the middle of the screw barrel 82. A liquid discharge port 85 is provided on the left side of the shell 81. The liquid discharge port 85 is fixedly connected to the reflux pipe 9. A solid discharge port 86 is provided at the lower right side of the shell 81.
[0027] Embodiment 2:
[0028] On the basis of Example 1, Example 2 is different from Example 1 in that the lower left end of the solid-liquid separator 8 is fixedly connected to the liquid inlet pipeline 3 through a reflux pipe 9, and a reflux pump 91 is provided in the middle of the reflux pipe 9.
[0029] Compared with Example 1, Example 2 re-enters the separated heavy liquid into the liquid inlet pipe 3 through the reflux pipe 9 to improve the quality of the separated heavy liquid. A reflux pump 91 is provided in the middle of the reflux pipe 9 to enhance the reflux efficiency of the liquid.
[0030] The working method of the above embodiment comprises the following steps:
[0031] S1, the pharmaceutical intermediate is introduced into the centrifugal shell 1 through the liquid inlet pipe 3, the stirring motor 6 drives the stirring rod 2 to rotate, the stirring rod 2 rotates to drive the liquid inside the centrifugal shell 1 to rotate, the heavy liquid is located on the outside of the centrifugal shell 1, the light liquid is located on the inside of the centrifugal shell 1, and the sediment is located below the outside of the centrifugal shell 1;
[0032] S2, the heavy liquid is collected by the heavy liquid collecting shell 41 in the heavy liquid separation mechanism 4, and then discharged through the heavy liquid outlet 42, and the light liquid passes through the separation sleeve 51, and the separation sleeve 51 guides the light liquid to the light liquid collecting shell 52, and then discharged through the light liquid outlet 53;
[0033] The mixture of S3, sediment and heavy liquid is introduced into the screw barrel 82 through the connecting pipe 7 and discharged through the material discharge port 84. The separation motor 83 rotates to drive the screw barrel 82 to rotate. The solid sediment is driven by the screw barrel 82 to move to the right end of the solid-liquid separator 8, and then discharged through the solid discharge port 86. The heavy liquid is discharged through the liquid discharge port 85 and finally enters the reflux pipe 9 and re-enters the liquid inlet pipe 3 under the action of the reflux pump 91.
[0034] In the above embodiments, the stirring motor 6, the reflux pump 91 and the separation motor 83 are all commercially available products. As long as they can achieve the functions of the utility model, those skilled in the art can choose to use them according to common sense, and no special limitation is made here.
Claims
1. A purification device for compound production, characterized in that: The centrifugal shell (1) comprises a centrifugal shell (1), a connecting pipe (7), and a reflux pipe (9); the top of the centrifugal shell (1) is rotatably connected to a stirring rod (2); the bottom of the centrifugal shell (1) is provided with a liquid inlet pipe (3); the top of the centrifugal shell (1) is provided with a heavy liquid separation mechanism (4) and a light liquid separation mechanism (5); the top of the light liquid separation mechanism (5) is fixedly connected to a stirring motor (6) for driving the stirring rod (2) to rotate; and the bottom side of the centrifugal shell (1) is fixedly connected to a solid-liquid separator (8) via the connecting pipe (7).
2. A purification device for compound production according to claim 1, characterized in that: The heavy liquid separation mechanism (4) comprises a heavy liquid collection shell (41), the heavy liquid collection shell (41) is fixedly connected to the outer wall of the centrifugal shell (1), and a heavy liquid outlet (42) is provided on the side of the heavy liquid collection shell (41).
3. A purification device for compound production as claimed in claim 2, characterized in that: The light liquid separation mechanism (5) comprises a separation sleeve (51), the separation sleeve (51) is located on the inner side of the heavy liquid collection shell (41), the top of the separation sleeve (51) is fixedly connected to the light liquid collection shell (52), the bottom of the light liquid collection shell (52) is fixedly connected to the heavy liquid collection shell (41), and a light liquid outlet (53) is provided on the left side of the light liquid collection shell (52).
4. A purification device for compound production as claimed in claim 1, characterized in that: The solid-liquid separator (8) comprises a shell (81), a screw barrel (82) is rotatably connected inside the shell (81), a separation motor (83) is fixedly connected to the left end of the shell (81) for driving the screw barrel (82) to rotate, the right end of the screw barrel (82) is fixedly connected to the connecting pipe (7), a material discharge port (84) is provided in the middle of the screw barrel (82), a liquid discharge port (85) is provided on the left side of the shell (81), the liquid discharge port (85) is fixedly connected to the reflux pipe (9), and a solid discharge port (86) is provided at the lower right side of the shell (81).
5. A purification device for compound production as claimed in claim 1, characterized in that: The lower left end of the solid-liquid separator (8) is fixedly connected to the liquid inlet pipeline (3) via the reflux pipe (9).