Biological reaction bag ventilation disc assembly and biological reaction bag

Abstract

The utility model provides a biological reaction bag ventilation disc assembly and a biological reaction bag, the ventilation disc assembly comprises a base plate and at least one first ventilation piece, the base plate is provided with second ventilation pieces, the number of the second ventilation pieces is matched with the number of the first ventilation pieces, the second ventilation pieces are provided with ventilation holes, and the ventilation holes are communicated with the first ventilation pieces. The ventilation hole penetrates through the second ventilation piece in the height direction of the second ventilation piece; the first ventilation piece is arranged above the second ventilation piece, and at least one through hole is formed in the height direction of the first ventilation piece; the through hole is communicated with the ventilation hole, and the first ventilation piece is detachably connected to the second ventilation piece. The ventilation disc assembly is simpler in the initial installation process, meanwhile, when the first ventilation piece is blocked in the use process, replacement is more convenient, maintenance is simpler, and the maintenance cost is reduced.

Description

Technical Field

[0001] The utility model relates to the field of bioreactor bags, in particular to a bioreactor bag ventilation disc component and a bioreactor bag. Background Art

[0002] In the field of bioreactor bags, the ventilation disc assembly can introduce external air or oxygen into the bioreactor bag to provide the necessary oxygen for biological cell culture. At the same time, it can also help to discharge carbon dioxide or other gases produced during cell culture to maintain the gas balance in the reaction bag. By controlling the ventilation volume and ventilation method, the ventilation disc assembly helps to maintain the stability of environmental parameters such as temperature and pH value in the bioreactor bag, creating a suitable environment for biological reactions, and plays a vital role in the biological reaction process.

[0003] The existing vent plate assembly includes a chassis and a vent member. The chassis and the vent member are mostly fixedly connected, the installation process is relatively complicated, and it is not easy to replace the vent member. Utility Model Content

[0004] The first purpose of the utility model is to provide a bioreactor bag ventilation disc assembly, which is used to solve the problems of complex installation of existing ventilation disc assemblies and difficulty in replacing ventilation parts.

[0005] The second object of the utility model is to provide a bioreactor bag, comprising the above-mentioned bioreactor bag ventilation disc assembly.

[0006] In order to achieve the above-mentioned first purpose, the utility model provides a bioreactor bag vent tray assembly, which includes a chassis and at least one first ventilator, a second ventilator is arranged on the chassis, the number of the second ventilators matches the number of the first ventilators, the second ventilator is provided with vent holes, and the vent holes penetrate the second ventilator in the height direction of the second ventilator; the first ventilator is arranged above the second ventilator, and at least one through hole is arranged in the height direction of the first ventilator; the through hole is connected to the ventilator, and the first ventilator is detachably connected to the second ventilator. The vent hole can be connected to an external air source.

[0007] It can be seen from the above scheme that the connection between the through hole and the vent hole ensures the effective circulation of gas, and the first vent member can be detachably connected to the second vent member, making the vent disc assembly simpler during the initial installation process. At the same time, when the first vent member is blocked during use, replacement is more convenient, maintenance is simpler, and maintenance costs are reduced.

[0008] A further solution is that the inner wall of the second ventilator is circumferentially provided with internal threads, one end of the first ventilator is provided with external threads matching the internal threads, and the first ventilator is detachably mounted on the second ventilator via the matching external threads and internal threads.

[0009] It can be seen from the above solution that by rotatably installing and fixing the first ventilator on the second ventilator, the fixing method is simple and the fixing is stable.

[0010] A further solution is that the vent disc assembly also includes a sleeve, a protrusion is provided on the second vent piece, the protrusion is provided with a through hole in the height direction, the through hole is connected with the vent hole, the first vent hole is located above the protrusion, the sleeve is sleeved outside the first vent hole and the protrusion, the sleeve and the first vent piece, the protrusion and the sleeve are all interference fit, and the through hole, the through hole and the vent hole are connected.

[0011] It can be seen from the above scheme that the protrusion is fixedly arranged on the second ventilator, and the sleeve and the first ventilator, as well as the protrusion of the second ventilator and the sleeve are interference fit, which ensures the stability and efficiency of the installation.

[0012] A further solution is that the sleeve is fixedly connected to the outside of the protruding member.

[0013] It can be seen from the above solution that the fixed arrangement of the sleeve makes the installation and removal of the first ventilation member faster and more convenient.

[0014] A further solution is that part of the first ventilator extends out of the sleeve, and part of the protruding member is inserted into the sleeve.

[0015] It can be seen from the above solution that part of the first ventilator extends out of the sleeve, which is convenient for replacement.

[0016] A further solution is that the first ventilation member is a PE sintered rod, and the through hole penetrates the PE sintered rod in the height direction.

[0017] A further solution is that the first ventilation piece is a PE sintered rod with an opening on one side and a hollow interior, the opening is close to the second ventilation piece, and the through hole penetrates the wall of the PE sintered rod away from the second ventilation piece.

[0018] It can be seen from the above scheme that the venting parts made of PE material have lower cost, are more in line with the safety of related drugs, can be used in reactions under various conditions, and have a wider range of applications.

[0019] A further solution is that there are multiple second ventilation members, and the multiple second ventilation members are evenly distributed along the circumference of the chassis.

[0020] It can be seen from the above scheme that the above arrangement makes the gas flow smoother.

[0021] In order to achieve the above second purpose, the utility model provides a bioreactor bag, which is provided with a bioreactor bag ventilation plate assembly as described in any one of the above, the bottom plate is fixedly connected to the bioreactor bag, and the first ventilation piece is located in the bioreactor bag.

[0022] A further solution is that a connection portion is provided on one surface of the chassis outside the bioreactor bag, the connection portion is detachably connected to an external air supply pipe, and the vent hole is communicated with the air supply pipe.

[0023] It can be seen from the above solution that the setting of the connecting part ensures the effective circulation of gas. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 1 is a structural diagram of the ventilation plate assembly of the bioreactor bag according to the first embodiment.

[0025] Figure 2 FIG. 1 is an exploded view of the ventilation plate assembly of the bioreactor bag of the first embodiment.

[0026] Figure 3 FIG. 4 is a cross-sectional view of the vent plate assembly of the bioreactor bag according to the first embodiment.

[0027] Figure 4 yes Figure 3 Enlarged view of point A in the middle.

[0028] Figure 5 Schematic diagram of the structure of the bioreactor bag of the second embodiment.

[0029] Figure 6 FIG. 4 is an exploded view of a bioreactor bag ventilation plate assembly according to the second embodiment.

[0030] Figure 7 2 is a structural diagram of a breather assembly according to a second embodiment.

[0031] The present invention will be further described below with reference to the accompanying drawings and embodiments. DETAILED DESCRIPTION

[0032] The utility model provides a bioreactor bag ventilation tray assembly, including a chassis and at least one first ventilation member, a second ventilation member is arranged on the chassis, the number of the second ventilation members matches the number of the first ventilation members, the second ventilation member is provided with ventilation holes that can be connected to an external air source, and the ventilation holes penetrate the second ventilation member in the height direction of the second ventilation member. The first ventilation member is arranged above the second ventilation member, and at least one through hole is arranged in the height direction of the first ventilation member; the through hole is connected to the ventilation hole, and the first ventilation member can be detachably connected to the second ventilation member. The following is a specific description in conjunction with the embodiment.

[0033] First embodiment

[0034] See also Figures 1 to 4The bioreactor bag venting tray assembly of this embodiment includes a first venting member 1, a sleeve 2 and a bottom plate 3. The bottom plate 3 is provided with second venting members 31, and the number of the second venting members 31 is the same as the number of the first venting members 1. In this embodiment, the number of the second venting members 31 is eight, and the second venting members 31 are evenly distributed along the circumference of the bottom plate 3.

[0035] The second ventilator 31 is provided with a vent hole 314 connected to an external air source, and the vent hole 314 penetrates the second ventilator 31 in the height direction of the second ventilator 31. The protrusion 311 is fixedly provided above the second ventilator 31. In this embodiment, the protrusion 311 and the second ventilator 31 are integrally formed. A through hole 315 is provided in the height direction of the protrusion 311, and the through hole 315 is connected to the vent hole 314. The outer diameter of the end of the protrusion 311 away from the second ventilator 31 is larger than the end of the protrusion 311 close to the second ventilator 31. In this embodiment, the end of the protrusion 311 away from the second ventilator 31 is provided with a first truncated cone 312, and the side with a larger surface area of ​​the first truncated cone 312 is close to the bottom plate of the second ventilator 31.

[0036] The first ventilator 1 is arranged above the protruding member 311, and the sleeve 2 is sleeved outside the first ventilator 1 and the protruding member 311. The sleeve 2 and the protruding member 311, and the second ventilator 31 and the sleeve 2 are all interference fit. Part of the first ventilator 1 extends out of the sleeve 2, and part of the protruding member 311 is inserted into the sleeve 2. The sleeve 2 can be detachably connected to the outside of the protruding member 311, or can be fixedly arranged outside the protruding member 311. In this embodiment, the sleeve 2 is fixedly arranged outside the protruding member 311, so that the installation of the first ventilator 1 is more convenient.

[0037] In this embodiment, the first ventilation piece 1 is a PE sintered rod with an opening on one side and a hollow interior. The open side of the first ventilation piece 1 is close to the protruding piece 311. A through hole 12 is provided on a side wall of the first ventilation piece 1 away from the protruding piece 311. The through hole 12 is arranged along the height of the first ventilation piece 1. In this embodiment, there are multiple through holes 12, which are evenly arranged on a side wall of the first ventilation piece 1 away from the protruding piece 311. The through hole 12 is connected to the through hole 315.

[0038] The first ventilator 1 is provided with a boss 11 at one end close to the protrusion 311. The outer diameter of the boss 11 is larger than the outer diameter of the first ventilator 1 where the boss 11 is not provided. The boss 11 is integrally formed with the first ventilator 1. In this embodiment, the boss 11 is truncated.

[0039] The bioreactor bag venting disk assembly of this embodiment is arranged in the bioreactor bag, and the specific chassis 3 is welded to the bottom surface of the bioreactor bag body or the bottom surface of the bioreactor bag is partially welded to the chassis 3. The chassis 3 is made of a polymer material with biocompatibility, and the first ventilator 1 and the second ventilator 31 are located in the bioreactor bag. The chassis 3 is provided with a connection part 313 on one side outside the bioreactor bag, and the connection part 313 is detachably connected to an external gas supply pipe (not shown in the figure), and the vent hole 314 is connected to the gas supply pipe to achieve effective gas transportation.

[0040] In this embodiment, by setting the protrusion 311 and the sleeve 2 to be fixedly connected, only the first ventilator 1 can be removed, and the detachable connection between the first ventilator 1 and the second ventilator 31 can be effectively realized. The communication between the through hole 12 and the vent hole 314 and the through hole 315 ensures the effective circulation of gas. The first ventilator 1 can be detachably installed on the second ventilator 31, making the ventilation plate simpler in the initial installation process. At the same time, when the first ventilator 1 is blocked during use, it is more convenient to replace and simpler to repair, reducing maintenance costs. The sleeve 2 and the first ventilator 1, and the protrusion 311 and the sleeve 2 are all interference fit, ensuring the stability and efficiency of the installation.

[0041] Second embodiment

[0042] See also Figures 5 to 7 The bottom surface of the bioreactor bag 6 provided in this embodiment is provided with a bioreactor bag venting plate assembly, and the venting plate assembly includes a bottom plate 5 and a first venting member 4. A second venting member 51 is provided on the bottom plate 5, and the number of the second venting member 51 is at least one. In this embodiment, the number of the second venting members 51 is eight, and the second venting members 51 are evenly arranged along the circumference of the bottom plate 5.

[0043] The second ventilator 51 is provided with a vent hole 512 communicating with an external air source, and the vent hole 512 penetrates the second ventilator 51 in the height direction of the second ventilator 51. The inner wall of the second ventilator 51 is provided with an internal thread 511 in the circumferential direction.

[0044] The first ventilator 4 is disposed above the second ventilator 51. A through hole 42 is disposed in the height direction of the first ventilator 4, and the through hole 42 is communicated with the ventilator 512. An external thread 41 matching the internal thread 511 is disposed at one end of the first ventilator 4. The first ventilator 4 is detachably mounted on the second ventilator 51 through the matching external thread 41 and internal thread 511.

[0045] In this embodiment, the vent is a PE sintered rod, the through hole 42 penetrates the PE sintered rod in the height direction, and the PE sintered rod complies with biopharmaceutical safety.

[0046] The chassis 5 is welded to the bottom surface of the bioreactor bag 6 or the bottom surface of the bioreactor bag 6 is partially welded to the chassis 5. The chassis 5 is made of a biocompatible polymer material. The first ventilator 4 and the second ventilator 51 are located in the bioreactor bag 6. A connecting portion 52 is provided on one side of the chassis 5 located outside the bioreactor bag. The connecting portion 52 is detachably connected to an external gas supply pipe (not shown in the figure), and the vent hole 512 is connected to the gas supply pipe to achieve effective gas transportation.

[0047] In this embodiment, the first vent 4 is detachably mounted on the second vent 51 by matching the external thread 41 and the internal thread 511. The communication between the through hole 12 and the vent hole 314 ensures the effective flow of gas, making the vent disc assembly simpler in the initial installation process. At the same time, when the first vent 4 is blocked during use, replacement is more convenient, maintenance is simpler, and maintenance costs are reduced. The first vent 4 made of PE material is more suitable for the pharmaceutical industry and can be used in reactions under various conditions, with a wider range of applications.

[0048] The above embodiments are only preferred examples of the present invention and are not intended to limit the scope of implementation of the present invention. Therefore, any equivalent changes or modifications made based on the structure, features and principles of the present invention should be included in the scope of the present invention patent application.

Claims

1. A bioreactor bag vent tray assembly, the vent tray assembly comprising a base and at least one first vent member, characterized in that: The chassis is provided with a second ventilator, the number of the second ventilators matches the number of the first ventilators, the second ventilator is provided with vent holes, and the vent holes penetrate the second ventilator in the height direction of the second ventilator; The first ventilator is arranged above the second ventilator, and at least one through hole is arranged in the height direction of the first ventilator; The through hole is communicated with the vent hole, and the first vent piece is detachably connected to the second vent piece.

2. A bioreactor bag venting disc assembly as claimed in claim 1, characterized in that: The inner wall of the second ventilator is circumferentially provided with internal threads, one end of the first ventilator is provided with external threads matching the internal threads, and the first ventilator is detachably mounted on the second ventilator through the matching external threads and the internal threads.

3. A bioreactor bag venting disc assembly as claimed in claim 1, characterized in that: The vent disc assembly also includes a sleeve, a protrusion is provided on the second vent member, the protrusion is provided with a through hole in the height direction, the through hole is connected with the vent hole, the first vent member is located above the protrusion, the sleeve is sleeved outside the first vent member and the protrusion, the sleeve and the first vent member, the protrusion and the sleeve are all interference fit, and the through hole, the through hole and the vent hole are connected.

4. A bioreactor bag venting disc assembly as claimed in claim 3, characterized in that: The sleeve is fixedly connected to the outside of the protruding member.

5. A bioreactor bag venting disc assembly as claimed in claim 3, characterized in that: A portion of the first vent member protrudes from the sleeve, and a portion of the protruding member is inserted into the sleeve.

6. A bioreactor bag venting disc assembly according to any one of claims 1 to 5, characterized in that: The first ventilation member is a PE sintered rod, and the through hole penetrates the PE sintered rod in the height direction.

7. A bioreactor bag venting disc assembly as claimed in claim 6, characterized in that: The first ventilation piece is a PE sintered rod with an opening on one side and a hollow interior. The opening is close to the second ventilation piece, and the through hole penetrates the wall of the PE sintered rod away from the second ventilation piece.

8. A bioreactor bag venting disc assembly according to any one of claims 1 to 5, characterized in that: There are multiple second ventilators, and the multiple second ventilators are arranged along the circumference of the chassis.

9. A bioreactor bag, characterized in that: The bioreactor bag is provided with a bioreactor bag vent plate assembly according to any one of claims 1 to 8, the bottom plate is fixedly connected to the bioreactor bag, and the first vent is located in the bioreactor bag.

10. A bioreactor bag as claimed in claim 9, characterized in that: A connection portion is provided on a surface of the bottom plate outside the bioreactor bag. The connection portion is detachably connected to an external air supply pipe, and the air vent is communicated with the air supply pipe.

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