Cell incubator with artificial intelligence monitoring function

Abstract

A cell incubator with an artificial intelligence monitoring function is used for storing at least one specimen box and comprises an incubator body, an electron microscope, an intelligent control unit and a notification unit, and the cell incubator obtains a microscopic image of a specimen in the specimen box through the electron microscope and sends the microscopic image to the intelligent control unit. The intelligent control unit compares whether the microscopic images at different times meet a notification condition or not and generates a notification signal according to the comparison result, and the notification unit is used for receiving the notification signal and then sending out an alarm notification. Therefore, the intelligent control unit can automatically judge whether the microscopic image meets a notification condition or not and send out the alarm notice according to the microscopic image, the opening frequency of the box door can be reduced, the growth state of cells in the detected body can be automatically and continuously monitored, the working hours of workers are reduced, and the requirement for automatically culturing the cells is met.

Description

Technical Field

[0001] The utility model relates to a cell culture box, in particular to a cell culture box with artificial intelligence monitoring. Background Art

[0002] The cell culture incubator has a cabin space isolated from the outside world. The cell culture incubator is to maintain a constant temperature and humidity in the cabin space for cell culture. And for the convenience of use, the cabin space usually has layered spaces, which can store specimen boxes in layers. The specimen boxes are used to store specimens to be cultured.

[0003] The specimen is collected from the human body or animals, and the specimen can be blood, urine, body fluids, feces, secretions, etc. When a doctor suspects that a patient is infected with a specific type of bacteria or a person undergoing a health check-up needs routine examination, the collected specimen will be placed in a cell culture incubator for cell culture. When the specimen contains infected bacteria, the specimen that has been cultured can easily detect the presence of bacteria, thus determining whether the patient is infected with a specific type of bacteria.

[0004] In addition, in genetic engineering experiments, cell culture is a very important part of the process, which allows specific cells to be increased to facilitate subsequent experiments.

[0005] In order to avoid interference from bacteria in the environment, the cell culture incubator needs to be sterilized as long as the cabin space has been opened during cell culture. For experiments with high uncertainty, in order to grasp the progress and changes of cell culture at the first time, the cabin space will be opened quite a lot, so not only the sterilization cost is high, but also a large number of man-hours are used, and there is room for improvement. Utility Model Content

[0006] The main purpose of the utility model is to disclose a cell culture box with artificial intelligence monitoring, which can reduce the number of times the cell culture box is opened and can continuously monitor the specimen.

[0007] To achieve the above-mentioned purpose, the utility model is a cell culture box with artificial intelligence monitoring, for storing at least one specimen box, including an incubator, an electron microscope, an intelligent control unit, a display unit and a notification unit; wherein the incubator has a cabin space, an opening, a door and a plurality of layers, the opening is connected to the cabin space, the door closes the opening, the plurality of layers are arranged in the cabin space, and divide the cabin space to form a plurality of layered spaces, the plurality of layered spaces can place the at least one specimen box. The electron microscope is arranged on any of the plurality of layered spaces, and the electron microscope has an observation position and a camera lens, the observation position is for placing the specimen box, and the camera lens is aligned with the observation position.

[0008] The intelligent control unit is connected to and controls the electron microscope, and performs an image capture operation on the specimen box placed at the observation position through the photographic lens to obtain a microscopic image of a specimen in the specimen box, and the intelligent control unit compares the microscopic images at different times to see whether they meet a notification condition, and after the notification condition is met, the intelligent control unit generates a notification signal. The display unit is arranged outside the incubator, and is connected to the intelligent control unit, and displays the microscopic image. The notification unit is connected to the intelligent control unit, and sends an alarm notification after receiving the notification signal.

[0009] In one embodiment of the present invention, it further comprises at least one isolation storage box capable of being placed in the layered space, and the at least one isolation storage box is used to place the at least one specimen box.

[0010] In an embodiment of the present invention, the electron microscope is disposed at the bottom layer of the plurality of layered spaces.

[0011] In one embodiment of the present invention, a layer box adjacent to the electron microscope is disposed at the bottom layer of the plurality of layered spaces, and the layer box has a top surface adjacent to and at the same height as the observation position.

[0012] In one embodiment of the present invention, a temperature and humidity regulator connected to the intelligent control unit is arranged in the layer box.

[0013] In one embodiment of the present invention, the electron microscope has a light source directed toward the observation position.

[0014] In an embodiment of the present invention, the light source is disposed below the observation position.

[0015] In an embodiment of the present invention, the display unit is fixed on the incubator via an adjustment rod.

[0016] In an embodiment of the present invention, the intelligent control unit is further wirelessly connected to a remote control device.

[0017] In one embodiment of the present invention, the incubator is provided with a plurality of moving wheels.

[0018] In summary, the cabin space of the utility model can be used to accommodate at least one specimen box, and the microscopic image of one of the specimens is obtained through the electron microscope, and the microscopic image is automatically judged by the intelligent control unit. When the notification conditions are met, such as changes in cell morphology, changes in culture medium color, changes in cell number count, etc., the intelligent control unit sends the notification signal to allow the notification unit to generate the alarm notification, thereby reducing the number of times the box door is opened, and automatically and continuously monitors the growth status of the cells in the specimen to reduce manpower hours. It is AI automated processing that meets the needs of automated cell culture. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 , is a schematic diagram of the overall appearance structure of the utility model;

[0020] Figure 2 , is a schematic diagram of the internal space structure of the utility model;

[0021] Figure 3 , is a schematic diagram of the implementation of the utility model;

[0022] Figure 4 , is a block diagram of the components of the utility model;

[0023] Figure 5 , is an artificial intelligence judgment flow chart of the intelligent control unit of the utility model. DETAILED DESCRIPTION

[0024] The detailed description and technical content of the utility model are now described as follows with reference to the accompanying drawings:

[0025] See also Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, the utility model is a cell culture box with artificial intelligence monitoring for storing at least one specimen box 10, including a culture box 20, an electron microscope 30, an intelligent control unit 40, a display unit 50 and a notification unit 60.

[0026] The incubator 20 has a cabin space 21, an opening 22, a door 23 and a plurality of shelves 24. The opening 22 is connected to the cabin space 21, and the door 23 closes the opening 22. The plurality of shelves 24 are arranged in the cabin space 21 and divide the cabin space 21 into a plurality of layered spaces 211. The plurality of layered spaces 211 can accommodate at least one specimen box 10.

[0027] like Figure 3As shown, in order to prevent the leakage of a single specimen box 10 from causing contamination of the entire cabin space 21, the utility model further comprises at least one isolation storage box 70, which can be placed in the layered space 211, and the at least one isolation storage box 70 is used to place the at least one specimen box 10. In order to facilitate the movement of the incubator 20, the incubator 20 can be provided with a plurality of moving wheels 80.

[0028] like Figure 2 and Figure 3 As shown, the electron microscope 30 is arranged on any one of the multiple layered spaces 211, and the electron microscope 30 has an observation position 31 and a photographic lens 32. The photographic lens 32 is suspended above the observation position 31 by a cantilever 33, and the cantilever 33 can be provided with a height adjustment mechanism (not shown) to adjust the relative distance between the photographic lens 32 and the observation position 31 for focusing. The observation position 31 is for placing the specimen box 10, and the photographic lens 32 is aligned with the observation position 31.

[0029] In one embodiment, the electron microscope 30 is disposed at the bottom layer of the multiple layered spaces 211, and a layer box 90 can be disposed at the bottom layer of the multiple layered spaces 211. The layer box 90 is adjacent to the electron microscope 30. The layer box 90 has a top surface 91, and the top surface 91 is adjacent to and at the same height as the observation position 31 to facilitate the placement of the specimen box 10.

[0030] A temperature and humidity regulator 92 may be disposed in the layer box 90 . The temperature and humidity regulator 92 is connected to the intelligent control unit 40 . The intelligent control unit 40 may adjust the temperature and humidity of the cabin space 21 through the temperature and humidity regulator 92 .

[0031] In one embodiment, the electron microscope 30 may have a light source 34, which is aimed at the observation position 31. The light source 34 may be visible light or invisible light, such as fluorescence, ultraviolet light, infrared light, etc.; and preferably, the light source 34 is arranged below the observation position 31, and the light source 34 is an adjustable light source that can adjust the appropriate brightness and spectrum (color) according to different specimens to achieve the best observation effect.

[0032] Please also refer to Figure 4 and Figure 5 As shown, Figure 5 This is a flowchart of artificial intelligence judgment of the utility model, which includes step S1: image capture, step S2: AI judgment and step S3: warning notification.

[0033] The intelligent control unit 40 is connected to and controls the electron microscope 30 to perform step S1: image capture. The intelligent control unit 40 performs an image capture operation on the specimen box 10 placed on the observation position 31 through the camera lens 32 to obtain a microscopic image of a specimen in the specimen box 10. In practice, one of the multiple specimen boxes 10 of the same batch number can be selected and placed on the observation position 31 as a representative of the same batch number. The display unit 50 is disposed outside the incubator 20 and connected to the intelligent control unit 40 to display the microscopic image. Preferably, the display unit 50 is fixed to the incubator 20 through an adjustment rod 51. The operator can freely adjust the position and viewing angle of the observation position 31 according to needs.

[0034] Then the intelligent control unit 40 performs step S2: AI judgment, the intelligent control unit 40 compares the microscopic images at different times to see whether a notification condition is satisfied. More specifically, the intelligent control unit 40 uses AI to judge whether the microscopic image of the specimen has abnormalities such as changes in cell morphology, changes in culture medium color, changes in cell quantity, etc. If so, it is judged that the notification condition is satisfied; and after the notification condition is satisfied, the intelligent control unit 40 generates a notification signal to perform step S3: alarm notification. If the notification condition is not satisfied, it returns to step S1 to continuously monitor the specimen in the specimen box 10.

[0035] Finally, the intelligent control unit 40 performs step S3: alarm notification, and the notification unit 60 is connected to the intelligent control unit 40. The intelligent control unit 40 uses the notification unit 60 to issue an alarm notification after receiving the notification signal. The alarm notification can be an alarm sound or a warning screen. If the alarm sound is issued by a speaker (not shown), or the warning screen can be displayed by the display unit 50.

[0036] In addition, the intelligent control unit 40 can be wirelessly connected to a remote control device 41, which can be a personal computer, a tablet or a smart phone, and can remotely receive the warning notification and receive and display the microscopic image, so that the operator can remotely know the warning notification in the first time and understand the condition of the specimen through the microscopic image. After completing step S3, the process returns to step S1 to continuously monitor the specimen in the specimen box 10.

[0037] Thus, the utility model is a cell culture box with artificial intelligence monitoring, having the following characteristics:

[0038] 1. The microscopic image of one of the specimens is obtained through the electron microscope, and the intelligent control unit automatically compares the microscopic images taken at different times. When the notification conditions are met, such as changes in cell morphology, culture medium color, cell number count, etc., the intelligent control unit sends the notification signal to allow the notification unit to generate the alarm notification, thereby reducing the number of times the door is opened.

[0039] 2. The microscopic image of one of the specimens can be automatically and continuously monitored to grasp the cell growth status in real time to reduce operator time. When the operator receives the alarm notification, the operator can properly dispose of the multiple specimen boxes of the same batch number.

[0040] 3. AI automated processing can meet the needs of automated cell culture.

[0041] 4. It can be monitored through a remote control device, and the condition of the specimen can be understood immediately.

Claims

1. A cell culture box with artificial intelligence monitoring for storing at least one specimen box, characterized in that: Included are: An incubator, the incubator comprising a cabin space, an opening communicating with the cabin space, a door closing the opening, and a plurality of layers arranged in the cabin space, the plurality of layers dividing the cabin space to form a plurality of layered spaces capable of placing the at least one specimen box; an electron microscope, the electron microscope being disposed on any one of the plurality of layered spaces, and the electron microscope having an observation position for placing the specimen box and a camera lens aligned with the observation position; an intelligent control unit connected to and controlling the electron microscope, performing an image capture operation on the specimen box placed at the observation position through the photographic lens to obtain a microscopic image of a specimen in the specimen box, and comparing the microscopic images at different times to see whether they meet a notification condition, and generating a notification signal when the notification condition is met; a display unit, which is disposed outside the incubator and connected to the intelligent control unit and displays the microscopic image; and A notification unit is connected to the intelligent control unit and sends out an alarm notification after receiving the notification signal.

2. A cell culture incubator with artificial intelligence monitoring according to claim 1, characterized in that: It also comprises at least one isolation storage box which can be placed in the layered space, and the at least one isolation storage box is used to place the at least one specimen box.

3. The cell culture incubator with artificial intelligence monitoring according to claim 1, characterized in that: The electron microscope is arranged at the bottom layer of the plurality of layered spaces.

4. A cell culture incubator with artificial intelligence monitoring according to claim 3, characterized in that: The bottom layer of the plurality of layered spaces is provided with a layer box adjacent to the electron microscope, and the layer box has a top surface adjacent to and at the same height as the observation position.

5. The cell culture incubator with artificial intelligence monitoring according to claim 4, characterized in that: A temperature and humidity regulator connected to the intelligent control unit is arranged in the layer box.

6. The cell culture incubator with artificial intelligence monitoring according to claim 1, characterized in that: The electron microscope has a light source directed toward the observation position.

7. A cell culture incubator with artificial intelligence monitoring according to claim 6, characterized in that: The light source is arranged below the observation position.

8. The cell culture incubator with artificial intelligence monitoring according to claim 1, characterized in that: The display unit is fixed on the incubator through an adjusting rod.

9. The cell culture incubator with artificial intelligence monitoring according to claim 1, characterized in that: The intelligent control unit is further wirelessly connected to a remote control device.

10. The cell culture incubator with artificial intelligence monitoring according to claim 1, characterized in that: The incubator is provided with a plurality of moving wheels.

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