Reagent container storage device, reagent interaction module, sample analyzer and system

Abstract

The utility model provides a reagent container storage device which comprises a reagent container containing box and a storage chamber internally provided with a containing space. The reagent container accommodating box comprises a reagent puncturing part; the storage chamber is provided with an assembly opening, and a reagent needle is fixed in the accommodating space; the reagent container accommodating box and the storage chamber are assembled and combined in a drawer manner; the reagent container containing box is loaded into the containing space from the assembling opening in the first direction or withdrawn from the containing space in the reverse direction, and the reagent needle is punctured or drawn out from the reagent puncturing part. The utility model also provides a reagent interaction module, a sample analyzer and a sample analysis system. According to the scheme, the reagent container containing box and the containing space of the storage chamber are pushed in or withdrawn in a drawer combination mode, when the reagent container containing box is pushed in or withdrawn, the reagent needle and the reagent puncture part are punctured or drawn out synchronously, reagent interaction and replacement are easier and more convenient, the distance between the position of the reagent needle and an assembly opening is far, and the reagent needle is not prone to falling off. The replacement process is safe.

Description

Technical Field

[0001] The utility model relates to the technical field of blood analysis, in particular to a reagent container storage device, a reagent interaction module, a sample analyzer and a system. Background Art

[0002] A hemocytometer is a medical device used to detect the number and type of white blood cells in the blood. It measures indicators such as the number of white blood cells, the type of white blood cells, and the platelet count in the blood. The important reagents used in conjunction with the hemocytometer for testing include fluorescent dye reagents, which contain a fluorescent dye that can bind to certain proteins or molecules in the blood to enhance its fluorescent signal. This reagent can improve the detection sensitivity and accuracy of the hemocytometer and help doctors diagnose and treat diseases more accurately. However, fluorescent dye reagents are toxic, and human hands cannot touch the reagents directly; and some manufacturers' reagents cannot be exposed to air. When using the fluorescent dye reagents of the hemocytometer, it is necessary to follow the correct operating steps and instructions for use to minimize the harm to the human body. However, the current replacement process of the fluorescent dye reagent is cumbersome, and it is easy to touch the reagent if you are not careful. The reagent bag is soft, and when it is assembled by hand, it will either contaminate the reagent or touch the reagent and harm the human body.

[0003] For example, in some technical solutions, an aluminum foil bag is used. The aluminum foil bag is located on the front of the face shell, which is flipped open. The reagent is contained in the aluminum foil bag, which is hung on the sheet metal bracket through a nozzle. The aluminum foil bag needs to be held and touch the nozzle and the cover. The cover and the sheet metal bracket are manually rotated to clamp or remove and replace. After fixing, the steel needle of the connecting pipeline is inserted into the nozzle of the aluminum foil bag downwards, and finally the face shell is covered. The reagent replacement process will contact the bag opening area. The steel needle punctures from the bag opening area, and the reagent is easily contaminated. If there is a slight leak in the bag opening area, it will come into contact with human hands and endanger the human body.

[0004] For example, in some other technical solutions, reagent bottles are used, but a needle is needed to be manually used to puncture the seal of the reagent bottle mouth, or a mechanism is used to assist a sliding needle to puncture the seal of the reagent bottle mouth. There is a possibility of error in puncturing the seal of the reagent bottle mouth, and the puncture needle may prick the hand, endangering the body and contaminating the reagent.

[0005] In the current various models, the replacement of reagents involves many and complicated steps, and there is a risk of human contact with the reagents. Therefore, there is an urgent need for a replacement structure that is both safe and simple and convenient in the reagent replacement process. Summary of the invention

[0006] In view of the above-mentioned shortcomings of the prior art, the purpose of the present invention is to:

[0007] In a first aspect, a reagent container storage device is provided, which mainly comprises:

[0008] A reagent container accommodating box, wherein the reagent container accommodating box is provided with an accommodating cavity for accommodating the reagent container;

[0009] A storage chamber, wherein at least one accommodating space is provided inside the storage chamber, an assembly opening is opened in the storage chamber, and a reagent needle is fixed in the accommodating space;

[0010] The reagent container accommodating box is movably mounted in the storage chamber and extends into the accommodating space along a first direction;

[0011] The storage chamber has a locking position and an unlocking position. When the reagent container accommodating box is located in the locking position, the reagent needle is connected to the reagent container; when the reagent container accommodating box is located in the unlocking position, the reagent needle is separated from the reagent container.

[0012] In combination with the first aspect, in some implementations, the storage chamber further has a replacement position, and when the reagent container accommodating box is located at the replacement position, the reagent container is loaded or removed.

[0013] In combination with the first aspect, in some implementations, the reagent container accommodating box includes a positioning structure, and a fixing structure is provided on the reagent container corresponding to the positioning structure, and the fixing structure cooperates with the positioning structure to position and fix the reagent container in the accommodating cavity.

[0014] In combination with the first aspect, in some implementations, the positioning structure is a U-shaped card interface, the fixing structure is inserted into the U-shaped card interface, and the fixing structure is limited in the first direction.

[0015] In combination with the first aspect, in some implementations, the accommodating cavity of the reagent container accommodating box has an opening for loading or removing the reagent container in the second direction, and the second direction is perpendicular to the first direction.

[0016] In combination with the first aspect, in some implementations, a guide groove is provided in the storage space for directionally guiding the reagent container storage box to be loaded into or out of the storage space, and the guide groove extends along the first direction. A guide seat is also provided at the bottom of the reagent container storage box, and the guide seat is provided with a sliding shaft for cooperating with the guide groove and sliding in a direction, and the sliding shaft is arranged near the front end of the guide seat.

[0017] In combination with the first aspect, in some implementations, a first mark is provided on a side of the reagent container storage box away from the positioning structure. The reagent container storage box also includes a refrigeration module for controlling the reagent in the reagent container within a preset temperature range.

[0018] In combination with the first aspect, in some implementations, the storage chamber includes at least three storage spaces, and each of the storage spaces corresponds to installing one of the reagent container storage boxes.

[0019] In combination with the first aspect, in some implementations, the reagent container accommodating box is in the storage chamber, and is switched between the locked position and the unlocked position by pressing the reagent container accommodating box.

[0020] In combination with the first aspect, in some implementations, a locking tongue unit is further provided in the storage chamber, the reagent container storage box is provided with a locking unit that cooperates with the locking tongue unit, and the locking tongue unit provides a first elastic force to the locking unit;

[0021] When the reagent container storage box is pressed, the locking tongue unit is connected to the locking unit through a first elastic force, and the reagent container storage box is in a locked position; when the reagent container storage box is pressed to provide a force to overcome the first elastic force, the connection between the locking tongue unit and the locking unit is released, and the reagent container storage box is in an unlocked position.

[0022] In combination with the first aspect, in some implementations, a movable locking chamber is provided below the accommodating space, and the locking tongue unit is provided in the movable locking chamber. The locking tongue unit includes a base, a protrusion provided on the base, and an elastic portion connected to the protrusion. One end of the elastic portion is fixed to the protrusion, and the other end is extended in a first direction. When the elastic portion is subjected to a downward extrusion force, it provides the first upward elastic force. When the reagent container accommodating box is loaded into the locking position in the storage chamber, the elastic portion is connected to the locking unit under the action of the first elastic force; the protrusion abuts against the reagent container accommodating box for positioning.

[0023] In combination with the first aspect, in some implementations, the base is arranged to slide back and forth in the first direction, a draw hook and a first elastic element are provided in the storage chamber, the draw hook tail is fixed in the first direction, the draw hook head hooks the base in an initial position or a locking position along the first direction, and the first elastic element provides a reset elastic force to the base in the opposite direction of the first direction;

[0024] The reagent container storage box is loaded into the storage chamber and pushes the base to move to the locking position along the first direction, the head of the hook moves from the initial position of the base to the locking position and hooks the locking position, and the reset elastic force of the hook is balanced with that of the first elastic element; the reagent container storage box is unlocked and exits the locking position along the first direction, the head of the hook is unhooked from the locking position and moves to the initial position under the action of the reset elastic force of the first elastic element, and the base pushes the reagent container storage box to pop out from the locking position.

[0025] In combination with the first aspect, in some implementations, the initial position and the locking position are connected by a first slide and a second slide, the first slide and the second slide are connected end to end, the head of the hook moves from the initial position to the locking position along the first slide and is limited at a fixed point in the locking position, and moves from the locking position to the initial position along the second slide and is limited at a fixed point in the initial position.

[0026] In combination with the first aspect, in some implementations, along the moving direction of the head of the hook, the first slide and the second slide are divided into a first section, a second section, a third section and a fourth section in sequence, the connection between the first section and the second section serves as a first turning point for guiding the head of the hook to move to the second section, the second section and the third section are combined to form a "V"-shaped slide, the bending portion of the "V"-shaped slide serves as the locking position, the connection between the third section and the fourth section serves as a second turning point for guiding the head of the hook to move to the fourth section; the starting end of the first section and the ending end of the fourth section converge as the starting position.

[0027] In combination with the first aspect, in some implementations, from the starting end of the first section to the bending portion, the depth of the first slide first decreases and then increases after reaching the first inflection point; from the bending portion to the end end of the fourth section, the depth of the second slide first decreases and then increases after reaching the second inflection point.

[0028] In combination with the first aspect, in some implementations, the curved portion of the "V"-shaped slide includes a locking portion recessed in the side wall and a guiding portion protruding out of the side wall, and when the hook is in the locking position, the head of the hook hooks the locking portion, the head of the hook exits the locking portion, and the guiding portion guides the head of the hook to deviate toward the third section.

[0029] In combination with the first aspect, in some implementations, a support partition for supporting the reagent container storage box is provided between the motion locking chamber and the storage space, and a guide hole extending along the first direction is opened on the support partition, and the base cooperates with the guide hole through the protrusion and is arranged to slide back and forth in the first direction.

[0030] In combination with the first aspect, in some implementations, a guide rail extending along a first direction is provided on the lower side of the supporting partition, a directional sliding groove is provided on the base, and the base slides in cooperation with the guide rail through the directional sliding groove.

[0031] In combination with the first aspect, in some implementations, a second elastic element is disposed below the base, the second elastic element provides a second elastic force to the hook, and the second elastic force pushes the hook toward the base.

[0032] In combination with the first aspect, in some implementations, the support baffle extends to the assembly opening, and the support baffle is provided with a guide slope at the assembly opening.

[0033] In combination with the first aspect, in some implementations, a micro switch is provided in the motion locking chamber for determining whether the reagent container housing box is loaded into a locking position.

[0034] In combination with the first aspect, in some implementations, a plurality of ribs are provided on the inner wall of the accommodating space, the ribs are extended along a first direction, and the plurality of ribs are evenly distributed in parallel in a direction perpendicular to the first direction.

[0035] In combination with the first aspect, in some implementations, a guide groove is provided in the storage space for directionally guiding the reagent container storage box to be loaded into or out of the storage space, and the guide groove extends along the first direction. A guide seat is also provided at the bottom of the reagent container storage box, and the guide seat is provided with a sliding shaft for cooperating with the guide groove and sliding in a direction, and the sliding shaft is arranged near the front end of the guide seat, and the locking unit includes a locking hole arranged on the guide seat.

[0036] In combination with the first aspect, in some implementations, the reagent container includes a reagent bottle or a reagent bag.

[0037] In combination with the first aspect, in some implementations, the reagent container includes a container for accommodating a latex reagent, a hemolysis reagent, a dilution reagent, and a fluorescent reagent.

[0038] In combination with the first aspect, in some implementations, the reagent container further includes a refrigeration module for controlling the reagent in the reagent container within a preset temperature range.

[0039] In the second aspect, a reagent container is provided, the key of which is that it includes a suction nozzle and a body, the suction nozzle is provided with a reagent puncture part for reagent needle puncture, the neck of the suction nozzle is provided with a fixing structure for cooperating and fixing with the reagent container box, the fixing structure includes a front limit block, a rear limit block and a connecting block connected between the front limit block and the rear limit block, and the front limit block, the rear limit block and the connecting block are combined to form an I-shape.

[0040] In combination with the second aspect, in some implementations, the device body is provided with a liquid accumulation portion, the liquid accumulation portion is arranged close to the suction nozzle, and the suction nozzle and the liquid accumulation portion are both arranged at the bottom of the device body in the gravity direction.

[0041] In a third aspect, a reagent interaction module is provided, the key of which is that it includes a plurality of reagent container storage devices connected in parallel, and the reagent container storage device is the reagent container storage device described in any one of the implementation methods of the first aspect.

[0042] In combination with the third aspect, in some implementations, a gap covering plate is provided on the surface where the assembly port of the reagent container storage device is located, and the gap covering plate connects the reagent container storage devices and blocks the gaps between the reagent container storage devices. The gap covering plate is provided with assembly holes corresponding to the assembly port of each reagent container storage device.

[0043] In combination with the third aspect, in some implementations, an electronic tag card and an antenna card are provided on the rear side surface away from the surface where the assembly port of the reagent container storage device is located.

[0044] In combination with the third aspect, in some implementations, a mounting plate is fixedly provided on the bottom surface of the reagent interaction module.

[0045] In a fourth aspect, a sample analyzer is provided, the key of which is that it includes the reagent interaction module described in any implementation of the fourth aspect.

[0046] In a fifth aspect, a sample analysis system is provided, the key of which is to include:

[0047] A detection subsystem, wherein the detection subsystem comprises a reaction cell;

[0048] A reagent container storage device, wherein the reagent container storage device is the reagent container storage device in any one of the implementations of the first aspect, wherein at least two accommodating spaces are provided inside the storage chamber, and the reagent container accommodating box is arranged one-to-one with the accommodating spaces;

[0049] The reagent management subsystem is used to control the supply of reagents and the loading and / or replacement of reagent containers.

[0050] In conjunction with the fifth aspect, in some implementations, the sample analysis system further includes an information reading module for reading information of the reagent container housing box.

[0051] In conjunction with the fifth aspect, in some implementations, the information reading module includes an information reading unit, which can simultaneously read the information of multiple reagent container boxes; the reagent management subsystem is communicatively connected to the information reading module.

[0052] In combination with the fifth aspect, in some implementations, the information reading module includes a plurality of information reading units, the information reading units are arranged one-to-one with the reagent container holding box, and the reagent management subsystem is communicatively connected with the information reading module.

[0053] In combination with the fifth aspect, in some implementations, upon receiving a reagent loading and / or reagent replacement instruction, the reagent management subsystem controls the information reading unit to start information reading.

[0054] As described above, the reagent container storage device and sample analysis system of the present invention have at least the following beneficial effects:

[0055] In the reagent container storage device, the reagent container box and the storage chamber are pushed in or out in the form of a drawer combination. The reagent container box can be locked in the locking position and unlocked in the unlocking position of the storage chamber. When the reagent container box is pushed in to lock or pulled out to unlock, the reagent needle and the reagent container are connected or separated synchronously. The loading or replacement operation of the reagent container box is carried out synchronously with the connection or separation operation of the reagent needle, making reagent loading or replacement easier and more convenient, and the replacement process safer.

[0056] In the sample analysis system, the detection subsystem is used for the reaction application between reagents and samples. Based on the reagent container storage device, when the reagent needs to be actively loaded or replaced with a new reagent, the reagent management subsystem can detect whether the reagent needs to be loaded or replaced, and assist the reagent container storage device to confirm and identify the relevant information of the newly loaded or newly replaced reagent, thereby ensuring the successful loading or replacement of the reagent, and can further simplify the reagent loading or replacement operation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0057] Figure 1 It is a structural schematic diagram of a sample analyzer shown in an exemplary embodiment of the utility model;

[0058] Figure 2 It is a schematic structural diagram of a reagent interaction module from a front perspective shown in an exemplary embodiment of the present utility model;

[0059] Figure 3 A three-dimensional diagram of a reagent interaction module from a rear perspective shown in an exemplary embodiment of the present invention;

[0060] Figure 4 for Figure 2 Exploded diagram of

[0061] Figure 5 for Figure 4 An exploded view of the reagent container storage device;

[0062] Figure 6 for Figure 5 A schematic diagram of the structure of the middle lock tongue unit;

[0063] Figure 7 It is a schematic diagram of the assembly of the right housing and the reagent container accommodating box;

[0064] Figure 8 for Figure 7 Bottom view of

[0065] Figure 9-1 A schematic diagram of the relationship between the initial position and the locking position of the bottom viewing angle of the base and the position of the first slideway and the second slideway;

[0066] Figure 9-2 is a plan view of the first slide and the second slide;

[0067] Figure 9-3 Detailed structural diagrams of the first, second, third and fourth sections of the slide;

[0068] Figure 9-4 Detailed structural diagrams of the first, second, third and fourth sections of the slide;

[0069] Fig.10 for Figure 7 Stereoscopic image of

[0070] Fig.11 for Fig.10 Stereoscopic image from an upward angle;

[0071] Fig.12 A schematic diagram of the structure in the locking chamber for assembling the second elastic element;

[0072] Fig.13 It is a structural schematic diagram of the right shell;

[0073] Fig.14 It is a structural schematic diagram of the left shell;

[0074] Fig.15 A state change diagram of the reagent container accommodating box during the process of exiting the right shell;

[0075] Fig.16 is a schematic structural diagram of a reagent container accommodating box;

[0076] Fig.17 is an internal cross-sectional view of a reagent container housing box;

[0077] Fig.18 Schematic diagram of the structure of the reagent bag;

[0078] Fig.19 A three-dimensional diagram of a reagent container housing box and a guide seat assembly;

[0079] Fig. 20 for Fig.19 A three-dimensional view of the bottom surface of the middle guide seat;

[0080] Fig.21 A flow chart of a reagent loading method in a sample analyzer shown in an exemplary embodiment of the present invention

[0081] Fig. 22 A flow chart of a reagent replacement method in a sample analyzer shown in an exemplary embodiment of the present invention

[0082] Fig.23The present invention is a flowchart of a reagent replacement method in a sample analyzer according to another exemplary embodiment of the present invention.

[0083] The reference numerals are as follows:

[0084] Box 1, reagent interaction module 3, reagent container storage device 2, gap-covering plate 4, assembly hole 401, electronic label card 5, antenna card 6, installation plate 7,

[0085] Reagent container accommodating box 301, storage chamber 302, reagent puncture part 303, accommodating space 304, motion locking chamber 305, reagent needle 306, lock tongue unit 307, locking unit 308, retractor 309, first elastic element 310, supporting partition 311, micro switch 312, rib 313, guide groove 314, guide seat 315, slide shaft 316, positioning groove 317, guide plate 318,

[0086] The first direction is X, the second direction is Y,

[0087] The left shell 3021 and the right shell 3022,

[0088] Base 3071, protrusion 3072, elastic part 3073, limiting protrusion 3074, initial position 3001, locking position 3002, first slide 3003, second slide 3004, first section A, second section B, third section C, fourth section D, first inflection point M, second inflection point N, bending part E, locking part E1, guide part E2, first step 3005, second step 3006, third step 3007,

[0089] The guide hole 3111, the guide rail 3112, the sliding groove 3113, the second elastic element 3114, and the guide slope 3115,

[0090] Reagent container box 3011, reagent bag 3012,

[0091] The nozzle 3013, the body 3014, the fixing structure 3015, the front limit block 3151, the rear limit block 3152, the connecting block 3153, the electronic tag 3154, and the liquid accumulation part 3155,

[0092] The card slot 3016, the positioning structure 3017, and the panel 3018,

[0093] Bottom plate 3161 , side plate 3162 , guide ribs 3163 , device body card interface 3164 , guide opening 3165 , positioning hole 3166 , and inclined surface 317 . DETAILED DESCRIPTION

[0094] The following is an explanation of the implementation of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific implementations, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0095] It should be understood that the utility model can be implemented in different forms and should not be interpreted as being limited to the embodiments proposed herein. On the contrary, providing these embodiments will make the disclosure thorough and complete, and will fully convey the scope of the utility model to those skilled in the art.

[0096] In the first embodiment, a sample analyzer is provided, including a housing 1 and a reagent interaction module 3 arranged at a reagent assembly site on the front of the housing 1. The reagent interaction module 3 of the utility model includes a reagent container storage device 2, and the reagent container storage device 2 includes a storage chamber 302 with three accommodating spaces 304, and a reagent container accommodating box 301 arranged one-to-one with the accommodating spaces 304. In the specific implementation process, according to the specific sample detection needs, the accommodating spaces 304 can be appropriately increased or decreased, and the number of storage chambers 302 can also be increased.

[0097] In addition, in a second embodiment, a sample analyzer is provided, including a housing 1 and a reagent interaction module 3 disposed at a reagent assembly site on the front side of the housing 1. Different from the first embodiment, the reagent interaction module 3 of this embodiment may include three reagent container storage devices 2 arranged side by side, each of which includes a storage chamber 302 having a storage space 304 and a reagent container storage box 301 disposed one-to-one with the storage space 304.

[0098] The following is an extended description based on the second embodiment: Figure 1 This is a schematic diagram of the structure of a sample analyzer of the utility model; Figure 2 It is a schematic diagram of the structure of the reagent interaction module 3 of the present invention.

[0099] Please refer to the attached Figure 1 As shown, a sample analyzer includes a box 1 and a reagent interaction module 3 arranged at a reagent assembly site on the front side of the box 1. Figure 2 and 3As shown in Figure 4, the reagent interaction module 3 of the utility model includes three reagent container storage devices 2 connected side by side, and the front of the reagent container storage device 2 is provided with a gap-covering plate 4, which connects the reagent container storage devices 2 and blocks the gaps between the reagent container storage devices 2. The gap-covering plate 4 is provided with an assembly hole 401 corresponding to each reagent container storage device 2. The rear side of the reagent container storage device 2 is provided with an electronic tag card 5 and an antenna card 6. The bottom surface of the reagent interaction module 3 is fixedly provided with a mounting plate 7.

[0100] Please refer to the attached Figure 4 As shown: the reagent container storage device 2 includes a reagent container storage box 301 and a storage chamber 302. The reagent container storage box 301 is provided with a storage cavity, the storage cavity is used to position and fix the reagent container, and the reagent container is provided with a reagent puncture portion 303; a storage space 304 is provided inside the storage chamber 302, the storage chamber 302 is provided with an assembly port, and a reagent needle 306 is fixed in the storage space 304; the reagent container storage box 301 is movably installed in the storage chamber 302, specifically in a drawer-type assembly combination, and the storage chamber 302 has a locking position and an unlocking position; the reagent container storage box 301 is loaded into the storage space 304 from the assembly port along the first direction X, first passes through the unlocking position and then is assembled to the locking position, and in the locking position, the reagent needle 306 pierces from the reagent puncture portion 303 and connects with the reagent container. When the reagent container accommodating box 301 withdraws from the accommodating space 304 to the unlocking position from the assembly port along the reverse direction of the first direction X, the reagent needle 306 is separated from the reagent container. In the specific implementation process, as shown in the figure, the first direction X is the loading direction of the reagent container accommodating box 301, and is also the direction in which the reagent puncture portion 303 pushes against the reagent needle 306, ensuring that assembly and puncture are carried out simultaneously.

[0101] In some embodiments, Fig.15 As shown in Figure c, the storage chamber 302 also has a replacement position. When the reagent container holding box 301 is located at the replacement position, reagent containers can be loaded into or taken out of the reagent container holding box 301. At the replacement position, the reagent container holding box 301 is not completely separated from the storage chamber 302. Of course, in the specific implementation process, the storage chamber 302 may not have a replacement position, which is not shown in the figure, which is equivalent to the reagent container holding box 301 being able to completely withdraw from the storage chamber 302. In this way, after the actual container holding box is separated from the storage chamber 302, reagent containers can be loaded into or taken out of the reagent container holding box 301.

[0102] For specific implementation process, please refer to the attached Figure 5As shown, the storage chamber 302 is formed by a left shell 3021 and a right shell 3022 that are snapped together, and the accommodating space 304 is formed between the left shell 3021 and the right shell 3022. A motion locking chamber 305 is arranged at the lower part of the accommodating space 304, the assembly port is located at the front of the accommodating space 304, and the reagent needle 306 is arranged at the back of the accommodating space 304.

[0103] In some embodiments, Figure 5 As shown, the reagent container storage box 301 includes a positioning structure 3017, and a fixing structure 3015 is provided on the reagent container corresponding to the positioning structure 3017. The fixing structure 3015 cooperates with the positioning structure 3017 to position and fix the reagent container in the storage cavity. In the specific implementation process, the positioning structure 3017 is a U-shaped card interface, and the fixing structure 3015 is inserted into the U-shaped card interface, and the fixing structure 3015 is limited in the first direction. The storage cavity of the reagent container storage box 301 is provided with an opening, and the opening is used to load or reversely remove the reagent container along the second direction, and the second direction is perpendicular to the first direction.

[0104] In the specific implementation process, Fig.19 As shown, the reagent container storage box 301 specifically includes a bottom plate 3161 on the bottom side, side plates 3162 arranged on both sides of the bottom plate 3161, and a panel 3018 away from the positioning structure 3017. The reagent container storage box 301 is designed for the reagent bag 3012, and the opening is arranged on the top side. The positioning structure 3017 and the panel 3018 are respectively arranged at the front end and the rear end of the bottom plate 3161. The inner surface of the bottom plate 3161 is a slope 317 with the front end lower than the rear end; the bottom plate 3161, the side plate 3162 and the panel 3018 protect and isolate the rear of the reagent bag 3012. The setting of the slope 317 is used to accumulate the reagent in the reagent bag 3012 to the side of the suction nozzle 3013, so that the reagent in the reagent bag 3012 can be left as little as possible and the reagent can be used as much as possible. In the specific implementation process, when there are multiple said storage cavities, a side plate 3162 is shared between adjacent storage cavities. At least two pairs of guide ribs 3163 are provided on the inner walls of the two side plates 3162 of the accommodating cavity, and each pair of the guide ribs 3163 is evenly distributed from the front end to the rear end of the accommodating cavity, and each guide rib 3163 is extended upward from the bottom plate 3161, and a body clamping interface 3164 for positioning and clamping the reagent bag 3012 is formed between each pair of the guide ribs 3163. The ribs 313 are used to position and straighten the reagent bag 3012.

[0105] To prevent the reagent bag 3012 from getting stuck when it is loaded into the receiving cavity, Fig.19As shown, a horn-shaped guide opening 3165 for guiding and positioning is provided on the upper part of the body card interface 3164. The setting of the guide opening 3165 can guide the reagent bag 3012 to fall into the card slot 3016. The body card interface 3164 positions the lower side of the reagent bag 3012 and straightens the reagent bag 3012. The side plate 3162 is a wedge-shaped plate with a front end height lower than the rear end height. The low front end height can expose the front upper corner of the reagent bag 3012, which is convenient for taking and placing the reagent bag 3012. In addition, the wedge-shaped plate structure facilitates the overall guiding installation of the reagent container accommodating box 301.

[0106] Please refer to the attached Fig.14 and 15 As shown in Figs. 15a, 15b and 15c: In some embodiments, the containing space 304 is provided with a guide groove 314 for directional guidance of the reagent container containing box 301 to be loaded into or out of the containing space 304. The guide grooves 314 are arranged in pairs and extend along the first direction X and are respectively arranged on the inner walls of the left shell 3021 and the right shell 3022. The bottom of the reagent container containing box 301 is also provided with a guide seat 315. The guide seat 315 is provided with a slide shaft 316 for cooperating with the guide groove 314 and directional sliding. The slide shaft 316 is arranged near the front end of the guide seat 315. Fig.15 As shown in FIG. 3 , for the replacement position, the guide groove 314 can be designed as a closed groove, the slide shaft 316 is restricted in the guide groove 314, and the main part of the reagent container box 301 can be pulled out of the storage chamber 302, but not completely separated; the guide groove 314 can also be designed to be open on the assembly port side, as shown in FIG. 3 , the slide shaft 316 can be disengaged from the guide groove 314, and the reagent container box 301 and the reagent bag 3012 can be completely pulled out of the storage chamber 302 together. In addition, a first mark is provided on the side of the reagent container box 301 away from the positioning structure 3017. The first mark can be a character such as FN, FR, FD, or an indicator light.

[0107] In some embodiments, the reagent container storage box 301 is in the storage chamber 302 and is switched between the locked position and the unlocked position by pressing the reagent container storage box 301. Fig.15 and 17As shown: in order to maintain the pressing switch between the locking position and the unlocking position after the reagent container storage box 301 and the storage chamber 302 are assembled, a locking tongue unit 307 is further provided in the storage chamber 302, and the reagent container storage box 301 is provided with a locking unit 308 that cooperates with the locking tongue unit 307, and the locking tongue unit 307 provides a first elastic force to the locking unit 308; the reagent container storage box 301 is pressed, and the locking tongue unit 307 is connected to the locking unit 308 through the first elastic force, and the reagent container storage box 301 is in the locking position; the reagent container storage box 301 is pressed to provide a force to overcome the first elastic force, release the connection between the locking tongue unit 307 and the locking unit 308, and the reagent container storage box 301 is in the unlocking position. When the reagent container storage box 301 is pressed and pushed into the storage chamber 302, the reagent container storage box 301 is stably connected to the storage chamber 302 through the cooperation and locking of the locking tongue unit 307 and the locking unit 308. When the reagent container storage box 301 is pulled out, the first elastic force is overcome by the pulling force or the component force of the pulling force, and the connection between the locking tongue unit 307 and the locking unit 308 is released, so that the reagent container storage box 301 and the storage chamber 302 are unlocked.

[0108] In the specific implementation process, according to the specific installation space and assembly requirements, the specific setting position and structure of the lock tongue unit 307 are as follows: the lock tongue unit 307 is arranged in the motion locking chamber 305, such as Figure 5 and 6 As shown, the locking tongue unit 307 includes a base 3071, a protrusion 3072 arranged on the base 3071, and an elastic part 3073 connected to the protrusion 3072. One end of the elastic part 3073 is fixed to the protrusion 3072, and the other end is extended in the first direction X. The elastic part 3073 provides the first upward elastic force when subjected to a downward extrusion force. When the reagent container storage box 301 is loaded into the locking position in the storage chamber 302, the elastic part 3073 is connected to the locking unit 308 under the action of the first elastic force; the protrusion 3072 is abutted against the reagent container storage box 301 for positioning. It should be noted that the locking unit 308 that cooperates with the locking tongue unit 307 here can be a locking hole or a positioning protrusion that directly cooperates with the elastic part 3073. A limiting protrusion 3074 is set in the cooperating area between the elastic part 3073 and the locking hole or the positioning protrusion. The limiting protrusion 3074 is partially inserted into the locking hole or engaged with the positioning protrusion. The limiting protrusion 3074 is provided with inclined surfaces 317 on both sides in the first direction X to prevent the elastic part 3073 and the locking unit 308 from being stuck, so as to facilitate overcoming the first elastic force for assembly or withdrawal.

[0109] Please refer to the attached Figure 5 and 11As shown in 12 and 9-1: the base 3071 is reciprocatingly slidable in the first direction X, a hook 309 and a first elastic element 310 are provided in the storage chamber 302, the tail of the hook 309 is fixed in the first direction X, the head of the hook 309 hooks the initial position 3001 or the locking position 3002 of the base 3071 along the first direction X, and the first elastic element 310 provides a reset elastic force to the base 3071 in the opposite direction of the first direction X; the reagent container accommodating box 301 is loaded into the storage chamber 302 and pushes the base 3071 along the first direction X. The first direction X moves to the locking position, the head of the hook 309 moves from the initial position 3001 of the base 3071 to the locking position 3002 and hooks the locking position 3002, and the hook 309 is balanced with the reset elastic force of the first elastic element 310; the reagent container accommodating box 301 is unlocked and exits the locking position along the first direction X, the head of the hook 309 is unhooked from the locking position 3002 and moves to the initial position 3001 under the action of the reset elastic force of the first elastic element 310, and the base 3071 pushes the reagent container accommodating box 301 to pop out from the locking position.

[0110] That is, the reagent container storage box 301 is pushed into the storage space 304, the reagent container storage box 301 abuts against the protruding portion of the base 3071, and the locking tongue unit 307 is connected and locked with the locking unit 308, and at the same time, the base 3071 is pushed and overcomes the restoring elastic force of the first elastic element 310 to move in the first direction X until the reagent needle 306 penetrates the reagent puncture portion 303, at this time, the hook 309 hooks the locking position 3002 of the base 3071, so that the reagent container storage box 301 is kept in the locked position; the reagent container storage box 301 is pressed again, and the hook 309 is pulled The first elastic element 310 drives the base 3071 and pushes the reagent container box 301 to move in the opposite direction of the first direction X until the hook 309 hooks the initial position 3001 of the base 3071, so that the reagent container box 301 pops out a certain distance. At this time, the reagent container box 301 is pulled by external force to release the locking state of the locking tongue unit 307 and the locking unit 308, and the reagent container box 301 is taken out from the storage space 304, completing the extraction from the storage chamber 302. In the specific implementation process, the first elastic element 310 can be a tension spring.

[0111] Please refer to the attached Figure 9-2As shown: In some embodiments, in order to make the head of the hook 309 switch between the initial position 3001 and the locking position 3002 more smoothly, two guiding slides are set between the initial position 3001 and the locking position 3002, namely the first slide 3003 and the second slide 3004, the first slide 3003 and the second slide 3004 are connected end to end to form a loop, the head of the hook 309 moves from the initial position 3001 to the locking position 3002 along the first slide 3003 and is fixed at the locking position 3002, and moves from the locking position 3002 to the initial position 3001 along the second slide 3004 and is fixed at the initial position 3001.

[0112] Combined with Figure 8 and 9-2 As shown: In some embodiments, along the moving direction of the head of the hook 309, the first slide 3003 and the second slide 3004 are divided into a first section A, a second section B, a third section C and a fourth section D in sequence, the connection between the first section A and the second section B serves as a first inflection point M, which is used to guide the head of the hook 309 to transfer to the second section B, the second section B and the third section C are combined to form a "V"-shaped slide, the bending portion E of the "V"-shaped slide serves as the locking position 3002, and the connection between the third section C and the fourth section D serves as a second inflection point N, which is used to guide the head of the hook 309 to transfer to the fourth section D; the starting end of the first section A and the end end of the fourth section D converge as the starting position.

[0113] Please refer to the attached Figure 9-2As shown: when the reagent container storage box 301 is pushed in, the reagent container storage box 301 is pushed into the storage space 304 along the first direction X until the locking tongue unit 307 is connected to the locking unit 308, and the reagent container storage box 301 is continuously pressed inward, and the base 3071 is pushed to move toward the tail of the hook 309, and the head of the hook 309 moves from the initial position 3001 along the first section A to the first inflection point M, and the pressing is released, the base 3071 is slightly reset, and the head of the hook 309 turns into the second section B at the first inflection point M and moves along the second section B to the curved portion E of the "V"-shaped slideway, i.e., the locking position 3002, and the head of the hook 309 can be stably hooked on the curved portion E, and the installation of the reagent container storage box 301 is completed. When the reagent container storage box 301 is pulled out, the reagent container storage box 301 is slightly pressed. The reagent container box 301 is inserted into the storage chamber 302, so that the head of the hook 309 is separated from the curved portion E of the "V"-shaped slide and moves along the third section C to the second turning point N. The pressure is released, and the base 3071 moves in the opposite direction of the first direction X under the action of the reset elastic force of the first elastic element 310. The head of the hook 309 turns into the fourth section D at the second turning point N and moves along the fourth section D to the initial position 3001. At this time, the base 3071 pops the reagent container box 301 out of the storage chamber 302 for a distance, providing a fulcrum for the external force. Under the action of the external force, the reagent container box 301 continues to be pulled out of the storage chamber 302. The external force overcomes the resistance of the first elastic force, separates the reagent container box 301 from the base 3071, and partially or completely pulls the reagent container box 301 out of the storage chamber 302. The distance of slightly pressing the reagent container box 301 includes but is not limited to 2-5 mm, and the distance of the reagent container box 301 popping out includes but is not limited to 20-30 mm, which can be designed according to the specific size and space of the product.

[0114] Please refer to the attached Figure 9-3 and 9-4As shown: In some embodiments, from the starting end of the first section A to the bend E, the depth of the first slide 3003 first decreases, and then increases after reaching the first inflection point M. At the first inflection point M; from the bend E to the end end of the fourth section D, the depth of the second slide 3004 first decreases, and then increases after reaching the second inflection point N. During the specific implementation process, the first slide 3003 and the second slide 3004 are both opened on the bottom surface relative to the base 3071, and relative to the bottom surface of the base 3071, the position of the first section A is gradually increased from low to the first inflection point M along the travel direction of the head of the hook 309 relative to the bottom surface; the position of the second section B is gradually decreased from high to low along the travel direction relative to the bottom surface, the highest point of the first section A is higher than the highest point of the second section B and forms a first step 3005 guiding the second section B to prevent the head of the hook 309 from returning to the starting end along the first section A; the position of the third section C is gradually increased from low to the second inflection point N along the travel direction relative to the bottom surface; the position of the fourth section D is gradually decreased from high to the bottom surface along the travel direction, and the highest point of the third section C is higher than the highest point of the fourth section D and forms a second step 3006 guiding the fourth section D to prevent the head of the hook 309 from returning to the curved portion E of the "V"-shaped slide along the third section C, and the area where the fourth section D is connected to the first section A forms a third step 3007 where the fourth section D is higher than the first section A. In addition, during the movement, the head of the hook 309 abuts against the bottom of the slide. When the head of the hook 309 moves from the starting end of the first section A to the first inflection point M, the depth of the slide gradually decreases, and the extrusion pressure on the hook 309 increases. After passing the first inflection point M, the depth increases, and the reaction force of the head of the hook 309 pushes the head of the hook 309 to move along the second section B to the deeper curved portion E of the "V"-shaped slide. The same is true for the third section C and the fourth section D, forcing the head of the hook 309 to move along a unique route, namely, along the first section A to the second section B to the third section C and then to the fourth section D.

[0115] Please refer to the attached Figure 8 As shown: In some embodiments, in order to further ensure the uniqueness of the travel route of the head of the hook 309, the curved portion E of the "V"-shaped slideway includes a locking portion E1 that is concave in the side wall and a guiding portion E2 that is protruding from the side wall. When the hook 309 is located at the locking position 3002, the head of the hook 309 hooks the locking portion E1, and the head of the hook 309 exits the locking portion E1, and the guiding portion E2 guides the head of the hook 309 to deviate toward the third section C. In other words, the center line of the main body of the hook 309 is biased toward the third section C, and the top of the guiding portion E2 is biased toward the second section B, ensuring that when the reagent container housing box 301 is pressed, the head of the hook 309 can be biased toward the third section C at the first time under the action of the guiding portion E2.

[0116] Please refer to the attached Figure 5 and 7As shown in the figure: In some embodiments, a supporting partition 3113 for supporting the reagent container accommodating box 301 is provided between the motion locking chamber 305 and the accommodating space 304. The supporting partition 3113, on the one hand, separates the motion locking chamber 305 and can support the reagent container accommodating box 301. On the other hand, the supporting partition 3113 also plays a certain guiding role, so that the reagent container accommodating box 301 can be smoothly pushed in. The supporting partition 311 is provided with a guiding hole 31113 extending along the first direction X. The base 3071 cooperates with the guiding hole 3111 through the protrusion 3072 and is reciprocatingly slidable in the first direction X. While providing the base 3071 with an installation position, a sliding space and a sliding direction, the maximum stroke of the reciprocating sliding of the base 3071 can be limited through the guiding hole 3111 to control the maximum distance of the reagent container accommodating box 301 to be ejected.

[0117] Please refer to the attached Fig.12 and 13 As shown in some embodiments, the lower side of the supporting partition 311 is provided with a guide rail 3112 extending along the first direction X, such as Figure 6 As shown, the base 3071 is provided with a directional sliding groove 311333, and the base 3071 slides in cooperation with the guide rail 3112 through the directional sliding groove 3113. The cooperation between the sliding groove 3113 and the guide rail 3112 can further improve the stability of the reciprocating sliding of the base 3071.

[0118] Please refer to the attached Figure 5 and 12 As shown in the figure: In some embodiments, a second elastic element 3114 is disposed below the base 3071, and the second elastic element 3114 provides a second elastic force to the hook 309, and the second elastic force pushes the hook 309 toward the base 3071 to prevent the hook 309 from falling out of the slideway of the base 3071. In the specific implementation process, the second elastic element 3114 adopts a spring structure, one end of the spring is fixed, and the main part of the spring is against the main part of the hook 309 to provide an upward elastic force.

[0119] Please refer to the attached Fig.10 As shown in FIG. 1 , in some embodiments, the support partition 311 extends to the assembly port, and the support partition 311 is provided with a guide slope 3115 at the assembly port. The front end of the reagent container storage box 301 is inclined at a certain angle along the guide slope 3115 to facilitate the placement and removal of the reagent bag 3012. Fig.15 As shown in Figs. 15a, 15b and 15c, it can be seen that the reagent container box 301 is pulled out of the storage chamber 302 in a dynamic process. At the guide slope 3115, the reagent container box 301 is tilted relative to the storage chamber 302 to make room for the reagent bag 3012 to be taken in and put out.

[0120] Please refer to the attached Figure 5 and 7 As shown: In some embodiments, a micro switch 312 for judging whether the reagent container box 301 is installed in the locking position is provided in the motion locking chamber 305. When the reagent container box 301 is pushed into the locking position, the micro switch 312 is triggered to generate an electrical signal, which can be displayed through an indicator light to remind the reagent container box 301 to be installed in place.

[0121] Please refer to the attached Figure 5 and 10 As shown in some embodiments, a plurality of ribs 313 are disposed on the inner wall of the accommodating space 304 , and the ribs 313 are extended along a first direction X, and the plurality of ribs 313 are evenly distributed in parallel in a direction perpendicular to the first direction X. Both sides of the reagent container accommodating box 301 are in contact with the ribs 313 , so as to reduce the sliding friction of the reagent container accommodating box 301 .

[0122] See also Figure 9-1 , Figure 9-2 , Figure 9-3 , Figure 9-4 and Fig. 20 In some embodiments, the locking unit 308 includes a locking hole disposed on the guide seat 315. The locking hole can cooperate with the elastic portion 3073 of the locking tongue unit 307. Fig. 20 As shown, a positioning groove 317 is also provided on the lower surface of the guide seat 315, which is mainly used for positioning and cooperating with the protrusion 3072 of the locking tongue unit 307 when the reagent container accommodating box 301 is replaced and installed. The guide groove 314 extends backward from the front end of the guide seat 315.

[0123] The utility model provides a reagent container storage device 2, which is mainly used as a container for storing fluorescent reagents.

[0124] The utility model provides a reagent container, which can be used to contain latex reagents, hemolysis reagents, dilution reagents, and fluorescent reagents. The reagent container includes a reagent bottle or a reagent bag 3012. The reagent bag 3012 is used as an example for specific description. Fig.17 and 18As shown: the reagent bag 3012 includes a nozzle 3013 and a body 3014, the nozzle 3013 is arranged along the first direction X, the reagent puncture part 303 is arranged on the nozzle 3013, and the neck of the nozzle 3013 is provided with the fixing structure 3015; when the reagent bag 3012 is assembled with the reagent container holding box 301 along the second direction Y, the fixing structure 3015 of the nozzle 3013 is easily placed into the positioning structure 3017 along the second direction Y, and the nozzle 3013 is limited in the first direction X by the positioning structure 3017, so no matter whether the reagent container holding box 301 is subjected to installation force or the nozzle 3013 is subjected to puncture force, it will not affect the stable assembly of the nozzle 3013 and the positioning structure 3017 in the first direction X.

[0125] Please refer to the attached Fig.18 and 19 As shown: In some embodiments, the fixed structure 3015 includes a front limit block 3151, a rear limit block 3152, and a connecting block 3153 connected between the front limit block 3151 and the rear limit block 3152. The front limit block 3151, the rear limit block 3152 and the connecting block 3153 are combined to form an I-shape, and the connecting block 3153 is inserted into the U-shaped card interface. The front limit block 3151 and the rear limit block 3152 clamp the two sides of the U-shaped card interface and limit it in the first direction X. Since the first direction X and the second direction Y are perpendicular, when the reagent is replaced, the fixed structure 3015 can be easily placed in the U-shaped card interface along the second direction Y without causing excessive squeezing of the reagent bag 3012. At the same time, the U-shaped card interface can also limit the fixed structure 3015 in the first direction X, which can stabilize the suction nozzle 3013. When the reagent container box 301 is installed and punctured, it can remain stable in the first direction X and will not move in the second direction Y. In the specific implementation process, the front limit block 3151 is provided with an electronic tag 3154 on the side facing the suction nozzle 3013 for identification, anti-counterfeiting, tracking, etc.

[0126] In addition, Fig.17 and 18 As shown, the suction nozzle 3013 is arranged near the bottom plate 3161, the body 3014 is provided with a liquid accumulation part 3155, the liquid accumulation part 3155 is arranged near the suction nozzle 3013, and the bottom plate 3161 is provided with a positioning hole 3166 for positioning the liquid accumulation part 3155 of the reagent bag 3012. After the reagent bag 3012 is assembled with the reagent container box 301, the suction nozzle 3013 and the liquid accumulation part 3155 are close to the bottom plate 3161, so that the reagent in the reagent bag 3012 can be accumulated in the liquid accumulation part 3155 as much as possible, which is convenient for the extraction of the puncture needle on the one hand, and can reduce the waste of reagent on the other hand.

[0127] Therefore, in the reagent container storage box 301, the reagent bag 3012 is loaded into the storage cavity of the reagent container storage box 301 along the second direction Y, and is positioned and straightened by the guide ribs 3163 to maintain the uniformity of the reagent distribution in the reagent bag 3012. The fixing structure 3015 of the suction nozzle 3013 is installed in coordination with the positioning structure 3017, taking into account the convenience of disassembly and assembly of the reagent bag 3012 and the reagent container storage box 301 in the second direction Y, and also ensuring the stability of the reagent bag 3012 in the first direction X. The wedge-shaped design of the side plate 3162 and the setting of the guide seat 315 make the guidance and positioning of the reagent container storage box 301 easier and more accurate during the replacement process. The entire replacement process only requires contacting the reagent container storage box 301. The hard reagent container storage box 301 not only plays an isolation role, but also the reagent container storage box 301 is more stable in force relative to the soft reagent bag 3012, and the assembly is more convenient and safe.

[0128] Please refer to the attached Figure 7 and 10 As shown: In some embodiments, a guide plate 318 for guiding the reagent puncture portion 303 of the reagent bag 3012 is provided in the accommodating space 304. The guide plate 318 can guide the suction nozzle 3013 of the reagent bag 3012 to prevent the reagent needle 306 from being inserted in an offset manner.

[0129] In addition, in some embodiments, the reagent container further includes a refrigeration module for controlling the reagent in the reagent container within a preset temperature range.

[0130] The utility model provides a sample analysis system, including a detection subsystem, a reagent container storage device 2 and a reagent management subsystem, wherein the reagent container storage device 2 includes a reaction pool, which is a reaction place between a sample and a reagent. The reagent container storage device 2 includes a storage chamber 302 and a reagent container holding box 301, wherein at least two holding spaces 304 are arranged inside the storage chamber 302, and the reagent container holding box 301 is arranged one-to-one with the holding spaces 304; the reagent container holding box 301 and the storage chamber 302 adopt the structure of the reagent container holding box 301 and the storage chamber 302 described in any of the above embodiments. The reagent management subsystem is used to control the supply of reagents and the loading and / or replacement of reagent containers.

[0131] In some embodiments, the sample analysis system further includes an information reading module for reading information of the reagent container housing box 301 .

[0132] In one embodiment, the information reading module includes an information reading unit, which can read information of multiple reagent container boxes 301 at the same time; the reagent management subsystem is in communication connection with the information reading module. The information reading unit includes multiple reading areas, which can read multiple RFID tags at the same time and display them at the same time; when the received "reagent loading and / or reagent replacement instructions" are for some of the reagent container boxes 301, the reagent management subsystem controls the information reading unit to only start the information reading area of ​​the reagent container box 301 corresponding to the instructions. For example, if there are three RFID tags FN, FR, and FD, only FN has a replacement instruction, and FR and FD are normal, the reagent management subsystem controls the information reading unit to only start the information reading area of ​​the reagent container box 301 corresponding to the FN tag, and also displays the read information of the reagent container box 301 corresponding to the instructions.

[0133] In another embodiment, the information reading module includes a plurality of information reading units, and the information reading units are arranged one-to-one with the reagent container holding box 301, and the reagent management subsystem is communicatively connected with the information reading module.

[0134] Based on the above two embodiments, when receiving reagent loading and / or reagent replacement instructions in the sample analysis system, the reagent management subsystem controls the information reading unit to start information reading. The reagent management subsystem determines whether the information read by the information reading unit includes one or more of the presence or absence of a label, whether it is within the validity period, and the type of reagent.

[0135] In some embodiments, the reagent management subsystem is further used to make a first judgment on the information read by the information reading unit: when the first judgment on the read information is yes, a normal signal is output; when the first judgment on the read information is no, an alarm signal is output. Based on the first judgment, if the first judgment is yes, a second judgment is also included:

[0136] If the second judgment is yes, a normal signal is output and the read information is stored in the sample analysis system; in specific implementation, a pop-up window is displayed when the normal signal is output; and after receiving the confirmation instruction, the information read by the information reading unit is stored in the sample analysis system and a success signal is output. If the second judgment is no, an alarm signal is output.

[0137] In some embodiments, the reagent management subsystem is further used to judge and store the information read by the information reading unit;

[0138] When the read information is judged to be yes, a normal signal is output and the read information is stored in the sample analysis system; in specific implementation, a pop-up window is displayed when a normal signal is output; and after receiving the confirmation instruction, the information read by the information reading unit is stored in the sample analysis system and a success signal is output.

[0139] When the read information is judged as negative, an alarm signal is output.

[0140] Based on the above two implementations, in some embodiments, when receiving an instruction or signal indicating successful reagent loading, reagent abnormality elimination and / or successful reagent replacement in the sample analysis system, the reagent management subsystem controls the information reading unit to close information reading.

[0141] Based on the above two implementation modes, in some embodiments, when receiving a reagent loading, reagent abnormality and / or reagent replacement instruction in the sample analysis system, the reagent management subsystem starts the reagent operation interface.

[0142] Based on the above two implementations, in some embodiments, when the sample analysis system receives an instruction or signal indicating successful reagent loading, reagent abnormality elimination and / or successful reagent replacement, the reagent management subsystem starts closing the reagent operation interface.

[0143] Based on the above system, the methods of reagent loading and replacement can be specifically the following three:

[0144] Fig.21 The flowchart of a fluorescent dye reagent interaction method in a sample analyzer is shown as an exemplary embodiment of the present application. Fig.21 As shown, the detailed steps of a reagent loading method in a sample analyzer are as follows:

[0145] Step 1: When the analyzer is powered on for the first time and reagents are actively loaded, the reagent scanning interactive command is actively triggered in the reagent management interface, and then the reagent loaded with the electronic tag 3154 is loaded into the analyzer. The specific operation is as follows: Press the button to pop out the reagent container box 301, load the reagent bag 3012 into the reagent container box 301, push the reagent bag 3012 and the reagent container box 301 back into the analyzer, automatically position and lock, and complete the loading of the reagent.

[0146] Step 2: Receive and respond to the reagent scanning interactive instruction issued by the reagent management interface and perform a first scanning and identification on the electronic tag 3154 of the reagent.

[0147] If the first scan and identification fails, the reagent management interface displays a reminder to reload the reagent. After reloading the reagent, the electronic tag 3154 is identified again. If the identification of the electronic tag 3154 fails, it is determined that the electronic tag 3154 is damaged or has other problems, and the reagent loading is terminated.

[0148] If the first scan and identification is successful to confirm that the reagent is preliminarily installed in place, then the electronic tag 3154 of the reagent is scanned and identified for the second time. The interval between the second scan and identification and the first scan and identification can be 1 second to confirm whether the reagent is stably installed in place.

[0149] If the second scan and identification fails, a reminder will be displayed on the reagent management interface to reload the reagent. After reloading the reagent, the electronic tag 3154 will be identified again. If the identification of the electronic tag 3154 fails, it is determined that the electronic tag 3154 is damaged or has other problems, and the reagent loading is terminated.

[0150] If the second scan recognition is successful, to confirm that the reagent is stably loaded and obtain the number of electronic tags 3154, when the number of electronic tags 3154 is 1, the information of electronic tags 3154 is directly read; when the number of electronic tags 3154 is greater than 1, the information of electronic tags 3154 is read sequentially.

[0151] Step 3: Process the read electronic tag 3154 information to generate reagent information, including reagent type and reagent validity period information. Of course, other reagent information can also be added, such as reagent remaining information, etc. In the hemocytometer, the types of fluorescent dye reagents include FR, FD, and FN. The three reagents FR, FD, and FN are arranged in a specific order;

[0152] Step 4: Identify and determine the type of reagent loaded at a specific location, and simultaneously or sequentially identify and determine the validity period of the reagent.

[0153] If the reagent type is identified as normal, the reagent information is generated; if the reagent type is identified as abnormal, an alarm is issued and / or the reason for the abnormal reagent type is displayed on the reagent management interface, and the reagent loading is terminated.

[0154] If the identified reagent is within the validity period, the reagent information is generated. If the identified reagent is not within the validity period, the reagent management interface displays a reminder that the reagent is not within the validity period, and the reagent loading is terminated.

[0155] If the reagent type and the corresponding reagent validity period are normal, the reagent information is displayed in the reagent interaction interface in the form of a check box.

[0156] Step 5: Select the displayed reagent type and reagent validity period in the check box to trigger the "Load reagent" interaction request, which means entering the new reagent information and replacing the original reagent information to complete the update, receiving and responding to the "Load reagent" interaction request, entering the new reagent information and replacing the original reagent information,

[0157] If the reagent information is loaded and updated abnormally, the reagent interaction interface will display "Loading Abnormal" and end the reagent loading.

[0158] If the reagent information is loaded and updated without exception, and the successful loading is prompted by sound and / or the reagent interactive interface, the electronic label 3154 scan is closed to complete the loading of the reagent.

[0159] Fig. 22 This is a flow chart showing a method for replacing reagents in a sample analyzer according to an exemplary embodiment of the present application. Fig. 22 As shown, a method for replacing reagents in a sample analyzer, wherein the fluorescent dye reagents include at least two kinds. In a specific implementation, the fluorescent dye reagents in the sample analyzer include three kinds of FR, FD, and FN. The three reagents FR, FD, and FN are loaded with electronic tags 3154 one by one. The steps of the interactive method are as follows:

[0160] Step 1: Acquire reagent failure information and display it on the reagent management interface, wherein the reagent failure information includes that any reagent is out of validity or any reagent is unavailable or any reagent needs to be replaced.

[0161] Step 2: Based on the reagent failure information, click on the trigger to eliminate the "reagent failure information" command in the reagent management interface to determine whether there is a "reagent out of stock" failure, where reagent out of stock means insufficient reagent remaining:

[0162] If there is a "reagent no" fault, replace the reagent with the electronic tag 3154; the specific replacement operation is as follows: press the button to eject the reagent container box 301, put the reagent bag 3012 into the reagent container box 301, push the reagent bag 3012 and the reagent container box 301 back into the analyzer, automatically locate and lock, and complete the reagent replacement. The reagent with the electronic tag 3154 includes a reagent bottle with the electronic tag 3154, a reagent bag 3012 or other reagent storage device. After the reagent is loaded, the electronic tag 3154 scan is automatically started.

[0163] If there is no "reagent out" fault, replace the reagents except FR, FD, and FN.

[0164] Step 3: Scan and identify the electronic tag 3154.

[0165] If the identification of electronic tag 3154 fails, the reagent management interface displays a reminder to reload the reagent. After reloading the reagent, the electronic tag 3154 is identified again. If the identification of electronic tag 3154 fails again, it is determined that the reagent is not loaded, the electronic tag 3154 is damaged or other problems occur, and the reagent replacement is terminated.

[0166] If the electronic tag 3154 is successfully identified, the number of electronic tags 3154 obtained is at least 1;

[0167] Step 4: If the number of electronic tags 3154 is 1, the information of electronic tags 3154 is directly read and converted to generate reagent information. If the number of electronic tags 3154 is greater than 1, the information of electronic tags 3154 is sequentially verified and read to convert and generate reagent information. The reagent information includes the type of reagent and the reagent validity period.

[0168] Step 5: In the process of generating reagent information, determine the reagent type and validity period one by one:

[0169] a. Identify and determine the type of reagent loaded at a specific position. If the identified reagent type is normal, generate the reagent information. If the identified reagent type is abnormal, issue an alarm and / or display the reason for the abnormal reagent type on the reagent management interface, and end the reagent replacement.

[0170] b. Identify and judge whether the reagent is within the validity period. If the reagent is identified to be within the validity period, the reagent information is generated. If the reagent is identified to be not within the validity period, the reagent management interface displays a reminder that the reagent is not within the validity period, and the reagent replacement ends.

[0171] Step 6: Display the acquired reagent information on the reagent management interface.

[0172] Step 7: Confirm that the obtained reagent information is correct. The reagent management interface displays the "Clear Fault" interaction request. Click "Clear Fault" to load and update the reagent information and determine whether it is successful. If successful, close the electronic label 3154 scan and complete the reagent replacement. If unsuccessful, the reagent management interface displays "Loading Abnormal" and ends the reagent replacement.

[0173] Fig.23 This is a flow chart showing a method for replacing reagents in a sample analyzer according to an exemplary embodiment of the present application. Fig.23As shown, a method for replacing reagents in a sample analyzer, the fluorescent dye reagents include at least 2 kinds. In a specific implementation, the types of fluorescent dye reagents in the sample analyzer include FR, FD, and FN. The three reagents FR, FD, and FN are loaded with electronic tags 3154 one-to-one. The sample analyzer is provided with trigger switches corresponding to the types of the fluorescent dye reagents one-to-one. The electronic tags 3154 scan one-to-one in response to the opening and closing signals of the trigger switches. The steps of the interactive method are as follows:

[0174] Step 1: Acquire reagent failure information and display it on the reagent management interface, wherein the reagent failure information includes that any reagent is out of validity or any reagent is unavailable or any reagent needs to be replaced.

[0175] Step 2: Based on the reagent failure information, click on the trigger to eliminate the "reagent failure information" command in the reagent management interface to determine whether there is a "reagent out of stock" failure, where reagent out of stock means insufficient reagent remaining:

[0176] If there is a "reagent no" fault, replace the reagent with the electronic label 3154; the reagent with the electronic label 3154 includes a reagent bottle with the electronic label 3154, a reagent bag 3012 or other reagent storage device. The specific replacement operation is as follows: press the button to eject the reagent container box 301, put the reagent bag 3012 into the reagent container box 301, push the reagent bag 3012 and the reagent container box 301 back into the analyzer, automatically position and lock, if the trigger switch is not turned on, it is judged that the reagent is not assembled in place or the reagent replacement is not performed, and the reagent can be reloaded; if the trigger switch is turned on, the reagent loading is completed, and the electronic label 3154 scanning is automatically started, wherein the electronic label 3154 corresponding to the reagent corresponding to the trigger switch is scanned.

[0177] Step 3: Scan and identify the electronic tag 3154.

[0178] If the identification of electronic tag 3154 fails, the reagent management interface displays a reminder to reload the reagent. After reloading the reagent, the electronic tag 3154 is identified again. If the identification of electronic tag 3154 fails again, it is determined that the reagent is not loaded, the electronic tag 3154 is damaged or other problems occur, and the reagent replacement is terminated.

[0179] If the electronic tag 3154 is successfully identified, the number of electronic tags 3154 obtained is at least 1;

[0180] Step 4: If the number of electronic tags 3154 is 1, the information of electronic tags 3154 is directly read and converted to generate reagent information. If the number of electronic tags 3154 is greater than 1, the information of electronic tags 3154 is sequentially verified and read to convert and generate reagent information. The reagent information includes the type of reagent and the reagent validity period.

[0181] Step 5: In the process of generating reagent information, determine the reagent type, validity period and batch number one by one:

[0182] a. Identify and determine the type of reagent loaded at a specific position. If the identified reagent type is normal, generate the reagent information. If the identified reagent type is abnormal, issue an alarm and / or display the reason for the abnormal reagent type on the reagent management interface, such as "XX reagent is misplaced", "XX reagent type is wrong", etc., and end the reagent replacement.

[0183] b. Identify and judge whether the reagent is within the validity period. If the reagent is identified to be within the validity period, the reagent information is generated. If the reagent is identified to be not within the validity period, the reagent management interface displays a reminder that the reagent is not within the validity period, and the reagent replacement ends.

[0184] c. Identify and judge whether the same batch number of reagents is used. If the reagents are identified as being of the same batch number, generate the reagent information, directly load and update the reagent information, and display a prompt on the reagent management interface indicating that the reagent replacement is successful; if the reagents are not identified as being of the same batch number, generate the reagent information and continue with the following steps.

[0185] Step 6: The acquired reagent information is displayed in a pop-up window on the reagent management interface, and only the reagent information generated by the reagent replaced at that time is refreshed and displayed in a pop-up window.

[0186] Step 7: Confirm that the acquired reagent information is correct. When actively replacing reagents, the reagent management interface displays an interactive request of "Replace reagents". When passively replacing reagents due to reagent failure, the reagent management interface displays an interactive request of "Clear failure". Click the interactive request "Replace reagents" or "Clear failure" to load and update the reagent information and determine whether it is successful. If successful, the reagent loading is successfully reminded through sound and / or interface display, and the electronic label 3154 scan is closed or the electronic label 3154 is reversed / rewritten to complete the reagent replacement. If it fails, the reagent management interface displays "Loading abnormality" to end this reagent replacement.

[0187] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the technology may modify or change the above embodiments without violating the spirit and scope of the present invention. Therefore, all equivalent modifications or changes made by a person with ordinary knowledge in the relevant technical field without departing from the spirit and technical ideas disclosed in the present invention shall still be covered by the claims of the present invention.

Claims

1. A reagent container storage device, characterized in that: include: A reagent container accommodating box, wherein the reagent container accommodating box is provided with an accommodating cavity for accommodating the reagent container; A storage chamber, wherein at least one accommodating space is provided inside the storage chamber, an assembly opening is opened in the storage chamber, and a reagent needle is fixed in the accommodating space; The reagent container accommodating box is movably installed in the storage chamber and extends into the accommodating space along a first direction; The storage chamber has a locking position and an unlocking position. When the reagent container accommodating box is located in the locking position, the reagent needle is connected to the reagent container; when the reagent container accommodating box is located in the unlocking position, the reagent needle is separated from the reagent container.

2. The reagent container storage device according to claim 1, characterized in that: The storage chamber also has a replacement position, and when the reagent container accommodating box is located at the replacement position, the reagent container is loaded or taken out.

3. The reagent container storage device according to claim 1, characterized in that: The reagent container accommodating box comprises a positioning structure, and a fixing structure is provided on the reagent container corresponding to the positioning structure, and the fixing structure cooperates with the positioning structure to position and fix the reagent container in the accommodating cavity.

4. The reagent container storage device according to claim 3, characterized in that: The positioning structure is a U-shaped card interface, and the fixing structure is inserted into the U-shaped card interface to limit the fixing structure in the first direction.

5. The reagent container storage device according to claim 4, characterized in that: The accommodating cavity of the reagent container accommodating box is provided with an opening for loading or removing the reagent container in a second direction, and the second direction is perpendicular to the first direction.

6. The reagent container storage device according to claim 4, characterized in that: A guide groove is provided in the accommodating space for directional guiding the reagent container accommodating box to be loaded into or out of the accommodating space, and the guide groove extends along the first direction. A guide seat is also provided at the bottom of the reagent container accommodating box, and the guide seat is provided with a sliding shaft for cooperating with the guide groove and directional sliding, and the sliding shaft is arranged near the front end of the guide seat.

7. The reagent container storage device according to claim 4, characterized in that: The reagent container accommodating box is provided with a first mark on a side away from the positioning structure; the reagent container accommodating box also includes a refrigeration module for controlling the reagent in the reagent container within a preset temperature range.

8. The reagent container storage device according to claim 1, characterized in that: The storage chamber includes at least three accommodating spaces, and each of the accommodating spaces is correspondingly installed with one of the reagent container accommodating boxes.

9. The reagent container storage device according to claim 1, characterized in that: The reagent container accommodating box is in the storage chamber, and is switched between the locking position and the unlocking position by pressing the reagent container accommodating box.

10. The reagent container storage device according to claim 9, characterized in that: The storage chamber is further provided with a locking tongue unit, the reagent container storage box is provided with a locking unit matched with the locking tongue unit, and the locking tongue unit provides a first elastic force to the locking unit; When the reagent container storage box is pressed, the locking tongue unit is connected to the locking unit through a first elastic force, and the reagent container storage box is in a locked position; when the reagent container storage box is pressed to provide a force to overcome the first elastic force, the connection between the locking tongue unit and the locking unit is released, and the reagent container storage box is in an unlocked position.

11. The reagent container storage device according to claim 10, characterized in that: A movable locking chamber is provided below the accommodating space, and the locking tongue unit is provided in the movable locking chamber. The locking tongue unit includes a base, a protrusion provided on the base, and an elastic portion connected to the protrusion. One end of the elastic portion is fixed to the protrusion, and the other end is extended in a first direction. The elastic portion provides the first upward elastic force when subjected to a downward extrusion force. When the reagent container accommodating box is loaded into the locking position in the storage chamber, the elastic portion is connected to the locking unit under the action of the first elastic force; the protrusion abuts against the reagent container accommodating box for positioning.

12. The reagent container storage device according to claim 11, characterized in that: The base is arranged to slide back and forth in the first direction, a draw hook and a first elastic element are arranged in the storage chamber, the tail of the draw hook is fixed in the first direction, the head of the draw hook hooks the initial position or locking position of the base along the first direction, and the first elastic element provides a reset elastic force to the base in the opposite direction of the first direction; The reagent container storage box is loaded into the storage chamber and pushes the base to move to the locking position along the first direction, the head of the hook moves from the initial position of the base to the locking position and hooks the locking position, and the reset elastic force of the hook is balanced with that of the first elastic element; the reagent container storage box is unlocked and exits the locking position along the first direction, the head of the hook is unhooked from the locking position and moves to the initial position under the action of the reset elastic force of the first elastic element, and the base pushes the reagent container storage box to pop out from the locking position.

13. The reagent container storage device according to claim 12, characterized in that: The initial position and the locking position are connected by a first slide and a second slide, the first slide and the second slide are connected end to end, the head of the hook moves from the initial position to the locking position along the first slide and is stopped at a fixed point in the locking position, and moves from the locking position to the initial position along the second slide and is stopped at a fixed point in the initial position.

14. The reagent container storage device according to claim 13, characterized in that: Along the moving direction of the head of the hook, the first slide and the second slide are divided into a first section, a second section, a third section and a fourth section in sequence, the connection between the first section and the second section serves as a first turning point, for guiding the head of the hook to transfer to the second section, the second section and the third section are combined to form a "V"-shaped slide, the bending portion of the "V"-shaped slide serves as the locking position, the connection between the third section and the fourth section serves as a second turning point, for guiding the head of the hook to transfer to the fourth section; the starting end of the first section and the ending end of the fourth section merge into the starting end.

15. The reagent container storage device according to claim 14, characterized in that: From the starting end of the first section to the curved portion, the depth of the first slideway first decreases and then increases after reaching the first inflection point; from the curved portion to the end end of the fourth section, the depth of the second slideway first decreases and then increases after reaching the second inflection point.

16. The reagent container storage device according to claim 14, characterized in that: The curved portion of the "V"-shaped slide includes a locking portion recessed in the side wall and a guiding portion protruding from the side wall. When the pull hook is located in the locking position, the head of the pull hook hooks the locking portion, and the head of the pull hook exits the locking portion, and the guiding portion guides the head of the pull hook to deviate to the third section.

17. The reagent container storage device according to claim 12, characterized in that: A supporting partition for supporting the reagent container storage box is provided between the moving locking chamber and the storage space, and a guide hole extending along a first direction is opened on the supporting partition, and the base cooperates with the guide hole through the protrusion and is arranged to slide back and forth in the first direction.

18. The reagent container storage device according to claim 17, characterized in that: A guide rail extending along a first direction is disposed on the lower side of the supporting partition, and a directional sliding groove is disposed on the base, and the base slides in cooperation with the guide rail through the directional sliding groove.

19. The reagent container storage device according to claim 17, characterized in that: A second elastic element is disposed below the base, and the second elastic element provides a second elastic force to the draw hook, and the second elastic force pushes the draw hook toward the base.

20. The reagent container storage device according to claim 17, characterized in that: The supporting baffle extends to the assembly opening, and the supporting baffle is provided with a guiding inclined surface at the assembly opening.

21. The reagent container storage device according to claim 11, characterized in that: A micro switch is provided in the motion locking chamber for judging whether the reagent container accommodating box is loaded into the locking position.

22. The reagent container storage device according to claim 11, characterized in that: A plurality of ribs are arranged on the inner wall of the accommodation space, the ribs are extended along a first direction, and the plurality of ribs are evenly distributed in parallel in a direction perpendicular to the first direction.

23. The reagent container storage device according to claim 11, characterized in that: A guide groove is provided in the accommodating space for directional guiding the reagent container accommodating box to be loaded into or withdrawn from the accommodating space, and the guide groove extends along the first direction. A guide seat is also provided at the bottom of the reagent container accommodating box, and the guide seat is provided with a sliding shaft for cooperating with the guide groove and directional sliding, and the sliding shaft is arranged near the front end of the guide seat, and the locking unit includes a locking hole arranged on the guide seat.

24. A reagent interaction module, characterized in that: The invention comprises a plurality of reagent container storage devices connected in parallel, wherein the reagent container storage device is the reagent container storage device according to any one of claims 1 to 23.

25. The reagent interaction module according to claim 24, characterized in that: A gap-covering plate is provided on the surface where the assembly opening of the reagent container storage device is located. The gap-covering plate connects the reagent container storage devices and blocks the gaps between the reagent container storage devices. An assembly hole is opened on the gap-covering plate corresponding to the assembly opening of each reagent container storage device.

26. The reagent interaction module according to claim 24, characterized in that: An electronic tag card and an antenna card are arranged on the rear side surface away from the surface where the assembly opening of the reagent container storage device is located.

27. The reagent interaction module according to claim 24, characterized in that: A mounting plate is fixedly provided on the bottom surface of the reagent interaction module.

28. A sample analyzer, characterized in that: Comprising the reagent interaction module as described in any one of claims 24 to 27.

29. A sample analysis system, characterized in that: include: A detection subsystem, wherein the detection subsystem comprises a reaction cell; A reagent container storage device, wherein the reagent container storage device is the reagent container storage device according to any one of claims 1 to 23, wherein at least two accommodating spaces are provided inside the storage chamber, and the reagent container accommodating box is arranged one-to-one with the accommodating spaces; The reagent management subsystem is used to control the supply of reagents and the loading and / or replacement of reagent containers.

30. The sample analysis system according to claim 29, characterized in that: The sample analysis system further comprises an information reading module for reading information of the reagent container housing box.

31. The sample analysis system according to claim 30, characterized in that: The information reading module includes an information reading unit, which can read the information of multiple reagent container boxes at the same time; the reagent management subsystem is communicatively connected with the information reading module.

32. The sample analysis system according to claim 30, characterized in that: The information reading module includes a plurality of information reading units, and the information reading units are arranged one-to-one with the reagent container accommodating box, and the reagent management subsystem is communicatively connected with the information reading module.

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