Freeze-dried microsphere collecting device

Abstract

The utility model discloses a freeze-dried microsphere collecting device. According to the scheme, the device comprises a heat preservation tank filled with liquid nitrogen, a gauze element layer and a separation part, wherein the gauze element layer and the separation part are arranged in a cavity of the heat preservation tank; the freeze-drying microsphere collecting device provided by the scheme is adaptive to a 96-channel full-automatic liquid workstation with 96 drippers in the prior art, 96 freeze-drying microspheres can be collected at a time, and the production efficiency of the freeze-drying microspheres is greatly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of freeze-dried microspheres, and in particular to a freeze-dried microsphere collection device. Background Art

[0002] At present, the process of freeze-dried balls is roughly to drop the reagent into liquid nitrogen and freeze it into balls, then transfer it to the freeze dryer for freeze drying, and then pack it in a low-humidity workshop after it leaves the freeze dryer. Among them, the reagent is dropped into liquid nitrogen and frozen into balls. Currently, automated bead dropping equipment and manual ball spotting devices are mostly used.

[0003] The existing automated bead spotting equipment is a high-throughput bead spotting equipment for a single reagent formula for production. Two drops of liquid are dripped into the liquid nitrogen box each time. After each drop, the liquid nitrogen box rotates, and the bead spotting device continues to drip reagents into different partition nets and form freeze-dried microspheres on the filter net. The partition net in the liquid nitrogen box is used to prevent adhesion between the droplets.

[0004] Generally, freeze-dried microspheres are packaged ninety-six times at a time. Currently, there is also a fully automatic liquid workstation with ninety-six droppers. However, in the prior art, there is no collection device that can be fully compatible with the 96-channel fully automatic liquid workstation.

[0005] Therefore, there is a need for a collection device for freeze-dried microspheres that can be matched with a 96-channel fully automatic liquid workstation in the prior art to improve the production efficiency of freeze-dried microspheres. Summary of the invention

[0006] In order to solve the above problems, this solution provides a freeze-dried microsphere collection device.

[0007] To achieve the above-mentioned purpose, the technical solution adopted in this scheme is: a freeze-dried microsphere collection device, including an insulation tank filled with liquid nitrogen and a gauze layer and a partition in its cavity, wherein the partition is evenly divided into ninety-six dripping tracks.

[0008] Furthermore, the four corners of the partition are provided with limiting ends, and the limiting ends are limited at the top of the insulation tank.

[0009] Furthermore, below the partition is the gauze layer;

[0010] The mesh layer and the grid frame fix the mesh and limit the mesh at the top of the heat preservation tank.

[0011] Furthermore, the grid comprises a fixing frame and an L-shaped bracket.

[0012] Furthermore, the mesh is fixed in the middle of the fixing frame, and an L-shaped bracket is arranged on each of the four sides and is limited at the top of the insulation tank.

[0013] Furthermore, the insulation tank is a rectangular structure and is made of PTFE material.

[0014] In summary, this solution has the following advantages:

[0015] The freeze-dried microsphere collection device provided in this solution is adapted to the 96-channel fully automatic liquid workstation with ninety-six drippers in the prior art, and can collect 96 freeze-dried microspheres at a time, greatly improving the production efficiency of freeze-dried microspheres. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of a freeze-dried microsphere collection device;

[0017] Figure 2 An exploded view of a freeze-dried microsphere collection device;

[0018] Figure 3 It is a schematic diagram of the gauze layer;

[0019] Figure 4 is a schematic diagram of the separation layer.

[0020] in:

[0021] 1. Insulation tank;

[0022] 2. mesh layer; 21. mesh; 22. mesh frame; 221. fixing frame; 222. L-shaped bracket;

[0023] 3. Partition; 31. Drip track; 32. Limit end. DETAILED DESCRIPTION

[0024] The present invention is further described below in conjunction with the accompanying drawings and embodiments:

[0025] Embodiment 1:

[0026] A freeze-dried microsphere collection device, such as Figure 1-4 As shown, it includes a mesh layer 2 and a partition 3 inside the heat preservation tank 1.

[0027] like Figure 1 and 2 As shown, the heat preservation tank 1 is used for heat preservation, and the inner cavity is filled with liquid nitrogen.

[0028] The insulation tank 1 is a rectangular structure, and commonly used liquid nitrogen storage materials include stainless steel, aluminum alloy, fiberglass and plastic. Among them, plastic is a light and easy-to-process material, which is more suitable for some special applications in liquid nitrogen storage. The insulation tank 1 in this embodiment is made of PTFE (polytetrafluoroethylene), which is an excellent corrosion-resistant material. The insulation tank 1 made of PTFE can be used at extreme temperatures and has good stability and durability.

[0029] Specifically, the dripper drips the liquid reagent into the insulation tank 1, and the liquid reagent is pre-frozen into a solid state by liquid nitrogen to form freeze-dried microspheres.

[0030] like Figure 1 , 2 As shown in FIG. 3 , the mesh layer 2 and the mesh 21 are limited in the inner cavity of the heat preservation tank 1 , and the grid frame 22 fixes the mesh 21 and limits it at the top of the heat preservation tank 1 .

[0031] The mesh 21 layer is used to store the formed freeze-dried microspheres. The formed freeze-dried microspheres can be removed by lifting the mesh rack 22 without putting hands into or getting too close to the insulation tank 1 to avoid frostbite of hands by liquid nitrogen.

[0032] The mesh 21 is made of stainless steel or iron. In the present embodiment, the mesh 21 is made of stainless steel. The mesh made of stainless steel has better corrosion resistance and can also withstand ultra-low temperatures.

[0033] The grid 22 includes a fixed frame 221 and an L-shaped bracket 222. The mesh 21 is fixed in the middle of the fixed frame 221. An L-shaped bracket 222 is arranged on each of the four sides of the fixed frame 221. The bending part of the L-shaped bracket 222 is limited to the top of the insulation tank 1.

[0034] like Figure 1 , 2 As shown in Figures 4 and 5, the partition 3 is placed on the mesh 21 and is limited within the top of the heat preservation tank 1.

[0035] The partition 3 is a frame structure, and the middle of the frame is evenly divided into ninety-six dripping tracks 31 , and liquid nitrogen is contained in the dripping tracks 31 .

[0036] The partition 3 is arranged to be adapted to a 96-channel fully automatic liquid workstation with ninety-six drippers in the prior art, and the 96-channel fully automatic liquid workstation is a 96-channel fully automatic liquid workstation of Nayo Biotech (Shanghai) Co., Ltd., model NAYO·N96S.

[0037] The interval size of the drip track 31 is adapted to the dripper of NAYO·N96S.

[0038] The four corners of the partition 3 are provided with limiting ends 32 . After the partition 3 is placed on the heat preservation tank 1 , the limiting ends 32 are placed and limited on the top of the heat preservation tank 1 .

[0039] The usage mechanism of the combination of the freeze-dried microsphere collection device and the 96-channel fully automatic liquid workstation is further explained:

[0040] The freeze-dried microsphere collection device is placed on a 96-channel fully automatic liquid workstation. After the 96-channel fully automatic liquid workstation is started, the dripper drips liquid, and the liquid reagent drips downward toward the drip track 31 by inertia. In the drip track 31, liquid nitrogen pre-freezes the liquid reagent into a solid state to form freeze-dried microspheres.

[0041] In summary, the freeze-dried microsphere collection device provided in the present application is adapted to the 96-channel fully automatic liquid workstation with ninety-six drippers in the prior art, and can collect 96 freeze-dried microspheres at a time, greatly improving the production efficiency of freeze-dried microspheres.

[0042] The above implementation is only to illustrate the technical concept and features of this solution, and its purpose is to enable people familiar with this technology to understand the content of this solution and implement it accordingly, and it cannot be used to limit the protection scope of this solution. Any equivalent transformation or modification made according to the spirit of this solution should be included in the protection scope of this solution.

[0043] In the description of this scheme, it should be noted that, unless otherwise clearly stipulated and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of two elements.

[0044] For those skilled in the art, the specific meanings of the above terms in this solution can be understood according to specific circumstances.

[0045] It should be understood that the above-mentioned embodiments are merely illustrative and not restrictive. Without departing from the basic principles of the present solution, various obvious or equivalent modifications or substitutions that can be made by technicians in this field to the above details will be included in the protection scope of the present solution.

Claims

1. A freeze-dried microsphere collection device, comprising a heat preservation tank (1) filled with liquid nitrogen and a gauze layer (2) and a partition (3) in the cavity thereof, characterized in that: The partition (3) is evenly divided into ninety-six drip tracks (31).

2. The freeze-dried microsphere collection device according to claim 1, characterized in that: Limiting ends (32) are arranged at four corners of the partition (3), and the limiting ends (32) are limited at the top of the heat preservation tank (1).

3. The freeze-dried microsphere collection device according to claim 2, characterized in that: Below the partition (3) is the gauze layer (2); The mesh layer (2) and the mesh frame (22) fix the mesh (21) and limit the position of the mesh at the top of the heat preservation tank (1).

4. The freeze-dried microsphere collection device according to claim 3, characterized in that: The grid frame (22) comprises a fixing frame (221) and an L-shaped bracket (222).

5. The freeze-dried microsphere collection device according to claim 4, characterized in that: The fixing frame (221) has the mesh (21) fixed in the middle of the frame, and an L-shaped bracket (222) is provided on each of the four sides and is limited at the top of the heat preservation tank (1).

6. The freeze-dried microsphere collection device according to claim 5, characterized in that: The heat preservation tank (1) is of rectangular structure and is made of PTFE material.

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