Shell for containing freezing and thawing bag and freezing and thawing system
By forming protrusions, reinforcement ribs and deformation zones on the bottom plate of the freezing bag shell, the problem of excessive expansion of the freezing bag during the freezing process is solved, and the uniformity of freezing and the activity of the biological fluid are improved.
Patent Information
- Application Number
- CN202421689065.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-16
- Publication Date
- 2025-05-16
- Estimated Expiration
- 2034-07-16
AI Technical Summary
During the freezing process, the excessive expansion of the biofilm liquid volume caused by the expansion of the biofilm liquid will damage the shell, and the uneven freezing will lead to a decrease in the activity of the biofilm liquid.
A shell containing the freeze-thaw bag is designed, the bottom plate forms a protrusion at the center of the freeze-thaw bag, and reinforcement ribs and deformation zones are provided on the protrusion to inhibit excessive expansion of the center of the freeze-thaw bag and promote dispersion of the biological material liquid to the periphery.
Effectively prevent excessive expansion of the center of the freeze-thaw bag, improve freezing uniformity, avoid shell damage, and improve the activity of the biological material liquid.
Smart Images
Figure CN222876589U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of biological liquid storage and transportation, in particular to a shell for accommodating a freeze-thaw bag and a freeze-thaw system. Background Art
[0002] In the process of biopharmaceuticals, in order to maintain the sterility of biological fluids such as antibodies and cells, the above-mentioned biological fluids are usually stored in disposable containers. The above-mentioned disposable containers are usually freeze-thaw bags made of flexible or pliable materials, and the outside of the freeze-thaw bags are usually connected with pipelines to enable the biological fluids to enter and exit the freeze-thaw bags. However, the above-mentioned freeze-thaw bags are easily damaged by vibration, wear, impact or other improper handling accidents caused by operator errors or improper protection of the bag during use during storage, transportation or refrigeration; in particular, when the volume of biopharmaceutical materials expands during the freezing process, it will push the freeze-thaw bag body to expand, which may destroy or damage the integrity of the bag body. Therefore, in order to protect the integrity of the freeze-thaw bag during the freezing process, the freeze-thaw bag is currently protected by placing it in a shell. The material of the shell is usually stiffer than that of the freeze-thaw bag, so as to provide sufficient mechanical support and protection for the freeze-thaw bag. The shell is provided with an inner cavity to accommodate the freeze-thaw bag, thereby protecting the integrity of the freeze-thaw bag and the effectiveness of the biological liquid inside it. During subsequent use, the shell receiving the freeze-thaw bag is placed in a flat environment such as a special medical freezer or a receiving rack.
[0003] However, during the freezing process of the freeze-thaw bag filled with biological liquid, the volume expansion of the freeze-thaw bag will also lead to the expansion of the volume of the freeze-thaw bag, and the periphery of the freeze-thaw bag is welded and fixed, and the membrane at the periphery has a relatively large constraint on the internal liquid, while the membrane at the center of the freeze-thaw bag has a relatively small constraint on the internal liquid. Therefore, the expansion of the freeze-thaw bag mainly occurs in the membrane part in the center of the freeze-thaw bag. As the freeze-thaw bag expands, the shell corresponding to the expanded part of the freeze-thaw bag is pushed toward the outer surface, and the center area of the freeze-thaw bag expands too much compared to the periphery of the freeze-thaw bag (that is, the thickness of the center area of the freeze-thaw bag is greater than that of the periphery of the freeze-thaw bag), thereby causing the hollow space of the shell corresponding to the expanded part of the freeze-thaw bag to increase, thereby prompting the biological liquid to tend toward the expansion of the shell corresponding to the freeze-thaw bag. The biological liquid flows at the expansion part of the shell corresponding to the freeze-thaw bag (i.e., the central area of the freeze-thaw bag), causing the amount of biological liquid carried by the expansion part of the shell corresponding to the freeze-thaw bag (i.e., the central area of the freeze-thaw bag) to increase, resulting in excessive pressure on the shell and further expansion toward the outer surface, further prompting the biological liquid to continue to flow toward the expansion part of the shell corresponding to the freeze-thaw bag (i.e., the central area of the freeze-thaw bag), thereby causing the amount of biological liquid at the expansion part of the freeze-thaw bag (i.e., the central area of the freeze-thaw bag) to be too large in the thickness direction of the freeze-thaw bag relative to the peripheral area of the freeze-thaw bag. As the freezing process proceeds, the biological liquid in the peripheral area of the freeze-thaw bag has frozen while the biological liquid at the expansion part of the freeze-thaw bag (i.e., the central area of the freeze-thaw bag) has not yet frozen, causing the expansion part of the freeze-thaw bag (i.e., the central area of the freeze-thaw bag) to form frozen concentration, resulting in high local concentration, thereby reducing the activity of the biological liquid. Summary of the invention
[0004] In order to overcome the shortcomings of the prior art, the utility model provides a shell and a freeze-thaw system for accommodating a freeze-thaw bag. The shell forms a convex portion at a position corresponding to the center of the freeze-thaw bag, which can effectively inhibit excessive expansion of the center of the freeze-thaw bag and is beneficial to the uniformity of freezing of the freeze-thaw bag.
[0005] The technical solution adopted by the utility model to solve the technical problem is: a shell for accommodating a freeze-thaw bag, comprising:
[0006] chamber to accommodate freeze-thaw bags;
[0007] A bracket, forming a boundary defining the chamber, comprising a bottom plate and an edge, wherein the bottom plate is bent toward the chamber to form the edge;
[0008] The bottom plate has an inner surface facing the cavity and an outer surface opposite to the inner surface, the inner surface of the bottom plate forms a convex portion facing the inside of the cavity, and at the junction of the edge and the bottom plate, there is a height difference between the convex portion and the inner surface of the bottom plate along the thickness direction of the bottom plate;
[0009] The projection of the raised portion along the thickness direction of the bottom plate covers the center of the freeze-thaw bag, and the raised portion is formed with a reinforcing rib, and the center of the freeze-thaw bag falls within the area surrounded by the outer periphery of the reinforcing rib;
[0010] There is a gap between the edge and the periphery of the reinforcing rib to form a deformation zone, so that the liquid in the freeze-thaw bag is distributed from the area corresponding to the reinforcing rib of the protruding part to the area corresponding to the deformation zone.
[0011] In the above scheme, there is no limitation on the formation method of the raised portion. The raised portion may be formed by bending the bottom plate or by protruding from the inner surface of the bottom plate, that is, the raised portion is relatively independent of the bottom plate. For the height difference of the raised portion, the calculation is started from the plane where the edge and the bottom plate meet (that is, the plane where the lowest point of the inner surface of the chamber corresponding to the junction of the bottom plate and the edge is located). The center of the freeze-thaw bag refers to the intersection of multiple diagonals or the midpoint of only one diagonal line, and the periphery of the freeze-thaw bag refers to the closed edge surrounding the inside of the freeze-thaw bag. The arrangement method of the reinforcing ribs includes convex formation from the inner surface of the bottom plate to the outer surface of the bottom plate, convex formation from the outer surface of the bottom plate to the inner surface of the bottom plate, and direct protrusion from the inner surface of the bottom plate. It should be noted that not all reinforcing ribs are necessarily in the raised portion, and some reinforcing ribs may be located in the raised portion and some reinforcing ribs may be located in the area outside the raised portion of the bottom plate. The periphery of the reinforcing ribs refers to the outer circle of all reinforcing ribs and the area defined by the shortest perimeter surrounded.
[0012] The utility model arranges a raised portion, a reinforcing rib and a deformation zone on the bottom plate to cooperate with each other, wherein the raised portion is arranged at the center of the corresponding freeze-thaw bag and covers the center of the freeze-thaw bag and the area between the center of the freeze-thaw bag and the periphery of the freeze-thaw bag, and is formed to be raised toward the inside of the chamber to press the center of the freeze-thaw bag and the area between the center of the freeze-thaw bag and the periphery of the freeze-thaw bag; excessive expansion of the center of the freeze-thaw bag can be prevented, thereby avoiding uneven freezing in various parts of the freeze-thaw bag; at the same time, the material liquid in the center of the freeze-thaw bag tends to disperse toward the periphery of the freeze-thaw bag after being squeezed by the raised portion, avoiding the expansion of the center of the freeze-thaw bag to form frozen concentration and cause high local concentration, thereby improving the activity of the biological material liquid; the expanded part of the center of the freeze-thaw bag will form a greater squeezing effect on the raised portion, and the arrangement of the reinforcing ribs on the raised portion makes it possible to increase the strength of the bottom plate along the extension direction of the reinforcing ribs when the freeze-thaw bag expands toward the outer surface of the bottom plate, which can make the raised portion more difficult to deform in the area corresponding to the reinforcing ribs, thereby preventing the freeze-thaw bag On the other hand, the corresponding area can be over-expanded, and on the other hand, it can also prevent the bottom plate from being damaged due to squeezing when the center of the freeze-thaw bag is over-expanded; the setting of the deformation zone makes the area where the deformation zone corresponds to the freeze-thaw bag less inhibited during the freezing expansion process and easier to expand. Under the squeezing of the protrusion, the biological liquid distributed from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag is easier to disperse to the periphery of the freeze-thaw bag, further improving the uniformity of the distribution of the biological liquid; therefore, the protrusion protrudes in the direction of the chamber to squeeze and disperse the biological liquid in the center of the freeze-thaw bag toward the periphery of the freeze-thaw bag, and the deformation zone is deformed in time, which is conducive to the dispersion of the biological liquid in the freeze-thaw bag from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag, and is conducive to the periphery of the freeze-thaw bag receiving the biological liquid dispersed from the center of the freeze-thaw bag, so that the biological liquid in the freeze-thaw bag will not be over-expanded in the center of the freeze-thaw bag during the freezing process, which is conducive to the relatively uniform freezing thickness of each area of the freeze-thaw bag after the freezing is completed, thereby improving the activity of the biological liquid.
[0013] Furthermore, the deformation zone is provided with a hollow portion, and at least a part of the hollow portion is located at the end of the reinforcing rib along the extension direction thereof.
[0014] The hollow part is a vacant structure penetrating the bottom plate. The setting of the hollow part makes it easier for the deformation zone to expand toward the outer surface of the bottom plate, thereby promoting the distribution of the biological liquid in the freeze-thaw bag from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag, which is beneficial to the small difference in the amount of biological liquid in various parts of the freeze-thaw bag in the shell along the thickness direction of the freeze-thaw bag, which is beneficial to uniform freezing, avoiding squeezing damage to the middle part of the shell due to excessive expansion of the center of the freeze-thaw bag, and ensuring the mechanical strength of the shell.
[0015] Furthermore, hollow portions are provided at both ends of the same reinforcing rib; or the area occupied by the reinforcing rib is S1, and the area occupied by the hollow portion is S2, and S1 / S2 is 0.5-5.
[0016] Providing hollow parts at both ends of the same reinforcing rib is conducive to making the shell corresponding to the end of the reinforcing rib easy to deform, and further promoting the liquid in the center of the freeze-thaw bag to be distributed toward the periphery of the freeze-thaw bag; or limiting the ratio between the area S1 of the reinforcing rib (i.e. the sum of the areas of all the reinforcing ribs) and the area S2 occupied by the hollow part (i.e. the sum of the areas of all the hollow parts), when the ratio S1 / S2 is greater than 5, it means that the space occupied by the reinforcing rib on the bottom plate is too large, which reduces the accommodation space for the biological liquid; when the ratio S1 / S2 is less than 0.5, it means that the space occupied by the hollow part on the bottom plate is too large, which easily causes the overall mechanical strength of the shell to decrease; under the above ratio, the mechanical strength of the shell and the accommodation space for the liquid can be taken into account; and as the internal volume of the freeze-thaw shell decreases, that is, the size of the freeze-thaw bag becomes smaller accordingly, while maintaining the strength of the freeze-thaw shell, the area of the reinforcing rib on the shell is larger than the area of the hollow part.
[0017] Furthermore, the protrusion is provided with an inhibition zone, which is formed by the inner surface of the protrusion protruding toward the inside of the chamber, the center of the inhibition zone coincides or tends to coincide with the center of the freeze-thaw bag, and reinforcing ribs are provided in the inhibition zone.
[0018] The inhibition zone further enhances the inhibitory effect of the protrusion on the center of the freeze-thaw bag, thereby preventing the center of the freeze-thaw bag from over-expanding; setting the inhibition zone can more specifically inhibit the over-expanding of the center of the freeze-thaw bag, while retaining the space outside the corresponding inhibition zone in the chamber, thereby prompting the liquid squeezed from the center of the freeze-thaw bag to be distributed to the periphery of the freeze-thaw bag as much as possible, so that the thickness of each area of the freeze-thaw bag is relatively balanced after the freeze-thaw bag is finally frozen; compared with raising the protrusion as a whole, setting the inhibition zone can prevent the protrusion from occupying too much space in the chamber, thereby ensuring that the chamber has enough accommodation space to accommodate the expansion of the freeze-thaw bag.
[0019] Furthermore, the hollow portion is located at the periphery of the inhibition zone; or the projection area of the inhibition zone along the thickness direction of the bottom plate is s1, and the projection area of the bottom plate along the thickness direction of the bottom plate is s, then s1 / s is 0.1-0.9.
[0020] The hollow portion is arranged at the periphery of the inhibition zone to ensure the effective inhibitory effect of the inhibition zone on the center of the freeze-thaw bag; when the ratio of s1 / s is less than 0.1, it means that the area of the inhibition zone is too small, and the coverage area of the inhibition zone on the freeze-thaw bag is small, and it is difficult to achieve the inhibitory effect on the center of the freeze-thaw bag, and the center of the freeze-thaw bag will over-expand; when the ratio of s1 / s is greater than 0.9, it means that the area of the inhibition zone is too large, and the coverage area of the inhibition zone on the freeze-thaw bag is too large. The inhibition zone occupies too much volume of the chamber, resulting in the internal volume of the chamber being too small, reducing the capacity for the biological liquid; under the above ratio, both the biological liquid loading capacity of the chamber and the inhibitory effect of the inhibition zone on the freeze-thaw bag can be taken into account.
[0021] Furthermore, auxiliary ribs are provided between adjacent reinforcing ribs, and the extending direction of the auxiliary ribs is the same as the extending direction of the reinforcing ribs.
[0022] The auxiliary ribs can further improve the strength of the bottom plate corresponding to the expansion of the freeze-thaw bag, which is helpful to prevent the bottom plate corresponding to the expansion of the freeze-thaw bag from deforming toward the outer surface; the auxiliary ribs and the reinforcing ribs extend in the same direction, which can ensure that the bottom plate has good mechanical strength.
[0023] Furthermore, the angle between the extension direction of the reinforcing rib and / or the auxiliary rib and the width direction of the bracket is 0-45°.
[0024] Such an arrangement makes the extension direction of the reinforcing ribs and / or auxiliary ribs as close as possible to the width direction of the bracket, which helps to avoid the shell from breaking at the bending parts of the reinforcing ribs and / or auxiliary ribs when the shell is moved along the width direction, thereby ensuring the service life of the shell.
[0025] Furthermore, the extending direction of the reinforcing ribs and / or the auxiliary ribs is parallel to the width direction of the bracket.
[0026] Such an arrangement helps to prevent the shell from breaking at the bending part of the reinforcing rib when the shell is moved along the width direction of the shell, thereby extending the service life of the shell.
[0027] Furthermore, a reinforcement block is provided at a position of the bottom plate corresponding to the deformation zone, and the auxiliary ribs extend to be connected to the reinforcement block.
[0028] In this arrangement, the auxiliary ribs are not connected to the edge, so no fracture is formed at the edge of the bracket, which helps to avoid damage to the bracket caused by the fracture when the freeze-thaw bag expands.
[0029] Furthermore, a gap for accommodating the tube body is formed between the reinforcement block and the edge; there are multiple reinforcement blocks and adjacent reinforcement blocks are arranged at intervals.
[0030] The setting of the gap separates the tube body and the freeze-thaw bag, avoids mutual pressure between the tube body and the freeze-thaw bag, avoids influence between the two, and ensures the relative independence of the two; multiple reinforcement blocks are arranged at intervals, so that the bottom plate is easy to deform at the intervals between adjacent reinforcement blocks, thereby promoting the distribution of biological fluid from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag, and at the same time, it is also beneficial for heat to flow and circulate through the intervals between adjacent reinforcement blocks, further improving the freezing uniformity of the freeze-thaw bag.
[0031] Furthermore, the protrusion is formed by the outer surface of the bottom plate bending in an arc shape toward the inner surface.
[0032] Such an arrangement enables the bottom plate to be formed integrally from the manufacturing material, and the protrusion is not separately arranged from the bending part of the bottom plate, so there is no mechanical connection between the protrusion and the bottom plate, making it difficult for the protrusion to break when subjected to stress, which is beneficial to avoiding damage to the separate connection caused by temperature changes during the freezing process. At the same time, the protrusion is formed by the bulge of the bottom plate, and its thickness is relatively uniform everywhere, so the freezing inhibition effect on each area of the freeze-thaw bag is relatively balanced.
[0033] Furthermore, the maximum height difference between the protrusion and the inner surface of the bottom plate along the bottom plate thickness direction is D1; when the two shells are in the engaged state, the maximum height difference between the inner surfaces of the bottom plates of the opposite chambers is D2, and D1 / D2 is 0.1-0.4.
[0034] When the ratio of D1 / D2 is greater than 0.4, it means that the protrusion height is too large, causing the protrusion to occupy too large a volume in the chamber, resulting in no space for the biological liquid to be accommodated in the chamber; when the ratio of D1 / D2 is less than 0.1, the protrusion bends too little toward the inner surface of the bottom plate and cannot effectively suppress the problem of excessive expansion in the center of the freeze-thaw bag; under the above ratio, the volume of the cavity and the inhibitory effect of the protrusion on the freeze-thaw bag can be taken into account.
[0035] Furthermore, the protrusion extends from the junction of the edge and the bottom plate toward the center of the bottom plate, and the deformation zone falls entirely into the protrusion.
[0036] The raised portion extends over the entire bottom plate, and the deformation zone and the raised portion partially overlap, so that the biological liquid in the center of the freeze-thaw bag tends to be distributed toward the periphery of the freeze-thaw bag, while the center of the freeze-thaw bag and the periphery of the freeze-thaw bag can instantly and effectively deform to receive the distributed liquid. The entire bottom plate can play a role in suppressing excessive expansion of the center of the freeze-thaw bag, and the suppression effect is better.
[0037] The utility model also discloses a freeze-thaw system, comprising the above-mentioned shell and a freeze-thaw bag, wherein the freeze-thaw bag is located in the shell, and the center of the freeze-thaw bag is located within the projection of the protrusion along the thickness direction of the bottom plate.
[0038] The beneficial effects of the utility model are:
[0039] 1) The utility model arranges a raised portion, a reinforcing rib and a deformation zone on the bottom plate to cooperate with each other, wherein the raised portion is arranged at the center of the corresponding freeze-thaw bag and covers the center of the freeze-thaw bag and the area from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag, and is formed to be raised toward the inside of the chamber to press the center of the freeze-thaw bag and the area from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag; excessive expansion of the center of the freeze-thaw bag can be prevented, thereby avoiding uneven freezing in various parts of the freeze-thaw bag; at the same time, the liquid in the center of the freeze-thaw bag tends to disperse toward the periphery of the freeze-thaw bag after being squeezed by the raised portion, avoiding the expansion of the center of the freeze-thaw bag to form frozen concentration and cause high local concentration, thereby improving the activity of the biological liquid; the expansion of the center of the freeze-thaw bag will form a greater squeezing effect on the raised portion, and the arrangement of the reinforcing ribs on the raised portion increases the strength of the bottom plate along the extension direction of the reinforcing ribs when the freeze-thaw bag expands toward the outer surface of the bottom plate, which can make the raised portion on the reinforcing ribs The corresponding area is more difficult to deform, thereby preventing the corresponding area of the freeze-thaw bag from over-expanding. On the other hand, it can also prevent the bottom plate from being damaged due to squeezing when the center of the freeze-thaw bag is over-expanded; the setting of the deformation zone makes it easier for the biological liquid distributed from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag under the squeezing of the protrusion to disperse toward the periphery of the freeze-thaw bag, further improving the uniformity of the distribution of the biological liquid; therefore, the protrusion protrudes in the direction of the chamber to squeeze and disperse the biological liquid in the center of the freeze-thaw bag toward the periphery of the freeze-thaw bag, and the deformation zone deforms in a timely manner, which is conducive to the dispersion of the biological liquid in the freeze-thaw bag from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag, and is conducive to the periphery of the freeze-thaw bag receiving the biological liquid dispersed from the center of the freeze-thaw bag, so that the biological liquid in the freeze-thaw bag will not be over-expanded in the center of the freeze-thaw bag during the freezing process, which is conducive to the relatively uniform freezing thickness of each area of the freeze-thaw bag after the freezing is completed, thereby improving the activity of the biological liquid;
[0040] 2) The hollow portion makes it easier for the deformation zone to expand toward the outer surface of the bottom plate, thereby promoting the distribution of the biological liquid in the freeze-thaw bag from the center of the freeze-thaw bag to the periphery of the freeze-thaw bag, which is conducive to the small difference in the amount of biological liquid in each part of the freeze-thaw bag in the thickness direction of the freeze-thaw bag, and is conducive to uniform freezing, avoiding the middle part of the shell from being squeezed and damaged due to excessive expansion of the center of the freeze-thaw bag, thereby ensuring the mechanical strength of the shell;
[0041] 3) The inhibition zone further enhances the inhibitory effect of the protrusion on the center of the freeze-thaw bag, thereby preventing the center of the freeze-thaw bag from over-expanding; the inhibition zone is set to more specifically inhibit the over-expanding of the center of the freeze-thaw bag, while retaining the space outside the corresponding inhibition zone in the chamber, thereby prompting the liquid squeezed from the center of the freeze-thaw bag to be distributed to the periphery of the freeze-thaw bag as much as possible, so that the thickness of each area of the freeze-thaw bag is relatively balanced after the freeze-thaw bag is finally frozen; compared with raising the protrusion as a whole, setting the inhibition zone can prevent the protrusion from occupying too much space in the chamber, thereby ensuring that the chamber has enough accommodation space to accommodate the expansion of the freeze-thaw bag. BRIEF DESCRIPTION OF THE DRAWINGS
[0042] Figure 1 This is a top view of the shell provided in Example 1 of the utility model.
[0043] Figure 2 This is a three-dimensional diagram of the shell and freeze-thaw bag provided in Example 1 of the utility model.
[0044] Figure 3 This is a cross-sectional view along the length direction of the shell provided in the first embodiment of the utility model.
[0045] Figure 4 A top view of the shell provided in the first embodiment of the utility model being relatively buckled and matched with the freeze-thaw bag.
[0046] Figure 5 for Figure 4 The AA section view in the figure shows the state before freezing.
[0047] Figure 6 This is a cross-sectional view of the shells provided in the first embodiment of the utility model stacked up and down and matched with the freeze-thaw bag, which is the state after freezing.
[0048] Figure 7 It is a partial cross-sectional view of another forming method of the raised portion in the utility model.
[0049] Figure 8 This is a top view of the shell provided in Example 2 of the utility model.
[0050] Fig. 9 This is a three-dimensional view of the shell provided in Example 2 of the utility model.
[0051] Fig.10 This is a cross-sectional view along the length direction of the shell provided in the second embodiment of the utility model.
[0052] Fig.11 This is a cross-sectional view along the width direction of the shell provided for the second embodiment of the utility model.
[0053] Fig.12 This is a three-dimensional diagram of the shell and freeze-thaw bag provided in the second embodiment of the present utility model.
[0054] Fig.13 This is a cross-sectional view of the shells provided in the second embodiment of the present invention stacked up and down and matched with the freeze-thaw bag, which is the state before freezing.
[0055] Fig.14 This is a cross-sectional view of the shells provided in the second embodiment of the present invention stacked up and down and matched with the freeze-thaw bag, which is the state after freezing.
[0056] Among them, 1-chamber, 2-freeze-thaw bag, 21-tube body, 3-bracket, 31-bottom plate, 311-inner surface of bottom plate, 312-outer surface of bottom plate, 32-edge, 4-raised portion, 41-reinforcement rib, 42-inhibition zone, 43-auxiliary rib, 5-deformation zone, 51-hollow portion, 6-reinforcement block, 7-gap. DETAILED DESCRIPTION
[0057] In order to enable those skilled in the art to better understand the solution of the utility model, the following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the utility model.
[0058] Embodiment 1
[0059] like Figure 1-Figure 3 As shown, a housing for accommodating a freeze-thaw bag comprises a chamber 1 for accommodating a freeze-thaw bag 2, and a bracket 3 for forming a boundary of the chamber 1, the bracket 3 having a bottom plate 31 and an edge 32, the outer periphery of the bottom plate 31 being bent toward the direction of the chamber 1 to form the above-mentioned edge 32. In this embodiment, the bottom plate 31 is square, and its four sides are upward (with Figure 3 The bottom plate 31 is bent to form an edge 32, and the edges 32 are connected in one piece. In other embodiments, the shapes of the bottom plate 31 and the edge 32 are not limited. The bottom plate 31 defines the bottom boundary of the chamber 1, the edge 32 defines the circumferential boundary of the chamber 1, and the top of the chamber 1 is open.
[0060] In the above structure, the number of the bracket 3 is one, but of course the number of the bracket 3 can also be two, such as Figure 4-Figure 6 As shown, the two brackets 3 are buckled up and down to form a chamber 1. At this time, the bottom boundary and the top boundary of the chamber 1 are respectively defined by the bottom plates 31 of the two brackets 3, and the circumferential boundary of the chamber 1 is defined by the edges 32 of the two brackets 3 being buckled up and down. At this time, both bottom plates 31 have convex parts 4 arranged opposite to each other, and the two convex parts 4 interact with each other to squeeze the center of the freeze-thaw bag 2. Before freezing, the thickness of the center of the freeze-thaw bag 2 is less than the thickness of the periphery of the freeze-thaw bag 2.
[0061] The bottom plate 31 has a bottom plate inner surface 311 facing the chamber 1 and a bottom plate outer surface 312 disposed opposite to each other in the thickness direction of the bottom plate 31. The bottom plate inner surface 311 forms a protrusion 4 facing the inside of the chamber 1. At the junction of the edge 32 and the bottom plate 31, there is a height difference between the protrusion 4 and the bottom plate inner surface 311 along the thickness direction of the bottom plate 31. Figure 3As shown in the figure as an example, the plane where the bottom plate 31 and the edge 32 intersect is the L1 plane. Specifically, the L1 plane is the plane where the lowest point of the inner surface of the chamber 1 corresponding to the intersection of the bottom plate 31 and the edge 32 is located. The raised portion 4 is formed by the upward protrusion of the inner surface 311 of the bottom plate. The highest point of the raised portion 4 is located in the plane of the L2 plane. There is a height difference D1 between the L2 plane and the L1 plane. The height difference D1 is the height difference between the bottom and the top of the raised portion 4.
[0062] The projection of the raised portion 4 along the thickness direction of the bottom plate 31 covers the center of the freeze-thaw bag 2, and the raised portion 4 is formed with a reinforcing rib 41, and the center of the freeze-thaw bag 2 falls within the area surrounded by the reinforcing rib 41. The center of the freeze-thaw bag 2 here refers to the intersection of multiple diagonals, or the midpoint of only one diagonal line, regardless of the shape of the freeze-thaw bag 2, and the periphery of the freeze-thaw bag refers to the closed edge surrounding the inside of the freeze-thaw bag; in this embodiment, the freeze-thaw bag 2 is close to a square as an example, Figure 2 As shown, the center of the freeze-thaw bag 2 is the intersection of its two diagonal lines. Of course, the center of the freeze-thaw bag 2 here is not limited to one point, but can be expanded to the area formed by extending outward with the center of the freeze-thaw bag 2 as the center of the circle. The periphery of the reinforcing rib 41 here refers to the area defined by the outer circle connecting all the reinforcing ribs 41 in the raised portion 4 and the shortest circumference enclosed. In other words, the center of the freeze-thaw bag 2 is located in the area where the reinforcing ribs 41 of the raised portion 4 are located. It should be noted that not all the reinforcing ribs 41 are necessarily in the raised portion 4, and some of the reinforcing ribs 41 may be located in the raised portion 4, and some of the reinforcing ribs 41 may be located in the area outside the raised portion 4.
[0063] There is a gap between the edge 32 and the periphery of the reinforcing rib 41 of the raised portion 4 to form a deformation zone 5. In other words, the periphery of the reinforcing rib 41 of the raised portion 4 and the edge 32 are not continuously arranged, and the reinforcing rib 41 does not extend the entire bottom plate 31. The area between the periphery of the reinforcing rib 41 on the raised portion 4 and the edge 32 is the deformation zone 5. The deformation zone 5 makes it easier for the liquid in the freeze-thaw bag 2 to be distributed from the area corresponding to the reinforcing rib 41 of the raised portion 4 to the area corresponding to the deformation zone 5. In other words, under the action of the raised portion 4 and the reinforcing rib 41 thereon, the liquid in the center of the freeze-thaw bag 2 is easier to be distributed to the periphery of the freeze-thaw bag 2.
[0064] The freeze-thaw bag 2 on the market is usually formed by welding two membrane bodies at the periphery, so the membrane body at the periphery has a relatively large constraint on the internal biological liquid, and the middle membrane body has a relatively small constraint on the internal biological liquid. When the biological liquid in the freeze-thaw bag 2 is frozen, the expansion of the central area of the freeze-thaw bag 2 is greater than the expansion of the peripheral area of the freeze-thaw bag 2; in this expansion process, the central area of the freeze-thaw bag 2 expands the corresponding area of the shell, and then the biological liquid at the periphery of the freeze-thaw bag 2, under the compression of the outer periphery of the shell, tends to flow to the expanded area of the freeze-thaw bag 2 at the periphery of the shell corresponding to the shell, resulting in an excessively large thickness of the central area of the freeze-thaw bag 2; on the other hand, an excessively large thickness of the central area of the freeze-thaw bag 2 will result in the biological liquid in the peripheral area of the freeze-thaw bag 2 being completely frozen, while the biological liquid in the central area of the freeze-thaw bag 2 is not completely frozen, ultimately resulting in uneven freezing speeds in various areas of the freeze-thaw bag 2, which has an adverse effect on the activity of the biological liquid, and even causes frozen concentration to form at the expanded center of the freeze-thaw bag 2, resulting in high local concentration and reducing the activity of the biological liquid.
[0065] The utility model provides a raised portion 4 on the bottom plate 31, and the raised portion 4 is formed to be raised toward the side where the chamber 1 is located, and the projection of the raised portion 4 along the thickness direction of the bottom plate 31 covers the center of the freeze-thaw bag 2. In other words, the raised portion 4 is provided in the area corresponding to the center of the freeze-thaw bag 2, so that whether it is the raised portion 4 on a single bracket 3 or the raised portions 4 of two brackets 3 interacting with each other, it can suppress the excessive expansion of the central area of the freeze-thaw bag 2, avoid causing a large amount of biological liquid to be concentrated in the expanded area at the center of the freeze-thaw bag 2, and improve the uniformity of freezing. Since the expanded area at the center of the freeze-thaw bag 2 will form a large squeezing effect on the raised portion 4, the provision of the reinforcing ribs 41 on the raised portion 4 increases the strength of the bottom plate 31 along the extension direction of the reinforcing ribs 41 when the freeze-thaw bag 2 expands toward the outer surface 312 of the bottom plate, and avoids the freeze-thaw bag 2 from being squeezed by the bottom plate 31 and damaged when it is excessively expanded. The setting of the deformation zone 5 makes it easier for the biological liquid distributed from the center of the freeze-thaw bag 2 to the periphery of the freeze-thaw bag 2 under the squeezing of the protrusion 4 to disperse toward the periphery of the freeze-thaw bag 2, further improving the uniform distribution of the biological liquid. In other words, when the protrusion 4 squeezes toward the center of the freeze-thaw bag 2 to avoid excessive expansion of the center of the freeze-thaw bag 2, the deformation zone 5 is easy to deform, so that the biological liquid in the center of the freeze-thaw bag 2 squeezed by the protrusion 4 is more likely to flow and distribute toward the periphery of the freeze-thaw bag 2, thereby improving the uniformity of the biological liquid in each area of the freeze-thaw bag 2. The protrusion 4, the reinforcing rib 41 and the deformation zone 5 cooperate with each other. The protrusion 4 protrudes in the direction of the chamber 1 to squeeze and disperse the biological liquid in the center of the freeze-thaw bag 2 outward. The deformation zone 5 deforms in a timely manner, which is conducive to the dispersion of the biological liquid in the freeze-thaw bag 2 from the center of the freeze-thaw bag 2 to the periphery of the freeze-thaw bag 2, and is conducive to the periphery of the freeze-thaw bag 2 receiving the biological liquid dispersed from the center of the freeze-thaw bag 2, so that the biological liquid in the freeze-thaw bag 2 will not be excessively expanded in the center of the freeze-thaw bag 2 during the freezing process. Figure 6As shown, it is beneficial for the freezing thickness of each area of the freeze-thaw bag 2 to be relatively uniform after the freezing is completed, thereby ultimately improving the activity of the biological liquid.
[0066] Regarding the formation of the protrusion 4, it can be as follows Figure 3 As shown, the raised portion 4 is formed by bending the bottom plate 31, and can also be as follows Figure 7 As shown, the protrusion 4 is formed by protruding from the inner surface of the bottom plate, that is, the protrusion 4 is relatively independent from the bottom plate 31, and there is no specific limitation.
[0067] like Figure 1 As shown, in this embodiment, the reinforcing ribs 41 are three short rib structures extending along the width direction of the bottom plate 31. Here, the shorter side of the bottom plate 31 is defined as the width direction, and the longer side is defined as the length direction. The reinforcing ribs 41 are formed to bulge outward from the bottom plate inner surface 311 to the bottom plate outer surface 312. At this time, the reinforcing ribs 41 can not only play a reinforcing role, but also play a role in accommodating the biological liquid. In some other specific embodiments, the reinforcing ribs 41 can also be formed to bulge inward from the bottom plate outer surface 312 to the bottom plate inner surface 311, or the reinforcing ribs 41 can also be formed by directly bulging from the bottom plate inner surface 311, without specific limitation.
[0068] The deformation zone 5 is provided with a hollow portion 51, which is a vacant structure penetrating the bottom plate 31, and at least part of the hollow portion 51 is located at the end of the reinforcing rib 41 along its extension direction. The setting of the hollow portion 51 makes it easier for the deformation zone 5 to expand toward the outer surface 312 of the bottom plate, thereby promoting the distribution of the biological liquid in the freeze-thaw bag 2 from the center of the freeze-thaw bag 2 to the periphery of the freeze-thaw bag 2, which is conducive to the small difference in the amount of biological liquid at each location of the freeze-thaw bag 2 in the shell along the thickness direction of the freeze-thaw bag 2, which is conducive to uniform freezing, avoiding the middle of the shell from being squeezed and damaged due to excessive expansion of the center of the freeze-thaw bag 2, and ensuring the mechanical strength of the shell. In this embodiment, the hollow portion 51 is located at both ends of the reinforcing rib 41, which is circular. In other specific embodiments, the hollow portion 51 can also be located only at one end of the reinforcing rib 41, which is not specifically limited. Since the reinforcing ribs 41 can increase the strength of the bottom plate 31 along the extension direction of the reinforcing ribs 41, the deformation of the bottom plate 31 corresponding to the reinforcing ribs 41 is small. Through the hollow portion 51 at the end where the reinforcing ribs 41 extend, the strength of the bottom plate 31 corresponding to the hollow portion 51 is low and easy to deform, which further promotes the distribution of the biological liquid from the protrusion 4 to the hollow portion 51, and further improves the uniformity of the freezing of the biological liquid.
[0069] Define the area occupied by the reinforcing ribs 41 as S1 (i.e., the sum of the areas of all reinforcing ribs), define the area occupied by the hollow portion 51 as S2 (i.e., the sum of the areas of all hollow portions), then S1 / S2 is 0.5-5. When the ratio of S1 / S2 is greater than 5, it means that the space occupied by the reinforcing ribs 41 on the bottom plate 31 is too large, reducing the space for accommodating biological liquid; when the ratio of S1 / S2 is less than 0.5, it means that the space occupied by the hollow portion 51 on the bottom plate 31 is too large, which is likely to cause the overall mechanical strength of the shell to decrease. Under the above ratio, both the mechanical strength of the shell and the space for accommodating the liquid can be taken into account.
[0070] like Figure 1 As shown, auxiliary ribs 43 are provided between adjacent reinforcing ribs 41, and the extension direction of the auxiliary ribs 43 is the same as the extension direction of the reinforcing ribs 41, so that the auxiliary ribs 43 can further improve the strength of the expansion portion of the bottom plate 31 corresponding to the freeze-thaw bag 2, which is conducive to preventing the expansion portion of the bottom plate 31 corresponding to the freeze-thaw bag 2 from deforming toward the outer surface 312 of the bottom plate. In this embodiment, the auxiliary ribs 43 are formed to bulge outward from the inner surface 311 of the bottom plate to the outer surface 312 of the bottom plate, and the formation method is the same as that of the reinforcing ribs 41.
[0071] Specifically, the angle between the extension direction of the reinforcing rib 41 and the width direction of the bracket 3 is 0-45°, or the angle between the extension direction of the auxiliary rib 43 and the width direction of the bracket 3 is 0-45°, or the angle between the extension direction of the reinforcing rib 41 and the auxiliary rib 43 and the width direction of the bracket 3 is 0-45°. In this embodiment, the angle between the extension direction of the reinforcing rib 41 and the width direction of the bracket 3 is 0°, that is, the extension direction of the reinforcing rib 41 is parallel to the width direction of the bracket 3, and the extension direction of the auxiliary rib 43 is parallel to the extension direction of the reinforcing rib 41, that is, the extension direction of the auxiliary rib 43 is parallel to the width direction of the bracket 3. Such a setting is conducive to preventing the shell from breaking at the bend of the reinforcing rib 41 when the shell is moved along the width direction of the shell, thereby extending the service life of the shell.
[0072] A reinforcing block 6 is provided at the position of the bottom plate 31 corresponding to the deformation zone 5, and the auxiliary rib 43 extends to be connected to the reinforcing block 6. It is explained that the extension length of the auxiliary rib 43 is large, which is beneficial for the auxiliary rib 43 to improve the mechanical strength of the bracket 3. At the same time, the auxiliary rib 43 is not connected to the edge 32, so no fracture is formed at the edge 32 of the bracket 3, avoiding the fracture from breaking when the freeze-thaw bag 2 expands and causing damage to the bracket 3. In this embodiment, the number of reinforcing blocks 6 is multiple, which corresponds to the number of auxiliary ribs 43, and adjacent reinforcing blocks 6 are arranged at intervals, that is, the reinforcing blocks 6 are disconnected and discontinuous in their extension direction, so that the bottom plate 31 is easy to deform at the intervals between adjacent reinforcing blocks 6, thereby promoting the distribution of the biological material liquid from the center of the freeze-thaw bag 2 to the periphery of the freeze-thaw bag 2, and at the same time, it is also beneficial for heat to flow and circulate through the intervals of adjacent reinforcing blocks 6, further improving the freezing uniformity of the freeze-thaw bag 2. In some other specific embodiments, the number of reinforcing blocks 6 can also be one, that is, the reinforcing blocks 6 are continuous in their extension direction, and the ends of multiple auxiliary ribs 43 are connected to the same reinforcing block 6.
[0073] The freeze-thaw bag 2 is connected to a tube body 21, and a gap 7 for accommodating the tube body 21 is formed between the reinforcing block 6 and the edge 32, so that the tube body 21 and the freeze-thaw bag 2 are separated, avoiding mutual compression between the tube body 21 and the freeze-thaw bag 2, avoiding influence between the two, and ensuring the relative independence of the two.
[0074] In this embodiment, the raised portion 4 is formed by the arc bending of the outer surface 312 of the bottom plate toward the inner surface 311 of the bottom plate, so that the bottom plate 31 can be formed by the manufacturing material in one piece, and the connection of the raised portion 4 is not separated from the bottom plate 31. The raised portion 4 is not easy to break under stress, which is conducive to avoiding the damage of the split connection caused by temperature changes during the freezing process. At the same time, the raised portion 4 is formed by the bulge of the bottom plate 31, and its thickness is relatively uniform at various places, and the freezing inhibition effect on various areas of the freeze-thaw bag 2 is relatively balanced. Of course, the above structure also ensures the uniformity of the thickness of the bottom plate 31 at various places, which is conducive to the uniform transfer of heat through the bottom plate 31, so that the heat transfer in various areas of the freeze-thaw bag 2 is relatively balanced, and the freezing uniformity of the freeze-thaw bag 2 is further improved. At the same time, the above structure allows the bottom plate 31 to be formed by the manufacturing material in one piece, which is conducive to avoiding the damage of the split connection caused by temperature changes during the freezing process.
[0075] The maximum height difference between the protrusion 4 and the inner surface 311 of the bottom plate along the thickness direction of the bottom plate 31 is D1, that is, Figure 3The height difference between the L2 plane and the L1 plane; when the two shells are in the locked state, the maximum height difference between the bottom plate inner surfaces 311 of the relative chamber 1 is D2, and D1 / D2 is 0.1-0.4. When the ratio of D1 / D2 is greater than 0.4, it means that the protrusion 4 has a too large height, that is, the protrusion 4 tends to bend excessively toward the bottom plate inner surface 311, causing the protrusion 4 to occupy too much volume in the chamber 1, thereby causing no space for the biological liquid to be accommodated in the chamber 1; when the ratio of D1 / D2 is less than 0.1, it means that the protrusion 4 has a too small height, that is, the protrusion 4 tends to bend too little toward the bottom plate inner surface 311, and it cannot effectively suppress the problem of excessive expansion of the center of the freeze-thaw bag 2.
[0076] In this embodiment, the raised portion 4 extends from the junction of the edge 32 and the bottom plate 31 to the center of the bottom plate 31, and the deformation zone 5 falls into the raised portion 4 as a whole. In other words, the raised portion 4 extends the entire bottom plate 31, and the deformation zone 5 and the raised portion 4 partially overlap, so that the biological liquid in the center of the freeze-thaw bag 2 is distributed to the periphery of the freeze-thaw bag 2, and the freeze-thaw bag can be instantly and effectively deformed to receive the distributed liquid, and the entire bottom plate 31 can play a role in inhibiting excessive expansion of the center of the freeze-thaw bag 2, and the inhibition effect is better. In some other specific embodiments, the raised portion 4 can also extend from the inner side of the junction of the edge 32 and the bottom plate 31, that is, the outer periphery of the raised portion 4 is spaced from the junction of the edge 32 and the bottom plate 31, and at this time, the deformation zone 5 partially falls into the raised portion 4, and part is located on the bottom plate 31 outside the raised portion 4.
[0077] Embodiment 2
[0078] like Figure 8-Figure 14 As shown, in this embodiment, the raised portion 4 is provided with an inhibition zone 42, which is formed by the inner surface of the raised portion 4 protruding toward the interior of the chamber 1, the center of the inhibition zone 42 coincides or tends to coincide with the center of the freeze-thaw bag 2, and a reinforcing rib 41 is provided in the inhibition zone 42.
[0079] The hollow portion 51 is located at the periphery of the suppression area 42 , and is not necessarily disposed at the end of the reinforcing rib 41 in the extending direction. The auxiliary rib 43 is also disposed at the periphery of the suppression area 42 .
[0080] The projection area of the inhibition zone 42 along the thickness direction of the bottom plate 31 is defined as s1, and the projection area of the bottom plate 31 is defined as s, then s1 / s is 0.1-0.9. When the ratio of s1 / s is less than 0.1, it means that the area of the inhibition zone 42 is too small, and the coverage area of the inhibition zone 42 for the freeze-thaw bag 2 is small, and it is difficult to achieve the inhibitory effect on the center of the freeze-thaw bag 2, and the center of the freeze-thaw bag 2 will be over-expanded; when the ratio of s1 / s is greater than 0.9, it means that the area of the inhibition zone 42 is too large, and the coverage area of the inhibition zone 42 for the freeze-thaw bag 2 is too large. The inhibition zone 42 occupies too much volume of the chamber 1, resulting in a reduction in the internal volume of the chamber 1, and reducing the capacity for the biological liquid; under the above ratio, the biological liquid loading capacity of the chamber 1 and the inhibitory effect of the inhibition zone 42 on the freeze-thaw bag 2 can be taken into account.
[0081] The inhibition zone 42 further enhances the inhibitory effect of the protrusion 4 on the center of the freeze-thaw bag 2, thereby preventing the center of the freeze-thaw bag 2 from over-expanding. Setting the inhibition zone 42 can more specifically inhibit the over-expanding of the center of the freeze-thaw bag 2, while retaining the space around the inhibition zone 42, so that the liquid squeezed from the center of the freeze-thaw bag 2 is distributed to the periphery of the freeze-thaw bag 2 as much as possible, so that the thickness of each area of the freeze-thaw bag 2 is relatively balanced after the freezing is finally completed. Compared with raising the protrusion 4 as a whole, setting the inhibition zone 42 can prevent the protrusion 4 from occupying the chamber 1, thereby ensuring that the chamber 1 has sufficient accommodation space.
[0082] The other structures are the same as those in the first embodiment and will not be described in detail.
[0083] Embodiment 3
[0084] like Figures 2 to 14 As shown, a freeze-thaw system includes the shell of the above-mentioned embodiment 1 or embodiment 2, and a freeze-thaw bag 2, wherein the freeze-thaw bag 2 is located in the shell, and the center of the freeze-thaw bag 2 is located in the projection of the protrusion 4 along the thickness direction of the bottom plate.
[0085] The above specific implementation modes are used to explain the present invention rather than to limit the present invention. Any modification and change made to the present invention within the spirit of the present invention and the protection scope of the claims shall fall within the protection scope of the present invention.
Claims
1. A housing for accommodating a freeze-thaw bag, characterized in that: include: chamber to accommodate freeze-thaw bags; A bracket, forming a boundary defining the chamber, comprising a bottom plate and an edge, wherein the bottom plate is bent toward the chamber to form the edge; The bottom plate has a bottom plate inner surface facing the cavity and a bottom plate outer surface opposite to the bottom plate inner surface, the bottom plate inner surface forms a convex portion facing the interior of the cavity, and at the junction of the edge and the bottom plate, there is a height difference between the convex portion and the bottom plate inner surface along the bottom plate thickness direction; The projection of the raised portion along the thickness direction of the bottom plate covers the center of the freeze-thaw bag, and the raised portion is formed with a reinforcing rib, and the center of the freeze-thaw bag falls within the area surrounded by the outer periphery of the reinforcing rib; There is a gap between the edge and the periphery of the reinforcing rib to form a deformation zone, so that the liquid in the freeze-thaw bag is distributed from the area corresponding to the reinforcing rib of the protruding part to the area corresponding to the deformation zone.
2. The housing for accommodating a freeze-thaw bag according to claim 1, characterized in that: The deformation zone is provided with a hollow portion, and at least a part of the hollow portion is located at the end of the reinforcing rib along the extension direction thereof.
3. The housing for accommodating a freeze-thaw bag according to claim 2, characterized in that: There are hollow parts at both ends of the same reinforcing rib; or the area occupied by the reinforcing rib is S1, and the area occupied by the hollow part is S2, then S1 / S2 is 0.5-5.
4. The housing for accommodating a freeze-thaw bag according to any one of claims 2 or 3, characterized in that: The convex part is provided with an inhibition zone, which is formed by the inner surface of the convex part protruding toward the inside of the chamber, the center of the inhibition zone coincides or tends to coincide with the center of the freeze-thaw bag, and a reinforcing rib is provided in the inhibition zone.
5. The housing for accommodating a freeze-thaw bag according to claim 4, characterized in that: The hollow portion is located at the periphery of the inhibition zone; or the projection area of the inhibition zone along the thickness direction of the bottom plate is s1, and the projection area of the bottom plate along the thickness direction of the bottom plate is s, then s1 / s is 0.1-0.
9.
6. The housing for accommodating a freeze-thaw bag according to claim 1, characterized in that: Auxiliary ribs are provided between adjacent reinforcing ribs, and the extending direction of the auxiliary ribs is the same as the extending direction of the reinforcing ribs.
7. The housing for accommodating a freeze-thaw bag according to claim 6, characterized in that: The angle between the extension direction of the reinforcing rib and / or the auxiliary rib and the width direction of the bracket is 0-45°.
8. The housing for accommodating a freeze-thaw bag according to claim 7, characterized in that: The extending direction of the reinforcing ribs and / or the auxiliary ribs is parallel to the width direction of the bracket.
9. The housing for accommodating a freeze-thaw bag according to claim 6, characterized in that: A reinforcing block is provided at a position of the bottom plate corresponding to the deformation zone, and the auxiliary ribs extend to be connected to the reinforcing block.
10. The housing for accommodating a freeze-thaw bag according to claim 9, characterized in that: A gap for accommodating the tube body is formed between the reinforcement block and the edge; there are multiple reinforcement blocks and adjacent reinforcement blocks are arranged at intervals.
11. The housing for accommodating a freeze-thaw bag according to claim 1, characterized in that: The protrusion is formed by the outer surface of the bottom plate being bent in an arc shape toward the inner surface.
12. The housing for accommodating a freeze-thaw bag according to claim 11, characterized in that: The maximum height difference between the protrusion and the inner surface of the bottom plate along the bottom plate thickness direction is D1; when the two shells are in the engaged state, the maximum height difference between the inner surfaces of the bottom plates of the opposite chambers is D2, and D1 / D2 is 0.1-0.
4.
13. The housing for accommodating a freeze-thaw bag according to claim 1, characterized in that: The protrusion extends from the junction of the edge and the bottom plate toward the center of the bottom plate, and the deformation zone falls entirely into the protrusion.
14. A freeze-thaw system, characterized in that: It comprises a shell and a freeze-thaw bag as described in any one of claims 1 to 13, wherein the freeze-thaw bag is located in the shell, and the center of the freeze-thaw bag is located within the projection of the protrusion along the thickness direction of the bottom plate.