Purification reaction kettle

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By designing a purification reactor including a stirring assembly, a pressing mechanism and a heating member, the problem of insufficient contact between the dissolved agent and the yew raw material in the traditional reactor is solved, and the preparation time of paclitaxel and the energy consumption are reduced.

CN222889799UActive Publication Date: 2025-05-23FUJIAN ZISHANYUAN BIOLOGY CO LTD

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Patent Information

Application Number: CN202421742541.7
Authority / Receiving Office: CN · China
Patent Type: Utility models(China)
Current Assignee / Owner
Filing Date: 2024-07-23
Publication Date: 2025-05-23
Estimated Expiration: 2034-07-23

AI Technical Summary

Technical Problem

During the preparation and purification of paclitaxel in traditional reactors, due to the low density of yew raw materials, the dissolving agent is insufficiently in contact with yew raw materials, which extends the preparation time and increases energy consumption.

Method used

A purification reactor is designed, including the kettle body, agitating assembly, pressing mechanism and heating parts. The lifting disc and pressing parts are driven by a linear drive member, and the yew raw material is repeatedly pressed into the dissolving agent to ensure full contact.

Benefits of technology

The full contact between the dissolved agent and the yew raw material is achieved, which shortens the preparation time of paclitaxel and reduces production energy consumption.

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Abstract

The utility model relates to a purification reaction kettle which comprises a kettle body, a stirring assembly, a material pressing mechanism and a heating piece, in the actual paclitaxel production and processing process, when paclitaxel needs to be prepared and purified, a taxus chinensis raw material and a dissolving agent can be put into the kettle body through the discharging opening, then the heating piece is operated to heat the taxus chinensis raw material and the dissolving agent, then the stirring assembly is operated, and the taxus chinensis raw material and the dissolving agent are stirred to be uniform. The taxus chinensis raw material and the dissolving agent are stirred by the stirring assembly, then the linear driving piece is operated to drive the material pressing piece to press downwards through the lifting disc, the taxus chinensis raw material is repeatedly pressed into the dissolving agent through the material pressing piece, the taxus chinensis raw material makes full contact with the dissolving agent, and therefore paclitaxel can be better prepared and purified. In addition, the dissolving agent is more fully contacted with the taxus chinensis raw material, so that the preparation time of the paclitaxel is shortened, and the production energy consumption is reduced.

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Description

Technical Field

[0001] The utility model relates to the technical field of reaction kettles, in particular to a purification reaction kettle. Background Art

[0002] Paclitaxel is a new type of anticancer drug with a taxane diterpene skeleton isolated and extracted from Taxus plants. It is also the only drug known to date that can promote microtubule polymerization and stabilize polymerized microtubules. It has a strong inhibitory effect on most solid tumors, but has little effect on normal cells. It is especially effective for advanced ovarian cancer, breast cancer, non-small cell lung cancer and Kaposi's sarcoma, with fewer side effects. With further in-depth research, the anticancer effect of paclitaxel drugs has been more widely used, and it has now become a first-line anticancer drug and a broad-spectrum anti-tumor drug.

[0003] The preparation of paclitaxel is mainly through natural extraction, fermentation, chemical synthesis and semi-synthesis. Natural extraction: paclitaxel is mainly derived from the bark, leaves and branches of Taxus brevis, etc. The yew raw materials are minced and poured into the reactor together with the solvent, and then paclitaxel is prepared and purified in the reactor.

[0004] However, when preparing and purifying paclitaxel in traditional reactors, due to the low density of the yew raw material, the yew raw material often floats on the surface of the solvent in the early stage of dissolution, resulting in insufficient contact between the solvent and the yew raw material, which prolongs the preparation time of paclitaxel and increases energy consumption. Utility Model Content

[0005] 1. Technical issues to be resolved

[0006] In order to solve the above problems in the prior art, the utility model provides a purification reactor, which can better prepare and purify paclitaxel, and make the solvent contact with the yew raw material more fully, shorten the preparation time of paclitaxel, and reduce production energy consumption.

[0007] (II) Technical solution

[0008] In order to achieve the above-mentioned purpose, the main technical solutions adopted by the utility model include:

[0009] A purification reaction kettle, comprising a kettle body, a stirring assembly, a material pressing mechanism and a heating element, wherein a feed inlet is arranged in the middle of the kettle body, a discharge port is arranged at the bottom of the kettle body, the heating element is laid inside the kettle body, the stirring assembly is connected to the kettle body, the material pressing mechanism is arranged inside the kettle body, and the material pressing mechanism is connected to the stirring assembly;

[0010] The material pressing mechanism includes a mounting plate, a lifting plate, a linear driving member and a material pressing member. The mounting plate is fixedly connected to the stirring assembly. The lifting plate is arranged above the mounting plate. The lifting plate is slidably connected to the stirring assembly. The lifting plate is connected to the mounting plate through the linear driving member. A plurality of material pressing members are installed on the lower surface of the lifting plate. A plurality of sliding holes are arranged on the mounting plate. One material pressing member is slidably connected to one of the sliding holes.

[0011] Furthermore, the pressing piece includes a sliding rod and a pressing plate, the top of the sliding rod is fixedly connected to the lower surface of the lifting plate, the middle of the sliding rod is slidably connected to the sliding hole, and the bottom of the sliding rod is fixedly connected to the pressing plate.

[0012] Furthermore, the upper portion of the linear drive member is detachably connected to the mounting plate, and the lower portion of the linear drive member is linearly drivenly connected to the lifting plate.

[0013] Furthermore, the stirring assembly includes a rotating drive member, a connecting shaft, a stirring shaft and a stirring member, the rotating drive member is installed on the top of the kettle body, the connecting shaft is arranged inside the kettle body, the rotating drive member is drivingly connected to the top of the connecting shaft, the bottom of the connecting shaft is fixedly connected to the stirring shaft, the outer surface of the stirring shaft is fixedly connected to the stirring member, the bottom of the connecting shaft is fixedly connected to the mounting plate, and the lifting plate is slidably connected to the middle part of the connecting shaft.

[0014] Furthermore, a matching hole is provided at the center of the lifting plate, the matching hole is adapted to the connecting shaft, and the connecting shaft is passed through the matching hole and is slidably connected to the matching hole.

[0015] Furthermore, the cross section of the connecting shaft is rectangular, and the matching hole is rectangular.

[0016] Furthermore, it also includes a feed pipe, and the feed port is fixedly connected with the feed pipe.

[0017] Furthermore, it also includes a discharge pipe, the discharge port is fixedly connected with the discharge pipe, and a sealing cover is provided on the discharge pipe.

[0018] Furthermore, it also includes a support frame, and the outer surface of the kettle body is fixedly connected to the support frame.

[0019] Furthermore, it also includes a PLC controller, which is electrically connected to the stirring component, the pressing mechanism and the heating element respectively.

[0020] (III) Beneficial effects

[0021] The utility model has the beneficial effects that when paclitaxel needs to be prepared and purified during the actual production and processing of paclitaxel, a yew raw material and a solvent can be put into the kettle through a discharge port, and then a heating element is operated to heat the yew raw material and the solvent, and then a stirring component is operated to stir the yew raw material and the solvent, and then a linear driving element is operated to drive a pressing element to press down through a lifting plate, and the yew raw material is repeatedly pressed into the solvent through the pressing element, so that the yew raw material is fully contacted with the solvent, thereby better preparing and purifying paclitaxel, and the solvent is more fully contacted with the yew raw material, thereby shortening the preparation time of paclitaxel and reducing production energy consumption. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the overall structure of a purification reactor according to an embodiment of the utility model;

[0023] Figure 2 It is a front view of the overall structure of the purification reactor of an embodiment of the utility model;

[0024] Figure 3 It is a cross-sectional view of the overall structure of the purification reactor of an embodiment of the utility model;

[0025] [Description of Reference Numerals]

[0026] Rotating drive member 1, kettle body 2, feed pipe 3, sealing cover 4, support frame 5, discharge pipe 6, linear drive member 7, lifting plate 8, mounting plate 9, stirring member 10, stirring shaft 11, pressing plate 12, sliding rod 13, connecting shaft 14. DETAILED DESCRIPTION

[0027] In order to better explain the present invention and facilitate understanding, the present invention is described in detail below through specific implementation modes in conjunction with the accompanying drawings.

[0028] Please refer to Figures 1 to 3 As shown, a purification reaction kettle of the utility model comprises a kettle body 2, a stirring assembly, a material pressing mechanism and a heating element, wherein a feed inlet is arranged in the middle of the kettle body 2, a discharge port is arranged at the bottom of the kettle body 2, the heating element is laid inside the kettle body 2, the stirring assembly is connected to the kettle body 2, the material pressing mechanism is arranged inside the kettle body 2, and the material pressing mechanism is connected to the stirring assembly;

[0029] The pressing mechanism includes a mounting plate 9, a lifting plate 8, a linear drive member 7 and a pressing member. The mounting plate 9 is fixedly connected to the stirring assembly. The lifting plate 8 is arranged above the mounting plate 9. The lifting plate 8 is slidably connected to the stirring assembly. The lifting plate 8 is connected to the mounting plate 9 through the linear drive member 7. Several pressing members are installed on the lower surface of the lifting plate 8. Several sliding holes are arranged on the mounting plate 9. One pressing member is slidably connected to one sliding hole.

[0030] The working principle of the utility model is as follows: in the actual paclitaxel production and processing process, when paclitaxel is to be prepared and purified, the yew raw material and the solvent can be put into the kettle body 2 through the discharge port, and then the heating element is operated to heat the yew raw material and the solvent, and then the stirring component is operated to stir the yew raw material and the solvent, and then the linear driving component 7 is operated to drive the pressing component to press down through the lifting plate 8, and the yew raw material is repeatedly pressed into the solvent through the pressing component, so that the yew raw material is fully in contact with the solvent.

[0031] Furthermore, the pressing member includes a sliding rod 13 and a pressing plate 12, the top of the sliding rod 13 is fixedly connected to the lower surface of the lifting plate 8, the middle of the sliding rod 13 is slidably connected to the sliding hole, and the bottom of the sliding rod 13 is fixedly connected to the pressing plate 12.

[0032] From the above description, it can be seen that the lifting plate 8 is conducive to driving the slide bar 13 to move downward when descending, and slide with the slide hole at the same time, and then the slide bar 13 drives the pressing plate 12 to press the yew raw material into the solvent.

[0033] Furthermore, the upper portion of the linear drive member 7 is detachably connected to the mounting plate 9 , and the lower portion of the linear drive member 7 is linearly drivenly connected to the lifting plate 8 .

[0034] It can be seen from the above description that it is beneficial for the linear drive member 7 to better drive the lifting plate 8 to move up and down.

[0035] Furthermore, the stirring assembly includes a rotating drive member 1, a connecting shaft 14, a stirring shaft 11 and a stirring member 10, the rotating drive member 1 is installed on the top of the kettle body 2, the connecting shaft 14 is arranged inside the kettle body 2, the rotating drive member 1 is drivingly connected to the top of the connecting shaft 14, the bottom of the connecting shaft 14 is fixedly connected to the stirring shaft 11, the outer surface of the stirring shaft 11 is fixedly connected with the stirring member 10, the bottom of the connecting shaft 14 is fixedly connected to the mounting plate 9, and the lifting plate 8 is slidably connected to the middle part of the connecting shaft 14.

[0036] From the above description, it can be seen that when it is necessary to stir the yew raw material and the solvent, the rotating drive member 1 can be operated to drive the stirring shaft 11 to rotate through the connecting shaft 14, and at the same time, the stirring shaft 11 drives the stirring member 10 to stir the yew raw material and the solvent, and at the same time, the connecting shaft 14 drives the mounting plate 9 and the lifting plate 8 to rotate.

[0037] Furthermore, a matching hole is provided at the center of the lifting plate 8, and the matching hole is adapted to the connecting shaft 14. The connecting shaft 14 is passed through the matching hole and is slidably connected to the matching hole.

[0038] It can be seen from the above description that it is beneficial for the connecting shaft 14 to drive the lifting plate 8 to rotate through the matching hole.

[0039] Furthermore, the cross section of the connecting shaft 14 is rectangular, and the matching hole is rectangular.

[0040] It can be seen from the above description that the connecting shaft 14 is conducive to better driving the lifting plate 8 to rotate.

[0041] Furthermore, it also includes a feed pipe 3, and the feed port is fixedly connected with the feed pipe 3.

[0042] From the above description, it can be seen that it is beneficial to introduce the yew raw material and the dissolving agent into the kettle body 2 through the feeding pipe 3 .

[0043] Furthermore, it also includes a discharge pipe 6 , the discharge port is fixedly connected with the discharge pipe 6 , and a sealing cover 4 is provided on the discharge pipe 6 .

[0044] It can be seen from the above description that the processed paclitaxel is discharged through the discharge pipe 6 , and the discharge pipe 6 is sealed by the sealing cover 4 .

[0045] Furthermore, it also includes a support frame 5, and the outer surface of the kettle body 2 is fixedly connected with the support frame 5.

[0046] From the above description, it can be seen that it is beneficial to support the entire device through the support frame 5.

[0047] Furthermore, it also includes a PLC controller, which is electrically connected to the stirring component, the pressing mechanism and the heating element respectively.

[0048] It can be seen from the above description that it is more convenient for the user to control the entire device.

[0049] Embodiment 1

[0050] Please refer to Figures 1 to 3A purification reactor, comprising a reactor body 2, a stirring assembly, a material pressing mechanism and a heating element, wherein a feed inlet is arranged in the middle of the reactor body 2, a discharge port is arranged at the bottom of the reactor body 2, the heating element is laid inside the reactor body 2, the stirring assembly is connected to the reactor body 2, the material pressing mechanism is arranged inside the reactor body 2, and the material pressing mechanism is connected to the stirring assembly;

[0051] The heating element adopts electric heating wire;

[0052] The material pressing mechanism comprises a mounting plate 9, a lifting plate 8, a linear driving member 7 and a material pressing member, wherein the mounting plate 9 is fixedly connected to the stirring assembly, the lifting plate 8 is arranged above the mounting plate 9, the lifting plate 8 is slidably connected to the stirring assembly, the lifting plate 8 is connected to the mounting plate 9 through the linear driving member 7, a plurality of material pressing members are installed on the lower surface of the lifting plate 8, a plurality of sliding holes are arranged on the mounting plate 9, and one material pressing member is slidably connected to one of the sliding holes;

[0053] The linear drive member 7 adopts a telescopic motor;

[0054] The pressing member includes a slide bar 13 and a pressing plate 12, the top of the slide bar 13 is fixedly connected to the lower surface of the lifting plate 8 and is welded, the middle of the slide bar 13 is slidably connected to the slide hole, and the bottom of the slide bar 13 is fixedly connected to the pressing plate 12 and is welded;

[0055] The upper portion of the linear drive member 7 is detachably connected to the mounting plate 9 via bolts, and the lower portion of the linear drive member 7 is linearly drivenly connected to the lifting plate 8;

[0056] The stirring assembly includes a rotating driving member 1, a connecting shaft 14, a stirring shaft 11 and a stirring member 10, wherein the rotating driving member 1 is installed on the top of the kettle body 2 by bolts, and the connecting shaft 14 is arranged inside the kettle body 2, and the rotating driving member 1 is drivingly connected to the top of the connecting shaft 14 by a coupling, and the bottom of the connecting shaft 14 is fixedly connected to the stirring shaft 11 and welded, and the stirring member 10 is fixedly connected to the outer surface of the stirring shaft 11 and welded, and the bottom of the connecting shaft 14 is fixedly connected to the mounting plate 9 and welded, and the lifting plate 8 is slidably connected to the middle part of the connecting shaft 14;

[0057] The rotating drive member 1 adopts a reduction motor;

[0058] A matching hole is provided at the center of the lifting plate 8, and the matching hole is adapted to the connecting shaft 14. The connecting shaft 14 is passed through the matching hole and is slidably connected to the matching hole.

[0059] The cross section of the connecting shaft 14 is rectangular, and the matching hole is rectangular;

[0060] It also includes a feed pipe 3, and the feed port is fixedly connected to the feed pipe 3 by welding;

[0061] It also includes a discharge pipe 6, the discharge port is fixedly connected to the discharge pipe 6 by welding, and a sealing cover 4 is provided on the discharge pipe 6;

[0062] A stop valve is provided inside the discharge pipe 6;

[0063] It also includes a support frame 5, and the outer surface of the kettle body 2 is fixedly connected to the support frame 5 by welding;

[0064] It also includes a PLC controller, which is electrically connected to the stirring assembly, the pressing mechanism and the heating element respectively;

[0065] The PLC controller model is DATA-7311, and the PLC controller is electrically connected to the heating element, the linear driving element 7 and the rotating driving element 1 respectively.

[0066] The above shows and describes the basic principle, main features and advantages of the utility model, and the standard parts used in the utility model can be purchased from the market, special-shaped parts can be customized according to the description and the drawings, and the specific connection methods of each part adopt mature conventional means such as bolts, rivets, welding, etc. in the prior art. Machinery, parts and equipment all adopt conventional models in the prior art, and the circuit connection adopts the conventional connection method in the prior art, which will not be described in detail here.

[0067] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent transformations made using the contents of the specification and drawings of the present invention, or directly or indirectly applied in the relevant technical field, are also included in the patent protection scope of the present invention.

Claims

1. A purification reactor, characterized in that: It comprises a kettle body, a stirring assembly, a material pressing mechanism and a heating element, wherein a feeding port is arranged in the middle of the kettle body, a discharging port is arranged at the bottom of the kettle body, the heating element is laid inside the kettle body, the stirring assembly is connected to the kettle body, the material pressing mechanism is arranged inside the kettle body, and the material pressing mechanism is connected to the stirring assembly; The material pressing mechanism includes a mounting plate, a lifting plate, a linear driving member and a material pressing member. The mounting plate is fixedly connected to the stirring assembly. The lifting plate is arranged above the mounting plate. The lifting plate is slidably connected to the stirring assembly. The lifting plate is connected to the mounting plate through the linear driving member. A plurality of material pressing members are installed on the lower surface of the lifting plate. A plurality of sliding holes are arranged on the mounting plate. One material pressing member is slidably connected to one of the sliding holes.

2. The purification reactor according to claim 1, characterized in that: The material pressing piece includes a sliding rod and a pressing plate, the top of the sliding rod is fixedly connected to the lower surface of the lifting plate, the middle of the sliding rod is slidably connected to the sliding hole, and the bottom of the sliding rod is fixedly connected to the pressing plate.

3. The purification reactor according to claim 1, characterized in that: The upper portion of the linear drive member is detachably connected to the mounting plate, and the lower portion of the linear drive member is linearly drivenly connected to the lifting plate.

4. The purification reactor according to claim 1, characterized in that: The stirring assembly includes a rotating drive member, a connecting shaft, a stirring shaft and a stirring member, the rotating drive member is installed on the top of the kettle body, the connecting shaft is arranged inside the kettle body, the rotating drive member is drivingly connected to the top of the connecting shaft, the bottom of the connecting shaft is fixedly connected to the stirring shaft, the outer surface of the stirring shaft is fixedly connected to the stirring member, the bottom of the connecting shaft is fixedly connected to the mounting plate, and the lifting plate is slidably connected to the middle part of the connecting shaft.

5. The purification reactor according to claim 4, characterized in that: A matching hole is arranged at the center of the lifting plate, the matching hole is matched with the connecting shaft, and the connecting shaft is passed through the matching hole and is slidably connected with the matching hole.

6. The purification reactor according to claim 5, characterized in that: The cross section of the connecting shaft is rectangular, and the matching hole is rectangular.

7. The purification reactor according to claim 1, characterized in that: It also includes a feeding pipe, and the feeding port is fixedly connected with the feeding pipe.

8. The purification reactor according to claim 1, characterized in that: It also includes a discharge pipe, the discharge port is fixedly connected to the discharge pipe, and a sealing cover is arranged on the discharge pipe.

9. The purification reactor according to claim 1, characterized in that: It also includes a support frame, and the outer surface of the kettle body is fixedly connected to the support frame.

10. The purification reactor according to claim 1, characterized in that: It also includes a PLC controller, which is electrically connected to the stirring component, the pressing mechanism and the heating element respectively.