Microfluidic disc and microfluidic analyzer
By setting an asymmetric microgroove structure on the disc main body of the microfluidic disc and equiping a weight structure, the problem of difficulty in adjusting the center of gravity of the existing microfluidic disc is solved, and stability and accuracy are achieved during high-speed rotation.
Patent Information
- Application Number
- CN202421807018.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-26
- Publication Date
- 2025-05-27
- Estimated Expiration
- 2034-07-26
AI Technical Summary
The microgroove structure on the disc main body of the existing microfluidic disc is complex, which makes it difficult for the center of gravity to coincide with the center of the disc, resulting in high jitter and noise when rotating at high speed, affecting the accuracy of the detection results.
A microfluidic disk is designed, and an asymmetric micro groove structure is provided on the first surface of the disk main body and connected to the counterweight structure on the cover plate, to adjust the center of gravity of the disk so that it coincides with the center of the disk main body.
By adjusting the center of gravity, the microfluidic disc has better stability when rotating at high speed, reducing jitter and noise, ensuring the smoothness of the detection process, and thus improving the accuracy of the detection results.
Smart Images
Figure CN222901131U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of medical devices, in particular to a microfluidic disk and a microfluidic analyzer. Background Art
[0002] Microfluidic technology is a technology that uses microchannels to process and manipulate tiny fluids. It can integrate basic units such as sample preparation, reaction, separation, and detection in the fields of biology, chemistry, medicine, etc. onto a microfluidic disk with a micron scale. The entire analysis process is automatically completed by a microfluidic analyzer, and it has a wide range of applications in the field of in vitro diagnosis.
[0003] During the detection process of a microfluidic analyzer, the microfluidic disk rotates at a high speed inside the microfluidic analyzer, and the dynamic balance problem needs to be considered. If the center of gravity of the microfluidic disk is eccentrically set with respect to the center of the microfluidic disk, the microfluidic disk will vibrate during rotation, produce a large noise, and affect the accuracy of the detection result. However, the microgroove structure on the disk body of the existing microfluidic disk is relatively complex, with many asymmetric structures, resulting in it being difficult for the center of gravity of the microfluidic disk to coincide with the center of the microfluidic disk. Summary of the Utility Model
[0004] In view of this, the utility model provides a microfluidic disk and a microfluidic analyzer.
[0005] The microfluidic disk proposed in the first aspect of the utility model includes:
[0006] A disk body, including a first surface. The first surface of the disk body is provided with a microgroove structure, and the microgroove structure is asymmetrically arranged with respect to the center of the disk body, so that the center of gravity of the disk body is eccentrically arranged with respect to the center of the disk body;
[0007] A cover plate, connected to the disk body and covering the first surface of the disk body;
[0008] A weight structure, connected to the cover plate, and the weight structure is used to adjust the center of gravity of the microfluidic disk to coincide with the center of the disk body.
[0009] The microfluidic analyzer proposed in the second aspect of the utility model includes:
[0010] A rotation driving mechanism;
[0011] The above-mentioned microfluidic disk;
[0012] Wherein, the rotation driving mechanism is used to drive the microfluidic disk to rotate.
[0013] As can be seen from the above technical solution, the microfluidic disc proposed in the first aspect of the present utility model adjusts the center of gravity of the microfluidic disc to coincide with the center of the disc body by setting a weight structure, so that the microfluidic disc has good stability during high-speed rotation, will not generate large fluctuations, and has low noise, thereby enabling the detection process to proceed smoothly and being conducive to improving the accuracy of the detection results. BRIEF DESCRIPTION OF THE DRAWINGS
[0014] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the accompanying drawings required for the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings in the following description are some embodiments of the present utility model. For those of ordinary skill in the art, other accompanying drawings can be obtained from these accompanying drawings without creative efforts.
[0015] Figure 1 is a side view schematic diagram of the microfluidic disc proposed in an embodiment of the present utility model;
[0016] Figure 2 is an exploded schematic diagram of the microfluidic disc proposed in an embodiment of the present utility model;
[0017] Figure 3 is a structural schematic diagram of the disc body proposed in an embodiment of the present utility model;
[0018] Figure 4 is a three-dimensional structural schematic diagram of the disc body proposed in an embodiment of the present utility model;
[0019] Figure 5 is a top view schematic diagram of the microfluidic disc proposed in an embodiment of the present utility model. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0020] The technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are some, but not all, of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.
[0021] Such as Figure 1 and Figure 2As shown in the figure, an embodiment of the present utility model proposes a microfluidic disc 100. The proposed microfluidic disc 100 includes a disc body 10, a cover plate 20, and a weight structure 30. The disc body 10 includes a first surface A. A micro-groove structure 40 is provided on the first surface A of the disc body 10. The micro-groove structure 40 is asymmetrically arranged relative to the center of the disc body 10, so that the center of gravity of the disc body 10 is eccentrically arranged relative to the center of the disc body 10. The cover plate 20 is connected to the disc body 10 and covers the first surface A of the disc body 10. The weight structure 30 is connected to the cover plate 20. The weight structure 30 is used to adjust the center of gravity of the microfluidic disc 100 to coincide with the center of the disc body 10.
[0022] For the microfluidic disc 100 proposed by the present utility model, by setting the weight structure 30 to adjust the center of gravity of the microfluidic disc 100 to coincide with the center of the disc body 10, the microfluidic disc 100 has better stability during high-speed rotation, will not generate large fluctuations, has low noise, so that the detection process can proceed smoothly, which is beneficial to improving the accuracy of the detection results.
[0023] As Figure 3 and Figure 4 shown, in some embodiments, the micro-groove structure 40 includes a sample quantification groove 41, a diluent quantification groove 42, a mixing groove 43, and a colorimetric groove 44. The sample quantification groove 41 and the diluent quantification groove 42 are communicated with the mixing groove 43, so that the sample liquid in the sample quantification groove 41 and the diluent in the diluent quantification groove 42 can flow into the mixing groove 43 for mixing. The mixing groove 43 is communicated with the colorimetric groove 44, so that the mixed liquid in the mixing groove 43 can flow into the colorimetric groove 44 for detection.
[0024] As Figure 3 and Figure 4 shown, in some embodiments, the micro-groove structure 40 further includes a sample injection groove 45, a sample surplus groove 46, a diluent injection groove 47, and a diluent surplus groove 48. The sample injection groove 45 is used for injecting the sample liquid. Part of the sample liquid in the sample injection groove 45 flows into the sample quantification groove 41, and the excess sample liquid in the sample injection groove 45 flows into the sample surplus groove 46. The diluent injection groove 47 is used for injecting the diluent. Part of the diluent in the diluent injection groove 47 flows into the diluent quantification groove 42, and the excess diluent in the diluent injection groove 47 flows into the diluent surplus groove 48.
[0025] As Figures 2 to 5 shown, in some embodiments, a sample addition hole C is provided on the cover plate 20. The sample liquid enters the sample injection groove 45 from the sample addition hole C. For example, in some embodiments, a syringe or other tool can be used to inject the sample liquid into the sample injection groove 45 through the sample addition hole C.
[0026] As Figure 3 andFigure 4 As shown, in some embodiments, the microfluidic disc 100 further includes a diluent sac (not shown in the figure). The diluent sac is placed in the accommodation groove 50 in the middle of the disc body 10. A puncture part is provided at the position of the cover plate 20 facing the accommodation groove 50. The puncture part can be a sharp structure such as a cone or a needle, and the puncture part can pierce the sac cover of the diluent sac. A pushing member can be provided in the accommodation groove 50. The pushing member is used to push the diluent sac towards the puncture part under the action of an external force to pierce the sac cover and release the diluent in the diluent sac. The pushing member can be a structure such as a push rod or a push block. One end of the pushing member is located in the accommodation groove 50, and the other end of the pushing member is located on the side of the disc body 10 facing away from the cover plate 20.
[0027] As Figure 3 and Figure 4 shown, in some embodiments, the microgroove structure 40 further includes an arc-shaped flow channel 49. The arc-shaped flow channel 49 communicates the mixing groove 43 and the colorimetric groove 44. The mixed liquid in the mixing groove 43 flows into the colorimetric groove 44 through the arc-shaped channel.
[0028] As Figure 3 and Figure 4 shown, in some embodiments, the microgroove structure 40 further includes a first capillary flow channel 101, a second capillary flow channel 102, and a third capillary flow channel 103. The first capillary flow channel 101 is connected to the sample quantification groove 41 and the mixing groove 43. The sample liquid in the sample quantification groove 41 flows into the mixing groove 43 through the first capillary flow channel 101. The second capillary flow channel 102 is connected to the diluent quantification groove 42 and the mixing groove 43. The diluent in the diluent quantification groove 42 flows into the mixing groove 43 through the second capillary flow channel 102. The third capillary flow channel 103 is connected to the mixing groove 43 and the arc-shaped flow channel 49. After the sample liquid and the diluent are mixed in the mixing groove 43 to form a mixed liquid, the mixed liquid flows into the arc-shaped flow channel 49 through the third capillary flow channel 103. This setting uses capillary force to drive the liquid flow, and finally forms a siphon effect, and cooperates with the external centrifugal force to make the liquid flow into the corresponding tank to realize the quantification of the sample liquid, diluent, and mixed liquid.
[0029] As Figure 3 and Figure 4 shown, in some embodiments, the microgroove structure 40 further includes a first air vent 104. When the sample liquid flows into the sample quantification groove 41 and the sample surplus groove 46, the gas in the sample quantification groove 41 and the sample surplus groove 46 can be discharged in time from the first air vent 104. When the diluent flows into the diluent quantification groove 42 and the diluent surplus groove 48, the gas in the diluent quantification groove 42 and the diluent surplus groove 48 can also be discharged in time from the first air vent 104, avoiding the influence of the internal air pressure on the liquid inflow.
[0030] As Figure 3 and Figure 4As shown, in some embodiments, the micro-groove structure 40 further includes a second vent hole 105 communicating with the mixing tank 43. When the sample liquid and the diluent enter the mixing tank 43, the gas in the mixing tank 43 is discharged from the second vent hole 105 in a timely manner, avoiding the influence of the internal air pressure on the liquid inflow.
[0031] As Figure 3 and Figure 4 shown, in some embodiments, the micro-groove structure 40 further includes a third vent hole 106 communicating with the sample injection tank 45. When the sample liquid flows into the sample injection tank 45, the gas in the sample injection tank 45 is discharged from the third vent hole 106 in a timely manner, avoiding the influence of the internal air pressure on the liquid injection.
[0032] As Figure 2 shown, in some embodiments, the disc body 10 is a disc, and the center of the disc body 10 is the center of the disc.
[0033] As Figures 2 to 5 shown, in some embodiments, the number of colorimetric tanks 44 is multiple, and the multiple colorimetric tanks 44 are arranged around the center of the disc body 10. The cover plate 20 includes a disc cover 21 and a positioning cover 22. The disc cover 21 is connected to the disc body 10 and covers the first surface A of the disc body 10. The positioning cover 22 is disposed on the side of the disc cover 21 facing away from the disc body 10. The positioning cover 22 is annular, and an opening 221 opposite to the colorimetric tank 44 is provided on the positioning cover 22.
[0034] In some embodiments, the disc body 10 and the disc cover 21 are transparent members. For example, the disc body 10 and the disc cover 21 can be, but are not limited to, acrylic members. By setting the disc body 10 and the disc cover 21 as transparent members, it is convenient for users to observe the flow of the sample liquid and the diluent in the micro-groove structure 40.
[0035] Of course, the disc body 10 and the disc cover 21 are not limited to being integrally transparent. For example, in some other embodiments, the disc body 10 and the disc cover 21 are only transparent at positions opposite to the colorimetric tanks 44, and other positions are non-transparent, which can be determined according to actual design needs.
[0036] As Figure 2 and Figure 5 shown, in some embodiments, the weight structure 30 is connected to the positioning cover 22 and is located inside the positioning cover 22. It should be noted that the weight structure 30 is not limited to being disposed inside the positioning cover 22. For example, in some other embodiments, the weight structure 30 is disposed outside the positioning cover 22 or on the side of the positioning cover 22 facing away from the disc cover 21, which can be determined according to actual design needs.
[0037] It should also be noted that the counterweight structure 30 and the positioning cover 22 can be integrally formed. For example, the counterweight structure 30 and the positioning cover 22 can be integrally injection-molded using the same material. In some other embodiments, the counterweight structure 30 and the positioning cover 22 can also be formed by secondary injection molding, that is, the positioning cover 22 is first processed and formed, and then the counterweight structure 30 and the positioning cover 22 are connected together by injection molding. The counterweight structure 30 can be, but is not limited to, plastic.
[0038] As Figure 2 and Figure 5 shown, in some embodiments, the sample addition hole C is provided on the disc cover 21, and the counterweight structure 30 points to the sample addition hole C. In this embodiment, the user can timely find the position of the sample addition hole C according to the indication of the counterweight structure 30, especially when the entire disc cover 21 is a transparent part. It should be noted that by using the counterweight structure 30 as an indicator, there is no need to additionally provide an indicator, which is beneficial to simplifying the structural design, reducing the manufacturing difficulty of the microfluidic disc 100, and can play a role in reducing costs. Of course, in some other embodiments, the counterweight structure 30 does not point to the sample addition hole C, and it is also possible to additionally provide an indicator on the disc cover 21 to indicate the sample addition hole C. For example, an additional indicator arrow is provided on the disc cover 21 to indicate the position of the sample addition hole C.
[0039] As Figure 2 and Figure 5 shown, in some embodiments, the contour of the counterweight structure 30 is in the shape of an animal's paw. In this embodiment, through the decorative effect of the animal's paw, the overall appearance and visual effect of the microfluidic disc 100 are good, and the user can also identify the user object of the microfluidic disc 100 according to the shape of the animal's paw. Of course, the contour of the counterweight structure 30 is not set to the shape of an animal's paw, and it can be set to other shapes according to user needs, such as an animal image pattern or a pattern of other shapes, which can be determined according to actual design needs.
[0040] In some embodiments, the side of the positioning cover 22 facing away from the disc body 10 and the side of the counterweight structure 30 facing away from the disc body 10 are black. In this embodiment, the appearance and visual effect of the microfluidic disc 100 can be better, and the user can quickly observe the counterweight structure 30, and thus can quickly observe the sample addition hole C according to the indication of the counterweight structure 30.
[0041] It should be noted that the side of the positioning cover 22 facing away from the disc body 10 and the side of the counterweight structure 30 facing away from the disc body 10 are not limited to being set to black, and can also be other colors, which can be determined according to actual design needs.
[0042] It should also be noted that the side of the positioning cover 22 facing away from the disc body 10 and the side of the weight structure 30 facing away from the disc body 10 are black. It can be that only the side of the positioning cover 22 facing away from the disc body 10 and the side of the weight structure 30 facing away from the disc body 10 are coated or printed with black materials, or the positioning cover 22 and the weight structure 30 are made of black materials as a whole, so that the side of the positioning cover 22 facing away from the disc body 10 and the side of the weight structure 30 facing away from the disc body 10 appear black, which can be determined according to actual design needs specifically.
[0043] As Figure 2 and Figure 5 shown, in some embodiments, an indicating structure 211 is provided on the disc cover 21, and the indicating structure 211 is used to indicate the amount of the sample liquid injected into the microfluidic disc 100. During the specific use process, if it is observed that there is liquid flowing through the indicating structure 211, it indicates that the amount of the sample liquid injected into the microfluidic disc 100 is sufficient; otherwise, it is insufficient.
[0044] In some embodiments, the indicating structure 211 is a sunk groove provided on the disc cover 21, that is, the side of the disc cover 21 facing away from the disc body 10 is recessed towards the disc body 10 but does not penetrate the disc cover 21.
[0045] As Figure 2 shown, in some embodiments, the disc cover 21 is provided with a plurality of blind holes 212. The plurality of blind holes 212 are provided on the side of the disc cover 21 facing away from the disc body 10, and the plurality of blind holes 212 correspond one-to-one to the colorimetric grooves 44 on the disc body 10 and the openings 221 on the positioning cover 22.
[0046] In some embodiments, an information code (not shown in the figure) is provided on the side of the disc cover 21 facing away from the disc body 10, and the information code at least includes the effective use date information of the microfluidic disc 100.
[0047] As Figure 2 、 Figure 3 and Figure 5 shown, in some embodiments, the disc body 10 is provided with a first positioning hole 11, the disc cover 21 is provided with a second positioning hole (not shown in the figure), and the positioning cover 22 is provided with a third positioning hole 222. The first positioning hole 11, the second positioning hole and the third positioning hole 222 are arranged opposite to each other. In this implementation manner, on the one hand, it is convenient for the positioning and assembly among the disc body 10, the disc cover 21 and the positioning cover 22; on the other hand, the positioning through holes formed by the first positioning hole 11, the second positioning hole and the third positioning hole 222 enable the microfluidic disc 100 to be positioned and placed on the microfluidic analyzer.
[0048] In the above embodiments, the weight structure 30 is connected to the positioning cover 22. It should be noted that it is not limited to this implementation manner. For example, in some other embodiments, asFigure 3 As shown, the micro-groove structure 40 further includes a receiving groove 107, and the counterweight structure 30 is disposed on the disc cover 21 and embedded in the receiving groove 107. That is, in this embodiment, the counterweight structure 30 is not arranged to be connected to the positioning cover 22, but is connected to the disc cover 21, which can also play a role in adjusting the center of gravity of the microfluidic disc 100 to coincide with the center of the disc body 10.
[0049] In some embodiments, the counterweight structure 30 and the disc cover 21 may be integrally formed. For example, the counterweight structure 30 and the disc cover 21 may be integrally injection-molded with the same material. In some other embodiments, the counterweight structure 30 and the disc cover 21 may also be formed by secondary injection molding, that is, the disc cover 21 is first processed and formed, and then the counterweight structure 30 is connected to the disc cover 21 by injection molding. The counterweight structure 30 may be, but is not limited to, plastic.
[0050] An embodiment of the present invention further provides a microfluidic analyzer, including a rotation driving mechanism and the above-mentioned microfluidic disc 100, and the rotation driving mechanism is used to drive the microfluidic disc 100 to rotate.
[0051] The above is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims
1. A microfluidic disk, characterized in that: include: A disc body, comprising a first surface, wherein the first surface of the disc body is provided with a micro-groove structure, wherein the micro-groove structure is asymmetrically arranged relative to the center of the disc body, so that the center of gravity of the disc body is eccentrically arranged relative to the center of the disc body; a cover plate connected to the disc body and covering the first surface of the disc body; A counterweight structure is connected to the cover plate, and the counterweight structure is used to adjust the center of gravity of the microfluidic disk to coincide with the center of the disk body.
2. The microfluidic disk according to claim 1, characterized in that: The micro-groove structure includes a plurality of colorimetric grooves, and the plurality of colorimetric grooves are arranged around the center of the disc body; The cover plate includes a disc cover and a positioning cover, wherein the disc cover is connected to the disc body and covers the first surface of the disc body, and the positioning cover is arranged on the side of the disc cover facing away from the disc body, and the positioning cover is annular and is provided with an opening opposite to the colorimetric slot.
3. The microfluidic disk according to claim 2, characterized in that: The counterweight structure is connected to the positioning cover and is located on the inner side of the positioning cover.
4. The microfluidic disk according to claim 2, characterized in that: The disc cover is provided with a sample adding hole, and the counterweight structure points to the sample adding hole.
5. The microfluidic disk according to claim 2, characterized in that: The outline of the counterweight structure is in the shape of an animal's paw.
6. The microfluidic disk according to claim 2, characterized in that: The side of the positioning cover facing away from the disc body and the side of the counterweight structure facing away from the disc body are black.
7. The microfluidic disk according to claim 2, characterized in that: The micro-groove structure includes a receiving groove, and the counterweight structure is arranged on the disc cover and embedded in the receiving groove.
8. The microfluidic disk according to claim 2, characterized in that: Include at least one of the following characteristics: The disc body and the disc cover are transparent parts; The counterweight structure and the positioning cover are integrally formed; The disc cover is provided with an indication structure, and the indication structure is used to indicate the amount of sample liquid injected into the microfluidic disc; An information code is provided on a side of the disc cover facing away from the disc body, and the information code at least includes information on the effective use date of the microfluidic disc; The disc body is provided with a first positioning hole, the disc cover is provided with a second positioning hole, and the positioning cover is provided with a third positioning hole. The first positioning hole, the second positioning hole and the third positioning hole are arranged opposite to each other.
9. The microfluidic disk according to claim 1, characterized in that: The microgroove structure includes a sample quantitative groove, a diluent quantitative groove, a mixing groove and a colorimetric groove. The sample quantitative groove and the diluent quantitative groove are connected to the mixing groove so that the sample liquid in the sample quantitative groove and the diluent in the diluent quantitative groove can flow into the mixing groove for mixing. The mixing groove is connected to the colorimetric groove so that the mixed liquid in the mixing groove can flow into the colorimetric groove for detection.
10. A microfluidic analyzer, characterized in that: include: Rotary drive mechanism; The microfluidic disc according to any one of claims 1 to 9; Wherein, the rotation driving mechanism is used to drive the microfluidic disk to rotate.