Photosensitizer releaser

Abstract

The utility model discloses a photosensitizer releasing piece which comprises a cup body and a cover body. Due to the design of the cup body, accurate split charging and freeze-drying treatment of the liquid photosensitizer can be conveniently carried out in a sterile and clean environment, and the risks of bacterial pollution and excessive endotoxin and particles in the split charging and freeze-drying links of the photosensitizer are avoided. The cup body is provided with a liquid inlet connector and a liquid outlet connector which are collinear and communicated with the cup body; the cover body covers the port of the cup body; a baffle is arranged on the inner side of the cover body, and an angle is formed between the baffle and the connecting line of the liquid inlet connector and the liquid outlet connector. When the photosensitizer releasing piece is used for releasing the photosensitizer, after blood or other liquid flows into the cup body from the liquid inlet connector, the flowing direction of the liquid is blocked by the baffle, so that the liquid flows back in the cup body, the photosensitizer is uniformly dissolved, and the dissolving uniformity of the photosensitizer is further improved.

Description

Technical Field

[0001] The utility model relates to the technical field of blood pathogen inactivation equipment, in particular to a photosensitizer release member. Background Technique

[0002] Common blood pathogen inactivation methods include photochemical method, high-temperature heat treatment method, organic solvent / detergent method, nanofiltration method, etc. The photochemical method is one of the effective pathogen inactivation technologies. Under the action of a photosensitizer, blood components are irradiated with light of a certain wavelength, which can cause obstacles to the nucleic acid replication and protein synthesis of pathogens, thereby achieving the inactivation of pathogens. Currently available photochemical methods for blood pathogen inactivation include methylene blue photochemical treatment method, psoralen photochemical treatment method, riboflavin photochemical treatment method, and other newly developed photochemical treatment methods in recent years.

[0003] The photosensitizer is a key material for the photochemical method of blood pathogen inactivation. Before the blood is irradiated, the photosensitizer must be evenly released or dissolved into the blood to be treated. To ensure the biological activity and stability of the photosensitizer, the photosensitizer in current single-use blood pathogen inactivation equipment is generally stored in a plastic release container in a solid form. When the photosensitizer is formulated, it is in a liquid state. The current method is to air-dry it on a polyester film or make it into dehydrated particles or freeze-dried particles and then place them in the release container, which has problems such as cumbersome preparation process and inaccurate dosage, and is also prone to risks of bacterial contamination, endotoxin, and excessive particles. In addition, as a general circular cavity container for the photosensitizer release member, when blood flows through the release container, affected by factors such as the dissolution rate and shape of the photosensitizer, the release uniformity of the photosensitizer is not ideal. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a photosensitizer release member, aiming to facilitate the production and preparation of the photosensitizer; ensure the accuracy of the added dosage of the photosensitizer; avoid contamination in the sub-packaging and freeze-drying links of the photosensitizer; and improve the release uniformity of the photosensitizer.

[0005] To achieve this purpose, the utility model adopts the following technical solutions:

[0006] A photosensitizer release member includes a cup body and a cover body; the cup body is provided with a liquid inlet joint and a liquid outlet joint that are collinear and communicate with the cup body;

[0007] The cover body covers the port of the cup body; a baffle is arranged on the inner side of the cover body, and the baffle is arranged at an angle with the connection line of the liquid inlet joint and the liquid outlet joint.

[0008] In one embodiment, the baffle is perpendicular to the connection line of the liquid inlet joint and the liquid outlet joint.

[0009] In one embodiment, a secondary baffle is further provided on the inner side of the cover body; the height dimension of the baffle along the cup body is H1, and the height dimension of the secondary baffle along the cup body is H2, where H1≥H2.

[0010] In one embodiment, scale lines are provided inside the cup body.

[0011] In one embodiment, a convex ring is provided on the side wall of the cover body, and a concave ring is formed on the inner wall of the cup body, and the convex ring and the concave ring are tightly fitted.

[0012] In one embodiment, the internal space of the cup body is elliptical.

[0013] In one embodiment, the outer part of the liquid inlet joint and / or the liquid outlet joint is frustum-shaped.

[0014] Compared with the prior art, the present utility model has the following beneficial effects:

[0015] In the technical solution of the present utility model, the actual application of the photosensitizer is to accurately and quantitatively dispense the prepared photosensitizer liquid into the cup body in a sterile and clean environment, and the cup body containing the photosensitizer liquid is placed in a freeze-drying device for freeze-drying treatment. After freeze-drying is completed, the cover body is covered on the port of the cup body, and the freeze-dried solid photosensitizer is configured in the cup body. This process meets the requirements of the Good Manufacturing Practice for Drugs, reducing the risks of bacterial contamination, endotoxin, and particulate matter exceeding the standard of the photosensitizer in the cup body. The cover body is covered on the port of the cup body; a baffle is provided on the inner side of the cover body, and the baffle is arranged at an angle with the connection line of the liquid inlet joint and the liquid outlet joint. Specifically, when the photosensitizer releasing member is used to release the photosensitizer, the flow direction of the blood or other liquid flowing into the cup body from the liquid inlet joint is blocked by the baffle, so that the liquid generates a backflow in the cup body, thereby uniformly dissolving the photosensitizer, and further improving the uniformity of the dissolution of the photosensitizer. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0017] The structures, proportions, sizes, etc. shown in the attached drawings of this specification are only used to cooperate with the content disclosed in the specification for those familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the present utility model. Therefore, they do not have substantial technical significance. Any modification of the structure, change in the proportional relationship, or adjustment of the size, without affecting the effects that the present utility model can produce and the purposes that can be achieved, should still fall within the scope that can be covered by the technical content disclosed in the present utility model.

[0018] Figure 1 It is a schematic structural diagram of an embodiment of the cup body of the present utility model;

[0019] Figure 2 It is a sectional view of an embodiment of the cup body of the present utility model;

[0020] Figure 3 It is a schematic structural diagram of an embodiment of the cup body of the present utility model;

[0021] Figure 4 It is a schematic structural diagram of an embodiment of the lid body of the present utility model

[0022] Figure 5 It is a sectional view of an embodiment of the lid body of the present utility model;

[0023] Figure 6 It is a schematic structural diagram of an embodiment of the lid body of the present utility model;

[0024] Figure 7 It is a sectional view of an embodiment of the present utility model;

[0025] Illustration: 100, photosensitizer release member;

[0026] 110, cup body; 110a, concave ring;

[0027] 120, lid body; 121, baffle; 122, secondary baffle; 120a, convex ring;

[0028] 130, liquid inlet joint; 140, liquid outlet joint. Detailed implementation manners

[0029] In order to make the technical objectives, features, and advantages of the present utility model more obvious and understandable, the following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the embodiments described below are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the scope of protection of the present utility model.

[0030] In the description of the present utility model, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model. It should be noted that when a component is considered to be "connected" to another component, it can be directly connected to the other component or there may be an intermediate component present at the same time.

[0031] The technical solution of the present utility model will be further described below with reference to the drawings and through specific embodiments.

[0032] An embodiment of the present utility model provides a photosensitizer release member 100.

[0033] Please refer to Figures 1 to 7 , in an embodiment of the present utility model, the photosensitizer release member 100 includes a cup body 110 and a cover body 120; the cup body 110 is provided with a liquid inlet joint 130 and a liquid outlet joint 140 that are collinear and communicate with the cup body 110;

[0034] The cover body 120 covers the port of the cup body 110; a baffle 121 is provided on the inner side of the cover body 120, and the baffle 121 is arranged at an angle with the connection line of the liquid inlet joint 130 and the liquid outlet joint 140.

[0035] It can be understood that in the above embodiment, the actual application of the photosensitizer is to accurately and quantitatively dispense the prepared photosensitizer liquid into the cup body 110 in a sterile and clean environment. The cup body 110 containing the photosensitizer liquid is placed in a freeze-drying device for freeze-drying treatment. After the freeze-drying process is completed, the cover body 120 is covered on the port of the cup body 110, and the freeze-dried solid photosensitizer is configured in the cup body 110. This process meets the requirements of the "Good Manufacturing Practice for Drugs", avoiding the risks of bacterial contamination, endotoxin, and particulate matter exceeding the standard of the photosensitizer in the cup body 110. A baffle 121 is provided on the inner side of the cover body 120, and the baffle 121 is arranged at an angle with the connection line of the liquid inlet joint 130 and the liquid outlet joint 140. Specifically, when using the photosensitizer release member 100 to release the photosensitizer, the flow direction of the blood or other liquid is blocked by the baffle 121 after flowing into the cup body 110 from the liquid inlet joint 130, causing the liquid to generate a backflow in the cup body 110 so that the photosensitizer is uniformly dissolved, thereby improving the uniformity of the photosensitizer dissolution.

[0036] In addition, the cup body 110 is an open container. The prepared photosensitizer liquid is accurately and quantitatively filled into the cup body 110 in a sterile and clean environment. The cup body 110 containing the photosensitizer liquid is placed in a freeze-drying device for freeze-drying treatment. After the freeze-drying process is completed, the cover body 120 is covered on the port of the cup body 110. The freeze-dried solid photosensitizer is configured in the cup body 110. This process meets the GMP requirements and avoids the risks of bacterial contamination, endotoxin, and excessive particles of the photosensitizer in the cup body 110.

[0037] It can also be understood that, as Figure 3 shown, the liquid inlet joint 130 and the liquid outlet joint 140 are arranged collinearly, which mainly means that the liquid inlet joint 130 and the liquid outlet joint 140 are arranged on the same axis. Arranging the liquid inlet joint 130 and the liquid outlet joint 140 on the same axis helps to improve the uniformity of the liquid flow in the cup body 110.

[0038] Please refer to Figure 4 、 Figure 5 and Figure 7 , in a specific embodiment, the baffle 121 is perpendicular to the connection line of the liquid inlet joint 130 and the liquid outlet joint. It can be understood that the baffle 121 being perpendicular to the connection line of the liquid inlet joint 130 and the liquid outlet joint 140 can make the dissolution rate of the photosensitizer more uniform.

[0039] Please refer to Figure 4 、 Figure 5 and Figure 6 , in another specific embodiment, a secondary baffle 122 is further provided on the inner side of the cover body 120; the height dimension of the baffle 121 along the cup body 110 is H1, and the height dimension of the secondary baffle 122 along the cup body 110 is H2, where H1 ≥ H2.

[0040] It can be understood that when the height dimension of the secondary baffle 122 is smaller than the height dimension of the baffle 121 along the cup body 110, the influence of the baffle 121 on the liquid flow rate can be reduced, and the setting of the secondary baffle 122 can further make the dissolution rate of the photosensitizer more uniform.

[0041] In a preferred embodiment, the interior of the cup body 110 has scale lines (not shown in the figure). It can be understood that the setting of the scale lines facilitates checking the accuracy of the amount of photosensitizer added.

[0042] Please refer to Figure 1 、 Figure 4 and Figure 7 , in a specific embodiment, a convex ring 120a is provided on the side wall of the cover body 120, and a concave ring 110a is formed on the inner wall of the cup body 110. The convex ring 120a and the concave ring 110a are tightly fitted.

[0043] It is understandable that the cup body 110 and the cover body 120 adopt a snap-ring type sealing structure to increase the tightness, and no additional accessories need to be added, thereby minimizing the generation of contamination as much as possible.

[0044] Optionally, for the convenience of installation, the concave ring 110a and the convex ring 120a have mutually adapted arc surfaces.

[0045] In a specific embodiment, the internal space of the cup body 110 is oval, or the outer shape of the cup body 110 is oval. Correspondingly, the cover body 120 is also adapted to be oval according to the cup body 110. It is understandable that the oval design facilitates the closing and assembly of the cup body 110 and the cover body 120, will not cause incorrect assembly directions, and has an anti-fooling effect. Moreover, the photosensitizer releasing member 100 adopting an oval design can make the structure of the cup body 110 more compact, the direct connection between the cup body 110 and the cover body 120 closer, and not easily deformed during the closing process.

[0046] Please refer to Figure 1 、 Figure 2 and Figure 3 , in a specific embodiment, the outer part of the liquid inlet joint 130 and / or the liquid outlet joint 140 is frustum-shaped. It is understandable that the frustum shape design is beneficial to improving the firmness of the hose connection when connecting the hose.

[0047] As mentioned above, the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A photosensitizer release member, characterized in that: It comprises a cup body and a cover body; the cup body is provided with a liquid inlet joint and a liquid outlet joint which are collinear and connected with the cup body; The cover body covers the port of the cup body; a baffle is arranged on the inner side of the cover body, and the baffle is arranged at an angle to the line connecting the liquid inlet connector and the liquid outlet connector.

2. The photosensitizer release member according to claim 1, characterized in that: The baffle is perpendicular to a line connecting the liquid inlet connector and the liquid outlet connector.

3. The photosensitizer release member according to claim 2, characterized in that: A secondary baffle is also provided on the inner side of the cover body; the height dimension of the baffle along the cup body is H1, and the height dimension of the secondary baffle along the cup body is H2, wherein H1≥H2.

4. The photosensitizer release member according to claim 1, characterized in that: The cup body has scale lines inside.

5. The photosensitizer release member according to claim 1, characterized in that: The side wall of the cover body is provided with a convex ring, the inner wall of the cup body is formed with a concave ring, and the convex ring is tightly matched with the concave ring.

6. The photosensitizer release member according to claim 1, characterized in that: The inner space of the cup body is oval.

7. The photosensitizer release member according to claim 1, characterized in that: The exterior of the liquid inlet joint and / or the liquid outlet joint is in a truncated cone shape.

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