Biosafety cabinet for extracting and purifying reagent by hypersensitive magnetic bead method

Abstract

The utility model relates to the technical field of reagent storage cabinets, and discloses a biosafety cabinet for extracting and purifying reagents by a hypersensitive paramagnetic particle method, which comprises a cabinet body, a shielding layer is fixedly sleeved on the inner wall surface of the cabinet body, and guide rod components are arranged in the cabinet body close to four corners. A plurality of groups of storage plate components for placing biological reagent bottles are arranged in the cabinet body, the guide rod component comprises an internal fixed rod and an external movable pipe, the internal fixed rod is fixedly arranged in the cabinet body, and the external movable pipe is rotatably arranged at the excircle of the internal fixed rod. The storage plate assemblies are limited through the multiple sets of limiting ball shafts extending outwards, the storage plate assemblies are kept at the adjusted height, the effect that the space in the cabinet body can be reasonably used is achieved by freely adjusting the positions and the intervals of the multiple sets of storage plate assemblies, and the storage rate of the space in the cabinet body is increased.

Description

Technical Field

[0001] The utility model relates to the technical field of reagent storage cabinets, in particular to a biosafety cabinet for extracting and purifying reagents by the ultrasensitive magnetic bead method. Background Technique

[0002] The ultrasensitive magnetic bead method is an advanced technology for nucleic acid extraction and purification, usually used for efficiently extracting DNA or RNA from samples; most reagent organisms should be stored at a specified temperature. Usually, the reagents of the ultrasensitive magnetic bead method should be stored at room temperature or in a refrigerator.

[0003] There is a conventional biological reagent storage cabinet with a heat preservation effect (its authorization announcement number is: CN214567317U). Aiming at the problems that the existing biological reagent storage cabinet cannot store storage test tubes of different sizes and is inconvenient for staff to access the storage test tubes, the following scheme is proposed. It includes a first box body, a second box body and a support plate. Self-locking universal wheels with the same structure are rotatably installed at the four corners of the bottom end of the first box body. The second box body is slidably installed in the first box body. A shock absorption device with the same structure and distributed in a rectangular array is installed between the inner wall of the bottom end of the first box body and the inner wall of the bottom end of the second box body. Support blocks with the same structure and distributed in a rectangular array are fixedly installed on both inner walls of the second box body. The above technical scheme has a novel structure, and the device not only is provided with a shock absorption device to protect the second box body and prevent the biological reagents in the second box body from being damaged.

[0004] In the above technical scheme, the positions of multiple groups of support plates in the cabinet cannot be adjusted, and the internal space of the cabinet is separated by multiple groups of support plates. For storage test tubes or reagent bottles with different heights, the space in the cabinet is easily wasted, and the utilization rate of the space in the cabinet is greatly reduced, which is not conducive to the reasonable storage of reagent bottles of different specifications. Therefore, we propose a biosafety cabinet for extracting and purifying reagents by the ultrasensitive magnetic bead method to solve the above problems. Content of the Utility Model

[0005] Aiming at the deficiencies of the prior art, the utility model provides a biosafety cabinet for extracting and purifying reagents by the ultrasensitive magnetic bead method to solve the above problems.

[0006] In order to achieve the above purpose, the utility model adopts the following technical scheme:

[0007] A biosafety cabinet for extracting and purifying reagents by hypersensitive magnetic beads method, comprising a cabinet body, the front side of the cabinet body is movably installed with a sealing door through a rotating shaft; a shielding layer is fixedly sleeved on the inner wall surface of the cabinet body, and the shielding layer is arranged to keep the internal environment of the cabinet cold and block heat; guide rod assemblies are arranged at four corner positions inside the cabinet body, and multiple sets of storage plate assemblies for placing biological reagent bottles are arranged inside the cabinet body. The guide rod assembly includes an internal fixed rod and an external movable tube. The internal fixed rod is fixedly installed inside the cabinet body, and the external movable tube is rotatably installed on the outer circle of the internal fixed rod. Multiple sets of through holes are formed through the outer surface of the external movable tube, multiple sets of spring columns are fixedly installed on the outer wall surface of the internal fixed rod, and a limiting ball shaft is slidably installed at the outer end of the spring column.

[0008] Preferably, the storage plate assembly includes two lifting plates, the two lifting plates are distributed symmetrically left and right, a connecting sleeve is fixedly installed on the lifting plate in an embedded manner, and the lifting plate is slidably installed between two corresponding guide rod assemblies before and after through the connecting sleeve.

[0009] Preferably, a sliding support plate is slidably installed between the two lifting plates, multiple placing grooves are formed on the sliding support plate, and the specifications of the placing grooves on the multiple sliding support plates are different.

[0010] Preferably, the internal fixed rod and the external movable tube are coaxially arranged, and a gap is formed between the internal fixed rod and the external movable tube.

[0011] Preferably, the structure of the limiting ball shaft is adapted to the structure of the through hole, so that the limiting ball shaft extends outward through the through hole under the elastic force of the spring column.

[0012] Preferably, a temperature and humidity controller is arranged on the outer wall surface of the cabinet body to control the humidity and temperature inside the cabinet body.

[0013] Preferably, the temperature and humidity controller is located at the left side wall position of the cabinet body, which is convenient for operating the temperature and humidity controller.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. When using the biosafety cabinet for the extraction and purification reagent of hypersensitive magnetic beads, during use, control the through hole and the limit ball shaft to be misaligned. At this time, the outer surface of the external movable tube is smooth. Pull the storage plate assembly up and down, so that the storage plate assembly can freely slide up and down along multiple groups of guide rod assemblies, thereby facilitating the adjustment of the distribution height of the storage plate assembly. At the same time, it is convenient to adjust the distance between multiple groups of storage plate assemblies in the cabinet body, facilitating the storage of biological reagent bottles at different heights. After the height positions of multiple groups of storage plate assemblies are adjusted, control the external movable tube to rotate so that the through hole and the limit ball shaft coincide with each other. The limit ball shaft extends outwards through the through hole under the elastic force of the spring column. At this time, the outer surface of the external movable tube is uneven. The multiple groups of limit ball shafts extending outwards play a limiting role on the storage plate assembly, keeping the storage plate assembly at the adjusted height. By freely adjusting the positions and spacing of multiple groups of storage plate assemblies, the effect of reasonable use of the space in the cabinet body is achieved, increasing the storage rate of the space in the cabinet body.

[0016] 2. When using the biosafety cabinet for the extraction and purification reagent of hypersensitive magnetic beads, place the biological reagent bottle in the suitable placement groove during use. The placement groove plays a fixing role on the biological reagent bottle. Pull the sliding tray outwards, so that the sliding tray drives the biological reagent bottle to move outwards, facilitating people to take the required biological reagent, achieving the improvement of the stability of the biological reagent bottle during taking. Description of the Drawings

[0017] Figure 1 It is a schematic three-dimensional structure diagram of the whole utility model;

[0018] Figure 2 It is a schematic three-dimensional structure diagram of the storage plate assembly of the utility model;

[0019] Figure 3 It is a schematic three-dimensional structure diagram of the guide rod assembly of the utility model;

[0020] Figure 4 It is a schematic plan structure diagram of the guide rod assembly of the utility model.

[0021] In the figure: 1. Cabinet body; 2. Temperature and humidity controller; 3. Shielding layer; 4. Sealed door; 5. Guide rod assembly; 6. Storage plate assembly; 601. Lifting plate; 602. Sliding tray; 603. Placement groove; 604. Connecting sleeve; 501. Built-in fixed rod; 502. External movable tube; 503. Through hole; 504. Spring column; 505. Limit ball shaft. Detailed Embodiment

[0022] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0023] Example 1. Refer to Figure 1 , a biosafety cabinet for extracting and purifying reagents by the ultrasensitive magnetic bead method, including a cabinet body 1. A temperature and humidity controller 2 is provided on the outer wall surface of the cabinet body 1. A sealing door 4 is movably installed on the front side of the cabinet body 1 through a rotating shaft. A shielding layer 3 is fixedly sleeved on the inner wall surface of the cabinet body 1. The shielding layer 3 is provided to keep the cold and block the heat in the environment inside the cabinet body 1, improving the stability of the temperature inside the cabinet body 1. The humidity and temperature inside the cabinet body 1 are controlled by the temperature and humidity controller 2;

[0024] Further, refer to Figure 1 , guide rod assemblies 5 are provided at the four corner positions inside the cabinet body 1, and multiple sets of storage plate assemblies 6 for placing biological reagent bottles are arranged inside the cabinet body 1;

[0025] Further, refer to Figure 2 , the storage plate assembly 6 includes two lifting plates 601. The two lifting plates 601 are distributed in a left-right mirror image. A connecting sleeve 604 is fixedly installed on the lifting plate 601 in an embedded manner. The lifting plate 601 is slidably installed between two corresponding front and rear guide rod assemblies 5 through the connecting sleeve 604. A sliding support plate 602 is slidably installed between the two lifting plates 601. Multiple placing grooves 603 are formed on the sliding support plate 602. The specifications of the placing grooves 603 on multiple sliding support plates 602 are different. During use, the biological reagent bottles are placed in the suitable placing grooves 603, and the biological reagent bottles are fixed by the placing grooves 603. When taking them, the sliding support plate 602 is pulled outwards, so that the sliding support plate 602 drives the biological reagent bottles to move outwards, facilitating people to take them;

[0026] Example 2. On the basis of Example 1, refer to Figure 3 and Figure 4 , the guide rod assembly 5 includes an internal fixed rod 501 and an external movable tube 502. The internal fixed rod 501 is fixedly installed inside the cabinet body 1. The external movable tube 502 is rotatably installed on the outer circle of the internal fixed rod 501. The internal fixed rod 501 and the external movable tube 502 are coaxially arranged and a gap is formed between the internal fixed rod 501 and the external movable tube 502. Multiple through holes 503 are formed through the outer surface of the external movable tube 502. Multiple spring columns 504 are fixedly installed on the outer wall surface of the internal fixed rod 501. The outer side end of the spring column 504 is slidably installed with a limit ball shaft 505. The structure of the limit ball shaft 505 is adapted to the structure of the through hole 503;

[0027] Refer to Figure 3 and Figure 4 to control the rotation of the external movable tube 502, so that the external movable tube 502 drives the through hole 503 to change its position. When the through hole 503 is misaligned with the limit ball shaft 505, the limit ball shaft 505 is squeezed by the inner wall surface of the external movable tube 502, resulting in the contraction of the spring column 504. At this time, the limit ball shafts 505 are distributed in the gap between the internal fixed rod 501 and the external movable tube 502. When the external movable tube 502 rotates to drive the through hole 503 to coincide with the limit ball shaft 505, the limit ball shaft 505 slides outwards under the elastic force of the spring column 504, so that the limit ball shaft 505 extends outwards through the through hole 503. During use, control the misalignment of the through hole 503 and the limit ball shaft 505. At this time, the outer surface of the external movable tube 502 is smooth. Pull the storage plate assembly 6 up and down, so that the storage plate assembly 6 can freely slide up and down along the multiple sets of guide rod assemblies 5, thereby facilitating the adjustment of the distribution height of the storage plate assembly 6. At the same time, it is convenient to adjust the distance between the multiple sets of storage plate assemblies 6 in the cabinet body 1, which is convenient for storing biological reagent bottles of different heights. After the height positions of the multiple sets of storage plate assemblies 6 are adjusted, control the rotation of the external movable tube 502 to make the through hole 503 coincide with the limit ball shaft 505. The limit ball shaft 505 extends outwards through the through hole 503 under the elastic force of the spring column 504. At this time, the outer surface of the external movable tube 502 is uneven. The multiple sets of limit ball shafts 505 extending outwards play a limiting role on the storage plate assembly 6, so that the storage plate assembly 6 is maintained at the adjusted height. By freely adjusting the positions and spacings of the multiple sets of storage plate assemblies 6, the space in the cabinet body 1 can be reasonably used, and the storage rate of the space in the cabinet body 1 is increased.

[0028] During use: The biological reagent bottle is placed in the suitable placement groove 603, and the placement groove 603 fixes the biological reagent bottle. When taking it, pull the sliding tray 602 outwards, so that the sliding tray 602 drives the biological reagent bottle to move outwards, facilitating people to take it. Control the through hole 503 to be misaligned with the limit ball shaft 505. At this time, the outer surface of the external movable tube 502 is smooth. Pull the storage plate assembly 6 up and down, so that the storage plate assembly 6 slides freely up and down along the multiple groups of guide rod assemblies 5, thereby facilitating the adjustment of the distribution height of the storage plate assembly 6. At the same time, it is convenient to adjust the distance between the multiple groups of storage plate assemblies 6 in the cabinet 1, facilitating the storage of biological reagent bottles of different heights. After the height positions of the multiple groups of storage plate assemblies 6 are adjusted, control the external movable tube 502 to rotate, so that the through hole 503 coincides with the limit ball shaft 505. The limit ball shaft 505 extends outwards through the through hole 503 under the elastic force of the spring column 504. At this time, the outer surface of the external movable tube 502 is uneven. The multiple groups of limit ball shafts 505 extending outwards limit the storage plate assembly 6, so that the storage plate assembly 6 is maintained at the adjusted height. By freely adjusting the positions and spacing of the multiple groups of storage plate assemblies 6, the space in the cabinet 1 can be reasonably used, increasing the storage rate of the space in the cabinet 1.

[0029] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0030] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A biological safety cabinet for extracting and purifying reagents using an ultrasensitive magnetic bead method, comprising a cabinet body (1), wherein a sealing door (4) is movably mounted on the front side of the cabinet body (1) via a rotating shaft; characterized in that: The inner wall surface of the cabinet (1) is fixedly sleeved with a shielding layer (3); the interior of the cabinet (1) is provided with guide rod assemblies (5) near four corners; a plurality of storage plate assemblies (6) for placing biological reagent bottles are arranged in the cabinet (1); the guide rod assembly (5) comprises an inner fixed rod (501) and an outer movable tube (502); the inner fixed rod (501) is fixedly mounted inside the cabinet (1); the outer movable tube (502) is rotatably mounted on the outer circle of the inner fixed rod (501); a plurality of through holes (503) are formed through the outer surface of the outer movable tube (502); a plurality of spring columns (504) are fixedly mounted on the outer wall surface of the inner fixed rod (501); a limiting ball shaft (505) is slidably mounted on the outer end of the spring column (504).

2. A biological safety cabinet for extracting and purifying reagents using ultra-sensitive magnetic beads according to claim 1, characterized in that: The storage plate assembly (6) comprises two groups of lifting plates (601), the two groups of lifting plates (601) are distributed in a left-right mirror image, a connecting sleeve (604) is embedded and fixedly installed on the lifting plate (601), and the lifting plate (601) is slidably installed between two groups of guide rod assemblies (5) corresponding to the front and rear through the connecting sleeve (604).

3. A biological safety cabinet for extracting and purifying reagents using ultra-sensitive magnetic beads according to claim 2, characterized in that: A sliding support plate (602) is slidably installed between the two groups of lifting plates (601), and multiple groups of placement grooves (603) are provided on the sliding support plate (602). The placement grooves (603) on the multiple groups of sliding support plates (602) have different specifications.

4. A biological safety cabinet for extracting and purifying reagents using ultra-sensitive magnetic beads according to claim 1, characterized in that: The internal fixing rod (501) and the external movable tube (502) are coaxially arranged, and a gap is formed between the internal fixing rod (501) and the external movable tube (502).

5. A biological safety cabinet for extracting and purifying reagents using ultra-sensitive magnetic beads according to claim 1, characterized in that: The structure of the limiting ball shaft (505) is compatible with the structure of the through hole (503).

6. A biological safety cabinet for extracting and purifying reagents using ultra-sensitive magnetic beads according to claim 1, characterized in that: The outer wall surface of the cabinet (1) is provided with a temperature and humidity controller (2).

7. A biological safety cabinet for extracting and purifying reagents using ultra-sensitive magnetic beads according to claim 6, characterized in that: The temperature and humidity controller (2) is located on the left side wall of the cabinet (1).

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