Mobile phase blending system of liquid chromatograph-mass spectrometer

Abstract

The utility model discloses a mobile phase blending system of a liquid chromatograph-mass spectrometer. The mobile phase blending system comprises a mixing shell and a splitter plate, liquid inlets in the front side face and the rear side face of the mixing shell are connected with liquid outlet pipes of the two corresponding micro pumps respectively, a liquid outlet pipe on the right side face of the mixing shell is connected with a liquid inlet in the left side face of the liquid separation head, liquid outlets in the front side face and the rear side face of the liquid separation head are fixedly provided with liquid guide pipes respectively, and liquid outlets in the right sides of the two liquid guide pipes are connected with a liquid inlet of a liquid conveying pipe. Impurities in mobile phases can be effectively filtered by the filter screen so as to prevent the impurities from entering the liquid guide pipe to cause blockage, various mobile phases can be mixed by the arranged mixing shell, and a proper temperature in the mixing shell is ensured by the heating pipe in the mixing shell so as to improve the uniform mixing efficiency of the mobile phases; meanwhile, the electromagnetic valve is matched with the flowmeter to control the flow velocity and flow of the mobile phase.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography - mass spectrometry instruments, and particularly relates to a mobile phase mixing system for a liquid chromatography - mass spectrometry instrument. Background Technique

[0002] Liquid chromatography - mass spectrometry instruments are mainly applied to drug metabolism and pharmacokinetics research, clinical pharmacology research, development research of natural drugs (such as Chinese herbal medicines), neonatal screening, identification of proteins and peptides, residue analysis, toxicant analysis, environmental analysis - industries such as public security, environmental protection, food, tap water, and health and epidemic prevention.

[0003] There is a mobile phase mixing device for a liquid chromatography - mass spectrometry instrument with a patent publication number of CN204269617U. It connects two three - way joints between the liquid phase pump and the six - port valve, and mixes and stabilizes the mobile phase through the shunt of the first three - way joint and the confluence of the second three - way joint. This mixing device is inconvenient to automatically adjust according to the flow rate of the mobile phase during use. Moreover, due to the lack of a filter residue structure inside the three - way mixer, it will also cause blockage of the subsequent mobile phase, and at the same time affect the mixing effect of the mobile phase. Therefore, a mobile phase mixing system for a liquid chromatography - mass spectrometry instrument is proposed. Content of the Utility Model

[0004] The technical problem to be solved by the utility model is to overcome the existing defects and provide a mobile phase mixing system for a liquid chromatography - mass spectrometry instrument. A filter screen can effectively filter impurities inside the mobile phase to prevent impurities from entering the liquid guiding tube and causing blockage. The provided mixing shell can mix multiple mobile phases, and the heating tube inside it can ensure an appropriate temperature inside the mixing shell to improve the mixing efficiency of the mobile phase. At the same time, the combination of an electromagnetic valve and a flowmeter can control the flow rate and flow volume of the mobile phase, effectively solving the problems in the background technique.

[0005] To achieve the above purpose, the utility model provides the following technical solution: A mobile phase mixing system for a liquid chromatography - mass spectrometry instrument, including a mixing shell and a shunt plate;

[0006] The liquid inlet ports on the front and rear sides of the mixing shell are respectively connected to the liquid outlet pipes of the corresponding two micro - pumps. The liquid outlet pipe on the right side of the mixing shell is connected to the liquid inlet port on the left side of the liquid distributor. The liquid outlet ports on the front and rear sides of the liquid distributor are respectively fixedly installed with liquid guiding tubes. The liquid outlet ports on the right sides of the two liquid guiding tubes are both connected to the liquid inlet port of the infusion pipe. The main electromagnetic valve is fixed on the outside of the infusion pipe. The liquid outlet port of the infusion pipe is connected to the liquid inlet port of the six - port valve. The shunt plates are evenly distributed inside the liquid guiding tubes.

[0007] Among them, a controller is further included. The controller is arranged on the surface of an external instrument. The input ends of the micro pump, the main solenoid valve and the six-way valve are electrically connected to the output end of the controller, and the input end of the controller is electrically connected to the output end of an external power supply.

[0008] Start the micro pump to deliver the mobile phase into the mixing shell for mixing. After the mixed mobile phase is shunted again through the liquid guide pipe, it enters the inside of the infusion pipe for confluence, so as to ensure that the mobile phase is evenly mixed and the mobile phase is transported with the connected six-way valve and the external instrument.

[0009] Furthermore, a filter screen, a sealing strip, a fixing cover and a clamping block are further included. The filter screen is slidably connected to the through groove on the top surface of the mixing shell. There are two sealing strips, which are respectively adhered to both sides of the top surface of the mixing shell. The fixing cover is snap-connected to the outside of the mixing shell. The clamping block is fixed on the side surface of the mixing shell, and the clamping block is snap-connected with the clamping hole to install the fixing cover, so that the filter screen can be fixed. The filter screen can effectively filter the impurities in the mobile phase to prevent the impurities from entering the inside of the liquid guide pipe and causing blockage.

[0010] Furthermore, a temperature sensor and a heating pipe are further included. The temperature sensor is fixed on the top surface of the mixing shell, and the heating pipe is installed on the bottom surface inside the mixing shell. The output end of the temperature sensor is electrically connected to the input end of the controller, and the input end of the heating pipe is electrically connected to the output end of the controller. The provided heating pipe ensures a suitable temperature inside the mixing shell to improve the mixing efficiency of the mobile phase, while the temperature sensor can detect the temperature inside the mixing shell in real time so as to keep the temperature within a suitable range.

[0011] Furthermore, a solenoid valve and a flowmeter are further included. The solenoid valve is installed at the left end outside the liquid guide pipe, and the flowmeter is installed at the right end outside the liquid guide pipe. The input ends of the solenoid valve and the flowmeter are electrically connected to the output end of the controller. The flowmeter can detect the flow rate of the mobile phase, so as to control the solenoid valve to control the flow rate of the mobile phase to improve the mixing effect of the mobile phase.

[0012] Furthermore, a fixing clip, an adhesive pad, a corrosion-resistant layer and a protective layer are further included. The fixing clip is snap-connected to the outside of the liquid guide pipe. The adhesive pad is adhered to the bottom surface of the fixing clip. The corrosion-resistant layer is evenly coated on the inner side surface of the liquid guide pipe, and the protective layer is coated on the outer side surface of the liquid guide pipe. The fixing clip facilitates the fixing of the position of the liquid guide pipe. The protective layer is used to prevent the liquid guide pipe from being bent and squeezed, which affects the transportation of the mobile phase. The corrosion-resistant layer can prevent the inner wall of the liquid guide pipe from being corroded and damaged by the corrosive substances in the mobile phase.

[0013] Further, it further includes a wireless transmitter, which is fixed on the left side of the hybrid housing. The output end of the wireless transmitter is electrically connected to the input end of the controller. The wireless transmitter can transmit the detected data to the personnel for convenient viewing and adjustment by the personnel.

[0014] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0015] 1. By starting the micro pump, the mobile phase is transported into the hybrid housing for mixing treatment. After the mixed mobile phase is further split through the liquid guide pipe, it enters the infusion pipe for confluence, so as to ensure the uniform mixing of the mobile phase and convey the mobile phase to the connected six-port valve and external instrument;

[0016] 2. The fixed cover fixes the filter screen by clamping the clamping block with the clamping hole, and the filter screen can effectively filter the impurities in the mobile phase to prevent the impurities from entering the liquid guide pipe and causing blockage;

[0017] 3. By setting the heating pipe, the appropriate temperature inside the hybrid housing is ensured to improve the mixing efficiency of the mobile phase, while the temperature sensor can detect the temperature inside the hybrid housing in real time to keep the temperature within the appropriate range. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a three-dimensional structural schematic diagram of the present utility model;

[0019] Figure 2 is a schematic diagram of the internal structure of the hybrid housing of the present utility model;

[0020] Figure 3 is a schematic diagram of the internal structure of the liquid guide pipe of the present utility model.

[0021] In the figure: 1 hybrid housing, 2 micro pump, 3 liquid separation head, 4 liquid guide pipe, 5 infusion pipe, 6 main solenoid valve, 7 six-port valve, 8 flow splitting plate, 9 filter screen, 10 sealing strip, 11 fixed cover, 12 temperature sensor, 13 heating pipe, 14 solenoid valve, 15 flow meter, 16 clamping block, 17 controller, 18 fixed clamp, 19 adhesive pad, 20 corrosion-resistant layer, 21 protective layer, 22 wireless transmitter. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0022] The technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0023] Please refer toFigures 1-3 , this embodiment provides a technical solution: a mobile phase mixing system for a liquid chromatography-mass spectrometry instrument, including a mixing shell 1 and a shunt plate 8; the liquid inlet ports on the front and rear sides of the mixing shell 1 are respectively connected to the liquid outlet pipes of two corresponding micro pumps 2, the liquid outlet pipe on the right side of the mixing shell 1 is connected to the liquid inlet port on the left side of the liquid distributor 3, the liquid outlet ports on the front and rear sides of the liquid distributor 3 are respectively fixedly installed with liquid guide pipes 4, the liquid outlet ports on the right sides of the two liquid guide pipes 4 are both connected to the liquid inlet port of the infusion pipe 5, a main solenoid valve 6 is fixed on the outer side of the infusion pipe 5, the liquid outlet port of the infusion pipe 5 is connected to the liquid inlet port of the six-port valve 7, and the shunt plate 8 is evenly distributed inside the liquid guide pipe 4;

[0024] Among them, it further includes a controller 17, the controller 17 is arranged on the surface of the external instrument, the input ends of the micro pump 2, the main solenoid valve 6 and the six-port valve 7 are electrically connected to the output end of the controller 17, and the input end of the controller 17 is electrically connected to the output end of the external power supply.

[0025] Start the micro pump 2 to transport the mobile phase into the mixing shell 1 for mixing treatment. The mixed mobile phase is further shunted through the liquid guide pipe 4 and then enters the infusion pipe 5 for confluence, so as to ensure that the mobile phase is evenly mixed and is used to transport the mobile phase to the external instrument through the connected six-port valve 7.

[0026] Among them, it further includes a filter screen 9, a sealing strip 10, a fixing cover 11 and a clamping block 16. The filter screen 9 is slidably connected to the through groove on the top surface of the mixing shell 1. There are two sealing strips 10, which are respectively bonded to both sides of the top surface of the mixing shell 1. The fixing cover 11 is clamped on the outside of the mixing shell 1, and the clamping block 16 is fixed on the side surface of the mixing shell 1. The clamping block 16 is clamped with the clamping hole to install the fixing cover 11, so that the filter screen 9 can be fixed. The filter screen 9 can effectively filter the impurities in the mobile phase to prevent impurities from entering the liquid guide pipe 4 and causing blockage.

[0027] Among them, it further includes a temperature sensor 12 and a heating pipe 13. The temperature sensor 12 is fixed on the top surface of the mixing shell 1, and the heating pipe 13 is installed on the bottom surface inside the mixing shell 1. The output end of the temperature sensor 12 is electrically connected to the input end of the controller 17, and the input end of the heating pipe 13 is electrically connected to the output end of the controller 17. The set heating pipe 13 ensures a suitable temperature inside the mixing shell 1 to improve the efficiency of mixing the mobile phase, while the temperature sensor 12 can detect the temperature inside the mixing shell 1 in real time to keep the temperature within a suitable range.

[0028] Among them, it also includes a solenoid valve 14 and a flowmeter 15. The solenoid valve 14 is installed at the left end outside the liquid guide pipe 4, and the flowmeter 15 is installed at the right end outside the liquid guide pipe 4. The input ends of the solenoid valve 14 and the flowmeter 15 are electrically connected to the output end of the controller 17. The flowmeter 15 can detect the flow rate of the mobile phase, so as to control the solenoid valve 14 to control the flow rate of the mobile phase, thereby improving the mixing effect of the mobile phase.

[0029] Among them, it also includes a fixing clip 18, an adhesive pad 19, a corrosion-resistant layer 20 and a protective layer 21. The fixing clip 18 is clamped on the outside of the liquid guide pipe 4. The bottom surface of the fixing clip 18 is bonded with the adhesive pad 19. The corrosion-resistant layer 20 is evenly coated on the inner side surface of the liquid guide pipe 4, and the protective layer 21 is coated on the outer side surface of the liquid guide pipe 4. The fixing clip 18 facilitates the fixation of the position of the liquid guide pipe 4, and cooperates with the protective layer 21 to prevent the liquid guide pipe 4 from being bent and squeezed, which affects the transportation of the mobile phase. The corrosion-resistant layer 20 can prevent the inner wall of the liquid guide pipe 4 from being corroded and damaged by the corrosive substances inside the mobile phase.

[0030] Among them, it also includes a wireless transmitter 22. The wireless transmitter 22 is fixed on the left side surface of the mixing shell 1. The output end of the wireless transmitter 22 is electrically connected to the input end of the controller 17. The wireless transmitter 22 can transmit the detected data to the personnel, so as to facilitate the personnel to view and adjust in time.

[0031] The working principle of the present utility model is as follows:

[0032] First, start the micro pump 2 to transport the mobile phase into the mixing shell 1 for mixing treatment. The filter screen 9 inside the mixing shell 1 can effectively filter the impurities inside the mobile phase to prevent the impurities from entering the inside of the liquid guide pipe 4 and causing blockage. The heating pipe 13 is provided to ensure a suitable temperature inside the mixing shell 1 to improve the mixing efficiency of the mobile phase, and the temperature sensor 12 can detect the temperature inside the mixing shell 1 in real time so as to keep the temperature within a suitable range;

[0033] The mixed mobile phase is shunted again through the liquid guide pipe 4 and then enters the infusion pipe 5 for confluence to ensure that the mobile phase is evenly mixed. The flowmeter 15 can detect the flow rate of the mobile phase, so as to control the solenoid valve 14 to control the flow rate of the mobile phase, thereby improving the mixing effect of the mobile phase. Finally, it is connected to the six-way valve 7 to transport the mobile phase to external instruments.

[0034] It should be noted that in the above embodiments, the controller 17 disclosed is of model S7-200. The temperature sensor 12 can be freely configured according to the actual application scenario. It is recommended to select a temperature sensor of model AS5600. The heating pipe 13 can be selected as a heating pipe of model DN4050. The flowmeter 15 can be selected as a flowmeter of model NK-CG-1000. The wireless transmitter 22 can be selected as a wireless transmitter of model WJL-207. The controller 17 controls the operation of the micro pump 2, the main solenoid valve 6, the solenoid valve 14, the six-way valve 7, the temperature sensor 12, the heating pipe 13, the flowmeter 15, and the wireless transmitter 22 by using the commonly used methods in the prior art.

[0035] The above are only the embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structure or equivalent process transformation made by using the content of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present invention.

Claims

1. A mobile phase mixing system for a liquid chromatography-mass spectrometer, characterized in that: It comprises a mixing shell (1) and a diverter plate (8); The liquid inlets on the front and rear sides of the mixing shell (1) are respectively connected to the liquid outlet pipes of the corresponding two micro pumps (2); the liquid outlet pipe on the right side of the mixing shell (1) is connected to the liquid inlet on the left side of the liquid dispensing head (3); the liquid outlets on the front and rear sides of the liquid dispensing head (3) are respectively fixedly mounted with liquid guide tubes (4); the liquid outlets on the right sides of the two liquid guide tubes (4) are both connected to the liquid inlet of the infusion tube (5); a main solenoid valve (6) is fixed to the outside of the infusion tube (5); the liquid outlet of the infusion tube (5) is connected to the liquid inlet of the six-way valve (7); and the diverter plates (8) are evenly distributed inside the liquid guide tubes (4); The device further comprises a controller (17), wherein the controller (17) is arranged on the surface of the external instrument, the input ends of the micro pump (2), the main solenoid valve (6) and the six-way valve (7) are electrically connected to the output end of the controller (17), and the input end of the controller (17) is electrically connected to the output end of the external power supply.

2. The mobile phase mixing system for liquid chromatography-mass spectrometry according to claim 1, characterized in that: It also comprises a filter screen (9), a sealing strip (10), a fixed cover (11) and a clamping block (16); the filter screen (9) is slidably connected to a through groove on the top surface of the mixing shell (1); there are two sealing strips (10) which are respectively bonded to two sides of the top surface of the mixing shell (1); the fixed cover (11) is clamped to the outside of the mixing shell (1); and the clamping block (16) is fixed to the side surface of the mixing shell (1).

3. The mobile phase mixing system for liquid chromatography-mass spectrometry according to claim 1, characterized in that: It also includes a temperature sensor (12) and a heating tube (13), wherein the temperature sensor (12) is fixed on the top surface of the mixing shell (1), and the heating tube (13) is installed on the bottom surface inside the mixing shell (1), the output end of the temperature sensor (12) is electrically connected to the input end of the controller (17), and the input end of the heating tube (13) is electrically connected to the output end of the controller (17).

4. The mobile phase mixing system for liquid chromatography-mass spectrometry according to claim 1, characterized in that: The invention also comprises an electromagnetic valve (14) and a flow meter (15), wherein the electromagnetic valve (14) is installed at the left end of the outer side of the liquid guiding tube (4), and the flow meter (15) is installed at the right end of the outer side of the liquid guiding tube (4), and the input ends of the electromagnetic valve (14) and the flow meter (15) are electrically connected to the output end of the controller (17).

5. The mobile phase mixing system for liquid chromatography-mass spectrometry according to claim 1, characterized in that: The invention also comprises a fixing clamp (18), an adhesive pad (19), a corrosion-resistant layer (20) and a protective layer (21), wherein the fixing clamp (18) is clamped on the outside of the catheter (4), the adhesive pad (19) is bonded to the bottom surface of the fixing clamp (18), the corrosion-resistant layer (20) is evenly coated on the inner side of the catheter (4), and the protective layer (21) is coated on the outer side of the catheter (4).

6. The mobile phase mixing system for liquid chromatography-mass spectrometry according to claim 1, characterized in that: It also includes a wireless transmitter (22), which is fixed on the left side of the mixing shell (1), and the output end of the wireless transmitter (22) is electrically connected to the input end of the controller (17).

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