Monoclonal antibody detection device

Abstract

The monoclonal antibody detection device comprises a centrifugal machine, a centrifugal cavity is formed in the inner side of the centrifugal machine, a temperature sensor is arranged on the inner wall of the centrifugal cavity, a heating cover is arranged at an opening in the top end of the centrifugal machine, a heating wire is integrated in the heating cover, and the bottom surface of the heating cover is communicated with the centrifugal cavity; an exhaust fan is arranged at the top of the inner side of the heating cover and used for driving airflow to bring heat of the heating wire into the centrifugal cavity, and a filter element is arranged at an opening in the top end of the heating cover and used for filtering air entering the centrifugal cavity. The heating cover is installed at the top of the centrifugal machine, the exhaust fan and the filter element are arranged at the top end of the heating cover, heat of the heating cover can be brought into the centrifugal machine through the exhaust fan, and therefore a greenhouse environment is formed in the centrifugal machine, and it is guaranteed that suspension can be stored in a greenhouse without being transferred out of the centrifugal machine; and the detection of the monoclonal antibody is greatly facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of antibody detection, in particular to a monoclonal antibody detection device. Background Technique

[0002] A common method for monoclonal antibody detection is to detect by immunoenzyme technology. When using immunoenzyme technology to detect monoclonal antibodies, a centrifugation device is needed to perform centrifugation on them.

[0003] In the prior art, the invention patent with the application number CN202310236473.0 discloses a reproductive antibody detection device, including an installation shell and a centrifugation device. The centrifugation device is rotatably installed inside the installation shell; the bottom of the centrifugation device is detachably installed inside the installation shell through a power motor arranged. The top of the power motor is sequentially rotatably connected with a connection cover, a first installation sleeve and a central column. The first installation sleeve and the connection cover are integrally arranged, and the connection cover is integrally in a circular arc-shaped cover shape; a second installation sleeve is sleeved outside the central column, and a plurality of uniformly distributed test tube sleeves are hinged on the side surface of the second installation sleeve. The bottom end of the test tube sleeve is slidably connected with the upper surface of the connection cover through an anti-vibration elastic sheet arranged, and an installation groove for inserting a test tube is opened inside the test tube sleeve.

[0004] The antibody detection device provided by the above patent can increase the stability of the centrifuge during long-term use and enhance the stability of the device. To ensure the accuracy of the detection results, the suspension after centrifugation needs to be stored in a greenhouse for a certain period of time. However, the above antibody detection device does not have the function of greenhouse storage. Therefore, after the suspension is centrifuged by it, the suspension still needs to be transferred from the inside of the device to the greenhouse, and it is very easy to cause the suspension to be contaminated during the transfer of the suspension, thereby affecting the detection results of monoclonal antibodies. Content of the Utility Model

[0005] The purpose of the utility model is to provide a monoclonal antibody detection device, aiming to improve the problem that the existing antibody detection device does not have the function of greenhouse storage, and the suspension after centrifugation still needs to be transferred from the inside of the antibody detection device to the greenhouse, and it is very easy to cause the suspension to be contaminated during the transfer of the suspension, thereby affecting the detection results of monoclonal antibodies.

[0006] The utility model is realized as follows:

[0007] A monoclonal antibody detection device comprises a centrifuge, wherein a centrifugal chamber is arranged inside the centrifuge, and a temperature sensor is arranged on the inner wall of the centrifugal chamber, a heating cover is arranged at the top opening of the centrifuge, a heating wire is integrated inside the heating cover, and the bottom surface of the heating cover is communicated with the centrifugal chamber, an exhaust fan is arranged on the top of the inner side of the heating cover for driving air flow to bring heat from the heating wire into the centrifugal chamber, and a filter element is arranged at the top opening of the heating cover for filtering air entering the centrifugal chamber.

[0008] Preferably, a control panel is provided on the front of the centrifuge, and supporting feet are provided at the corners of the bottom surface of the centrifuge. A first plug-in slot is provided on the side of the centrifuge for connecting with a heating cover.

[0009] Preferably, a transfer groove is provided at the top opening edge of the centrifuge, a centrifugal disk is provided in the middle of the centrifuge, and a plurality of perforations are provided at the edge of the centrifugal disk for placing samples to be centrifuged.

[0010] Preferably, an adapter ring is provided at the bottom end of the heating cover, and a wire is provided at the side of the heating cover, an electrical plug is provided at the end of the wire, a supporting plate is provided on the inner side of the heating cover along above the heating wire, an air vent is provided in the middle of the supporting plate for installing an exhaust fan, a clamping knob is provided on the side of the heating cover near the top, and a third plug-in slot is provided on the inner side of the heating cover for connecting the exhaust fan with the inside of the heating cover.

[0011] Preferably, the bottom of both sides of the exhaust fan are provided with fixed convex edges, the fixed convex edges are provided with a plurality of fixing holes, the side of the exhaust fan is provided with a connecting line, and the connecting line is provided with a connecting plug for connecting the exhaust fan with the heating cover.

[0012] Preferably, an insert ring is provided at the bottom end of the filter element for inserting into the opening at the top end of the heating cover.

[0013] Preferably, a second plug-in slot is provided on the side wall of the centrifugal chamber inside the centrifuge, an ultraviolet sterilization lamp is provided inside the centrifugal chamber of the centrifuge, a plug connector is provided at one end of the ultraviolet sterilization lamp, and the plug connector is connected to the second plug-in slot.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. The utility model installs a heating cover on the top of the centrifuge, and an exhaust fan and a filter element are arranged on the top of the heating cover. The exhaust fan can bring the heat of the heating cover into the inside of the centrifuge, so as to form a greenhouse environment inside the centrifuge, ensuring that the suspension does not need to be transferred out of the centrifuge and can be stored in the greenhouse, which greatly facilitates the detection of monoclonal antibodies and avoids the trouble of transferring the suspension back and forth when processing the suspension during the monoclonal detection process.

[0016] 2. The utility model is equipped with an ultraviolet germicidal lamp inside the centrifuge. Through the ultraviolet germicidal lamp, the suspension can be sterilized during the centrifugation process of the suspension, avoiding the problem of suspension contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic structural diagram of the utility model;

[0018] Figure 2 is a schematic structural diagram of the centrifuge of the utility model;

[0019] Figure 3 is a schematic structural diagram of the heating cover of the utility model;

[0020] Figure 4 is a schematic structural diagram of the exhaust fan of the utility model;

[0021] Figure 5 is a schematic structural diagram of the filter element of the utility model;

[0022] Figure 6 is a schematic structural diagram of the ultraviolet germicidal lamp of the utility model.

[0023] In the figure: 1. Centrifuge; 11. Control panel; 12. Support feet; 13. First socket; 14. Adapter slot; 15. Second socket; 16. Temperature sensor; 17. Centrifugal disc; 18. Perforation; 2. Heating cover; 21. Adapter ring; 22. Conductive wire; 23. Power plug; 24. Support plate; 25. Vent hole; 26. Heating wire; 27. Tightening knob; 28. Third socket; 3. Exhaust fan; 31. Fixed flange; 32. Fixed hole; 33. Connecting wire; 34. Connecting plug; 4. Filter element; 41. Insertion ring; 5. Ultraviolet germicidal lamp; 51. Plug connector. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] In the present utility model, unless otherwise clearly defined and limited, the terms "installation", "connection", "connection", "fixation" and other terms shall be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral body; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0025] The following is a further description with reference to the drawings and specific embodiments:

[0026] Embodiment 1

[0027] As Figure 1 and Figure 2As shown in the figure, a monoclonal antibody detection device includes a centrifuge 1. Inside the centrifuge 1, there is a centrifugal chamber which is convenient for storing the suspension to be centrifuged, thus facilitating the centrifuge 1 to drive the suspension for centrifugation operations. And a temperature sensor 16 is provided on the inner wall of the centrifugal chamber, which is convenient for sensing the temperature inside the centrifugal chamber. At the top opening of the centrifuge 1, there is a heating cover 2. Inside the heating cover 2, a heating wire 26 is integrated. And the bottom surface of the heating cover 2 communicates with the centrifugal chamber. At the inner top of the heating cover 2, there is an exhaust fan 3 for driving the air flow to bring the heat of the heating wire 26 into the centrifugal chamber. The heating cover 2 cooperating with the exhaust fan 3 enables the hot air to smoothly enter the centrifugal chamber. And at the top opening of the heating cover 2, there is a filter element 4 for filtering the air entering the centrifugal chamber.

[0028] As Figure 2 shown in the figure, on the front of the centrifuge 1, there is an operation panel 11 which is convenient for operating the centrifuge 1 and facilitating the operation and use of the centrifuge 1. And at the bottom corners of the centrifuge 1, there are support feet 12 which are convenient for supporting the centrifuge 1 and facilitating its stability. On the side of the centrifuge 1, there is a first socket 13 for connecting and using with the heating cover 2. At the edge of the top opening of the centrifuge 1, there is a transfer groove 14 which is convenient for connecting the centrifuge 1 and the heating cover 2. In the middle of the centrifuge 1, there is a centrifugal disc 17. At the edge of the centrifugal disc 17, there are multiple through holes 18 for placing the samples to be centrifuged.

[0029] As Figure 3 shown in the figure, at the bottom end of the heating cover 2, there is a transfer ring 21 which is convenient for the threaded connection between the heating cover 2 and the centrifuge 1. And on the side of the heating cover 2, there is a wire 22. At the end of the wire 22, there is an electric plug 23. The cooperation of the wire 22 and the electric plug 23 is convenient for the heating cover 2 to be connected to and powered by the machine body. Above the heating wire 26 along the inner side of the heating cover 2, there is a supporting plate 24. The heating wire 26 is convenient for the heating cover 2 to generate heat and be used. In the middle of the supporting plate 24, there is a ventilation opening 25 for installing the exhaust fan 3. At a position near the top on the side of the heating cover 2, there is a compression knob 27 which is convenient for fixing the position of the filter element 4. On the inner side surface of the heating cover 2, there is a third socket 28 for connecting the exhaust fan 3 to the inside of the heating cover 2.

[0030] As Figure 4 shown in the figure, at the bottom of both sides of the exhaust fan 3, there are fixed convex edges 31. On the fixed convex edges 31, there are multiple fixing holes 32. The cooperation of the fixed convex edges 31 and the fixing holes 32 is convenient for fixing the position of the exhaust fan 3 by bolts. On the side of the exhaust fan 3, there is a connecting wire 33. On the connecting wire 33, there is a connecting plug 34 for connecting the exhaust fan 3 to the heating cover 2.

[0031] As Figure 5 shown in the figure, at the bottom end of the filter element 4, there is an insertion ring 41 for inserting into the top opening of the heating cover 2.

[0032] Working principle: When in use, the exhaust fan 3 is installed inside the heating cover 2 according to the use requirements, and the filter element 4 is installed at the top opening of the heating cover 2, then the sample is placed on the centrifugal disk 17, and the heating cover 2 is covered on the top opening of the body, and then the heating cover 2 is connected to the centrifuge 1, and then the centrifuge 1 can be controlled to drive the sample to centrifuge, and the heating cover 2 is started after the centrifugation is completed, and the temperature inside the centrifugal chamber is raised to the specified temperature, and the sample inside the centrifugal chamber can be stored in a greenhouse. Compared with the prior art, the present application is equipped with a heating cover 2 on the top of the centrifuge 1, and an exhaust fan 3 and a filter element 4 are provided on the top of the heating cover 2. The exhaust fan 3 can bring the heat of the heating cover 2 into the centrifuge 1, thereby forming a greenhouse environment inside the centrifuge 1, ensuring that the suspension does not need to be transferred out of the centrifuge 1 and can be stored in a greenhouse, which greatly facilitates the detection of monoclonal antibodies and avoids the trouble of transferring the suspension back and forth when processing the suspension during the monoclonal detection process.

[0033] Example 2

[0034] like Figure 1 and Figure 2 As shown, a monoclonal antibody detection device includes a centrifuge 1, and a centrifugal chamber is provided inside the centrifuge 1. The centrifugal chamber is convenient for storing the suspension to be centrifuged, so that the centrifuge 1 can drive the suspension to perform centrifugal operation. A temperature sensor 16 is provided on the inner wall of the centrifugal chamber, and the temperature sensor 16 is convenient for sensing the temperature inside the centrifugal chamber. A heating cover 2 is provided at the top opening of the centrifuge 1, and a heating wire 26 is integrated inside the heating cover 2. The bottom surface of the heating cover 2 is connected to the centrifugal chamber. An exhaust fan 3 is provided on the top of the inner side of the heating cover 2 to drive the airflow to bring the heat of the heating wire 26 into the centrifugal chamber. The heating cover 2 cooperates with the exhaust fan 3 to allow the hot air to enter the centrifugal chamber smoothly. A filter element 4 is provided at the top opening of the heating cover 2 to filter the air entering the centrifugal chamber.

[0035] like Figure 2 As shown, a control panel 11 is provided on the front of the centrifuge 1, and the control panel 11 is convenient for controlling the centrifuge 1, and is convenient for the operation and use of the centrifuge 1. Support feet 12 are provided at the corners of the bottom surface of the centrifuge 1, and the support feet 12 are convenient for supporting the centrifuge 1 and stabilizing the centrifuge 1. A first plug-in slot 13 is provided on the side of the centrifuge 1 for connecting with the heating cover 2. A transfer slot 14 is provided on the edge of the top opening of the centrifuge 1, and the transfer slot 14 facilitates the connection between the centrifuge 1 and the heating cover 2. A centrifugal disc 17 is provided in the middle of the centrifuge 1, and a plurality of perforations 18 are provided on the edge of the centrifugal disc 17 for placing samples that need to be centrifuged.

[0036] like Figure 3As shown in the figure, a transfer ring 21 is provided at the bottom end of the heating cover 2. The transfer ring 21 facilitates the threaded connection between the heating cover 2 and the centrifuge 1. And a wire 22 is provided on the side of the heating cover 2, and an electric plug 23 is provided at the end of the wire 22. The cooperation of the wire 22 and the electric plug 23 facilitates the heating cover 2 to be connected and powered on with the body. A support plate 24 is provided above the heating wire 26 along the inner side of the heating cover 2. The heating wire 26 facilitates the heating cover 2 to generate heat and be used. A ventilation port 25 is provided in the middle of the support plate 24 for installing the exhaust fan 3. A compression knob 27 is provided at a position near the top of the side of the heating cover 2. The compression knob 27 facilitates fixing the position of the filter element 4. A third socket 28 is provided on the inner side of the heating cover 2 for connecting the exhaust fan 3 to the inside of the heating cover 2.

[0037] As Figure 4 shown in the figure, fixed convex edges 31 are provided at the bottom of both sides of the exhaust fan 3, and a plurality of fixing holes 32 are provided on the fixed convex edges 31. The cooperation of the fixed convex edges 31 and the fixing holes 32 facilitates fixing the position of the exhaust fan 3 by bolts. A connecting wire 33 is provided on the side of the exhaust fan 3, and a connecting plug 34 is provided on the connecting wire 33 for connecting the exhaust fan 3 to the heating cover 2.

[0038] As Figure 5 shown in the figure, an insertion ring 41 is provided at the bottom end of the filter element 4 for inserting into the top opening of the heating cover 2.

[0039] As Figure 6 shown in the figure, a second socket 15 is provided on the side wall of the centrifugal chamber inside the centrifuge 1. An ultraviolet germicidal lamp 5 is provided inside the centrifugal chamber of the centrifuge 1. The second socket 15 facilitates the insertion of the ultraviolet lamp into the centrifuge 1. The ultraviolet germicidal lamp 5 facilitates sterilizing the inside of the centrifugal chamber and ensures a sterile environment for sample centrifugation. One end of the ultraviolet germicidal lamp 5 is provided with a plug 51, and the plug 51 is connected to the second socket 15 to facilitate the power-on operation of the ultraviolet lamp.

[0040] The above is only the preferred embodiment of the present invention and is not used to limit the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A monoclonal antibody detection device, comprising a centrifuge (1), characterized in that: A centrifugal chamber is provided inside the centrifuge (1), and a temperature sensor (16) is provided on the inner wall of the centrifugal chamber. A heating cover (2) is provided at the top opening of the centrifuge (1), a heating wire (26) is integrated inside the heating cover (2), and the bottom surface of the heating cover (2) is communicated with the centrifugal chamber. An exhaust fan (3) is provided at the top of the inner side of the heating cover (2) for driving air flow to bring heat from the heating wire (26) into the centrifugal chamber, and a filter element (4) is provided at the top opening of the heating cover (2) for filtering air entering the centrifugal chamber.

2. A monoclonal antibody detection device according to claim 1, characterized in that: The centrifuge (1) is provided with a control panel (11) on the front, and supporting feet (12) are provided at the corners of the bottom surface of the centrifuge (1). The side of the centrifuge (1) is provided with a first plug-in slot (13) for connecting with the heating cover (2).

3. A monoclonal antibody detection device according to claim 2, characterized in that: The top opening edge of the centrifuge (1) is provided with a transfer groove (14), the middle of the centrifuge (1) is provided with a centrifugal disk (17), and the edge of the centrifugal disk (17) is provided with a plurality of perforations (18) for placing samples to be centrifuged.

4. A monoclonal antibody detection device according to claim 1, characterized in that: The bottom end of the heating cover (2) is provided with an adapter ring (21), and the side of the heating cover (2) is provided with a wire (22), and the end of the wire (22) is provided with an electrical plug (23). The inner side of the heating cover (2) is provided with a support plate (24) above the heating wire (26), and the middle part of the support plate (24) is provided with an air vent (25) for installing an exhaust fan (3). A clamping knob (27) is provided on the side of the heating cover (2) near the top, and a third plug-in slot (28) is provided on the inner side of the heating cover (2) for connecting the exhaust fan (3) with the inside of the heating cover (2).

5. A monoclonal antibody detection device according to claim 1, characterized in that: The bottoms of both sides of the exhaust fan (3) are provided with fixed convex edges (31), and the fixed convex edges (31) are provided with a plurality of fixing holes (32). A connecting line (33) is provided on the side of the exhaust fan (3), and a connecting plug (34) is provided on the connecting line (33) for connecting the exhaust fan (3) with the heating cover (2).

6. A monoclonal antibody detection device according to claim 1, characterized in that: The bottom end of the filter element (4) is provided with an insert ring (41) for inserting into the top opening of the heating cover (2).

7. A monoclonal antibody detection device according to any one of claims 1 to 6, characterized in that: A second plug-in slot (15) is provided on the side wall of the centrifugal chamber inside the centrifuge (1), an ultraviolet sterilization lamp (5) is provided inside the centrifugal chamber of the centrifuge (1), a plug-in connector (51) is provided at one end of the ultraviolet sterilization lamp (5), and the plug-in connector (51) is connected to the second plug-in slot (15).

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