Reaction device for raw material medicine production

Abstract

The utility model discloses a reaction device for raw material medicine production, which relates to the technical field of medicine production equipment and comprises a reaction kettle body, a stirring structure is connected inside the reaction kettle body, a feed port is arranged at the top of the reaction kettle body, and a discharge pipe is connected at the bottom of the reaction kettle body. The kettle wall in the reaction kettle body is spirally connected with a temperature control pipeline, and two ends of the temperature control pipeline extend to the outside of the reaction kettle body; the temperature control pipeline extending to the outer side of the top of the reaction kettle body is connected with a water inlet pipe, the water inlet pipe is connected with two water inlet branch pipes, the two water inlet branch pipes are respectively communicated with a cold water tank and a hot water tank, and the two water inlet branch pipes are respectively connected with a control valve and a water pump; a heating structure is connected in the hot water tank; a cooling structure is connected in the cold water tank; a temperature sensor is connected inside the reaction kettle body, and a temperature display in communication connection with the temperature sensor is connected outside the reaction kettle body; the temperature control pipeline extending to the outer side of the bottom of the reaction kettle body is connected with a water outlet pipe. The production efficiency is improved, and the quality of the produced raw material medicine is better.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical production equipment, and particularly relates to a reaction device for raw material drug production. Background Art

[0002] A raw material drug refers to a qualified drug ingredient prepared from natural drugs, chemical synthetic substances, microorganisms and other raw materials through a series of biochemical reactions, separation and purification processes, etc., providing qualified and stable raw materials for downstream drug manufacturers. In the production and processing of raw material drugs, a reaction device is required for production.

[0003] Patent CN201820301863.6 discloses a reaction kettle for freeze-dried raw material drug production, including a base, a rotating shaft and an observation window. A device main body is fixedly installed above the base, and a discharge port is arranged at the bottom of the device main body. A stirring blade is fixedly connected to the middle lower part of the rotating shaft, and a first fixing rod is installed above the stirring blade. The inside of the first fixing rod is connected to a second fixing rod through a return spring. The observation window is arranged above the device main body, and a chute is arranged on the surface of the device main body. A dust removal device is installed below the chute, and a brush is installed on one side of the dust removal device. This reaction kettle for raw material drug production solves the problems that the purity of the blanking of the current reaction kettle for freeze-dried raw material drug production cannot be well guaranteed, the stirring is uneven, the feeding amount control is inaccurate, and it is inconvenient to clean.

[0004] Most of the current raw material production devices are similar in structure to the reaction kettle disclosed in the above patent. Although the effect of uniform stirring can be achieved, most raw material drugs also need to control some other conditions during the production process, such as the temperature during the reaction. However, most of the current devices are difficult to achieve the effect of controlling the reaction temperature, which makes them have certain functional defects and a narrow scope of application during use. Moreover, if the temperature during the reaction of the raw material drug is not accurately controlled, it will not only affect the reaction efficiency of the raw material drug, but also affect the quality of the produced raw material drug. Summary of the Utility Model

[0005] The technical problem to be solved by the utility model is that the current reaction device for raw material drugs cannot achieve temperature adjustment, which not only affects the reaction efficiency of the raw material drugs, but also affects the quality of the produced raw material drugs. Based on this, a reaction device for raw material drug production is proposed. The reaction device can control the reaction temperature of the raw material drug by connecting a heating structure and a cooling structure, not only shortening the reaction time of the raw material drug, improving the production efficiency, but also producing better-quality raw material drugs.

[0006] The utility model is realized through the following technical solutions:

[0007] The present application provides a reaction device for the production of bulk drugs, including a reaction kettle body. A stirring structure is connected inside the reaction kettle body. A feed inlet is arranged at the top of the reaction kettle body, and a discharge pipe is connected to the bottom. A temperature control pipe is spirally connected to the inner wall of the reaction kettle body, and both ends of the temperature control pipe extend to the outside of the reaction kettle body.

[0008] The temperature control pipe extending to the outside of the top of the reaction kettle body is connected to a water inlet pipe. Two water inlet branch pipes are connected to the water inlet pipe. The two water inlet branch pipes are respectively communicated with a cold water tank and a hot water tank. Control valves and water pumps are connected to both water inlet branch pipes. A heating structure is connected inside the hot water tank, and a cooling structure is connected inside the cold water tank. A temperature sensor is connected inside the reaction kettle body, and a temperature display is connected to the outside of the reaction kettle body and is communicatively connected with the temperature sensor.

[0009] The temperature control pipe extending to the outside of the bottom of the reaction kettle body is connected to a water outlet pipe.

[0010] Among them, the control valves, water pumps on the water inlet branch pipes, and the temperature sensor can be connected to a PLC controller to achieve the effect of automatically opening and closing the control valves and water pumps, that is, to achieve the function of automatic temperature control.

[0011] Among them, the water in the cold water tank can be cooled by putting ice cubes into the cold water tank.

[0012] Further, two water outlet branch pipes are connected to the water outlet pipe. The two water outlet branch pipes are respectively communicated with the cold water tank and the hot water tank. Control valves are connected to both water outlet branch pipes.

[0013] Further, the tank wall of the hot water tank forms a sandwich structure by an inner wall and an outer wall. The heating structure includes an electric heating plate connected between the inner wall and the outer wall.

[0014] Further, the heating structure further includes an electric heating block connected to the bottom of the reaction kettle body.

[0015] Further, the electric heating block is slidably arranged at the bottom of the reaction kettle body.

[0016] An L-shaped support plate is connected to the bottom of the reaction kettle body. A slide rail is arranged on the horizontal bottom plate of the L-shaped support plate. A slider is connected to the slide rail. The electric heating block is connected to the slider. A driving structure for driving the slider to move is connected to the slider.

[0017] Further, the driving structure includes a spring connected to the vertical plate of the L-shaped support plate. One end of the spring is connected to the vertical plate of the L-shaped support plate, and the other end is connected to the slider.

[0018] The upper end of the reactor body is connected with a horizontal plate, the horizontal plate is connected with a vertical rotating shaft, the bottom of the vertical rotating shaft is connected with a cam for driving the slider to move, and the top of the vertical rotating shaft is connected with a first motor.

[0019] Further, the stirring structure includes a central stirring shaft connected inside the reactor body, stirring blades are connected to the central stirring shaft, the central stirring shaft extends outside the reactor body and is connected with a second motor for driving the central stirring shaft to rotate.

[0020] Further, a first gear ring is connected to the central stirring shaft, auxiliary stirring shafts are arranged on both sides of the central stirring shaft, a second gear ring is connected to the auxiliary stirring shafts, the first gear ring and the second gear ring are meshed with each other, and stirring blades are also connected to the auxiliary stirring shafts.

[0021] Further, a cleaning structure is connected inside the reactor body.

[0022] Further, the cleaning structure includes an annular pipeline connected to the top of the reactor body, a plurality of water spray heads are arranged on the annular pipeline, a water conveying pipeline is connected to the annular pipeline, the water conveying pipeline is communicated with the cold water tank and / or the hot water tank, and a water pump is connected to the water conveying pipeline.

[0023] Compared with the prior art, the utility model has the following advantages and beneficial effects:

[0024] (1) In this application, by connecting a heating structure and a cooling structure inside the reactor body, when it is necessary to increase the reaction temperature, heating treatment can be carried out through the heating structure, and when it is necessary to decrease the reaction temperature, cooling treatment can be carried out through the cooling structure, so that the raw materials in the reactor body are always at the optimal reaction temperature, shortening the reaction time of the raw drug and improving the production efficiency of the raw drug, and the quality of the produced raw drug is also higher; in addition, the temperature sensor connected inside the reactor body can intuitively reflect the temperature of the raw drug during the reaction process from the temperature display, and the staff can adjust the reaction temperature of the raw drug in time by observing the temperature value on the temperature display;

[0025] (2) In this application, when a hot water tank is connected for heating, an electric heating block is further connected to the bottom of the reactor body, which can further accelerate the heating speed inside the reactor body. At the same time, the electric heating block is connected to the bottom of the reactor body by a sliding structure, which can also make the heating at the bottom of the reactor body more uniform;

[0026] (3) In the present application, the central stirring shaft is connected to the reactor body, and then the auxiliary stirring shaft is connected through gear transmission. The combination of the central stirring shaft and the auxiliary stirring shaft can make the stirring structure have a better stirring effect on the raw materials in the reactor body, and the stirring is more uniform, which also has the effect of improving production efficiency and product quality.

[0027] (4) The present application connects a cleaning structure inside the reactor body. When the inside of the reactor body needs to be cleaned, cleaning water is introduced into the cavity through the cleaning structure, and then the cleaning water is sprayed out from the water spray head, thereby achieving a cleaning effect on the inside of the reactor body, making the cleaning of the inside of the reactor body more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The drawings described herein are used to provide a further understanding of the embodiments of the present utility model, constitute a part of this application, and do not constitute a limitation of the embodiments of the present utility model. In the drawings:

[0029] Figure 1 This is a schematic diagram of the structure of a reaction device for producing a raw material medicine in Example 1 of the utility model;

[0030] Figure 2 This is a schematic diagram of the structure of a reaction device for producing a raw material medicine in Example 2 of the utility model;

[0031] Figure 3 It is a top view of the connection relationship between the first gear ring and the second gear ring in the utility model;

[0032] Figure 4 This is a schematic diagram of the structure of a reaction device for producing a raw material medicine in Example 3 of the utility model;

[0033] Figure 5 This is a schematic diagram of the structure of a reaction device for producing a raw material medicine in Example 4 of the utility model;

[0034] Figure 6 It is a bottom view of the annular pipeline in the utility model.

[0035] Marks and corresponding parts names in the attached drawings:

[0036] 01 - Hot water tank, 02 - Electric heating plate, 03 - Water delivery pipe, 04 - Inlet branch pipe, 05 - Outlet branch pipe, 06 - Cold water tank, 07 - Reactor body, 08 - Second motor, 09 - First gear ring, 10 - Feed inlet, 11 - Second gear ring, 12 - Annular pipe, 13 - First motor, 14 - Sprinkler head, 15 - Central stirring shaft, 16 - Auxiliary stirring shaft, 17 - Stirring blade, 18 - Temperature control pipe, 19 - Vertical rotating shaft, 20 - Discharge pipe, 21 - Cam, 22 - Electric heating block, 23 - Slide block, 24 - Spring, 25 - L-shaped support plate, 26 - Temperature sensor, 27 - Temperature display. Detailed implementation manners

[0037] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are some but not all of the embodiments of the present utility model. Usually, the components of the embodiments of the present utility model described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations.

[0038] Therefore, the following detailed description of the embodiments of the present utility model provided in the accompanying drawings is not intended to limit the scope of the present utility model claimed, but merely represents selected embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the scope of protection of the present utility model.

[0039] It should be noted that: Similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0040] In the description of the present utility model, it should also be noted that, unless otherwise clearly defined and limited, the terms "set", "installed", "connected", and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0041] Embodiment 1

[0042] As Figure 1As shown, this embodiment provides a reaction device for raw material drug production, including a reaction kettle body 07. A stirring structure is connected inside the reaction kettle body 07. A feed inlet 10 is arranged at the top of the reaction kettle body 07, and a discharge pipe 20 is connected to the bottom. A temperature control pipe 18 is spirally connected to the inner wall of the reaction kettle body 07, and both ends of the temperature control pipe 18 extend to the outside of the reaction kettle body 07.

[0043] The temperature control pipe 18 extending to the outside of the top of the reaction kettle body 07 is connected to a water inlet pipe. Two water inlet branch pipes 04 are connected to the water inlet pipe. The two water inlet branch pipes 04 are respectively communicated with a cold water tank 06 and a hot water tank 01. Control valves and water pumps are connected to both water inlet branch pipes 04. A temperature increasing structure is connected inside the hot water tank 01, and a temperature decreasing structure is connected inside the cold water tank 06. A temperature sensor 26 is connected inside the reaction kettle body 07, and a temperature display 27 communicatively connected to the temperature sensor 26 is connected to the outside of the reaction kettle body 07. The temperature control pipe 18 extending to the outside of the bottom of the reaction kettle body 07 is connected to a water outlet pipe.

[0044] Among them, when it is necessary to cool the water in the cold water tank 06, putting ice cubes into the cold water tank 06 can lower the temperature of the water in the cold water tank 06. Other temperature decreasing structures can also be connected, such as condensers, radiators, etc.

[0045] Specifically, two water outlet branch pipes 05 are connected to the water outlet pipe. The two water outlet branch pipes 05 are respectively communicated with the cold water tank 06 and the hot water tank 01. Control valves are connected to both water outlet branch pipes 05.

[0046] Specifically, the tank wall of the hot water tank 01 forms a sandwich structure by an inner wall and an outer wall. The temperature increasing structure includes an electric heating plate 02 connected between the inner wall and the outer wall.

[0047] Specifically, the stirring structure includes a central stirring shaft 15 connected inside the reaction kettle body 07. Stirring blades 17 are connected to the central stirring shaft 15. The central stirring shaft 15 extends to the outside of the reaction kettle body 07 and is connected to a second motor 08 that drives the central stirring shaft 15 to rotate.

[0048] Working principle: When using the reaction device for the production of active pharmaceutical ingredients in this embodiment, the raw materials to be reacted are put into the feeding port 10 of the reactor body 07, and then the second motor 08 is started. The stirring shaft is driven to rotate by the second motor 08, so that the raw materials put into the reactor body 07 are evenly mixed and then react. During the reaction process, the staff judges the reaction temperature inside the reactor body 07 by observing the temperature value on the temperature display 27. When the temperature inside the reactor body 07 is lower than the required reaction temperature, the staff can open the water inlet branch pipe 04 connected to the hot water tank 01. At this time, the control valve and the water pump on the water inlet branch pipe 04 communicating with the hot water tank 01 are opened, and the control valve and the water pump on the water inlet branch pipe 04 communicating with the cold water tank 06 are closed. At the same time, the control valve on the water outlet branch pipe 05 communicating with the hot water tank 01 is opened, and the control valve on the water outlet branch pipe 05 communicating with the cold water tank 06 is closed. By introducing hot water into the temperature control pipeline 18, the temperature inside the reactor body 07 can be raised to make the temperature inside the reactor body 07 reach the optimal reaction temperature.

[0049] When the temperature inside the reactor body 07 is higher than the required reaction temperature, the staff can open the water inlet branch pipe 04 communicating with the cold water tank 06. At this time, the control valve and the water pump on the water inlet branch pipe 04 communicating with the cold water tank 06 are opened, and the control valve and the water pump on the water inlet branch pipe 04 communicating with the hot water tank 01 are closed. At the same time, the control valve on the water outlet branch pipe 05 communicating with the cold water tank 06 is opened, and the control valve on the water outlet branch pipe 05 communicating with the hot water tank 01 is closed. By introducing cold water into the temperature control pipeline 18, the temperature inside the reactor body 07 can be lowered to make the temperature inside the reactor body 07 reach the optimal reaction temperature.

[0050] By connecting a temperature-raising structure and a temperature-lowering structure inside the reactor body 07, when it is necessary to increase the reaction temperature, the temperature-raising structure can be used for temperature-raising treatment. When it is necessary to decrease the reaction temperature, the temperature-lowering structure can be used for temperature-lowering treatment, so that the raw materials in the reactor body 07 are always at the optimal reaction temperature, shortening the reaction time of the active pharmaceutical ingredients, improving the production efficiency of the active pharmaceutical ingredients, and the quality of the produced active pharmaceutical ingredients is also higher. In addition, the temperature sensor 26 connected inside the reactor body 07 can directly reflect the temperature of the active pharmaceutical ingredients during the reaction process from the temperature display 27. By observing the temperature value on the temperature display 27, the staff can timely adjust the reaction temperature of the active pharmaceutical ingredients.

[0051] Example 2

[0052] Such as Figure 2 And Figure 3As shown, based on Embodiment 1, this embodiment provides a reaction device for raw material drug production. Compared with Embodiment 1, the difference between this embodiment and Embodiment 1 is that a first toothed ring 09 is connected to the central stirring shaft 15, auxiliary stirring shafts 16 are arranged on both sides of the central stirring shaft 15, a second toothed ring 11 is connected to the auxiliary stirring shafts 16, the first toothed ring 09 and the second toothed ring 11 are meshed with each other, and stirring blades 17 are also connected to the auxiliary stirring shafts 16. Other technical features are exactly the same as those in Embodiment 1.

[0053] Compared with Embodiment 1, the advantage of the reaction device for raw material drug production in this embodiment is that: on the premise of connecting the central stirring shaft 15 inside the reaction kettle body 07, and then connecting the auxiliary stirring shafts 16 in the form of gear transmission, the combination of the central stirring shaft 15 and the auxiliary stirring shafts 16 can make the stirring structure have a better stirring effect on the raw material drug in the reaction kettle body 07, stir more evenly, and also play the role of improving production efficiency and product quality.

[0054] Embodiment 3

[0055] As Figure 4 shown, based on Embodiment 2, this embodiment provides a reaction device for raw material drug production. Compared with Embodiment 2, the difference between this embodiment and Embodiment 2 is that the heating-up structure of this embodiment further includes an electric heating block 22 connected to the bottom of the reaction kettle body 07.

[0056] Specifically, the electric heating block 22 is slidably arranged at the bottom of the reaction kettle body 07;

[0057] An L-shaped support plate 25 is connected to the bottom of the reaction kettle body 07. A slide rail is arranged on the horizontal bottom plate of the L-shaped support plate 25. A slider 23 is connected to the slide rail. The electric heating block 22 is connected to the slider 23, and a driving structure for driving the slider 23 to move is connected to the slider 23.

[0058] Specifically, the driving structure includes a spring 24 connected to the vertical plate of the L-shaped support plate 25. One end of the spring 24 is connected to the vertical plate of the L-shaped support plate 25, and the other end is connected to the slider 23;

[0059] A horizontal plate is connected to the upper end of the reaction kettle body 07. A vertical rotating shaft 19 is connected to the horizontal plate. A cam 21 for driving the slider 23 to move is connected to the bottom of the vertical rotating shaft 19, and a first motor 13 is connected to the top of the vertical rotating shaft 19.

[0060] Other technical features are exactly the same as those in Embodiment 2.

[0061] Compared with Embodiment 2, the advantages of the reaction device for raw material drug production in this embodiment are as follows: In this embodiment, when the reaction device is connected to the hot water tank 01 for heating up, an electric heating block 22 is further connected to the bottom of the reaction kettle body 07, which can further accelerate the heating rate inside the reaction kettle body 07. At the same time, the electric heating block 22 is connected to the bottom of the reaction kettle body 07 by a sliding structure, which can also make the heat received at the bottom of the reaction kettle body 07 more uniform.

[0062] Embodiment 4

[0063] As Figure 5 and Figure 6 shown, based on Embodiment 3, this embodiment provides a reaction device for raw material drug production. Compared with Embodiment 3, the difference between this embodiment and Embodiment 3 is that a cleaning structure is connected inside the reaction kettle body 07 of this embodiment.

[0064] Specifically, the cleaning structure includes an annular pipe 12 connected to the top of the reaction kettle body 07. A plurality of water spray heads 14 are arranged on the annular pipe 12. A water delivery pipe 03 is connected to the annular pipe 12. The water delivery pipe 03 is communicated with the cold water tank 06 and the hot water tank 01. A water pump is connected to the water delivery pipe 03.

[0065] Other technical features are exactly the same as those in Embodiment 3.

[0066] Compared with Embodiment 3, the advantages of the reaction device for raw material drug production in this embodiment are as follows: By connecting a cleaning structure inside the reaction kettle body 07 in this embodiment, when it is necessary to clean the inside of the reaction kettle body 07, clean water can be introduced into the cavity through the cleaning structure, and then the clean water is sprayed out from the water spray heads 14, so as to achieve the cleaning effect of the inside of the reaction kettle body 07, and it is more convenient to clean the inside of the reaction kettle body 07.

[0067] The specific embodiments described above have further elaborated on the purpose, technical solutions, and beneficial effects of the present invention. It should be understood that the above description is only the specific embodiments of the present invention and is not used to limit the protection scope of the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A reaction device for producing bulk drugs, comprising a reactor body (07), wherein a stirring structure is connected inside the reactor body (07), a feed inlet (10) is arranged at the top of the reactor body (07), and a discharge pipe (20) is connected at the bottom; characterized in that: A temperature control pipe (18) is spirally connected to the wall of the reactor body (07), and both ends of the temperature control pipe (18) extend to the outside of the reactor body (07); The temperature control pipe (18) extending to the outside of the top of the reactor body (07) is connected to a water inlet pipe, and the water inlet pipe is connected to two water inlet branches (04), and the two water inlet branches (04) are respectively connected to the cold water tank (06) and the hot water tank (01), and the two water inlet branches (04) are connected to a control valve and a water pump; the hot water tank (01) is connected to a heating structure, and the cold water tank (06) is connected to a cooling structure; the reactor body (07) is connected to a temperature sensor (26), and the reactor body (07) is connected to a temperature display (27) that is in communication with the temperature sensor (26); The temperature control pipe (18) extending to the outside of the bottom of the reactor body (07) is connected to the water outlet pipe.

2. A reaction device for producing bulk drugs according to claim 1, characterized in that: The water outlet pipe is connected to two water outlet branch pipes (05), the two water outlet branch pipes (05) are respectively connected to the cold water tank (06) and the hot water tank (01), and the two water outlet branch pipes (05) are both connected to a control valve.

3. A reaction device for producing bulk drugs according to claim 1, characterized in that: The tank wall of the hot water tank (01) is formed of an inner wall and an outer wall to form a sandwich structure, and the temperature-raising structure comprises an electric heating plate (02) connected between the inner wall and the outer wall.

4. A reaction device for producing bulk drugs according to claim 1 or 3, characterized in that: The temperature raising structure also includes an electric heating block (22) connected to the bottom of the reactor body (07).

5. A reaction device for producing bulk drugs according to claim 4, characterized in that: The electric heating block (22) is slidably arranged at the bottom of the reactor body (07); An L-shaped support plate (25) is connected to the bottom of the reactor body (07), a slide rail is arranged on the horizontal bottom plate of the L-shaped support plate (25), a slider (23) is connected to the slide rail, the electric heating block (22) is connected to the slider (23), and a driving structure for driving the slider (23) to move is connected to the slider (23).

6. A reaction device for producing bulk drugs according to claim 5, characterized in that: The driving structure comprises a spring (24) connected to the vertical plate of the L-shaped support plate (25), one end of the spring (24) is connected to the vertical plate of the L-shaped support plate (25), and the other end is connected to the slider (23); The upper end of the reactor body (07) is connected to a horizontal plate, and a vertical rotating shaft (19) is connected to the horizontal plate. A cam (21) for driving a slider (23) to move is connected to the bottom of the vertical rotating shaft (19), and a first motor (13) is connected to the top of the vertical rotating shaft (19).

7. A reaction device for producing bulk drugs according to claim 1, characterized in that: The stirring structure comprises a central stirring shaft (15) connected to the reactor body (07), a stirring blade (17) being connected to the central stirring shaft (15), and the central stirring shaft (15) extending to the outside of the reactor body (07) and connected to a second motor (08) for driving the central stirring shaft (15) to rotate.

8. A reaction device for producing bulk drugs according to claim 1, characterized in that: A cleaning structure is connected inside the reactor body (07).

9. A reaction device for producing bulk drugs according to claim 8, characterized in that: The cleaning structure comprises an annular pipe (12) connected to the top of the reactor body (07), a plurality of water spray heads (14) are arranged on the annular pipe (12), a water supply pipe (03) is connected to the annular pipe (12), the water supply pipe (03) is connected to the cold water tank (06) and / or the hot water tank (01), and a water pump is connected to the water supply pipe (03).

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