High-flux droplet microfluidics preparation device

Abstract

The utility model relates to a high flux droplet microfluidics preparation device, including preparation and collection mechanism and conveying mechanism, preparation and collection mechanism includes preparation chip that has a plurality of groups of mixed preparation flow channel, has the support that has corresponding mixed preparation flow channel's container, each group of mixed preparation flow channel has input and output end, the conveying mechanism comprises a conveying assembly with a conveying flow channel corresponding to the mixed preparation flow channel, a piston pipe correspondingly connected with the conveying flow channel, and a second driving assembly for driving the piston pipe; the conveying flow channel is provided with an input end connected with the injector conical head, an output end connected with the mixed preparation flow channel, an input / output end communicated with the piston pipe and a switching valve for controlling opening and closing of the input end and the output end. According to the utility model, the preparation of a plurality of preparation procedures can be simultaneously carried out under the same preparation condition, so that the preparation efficiency is improved, errors caused by graded preparation are avoided, and the reliability of experimental results is ensured. And solution supply is realized through an external injector, so that the stability and the safety are improved, and pollution is avoided.

Description

Technical Field

[0001] The utility model relates to a high-throughput droplet microfluidic preparation device, which is applicable to the technical field of biomedical processing. Background Art

[0002] Droplet microfluidics technology is a biovaccine preparation technology that can realize functions such as biochemical reactions, rapid mixing of reagents, and synthesis of microparticles, and is widely used in industries such as biovaccines and pharmaceutical processing. At present, the application of droplet microfluidics technology can generally be divided into two types: production type and experimental type. The equipment of the production type has a relatively large and complex structure, and pipelines, valves, and various monitoring and sensing devices need to be arranged, which is suitable for the scenario of enterprise production and processing. The equipment of the experimental type has a smaller structure, usually a tabletop preparation instrument, which is mainly used to deal with the scenario of small-scale reagent experiments in the laboratory. The solution throughput of the existing experimental equipment during preparation is mostly small. For example, the equipment disclosed in the patent with the publication number CN221359932U only has two input phases and can only mix two-phase liquids in a single preparation process. However, in the actual experimental process, in order to ensure the reliability of the experimental results, multiple control groups with the same preparation conditions are usually required to compare and verify each other. However, the equipment with the above structure can only prepare one set of test samples at a time, and multiple preparations are required to obtain experimental results with sufficient reliability, resulting in very low efficiency; and although the same preparation conditions can be set for multiple preparations, the manual participation links are prone to errors, which may lead to errors in the obtained results and affect the reliability of the final experimental results. Content of the Utility Model

[0003] In order to solve the defects existing in the above-mentioned prior art, the utility model proposes a high-throughput droplet microfluidic preparation device.

[0004] The technical solution adopted by the utility model is: a high-throughput droplet microfluidic preparation device, comprising:

[0005] A preparation and collection mechanism for preparing and collecting products. The preparation and collection mechanism includes a preparation chip having multiple groups of mixing and preparation channels, a bracket slidably disposed below the preparation chip and used for placing a collection container thereon, and a first driving component for driving the bracket to slide. Each group of mixing and preparation channels has at least two first input ends and one first output end. The bracket has a set of setting positions with the same number and one-to-one correspondence as the number of groups of mixing and preparation channels. Each set of setting positions includes a first setting position for placing a container for collecting good products and a second setting position for placing a container for collecting defective products. The bracket has at least two working positions through its sliding. When it is in the first working position, the first setting position in each set of setting positions is directly below the first output end of the corresponding preparation channel; when the bracket is in the second working position, the second setting position in each set of setting positions is directly below the first output end of the corresponding preparation channel.

[0006] A conveying mechanism, which is provided with at least two and used for supplying solutions participating in the preparation. Each conveying mechanism includes a machine base, a conveying component fixed on the machine base and having the same number of conveying channels as the number of mixing and preparation channels, piston tubes with the same number as the number of conveying channels and connected in one-to-one correspondence, and a second driving component for driving the piston handle of the piston tube to move. Each conveying channel has a second input end for connecting a syringe cone head, a second output end connected to one first input end of the corresponding mixing and preparation channel, an input / output end respectively communicating with the second input end and the second output end and communicating with the piston tube. The conveying component further includes a switching valve for controlling the opening or closing of the second input end and the second output end.

[0007] By providing multiple groups of mixing and preparation channels in the preparation chip, the preparation and sampling mechanism can simultaneously perform multiple groups of preparation processes. By driving the bracket to reciprocate through the first driving component, the containers on the bracket can be controlled to separately collect defective products and qualified products produced by the preparation chip for differentiation, preventing the defective products produced in the initial stage of preparation from affecting the product quality, and thus enabling the preparation and sampling mechanism to simultaneously perform multiple preparation processes for preparation and sampling. By providing at least two conveying mechanisms to separately convey the solutions for preparation to the first input ends of the respective mixing and preparation channels in the preparation chip to ensure the solution supply of each input phase in each mixing and preparation channel, and each conveying mechanism is provided with multiple piston tubes corresponding to multiple mixing and preparation channels. At the same time, by driving the piston handles of multiple piston tubes integrally through the second driving component, multiple preparation processes can be synchronously performed under the same preparation conditions. Moreover, the second input end of the conveying channel in the conveying component is connected to an external syringe to ensure that the piston tube can stably suck the solution, avoiding the unstable liquid suction caused by the position deviation of the hose when sucking the solution from other containers in the traditional way, ensuring the stability of sucking and outputting the solution, and thus ensuring the normal progress of the preparation process. At the same time, it also avoids the complexity brought by adding other containers and prevents the solution contained in other containers from being polluted by the external environment. By the preparation and sampling mechanism and the conveying mechanism, multiple preparation processes can be simultaneously performed under the same preparation conditions, which not only improves the preparation efficiency but also ensures that the preparation conditions of each group of reagents prepared are consistent, avoiding the errors existing in multiple separate preparations and ensuring the reliability of the experimental results obtained by comparative analysis. Moreover, the conveying mechanism realizes the solution supply by connecting an external syringe to the second input end, improving the stability and safety of solution suction, preventing the solution from being polluted during the conveying process, and avoiding affecting the preparation process.

[0008] Furthermore, the conveying mechanism has two working states. When it is in the first working state, the switching valve opens the second input end and closes the second output end, and the piston tube is in the suction state. When the conveying mechanism is in the second working state, the switching valve closes the second input end and opens the second output end, and the piston tube is in the pushing state; the suction state is defined as the piston handle moving outward along the tube body of the piston tube, and the pushing state is defined as the piston handle moving inward along the tube body of the piston tube. By switching the working state of the conveying mechanism through the switching valve, the piston tube can suck the solution from the external syringe and convey it to the preparation chip to realize the suction and output of the solution.

[0009] Furthermore, each conveying component is provided with a switching valve, which simultaneously controls all the second input ends and second output ends of the conveying component to be opened or closed; or each conveying component is provided with the same number of switching valves as the number of conveying channels, and each switching valve controls the second input end and second output end of the conveying component to be opened or closed one by one. Controlling all the second input ends and second output ends with one switching valve can ensure the consistency of each preparation process and guarantee the same preparation conditions; while controlling the second input ends and second output ends of each conveying channel one by one with multiple switching valves can improve the flexibility of use and avoid the normal operation of the whole device being affected by the failure of individual switching valves.

[0010] Furthermore, the first driving component includes a first slide rail fixedly arranged, a first slide seat slidably connected to the first slide rail, a first screw rod arranged along the extending direction of the first slide rail, and a first driver whose output shaft is connected to the first screw rod and is used to drive it to rotate. The first screw rod is threadedly connected to the first slide seat, and the bracket is fixedly connected to the first slide seat. By driving the first screw rod to rotate forward and backward by the first driver, the first slide seat is controlled to reciprocate along the first slide rail, thereby realizing the control of the bracket, and facilitating the separate collection of defective products and qualified products produced by the preparation.

[0011] Furthermore, a clamping groove for clamping and collecting the container of qualified products is arranged at the first setting position, and a clamping groove for clamping and collecting the container of defective products is arranged at the second setting position. By respectively clamping the two containers in the clamping grooves at the first setting position or the second setting position, it is convenient to control the positions of the two containers to receive the qualified products or defective products produced by the preparation.

[0012] Furthermore, the preparation and collection mechanism further includes a fixedly arranged chip holder, and the preparation chip is detachably connected to the chip holder, which is convenient to replace different preparation chips according to the process requirements and improves the versatility and practicability of the preparation device.

[0013] Furthermore, the second driving component includes a second screw rod arranged in the machine base along the sliding direction of the piston rod of the piston tube, a driving member threadedly connected to the second screw rod, and a second driver whose output shaft is connected to the second screw rod and is used to drive it to rotate. The driving member is fixedly connected to the piston rod of the piston tube. By driving the second screw rod to rotate clockwise or counterclockwise by the second driver, the driving member is driven to move back and forth along the second screw rod, thereby realizing the reciprocating drive of the piston rod of the piston tube, so as to extract the solution from the syringe or pump the solution in the tube into the preparation chip.

[0014] Furthermore, the second driving component further includes at least one second slide rail fixed on the machine base along the length direction of the second screw rod, and the driving member is slidably connected to the second slide rail, which improves the stability of the driving member when reciprocating.

[0015] Further, at least two conveying mechanisms are respectively arranged on both sides of the preparation and extraction mechanism, and the first input ends in the mixing and preparation flow channels are respectively arranged on the side surfaces of the preparation chip corresponding to the conveying mechanisms, so that the distances between the respective conveying channels in each conveying mechanism and the corresponding mixing and preparation flow channels are similar, which is convenient for controlling the liquid conveying rate in each preparation process and the amount of liquid conveyed into the preparation chip, keeping the parameters in each process consistent and avoiding differences.

[0016] Due to the application of the above technical solution, the present utility model has the following advantages compared with the prior art:

[0017] In the high-throughput droplet microfluidic control and preparation device of the present utility model, through the preparation and extraction mechanism and the conveying mechanism, multiple preparation processes can be carried out simultaneously under the same preparation conditions, which not only improves the preparation efficiency, but also ensures that the preparation conditions of each group of reagents prepared are consistent, avoiding the errors existing in the multiple preparations, and ensuring the reliability of the experimental results obtained by the comparative analysis. Moreover, the conveying mechanism realizes the solution supply through the second input end connected to an external syringe, improving the stability and safety of solution suction, preventing the solution from being contaminated during the conveying process, and avoiding affecting the preparation process. Description of the Drawings

[0018] Some specific embodiments of the present utility model will be described in detail hereinafter with reference to the drawings in an exemplary but non-limiting manner. The same reference numerals in the drawings denote the same or similar components or parts. Those skilled in the art should understand that these drawings are not necessarily drawn to scale. In the drawings:

[0019] Figure 1 is a schematic structural diagram of an embodiment of the present utility model;

[0020] Figure 2 is Figure 1 a schematic structural diagram of the shown embodiment when loading the syringe and the container;

[0021] Figure 3 is Figure 1 a schematic structural diagram of the preparation and extraction mechanism in the shown embodiment;

[0022] Figure 4 is Figure 1 a schematic structural diagram of the conveying mechanism in the shown embodiment;

[0023] Figure 5 is Figure 1 a schematic internal structural diagram of the shown embodiment;

[0024] The descriptions of the reference numerals are as follows:

[0025] 1. Preparation and collection mechanism; 11. Preparation chip; 111. First input end; 112. First output end; 12. Support; 121. First setting position; 122. Second setting position; 13. First driving component; 131. First slide rail; 132. First slide seat; 133. First screw; 134. First driver; 14. Chip holder; 2. Conveying mechanism; 21. Machine base; 22. Conveying component; 221. Second input end; 222. Second output end; 223. Input / output end; 224. Switching valve; 23. Piston tube; 24. Second driving component; 241. Second slide rail; 242. Driving part. Detailed implementation manners

[0026] The technical solutions of the present utility model will be described clearly and completely below with reference to the accompanying drawings. Obviously, the described embodiments are some but not all of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0027] In the description of the present utility model, it should be noted that the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance. In addition, the technical features involved in different embodiments of the present utility model described below can be combined with each other as long as they do not conflict with each other.

[0028] Refer to the attached Figures 1-5 , in this embodiment, the high-throughput droplet microfluidic control and preparation device includes a preparation and collection mechanism 1 for preparing and collecting products, and a conveying mechanism 2 provided with at least two and for supplying the solutions participating in the preparation.

[0029] The preparation and sampling mechanism 1 includes a preparation chip 11 having multiple groups of mixing and preparation channels, a bracket 12 slidably disposed below the preparation chip 11 and used for setting a sampling container thereon, and a first driving component 13 for driving the bracket 12 to slide. Each group of mixing and preparation channels has at least two first input ends 111 and one first output end 112. The bracket 12 has a set of installation positions corresponding one-to-one to the number of groups of mixing and preparation channels. Each set of installation positions includes a first installation position 121 for setting a container for sampling good products thereon and a second installation position 122 for setting a container for sampling defective products thereon. The bracket 12 has at least two working positions through its sliding. When it is in the first working position, the first installation position 121 in each set of installation positions is directly below the first output end 112 of the corresponding preparation channel; when the bracket 12 is in the second working position, the second installation position 122 in each set of installation positions is directly below the first output end 112 of the corresponding preparation channel. Each conveying mechanism 2 includes a machine base 21, a conveying component 22 fixed on the machine base 21 and having a number of conveying channels equal to the number of mixing and preparation channels, piston tubes 23 corresponding one-to-one to the number of conveying channels and connected thereto, and a second driving component 24 for driving the piston handle of the piston tube 23 to move. Each conveying channel has a second input end 221 for connecting a syringe cone head, a second output end 222 connected to one of the first input ends 111 of the corresponding mixing and preparation channel, and an input / output end 223 communicating with the second input end 221 and the second output end 222 and communicating with the piston tube 23. The conveying component 22 further includes a switching valve 224 for controlling the opening or closing of the second input end 221 and the second output end 222. The conveying mechanism 2 has two working states. When it is in the first working state, the switching valve 224 opens the second input end 221 and closes the second output end 222, and the piston tube 23 is in the suction state. The suction state is defined as the piston handle moving out of the tube body of the piston tube 23. In this state, the solution in the syringe is sucked into the piston tube. When the conveying mechanism 2 is in the second working state, the switching valve 224 closes the second input end 221 and opens the second output end 222, and the piston tube 23 is in the ejection state. The ejection state is defined as the piston handle moving into the tube body of the piston tube 23. In this state, the solution is output from the piston tube into the preparation chip 11. By switching the working state of the conveying mechanism 2, the piston tube 23 sucks the solution from an external syringe and transports it into the preparation chip 11, realizing the suction and output of the solution.

[0030] By providing multiple groups of mixing and preparation channels provided in the preparation chip 11, the preparation and sampling mechanism 1 can simultaneously perform multiple groups of preparation processes. By driving the support 12 to reciprocate through the first driving component 13, the containers on the support 12 can be controlled to separately collect defective products and good products produced by the preparation chip 11 for differentiation, preventing defective products produced in the initial stage of preparation from affecting the quality of subsequent products, and thus enabling the preparation and sampling mechanism 1 to simultaneously perform multiple preparation processes for preparation and sampling. By providing at least two conveying mechanisms to respectively convey the solutions for preparation to the first input ends 111 of the respective mixing and preparation channels in the preparation chip 11, the solution supply of each input phase in each mixing and preparation channel is ensured. Each conveying mechanism 2 is provided with a plurality of piston tubes 23 corresponding to the plurality of mixing and preparation channels. At the same time, the piston handles of the plurality of piston tubes 23 are integrally driven by the second driving component 24, enabling the plurality of preparation processes to be synchronously performed under the same preparation conditions. Moreover, the second input end 221 of the conveying channel in the conveying assembly 22 is connected to an external syringe, ensuring that the piston tube can stably suck the solution, avoiding the instability of liquid suction caused by the deviation of the position of the hose when sucking the solution from other containers in the traditional way, ensuring the stability of sucking and outputting the solution, thereby ensuring the normal progress of the preparation process. At the same time, it also avoids the complexity brought by adding other containers and prevents the solution contained in other containers from being polluted by the external environment. By the preparation and sampling mechanism 1 and the conveying mechanism 2, multiple preparation processes can be simultaneously performed under the same preparation conditions, not only improving the preparation efficiency but also ensuring the consistency of the preparation conditions of each group of reagents prepared, avoiding the errors existing in multiple separate preparations, and ensuring the reliability of the experimental results obtained by comparative analysis. Moreover, the conveying mechanism 2 realizes solution supply by connecting an external syringe to the second input end 221, improving the stability and safety of solution suction, preventing the solution from being polluted during the conveying process, and avoiding affecting the preparation process.

[0031] In an alternative embodiment, each conveying assembly 22 is provided with a switching valve 224, which simultaneously controls all the second input ends 221 and the second output ends 222 of the conveying assembly 22 to be opened or closed. Controlling all the second input ends 221 and the second output ends 222 by one switching valve 224 can ensure the consistency of each preparation process and guarantee the same preparation conditions;

[0032] In another alternative embodiment, each conveying assembly 22 is provided with the same number of switching valves 224 as the number of conveying channels. Each switching valve 224 controls the opening or closing of the second input end 221 and the second output end 222 of the conveying assembly 22 in a one-to-one correspondence. By controlling the second input ends 221 and the second output ends 222 of each conveying channel by multiple switching valves 224 in a one-to-one correspondence, the flexibility of use can be improved, and the normal operation of the entire device can be prevented from being affected by the failure of an individual switching valve 224.

[0033] In a more preferred embodiment, the first driving assembly 13 includes a first slide rail 131 fixedly arranged, a first slide block 132 slidably connected to the first slide rail 131, a first screw rod 133 arranged along the extending direction of the first slide rail 131, and a first driver 134 whose output shaft is connected to the first screw rod 133 and is used to drive its rotation. The first screw rod 133 is in threaded connection with the first slide block 132, and the bracket 12 is fixedly connected to the first slide block 132. By driving the first screw rod 133 to rotate forward and backward by the first driver 134, the first slide block 132 is controlled to reciprocally slide along the first slide rail 131, thereby realizing the control of the bracket 12 and facilitating the separate collection of defective products and qualified products produced by the preparation.

[0034] In a more preferred embodiment, a clamping groove (not marked in the drawing) for clamping and collecting the container of qualified products is arranged at the first setting position 121, and a clamping groove (not marked in the drawing) for clamping and collecting the container of defective products is arranged at the second setting position 122. By respectively clamping the two containers in the clamping grooves at the first setting position 121 or the second setting position 122, it is convenient to control the positions of the two containers to receive the produced qualified products or defective products. The containers for collecting qualified products and defective products in this embodiment are preferably test tubes.

[0035] In a more preferred embodiment, the preparation and collection mechanism 1 further includes a fixedly arranged chip holder 14, and the preparation chip 11 is detachably connected to the chip holder 14, which is convenient for replacing different preparation chips 11 according to the process requirements and improving the versatility and practicability of the preparation device.

[0036] In a more preferred embodiment, the second driving assembly 24 includes a second screw rod (not shown in the drawing) arranged in the machine base 21 along the sliding direction of the piston rod of the piston tube 23, a driving member 242 threadedly connected to the second screw rod, and a second driver (not shown in the drawing) whose output shaft is connected to the second screw rod and is used to drive its rotation. The driving member 242 is fixedly connected to the piston rod of the piston tube 23. By driving the second screw rod to rotate clockwise or counterclockwise by the second driver, the driving member 242 is driven to move back and forth along the second screw rod, thereby realizing the reciprocating driving of the piston rod of the piston tube 23, so as to extract the solution from the syringe or pump the solution in the tube into the preparation chip 11.

[0037] In a more preferred embodiment, the second driving assembly 24 further includes at least one second slide rail 241 fixed to the machine base 21 along the length direction of the second screw rod, and the driving member 242 is slidably connected to the second slide rail 241, which improves the stability of the driving member 242 when reciprocating.

[0038] In a more preferred embodiment, at least two conveying mechanisms 2 are respectively arranged on both sides of the preparation and extraction mechanism 1, and the first input ends 111 in the mixing and preparation flow channels are respectively arranged on the side surfaces of the preparation chip 11 corresponding to the conveying mechanisms 2, so that the distances between the respective conveying channels in each conveying mechanism 2 and the corresponding mixing and preparation flow channels are similar, facilitating the control of the liquid conveying rate in each preparation process and the amount of liquid conveyed into the preparation chip, keeping the parameters in each process consistent, and avoiding differences.

[0039] Due to the application of the above technical solution, the present utility model has the following advantages compared with the prior art:

[0040] In the high-throughput droplet microfluidic control preparation device of the present utility model, through the preparation and extraction mechanism and the conveying mechanism, multiple preparation processes can be carried out simultaneously under the same preparation conditions, which not only improves the preparation efficiency, but also ensures that the preparation conditions of each group of reagents prepared are consistent, avoids the errors existing in multiple separate preparations, and ensures the reliability of the experimental results obtained by comparative analysis. Moreover, the conveying mechanism realizes solution supply through the second input end externally connected to a syringe, improving the stability and safety of solution suction, preventing the solution from being contaminated during the conveying process, and avoiding affecting the preparation process.

[0041] The above embodiments are only used to illustrate the technical concept and characteristics of the present utility model, and their purpose is to enable those skilled in the art to understand the content of the present utility model and implement it accordingly. It should not be used to limit the protection scope of the present utility model. Any equivalent changes or modifications made according to the spirit and essence of the present utility model should be covered within the protection scope of the present utility model.

Claims

1. A high-throughput droplet microfluidics preparation device, characterized in that: include: A preparation and collection mechanism (1) is used for preparing and collecting products, the preparation and collection mechanism (1) comprising a preparation chip (11) having a plurality of groups of mixed preparation flow channels, a support (12) slidably arranged below the preparation chip (11) and used for setting a collection container thereon, and a first driving component (13) driving the support (12) to slide, each group of the mixed preparation flow channels having at least two first input ends (111) and a first output end (112), the support (12) having a number of setting position groups that is the same as the number of groups of the mixed preparation flow channels and corresponds one to one, each of the setting position groups comprising a first input end (111) and a first output end (112) for collecting good products. A first setting position (121) is provided at which a container for collecting defective products is provided, and a second setting position (122) is provided at which a container for collecting defective products is provided, the support (12) having at least two working positions by sliding, when it is in the first working position, the first setting position (121) in each of the setting position groups is located directly below the first output end (112) of the corresponding preparation flow channel; when the support (12) is in the second working position, the second setting position (122) in each of the setting position groups is located directly below the first output end (112) of the corresponding preparation flow channel; A delivery mechanism (2) is provided with at least two and is used to supply solutions involved in preparation, each of the delivery mechanisms (2) comprising a machine base (21), a delivery assembly (22) fixed on the machine base (21) and having a number of delivery channels equal to the number of the mixing preparation channels, piston tubes (23) equal to the number of the delivery channels and connected one-to-one, and a second drive assembly (24) for driving the piston handle of the piston tube (23) to move, each of the delivery channels having a second input end (221) for connecting to a syringe cone, a second output end (222) connected to a first input end (111) of the corresponding mixing preparation channel, and an input / output end (223) respectively connected to the second input end (221) and the second output end (222) and connected to the piston tube (23), and the delivery assembly (22) further comprising a switching valve (224) for controlling the second input end (221) and the second output end (222) to be opened or closed.

2. The high-throughput droplet microfluidics preparation device according to claim 1, characterized in that: The conveying mechanism (2) has two working states. When it is in the first working state, the switching valve (224) causes the second input end (221) to be opened and the second output end (222) to be closed, and the piston tube (23) is in the suction state. When the conveying mechanism (2) is in the second working state, the switching valve (224) causes the second input end (221) to be closed and the second output end (222) to be opened, and the piston tube (23) is in the push-out state. The suction state is defined as the piston handle moving along the body of the piston tube (23) toward the outside of the tube, and the push-out state is defined as the piston handle moving along the body of the piston tube (23) toward the inside of the tube.

3. The high-throughput droplet microfluidic control device according to claim 1 or 2, characterized in that: Each conveying component (22) is provided with a switching valve (224), and the switching valve (224) simultaneously controls all the second input ends (221) and the second output ends (222) of the conveying component (22) to be opened or closed; or each conveying component (22) is provided with the switching valves (224) whose number is the same as the number of the conveying flow channels, and each switching valve (224) controls the second input end (221) and the second output end (222) of the conveying component (22) to be opened or closed in a one-to-one correspondence.

4. The high-throughput droplet microfluidics preparation device according to claim 1, characterized in that: The first driving assembly (13) comprises a first fixedly arranged first slide rail (131), a first slide seat (132) slidably connected to the first slide rail (131), a first screw rod (133) arranged along the extension direction of the first slide rail (131), and a first driver (134) having an output shaft connected to the first screw rod (133) and used for driving the first screw rod (133) to rotate, the first screw rod (133) being threadedly connected to the first slide seat (132), and the bracket (12) being fixedly connected to the first slide seat (132).

5. The high-throughput droplet microfluidics preparation device according to claim 1, characterized in that: The first setting position (121) is provided with a slot for latching a container for collecting good products, and the second setting position (122) is provided with a slot for latching a container for collecting bad products.

6. The high-throughput droplet microfluidics preparation device according to claim 1, characterized in that: The preparation and sampling mechanism (1) further comprises a fixedly arranged chip rack (14), and the preparation chip (11) is detachably connected to the chip rack (14).

7. The high-throughput droplet microfluidics preparation device according to claim 1, characterized in that: The second drive assembly (24) comprises a second screw rod disposed in the machine base (21) along the sliding direction of the piston handle of the piston tube (23), a drive member (242) threadedly connected to the second screw rod, and a second driver having an output shaft connected to the second screw rod and used to drive the second screw rod to rotate, wherein the drive member (242) is fixedly connected to the piston handle of the piston tube (23).

8. The high-throughput droplet microfluidics preparation device according to claim 7, characterized in that: The second driving assembly (24) further comprises at least one second slide rail (241) fixed to the machine base (21) along the length direction of the second screw rod, and the driving member (242) is slidably connected to the second slide rail (241).

9. The high-throughput droplet microfluidics preparation device according to claim 1, characterized in that: At least two of the conveying mechanisms (2) are respectively arranged on both sides of the preparation and collection mechanism (1), and the first input end (111) in the mixed preparation flow channel is respectively arranged on the side of the preparation chip (11) corresponding to the conveying mechanism (2).

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