Living animal gastric juice sampling device for pharmaceutical analysis experiment

Abstract

The utility model discloses a live animal gastric juice sampling device for a pharmaceutical analysis experiment. The live animal gastric juice sampling device comprises a fixing plate, a fixing unit, an injector unit and an extraction unit, a first fixing frame is fixedly connected to the left side of the upper end of the fixing plate. The fixing unit comprises second fixing frames, first threaded rods, an arc-shaped fixing plate, a rubber pad and a rotating handle, the left side of the upper end of the fixing plate is fixedly connected with the two second fixing frames, the upper end of each second fixing frame is in threaded connection with the first threaded rod, and one end of the inner side of each first threaded rod is rotationally connected with the arc-shaped fixing plate; the inner side of each arc-shaped fixing plate is fixedly connected with a rubber pad, and the other end of the first threaded rod is fixedly connected with a rotating handle. During sampling, the injector can stably form negative pressure, meanwhile, when the sampling device is operated, the positions of the injector and the sampling pipeline do not need to be controlled at the same time, and meanwhile, the sampling pipeline can reduce the blocking condition.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmacokinetic bioanalysis experiments, and specifically relates to a living animal gastric juice sampling device for drug analysis experiments. Background Technique

[0002] At present, in the experiment of extracting animal body fluids, generally, a sampling device such as a syringe is first used to extract the body fluids, and then the body fluids temporarily stored in the sampling device are transferred into a storage container such as a centrifuge tube, so as to achieve the purpose of sampling.

[0003] In the prior art, a living body fluid sampling device for animal experiments proposed in the patent with the authorization announcement number of CN202693378U includes a collection container, the pipe orifice of which is provided with a pipe cap, and two pipe holes are provided on the pipe cap. A negative pressure pipe and a sample guiding pipe are respectively inserted into the two pipe holes. The upper ends of the negative pressure pipe and the sample guiding pipe are respectively connected with a pipe Ⅰ connected to a syringe and a pipe Ⅱ connected to the living body sampling part of the animal; in the prior art, the syringe is unstable when forming negative pressure during sampling, and at the same time, when operating the sampling device, it is necessary to control the positions of the syringe and the sampling pipeline simultaneously, so that mistakes will occur during operation, and at the same time, the sampling pipeline may be blocked. Content of the Utility Model

[0004] The technical problem to be solved by the utility model is to overcome the existing defects, and provide a living animal gastric juice sampling device for drug analysis experiments, in which the syringe can stably form negative pressure during sampling, and at the same time, it is not necessary to control the positions of the syringe and the sampling pipeline simultaneously when operating the sampling device, and at the same time, the sampling pipeline can reduce the occurrence of blockage, and the problems in the background technique can be effectively solved.

[0005] To achieve the above purpose, the utility model provides the following technical scheme: a living animal gastric juice sampling device for drug analysis experiments, including a fixing plate, a fixing unit, a syringe unit and an extraction unit;

[0006] A fixing frame Ⅰ is fixedly connected to the upper left side of the fixing plate;

[0007] The fixing unit includes a fixing frame Ⅱ, a first threaded rod, an arc-shaped fixing plate, a rubber pad and a rotating handle. Two fixing frames Ⅱ are fixedly connected to the upper left side of the fixing plate. The upper end of each fixing frame Ⅱ is threadedly connected with a first threaded rod. The inner end of each first threaded rod is rotatably connected with an arc-shaped fixing plate. A rubber pad is fixedly connected to the inner side of each arc-shaped fixing plate. The other end of the first threaded rod is fixedly connected with a rotating handle;

[0008] The syringe unit is installed on the fixing frame Ⅰ;

[0009] The extraction unit is installed on the fixing unit.

[0010] Furthermore, the fixing unit further includes a sponge pad, a centrifuge tube, and a sealing plug. A sponge pad is fixedly connected between two fixing brackets II at the upper end of the fixing plate. A centrifuge tube is fixedly connected to the upper end of the sponge pad, and a sealing plug is slidably connected to the upper end of the centrifuge tube. The sponge pad prevents the centrifuge tube from being damaged when placed, the sealing plug seals the inside of the centrifuge tube, and the centrifuge tube is used to store the sampled solution.

[0011] Furthermore, the syringe unit includes a syringe barrel, a rubber block, a threaded rod, a rotating disk, a clamping seat, and a clamping groove. The syringe barrel is clamped to the upper end of the fixing bracket I. The rubber block is slidably connected to the inside of the syringe barrel. One end of the threaded rod is fixedly connected to the left end of the rubber block. The outer side of the threaded rod is threadedly connected to the left end of the syringe barrel. The left end of the threaded rod is fixedly connected to the rotating disk. A clamping seat is fixedly connected to the outer side of the right end of the syringe barrel, and a clamping groove is formed inside the clamping seat. By rotating the syringe barrel, the threaded rod and the syringe barrel drive the rubber block to move under the action of the thread. The rubber block reduces the pressure inside the syringe barrel. The clamping groove on the clamping seat forms a negative pressure with the inside of the centrifuge tube through a connecting device, so that the gastric juice is drawn into the centrifuge tube through the negative pressure, thereby achieving the purpose of gastric juice sampling.

[0012] Furthermore, the syringe unit further includes a clamping cylinder, a clamping block, and a connecting pipe I. One end of the connecting pipe I is slidably connected to the upper left side of the sealing plug. The other end of the connecting pipe I is fixedly connected to the clamping cylinder. Four clamping blocks are fixedly connected to the outer side of the clamping cylinder, and the clamping cylinder is clamped to the clamping groove. The connecting pipe I is connected to the syringe barrel through the clamping cylinder and the clamping block. The syringe barrel and the centrifuge tube form a connected space through the connecting pipe I. The negative pressure inside the syringe barrel draws the gastric juice into the centrifuge tube through the negative pressure, thereby achieving the purpose of gastric juice sampling.

[0013] Furthermore, the extraction unit includes a connecting pipe II, a sealing valve, a threaded pipe, a threaded connection cylinder, an extraction pipe, and a mounting interface. The connecting pipe II is slidably connected to the upper right side of the sealing plug. A sealing valve is fixedly connected to the middle of the outer side of the connecting pipe II. The right end of the connecting pipe II is fixedly connected to the threaded pipe. A threaded connection cylinder is fixedly connected to the outer side of one end of the extraction pipe, and the inner side of the threaded connection cylinder is threadedly connected to the outer side of the threaded pipe. The other end of the extraction pipe is fixedly connected to the mounting interface. The gastric juice is extracted through the extraction pipe. The extraction pipe and the connecting pipe II are connected through the threaded pipe and the threaded connection cylinder. The sealing valve seals and connects the centrifuge tube and the outside. By opening and closing the sealing valve, the device extracts the gastric juice through the extraction pipe through the negative pressure, and a part is installed at the extraction opening through the mounting interface.

[0014] Further, it also includes a syringe needle, and the inner side of the installation interface is slidably connected to the outer side of the syringe needle. When extracting the living gastric juice, the syringe needle can prevent larger particles from entering and causing blockage of the pipeline.

[0015] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0016] 1. For this gastric juice sampling device for live animals used in pharmaceutical analysis experiments, during sampling, the syringe can stably form a negative pressure, and the threaded device enables the syringe not to move under the action of the external pressure when forming a negative pressure inside the pipeline.

[0017] 2. For this gastric juice sampling device for live animals used in pharmaceutical analysis experiments, the syringe is fixed through the thread and the fixing device. When operating the sampling device, it is not necessary to control the syringe, and by adding a syringe needle with a smaller aperture, the situation of blockage of the sampling pipeline can be reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a three-dimensional structural schematic diagram of the present utility model;

[0019] Figure 2 is the present utility model Figure 1 a partial enlarged structural schematic diagram at A in;

[0020] Figure 3 is the present utility model Figure 1 a partial enlarged structural schematic diagram at B in;

[0021] Figure 4 is a left-side structural schematic diagram of the present utility model;

[0022] Figure 5 is the present utility model Figure 4 a partial enlarged structural schematic diagram at C in.

[0023] In the figure: 1 fixing plate, 2 first fixing frame, 3 fixing unit, 31 second fixing frame, 32 first threaded rod, 33 arc-shaped fixing plate, 34 rubber pad, 35 rotating handle, 36 sponge pad, 37 centrifuge tube, 38 sealing plug, 4 syringe unit, 41 syringe barrel, 42 rubber block, 43 threaded rod, 44 rotating disk, 45 clamping seat, 46 clamping groove, 47 clamping cylinder, 48 clamping block, 49 first connecting pipe, 5 extraction unit, 51 second connecting pipe, 52 sealing valve, 53 threaded pipe, 54 threaded connection cylinder, 55 extraction pipe, 56 installation interface, 6 syringe needle. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0025] Please refer to Figures 1-5 , this embodiment provides a technical solution for a gastric juice sampling device for live animals in drug analysis experiments: A gastric juice sampling device for live animals in drug analysis experiments includes a fixing plate 1, a fixing unit 3, a syringe unit 4, and an extraction unit 5; A fixing frame one 2 is fixedly connected to the upper left side of the fixing plate 1;

[0026] Among them, the fixing unit 3 includes a fixing frame two 31, a threaded rod one 32, an arc-shaped fixing plate 33, a rubber pad 34, and a rotating handle 35. Two fixing frames two 31 are fixedly connected to the upper left side of the fixing plate 1. The upper end of each fixing frame two 31 is threadedly connected with a threaded rod one 32. The inner end of each threaded rod one 32 is rotatably connected to an arc-shaped fixing plate 33. A rubber pad 34 is fixedly connected to the inner side of each arc-shaped fixing plate 33. The other end of the threaded rod one 32 is fixedly connected to a rotating handle 35; The fixing unit 3 further includes a sponge pad 36, a centrifuge tube 37, and a sealing plug 38. A sponge pad 36 is fixedly connected between the two fixing frames two 31 at the upper end of the fixing plate 1. A centrifuge tube 37 is fixedly connected to the upper end of the sponge pad 36. A sealing plug 38 is slidably connected to the upper end of the centrifuge tube 37.

[0027] Among them, the syringe unit 4 is installed on the fixing frame one 2; The syringe unit 4 includes a syringe barrel 41, a rubber block 42, a threaded rod 43, a rotating disc 44, a clamping seat 45, and a clamping groove 46. The syringe barrel 41 is clamped to the upper end of the fixing frame one 2. A rubber block 42 is slidably connected to the inside of the syringe barrel 41. One end of a threaded rod 43 is fixedly connected to the left end of the rubber block 42. The outer side of the threaded rod 43 is threadedly connected to the left end of the syringe barrel 41. The left end of the threaded rod 43 is fixedly connected to a rotating disc 44. A clamping seat 45 is fixedly connected to the outer side of the right end of the syringe barrel 41. A clamping groove 46 is opened inside the clamping seat 45; The syringe unit 4 further includes a clamping cylinder 47, a clamping block 48, and a connecting pipe one 49. One end of a connecting pipe one 49 is slidably connected to the upper left side of the sealing plug 38. The other end of the connecting pipe one 49 is fixedly connected to a clamping cylinder 47. Four clamping cylinders 47 are fixedly connected to the outer side of the clamping cylinder 47. The clamping cylinder 47 is clamped to the clamping groove 46.

[0028] Among them, the extraction unit 5 is installed on the fixed unit 3. The extraction unit 5 includes a second connecting pipe 51, a sealing valve 52, a threaded pipe 53, a threaded connecting cylinder 54, an extraction pipe 55, and an installation interface 56. The upper right side of the sealing plug 38 is slidably connected to the second connecting pipe 51. The middle part of the outer side of the second connecting pipe 51 is fixedly connected to the sealing valve 52. The right end of the second connecting pipe 51 is fixedly connected to the threaded pipe 53. The outer side of one end of the extraction pipe 55 is fixedly connected to the threaded connecting cylinder 54. The inner side of the threaded connecting cylinder 54 is threadedly connected to the outer side of the threaded pipe 53. The other end of the extraction pipe 55 is fixedly connected to the installation interface 56. It further includes a syringe 6. The inner side of the installation interface 56 is slidably connected to the outer side of the syringe 6. When extracting living gastric juice, the syringe 6 is used to prevent larger particles from entering and causing pipeline blockage.

[0029] The working principle of the present utility model is as follows:

[0030] The provided fixed unit 3 rotates the rotating handle 35 so that the second fixing frame 31 and the first threaded rod 32 drive the arc-shaped fixing plate 33 and the rubber pad 34 to move under the action of the thread. The collection device is fixed by the two arc-shaped fixing plates 33, and the rubber pad 34 plays a buffering role during fixation, thereby achieving the purpose of fixing the collection device. The sponge pad 36 is used to prevent the centrifuge tube 37 from being damaged during placement. The sealing plug 38 seals the inside of the centrifuge tube 37, and the centrifuge tube 37 is used to store the sampled solution.

[0031] The provided syringe unit 4 rotates the syringe barrel 41 so that the threaded rod 43 and the syringe barrel 41 drive the rubber block 42 to move under the action of the thread. The rubber block 42 reduces the pressure inside the syringe barrel 41. The clamping groove 46 on the clamping seat 45 forms a negative pressure with the inside of the centrifuge tube 37 through the connecting device, so that the gastric juice is extracted into the centrifuge tube 37 through the negative pressure, thereby achieving the purpose of gastric juice sampling. The connecting tube 49 is connected to the syringe barrel 41 through the clamping cylinder 47 and the clamping block 48. The connecting tube 49 forms a communicating space between the syringe barrel 41 and the centrifuge tube 37. The negative pressure inside the syringe barrel 41 causes the gastric juice to be extracted into the centrifuge tube 37 through the negative pressure, thereby achieving the purpose of gastric juice sampling.

[0032] The provided extraction unit 5 extracts the gastric juice through the extraction pipe 55. The extraction pipe 55 is connected to the second connecting pipe 51 through the threaded pipe 53 and the threaded connecting cylinder 54. The sealing valve 52 seals and communicates the centrifuge tube 37 with the outside. By opening and closing the sealing valve 52, the device extracts the gastric juice through the extraction pipe 55 by negative pressure, and the installation interface 56 is used to install parts at the extraction opening.

[0033] The above are only the embodiments of the present utility model, and do not thus limit the patent scope of the present utility model. Any equivalent structure or equivalent process transformation made by using the content of the specification and drawings of the present utility model, or directly or indirectly applied in other related technical fields, shall similarly be included within the patent protection scope of the present utility model.

Claims

1. A gastric juice sampling device for living animals for drug analysis experiments, characterized in that: It comprises a fixing plate (1), a fixing unit (3), a syringe unit (4) and an extraction unit (5); The left side of the upper end of the fixing plate (1) is fixedly connected to a fixing frame 1 (2); The fixing unit (3) comprises a fixing frame (31), a threaded rod (32), an arc-shaped fixing plate (33), a rubber pad (34) and a rotating handle (35); the left side of the upper end of the fixing plate (1) is fixedly connected to two fixing frames (31); the upper end of each fixing frame (31) is threadedly connected to a threaded rod (32); the inner end of each threaded rod (32) is rotatably connected to the arc-shaped fixing plate (33); the inner side of each arc-shaped fixing plate (33) is fixedly connected to a rubber pad (34); the other end of the threaded rod (32) is fixedly connected to the rotating handle (35); The syringe unit (4) is mounted on a fixing frame (2); The extraction unit (5) is mounted on the fixing unit (3).

2. A gastric juice sampling device for living animals for drug analysis experiments according to claim 1, characterized in that: The fixing unit (3) further comprises a sponge pad (36), a centrifuge tube (37) and a sealing plug (38); a sponge pad (36) is fixedly connected between the two fixing frames (31) at the upper end of the fixing plate (1); a centrifuge tube (37) is fixedly connected to the upper end of the sponge pad (36); and a sealing plug (38) is slidably connected to the upper end of the centrifuge tube (37).

3. A gastric juice sampling device for living animals for drug analysis experiments according to claim 2, characterized in that: The syringe unit (4) comprises a syringe barrel (41), a rubber block (42), a threaded rod (43), a rotating disk (44), a clamping seat (45) and a clamping groove (46); the upper end of the fixing frame (2) is clamped with the syringe barrel (41); the inner side of the syringe barrel (41) is slidably connected with the rubber block (42); the left end of the rubber block (42) is fixedly connected with one end of the threaded rod (43); the outer side of the threaded rod (43) is threadedly connected with the left end of the syringe barrel (41); the left end of the threaded rod (43) is fixedly connected with the rotating disk (44); the outer side of the right end of the syringe barrel (41) is fixedly connected with the clamping seat (45); the inner side of the clamping seat (45) is provided with a clamping groove (46).

4. A gastric juice sampling device for living animals for drug analysis experiments according to claim 3, characterized in that: The syringe unit (4) further comprises a clamping cylinder (47), a clamping block (48) and a connecting tube (49); the upper left end of the sealing plug (38) is slidably connected to one end of the connecting tube (49); the other end of the connecting tube (49) is fixedly connected to the clamping cylinder (47); four clamping cylinders (47) are fixedly connected to the outer side of the clamping cylinder (47); the clamping cylinder (47) is clamped to the clamping groove (46).

5. The gastric juice sampling device for living animals used in drug analysis experiments according to claim 2, characterized in that: The extraction unit (5) comprises a second connecting pipe (51), a sealing valve (52), a threaded pipe (53), a threaded connection tube (54), an extraction pipe (55) and a mounting interface (56); the right side of the upper end of the sealing plug (38) is slidably connected to the second connecting pipe (51); the middle part of the outer side of the second connecting pipe (51) is fixedly connected to the sealing valve (52); the right end of the second connecting pipe (51) is fixedly connected to the threaded pipe (53); the outer side of one end of the extraction pipe (55) is fixedly connected to the threaded connection tube (54); the inner side of the threaded connection tube (54) is threadedly connected to the outer side of the threaded pipe (53); and the other end of the extraction pipe (55) is fixedly connected to the mounting interface (56).

6. A gastric juice sampling device for living animals for drug analysis experiments according to claim 5, characterized in that: It also includes a needle tube (6), and the inner side of the mounting interface (56) is slidably connected to the outer side of the needle tube (6).

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