Pharmaceutical adjuvant preparation reaction kettle
By using a combined structure of a sandwich tank and a spiral feed pipe in the pharmaceutical auxiliary material preparation reactor, the premixture of liquid and powder is premixed, and combined with the design of the heating sleeve and spiral heating pipe, the problem of easy agglomeration of powder and liquid during the preparation of pharmaceutical auxiliary material is solved, the mixing efficiency and production efficiency are improved, and the stability of the device and equipment is ensured.
Patent Information
- Application Number
- CN202422029753.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-21
- Publication Date
- 2025-06-13
- Estimated Expiration
- 2034-08-21
AI Technical Summary
During the preparation of existing pharmaceutical excipients, powders are prone to agglomeration when mixed with liquid, resulting in low stirring efficiency and poor production efficiency, and safety hazards in nitrogen input design.
A reaction kettle for preparation of pharmaceutical auxiliary materials was designed, using a combined structure of a sandwich tank and a spiral feed pipe. The liquid material was introduced from bottom to top, pre-mixed with the powder material, and then stirred with a stirring leaf. At the same time, a heating sleeve and a spiral heating pipe are installed to achieve uniform heating and reduce the risk of agglomeration.
It effectively reduces the possibility of material agglomeration, improves mixing efficiency and production efficiency, ensures the stability of the equipment and meets the usage needs.
Smart Images
Figure CN222969828U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of pharmaceutical processing, and particularly relates to a reaction kettle for preparing pharmaceutical excipients. Background Art
[0002] Pharmaceutical excipients refer to excipients and additives used in the production of drugs and the preparation of prescriptions. They are substances that have been reasonably evaluated in terms of safety and are included in pharmaceutical preparations in addition to the active ingredients. In addition to shaping, acting as a carrier, and improving stability, pharmaceutical excipients also have important functions such as solubilization, solubilization assistance, sustained and controlled release, etc. They are important components that may affect the quality, safety, and effectiveness of drugs.
[0003] In the prior art, the synthesis and preparation process of pharmaceutical excipients is mostly carried out by mixing in a reaction kettle. The traditional reaction kettle uses a stirring structure as the power source for mixing, and the mixing method is relatively single, and the stirring efficiency is limited. At the same time, a large amount of insoluble or poorly soluble powders are contained in the raw materials of pharmaceutical excipients. After being put into the reaction kettle and mixed with the liquid, they are easy to agglomerate and require long-term stirring to complete the mixing, which is a waste of time and affects the production efficiency. At present, in response to the above situation, people input nitrogen into the reaction kettle and use nitrogen to contact the materials, so that the materials can be mixed in the reaction kettle in an exploded manner. Although this method can improve the mixing effect between materials to a certain extent, the material mixing process is relatively cumbersome. At the same time, the output position of nitrogen is generally set on the rotating shaft, and this design will affect the use stability of the device and equipment and has a certain degree of danger, and cannot effectively meet the use requirements. Content of the Utility Model
[0004] The utility model aims at the technical problems existing in the processing and preparation process of the above-mentioned pharmaceutical excipients, and provides a reaction kettle for preparing pharmaceutical excipients with reasonable design, simple structure, convenient processing, which can effectively reduce the possibility of agglomeration during the material mixing process, ensure the mixing and processing effect between materials, improve the working process, and ensure the use stability of the device and equipment, and fully meet the use requirements.
[0005] In order to achieve the above object, the technical solution adopted by the utility model is a reaction kettle for preparing pharmaceutical excipients, which includes a reaction kettle body. The reaction kettle body includes a tank cover and a tank body that are designed in a split manner from top to bottom. A rotating shaft is provided on the tank cover, a feed port is provided on one side of the tank cover, a discharge port is provided below the tank body, a jacketed tank is provided inside the tank body, convex blocks designed in a spiral shape are provided on the outer periphery of the jacketed tank, a spiral feeding pipe is provided inside the convex blocks, a through groove communicating with the spiral feeding pipe is opened inside the jacketed tank, a heating jacket is provided outside the jacketed tank, a spiral heating pipe is provided inside the heating jacket, pipe orifices arranged diagonally are provided on the outer side of the tank body, and connecting pipes designed in a converging shape are provided inside the pipe orifices.
[0006] Preferably, small stirring blades are arranged on the outer periphery of the rotating shaft. A support rod is arranged on the rotating shaft on one side of the small stirring blades. Large stirring blades are arranged at the corners of a plurality of the support rods. A mixing plate designed in a triangular shape is arranged at the lower end of the rotating shaft.
[0007] Preferably, the cross-section of the jacketed tank is designed in an L shape. Sealing strips are arranged on both the upper and lower sides outside the upper part of the jacketed tank.
[0008] Preferably, the lower end surface of the mixing plate is designed in a wavy shape.
[0009] Compared with the prior art, the advantages and positive effects of the present utility model are as follows.
[0010] 1. A reaction kettle for preparing pharmaceutical excipients provided by the present utility model, through the arranged jacketed tank and spiral feeding pipe, from the lower outer side position of the reaction kettle, and using the spiral feeding pipe to introduce liquid materials from bottom to top, so that they can be pre-mixed with powdery materials, and then using the stirring blades to stir them. The two structures cooperate with each other, reducing the possibility of material caking to a certain extent, fully improving the working process, and saving production costs; by setting up a heating jacket cooperating with the jacketed tank and using a spiral heating pipe to convey heat medium into the kettle, the internal heating work of the reaction kettle body is carried out more evenly, and the bottom-to-top heating process ensures the formation of the heating atmosphere in the kettle, guaranteeing the effective progress of the material mixing and preparation work, fully meeting the use requirements; the device is reasonably designed, has a simple structure, is convenient to process, and can effectively reduce the possibility of material caking during the mixing process, ensuring the mixing and processing effect between materials, improving the working process, and guaranteeing the use stability of the device and equipment, fully meeting the use requirements. BRIEF DESCRIPTION OF THE DRAWINGS
[0011] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following described drawings are some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.
[0012] Figure 1 It is a schematic structural diagram of a reaction kettle for preparing pharmaceutical excipients;
[0013] Figure 2 It is a front view of the structure of a reaction kettle for preparing pharmaceutical excipients;
[0014] Figure 3 It is a front view of a partial internal structure of a reaction kettle for preparing pharmaceutical excipients;
[0015] In the above figures, 1 is the can lid; 2 is the can body; 3 is the rotating shaft; 31 is the small stirring blade; 32 is the support rod; 33 is the large stirring blade; 34 is the mixing plate; 4 is the feed inlet; 5 is the discharge outlet; 6 is the jacketed tank; 7 is the bump; 8 is the spiral feeding pipe; 9 is the through groove; 10 is the heating jacket; 11 is the spiral heating pipe; 12 is the pipe orifice; 121 is the connecting pipe; 13 is the sealing strip. Detailed implementation mode
[0016] In order to more clearly understand the above objects, features and advantages of the present invention, the present invention will be further described below with reference to the drawings and embodiments. It should be noted that, without conflict, the embodiments of the present application and the features in the embodiments can be combined with each other.
[0017] In the following description, many specific details are set forth in order to fully understand the present invention. However, the present invention can also be implemented in other ways different from those described herein. Therefore, the present invention is not limited by the specific embodiments disclosed in the following specification.
[0018] Embodiment, such as Figures 1 to 3As shown in the figure, a reaction kettle for preparing pharmaceutical excipients includes a reaction kettle body, which consists of a tank cover 1 and a tank body 2 designed in a split manner from top to bottom. For the connection between the tank cover 1 and the tank body 2, process holes can be opened on the outer sides of the tank cover 1 and the tank body 2. Bolts are used to pass through the process holes and cooperate with nuts to complete the connection between the split components, ensuring the effective progress of the mixing work of pharmaceutical excipients and meeting the usage requirements. Further, a rotating shaft 3 is provided on the tank cover 1, and an external electric motor is used to provide driving power to ensure the effective mixing and preparation of the materials in the reaction kettle and guarantee the working process. An inlet 4 is provided on one side of the tank cover 1 to facilitate the input of pharmaceutical excipients. A discharge port 5 is provided below the tank body 2 to facilitate the convenient discharge of the materials after mixing and preparation, improving the working process. Further, to effectively achieve the mixing of the materials in the kettle, especially to ensure the effective mixing of powdery materials and liquid materials and reduce the possibility of caking during the material mixing process, an interlayer tank 6 is provided in the tank body 2. A convex block 7 designed in a spiral shape is provided on the outer periphery of the interlayer tank 6, and a spiral feeding pipe 8 is provided inside the convex block 7. A through groove 9 communicating with the spiral feeding pipe 8 is opened in the interlayer tank 6. Specifically described as follows: a feeding pipe is provided on the outer side below the tank body 2 and is connected to the spiral feeding pipe 8. A three-way pipe is provided on the outer side of the feeding pipe. One connection port of the three-way pipe is communicated with the liquid material, and the other connection port can be connected to a nitrogen source. After the powdery material is put into the reaction kettle, first control the liquid material pipe to be communicated with the spiral feeding pipe 8 to mix the powder and liquid of the pharmaceutical excipients, and then, with the cooperation of the stirring blades, complete the mixing and preparation of the pharmaceutical excipients to reduce the occurrence of caking. When the input of the powder and liquid is completed according to the ratio, disconnect the liquid material pipe and open the nitrogen pipe to make the nitrogen source be transported into the tank body 2 in a blowing manner, which plays a role in blowing the materials to a certain extent and improving the mixing effect between the materials. Of course, a filter screen structure is also provided on the outer side of the through groove 9 to improve the rationality of the device and equipment. Further, considering the safety inside the equipment, a penetration pipe is provided above the tank cover 1. A pressure relief valve is provided at the upper end of the penetration pipe and is connected to an external nitrogen recovery pipe. That is to say, when nitrogen is used to improve the mixing effect of the materials in the tank body 2, the pressure in the tank body 2 is protected by the pressure relief valve. When the pressure is too high, it can be discharged by the pressure relief valve and recovered through the recovery pipe, saving resources;Further, in order to ensure good temperature processing conditions during the mixing and preparation of the materials in the tank body 2, a heating jacket 10 is provided on the outer side of the jacketed tank 6, a spiral heating pipe 11 is provided inside the heating jacket 10, and nozzles 12 arranged diagonally are provided on the outer side of the tank body 2. A connecting pipe 121 designed with a closed end is provided inside the nozzle 12. The specific description is as follows: The outer periphery of the heating jacket 10 can be adaptively engaged with the jacketed tank 6. After the two are closely fitted, they are placed into the tank body 2 together to ensure the effective formation of the reactor structure. When the reactor needs to be heated, the connecting pipe 121 in the lower nozzle 12 can be connected to an external heat source, such as hot water or hot air with a certain temperature. It flows along the spiral heating pipe 11 and heats the heating jacket 10 to create a heating atmosphere for the tank body 2 from bottom to top, ensuring the effective progress of the preparation work of pharmaceutical excipients, improving the work process, and meeting the use requirements;
[0019] In the above process: By providing the jacketed tank 6 and the spiral feeding pipe 8, starting from the lower outer side of the reactor and using the spiral feeding pipe 8 to introduce the liquid material from bottom to top, so that it can be pre-mixed with the powdery material, and then using the stirring blades to stir it. The two structures cooperate with each other, reducing the possibility of material caking to a certain extent, fully improving the work process, and saving production costs; By providing a heating jacket 10 that cooperates with the jacketed tank 6 and using the spiral heating pipe 11 to convey the heat medium into the kettle, the internal heating work of the reactor body is carried out more evenly, and the bottom-up heating process ensures the formation of the heating atmosphere in the kettle, ensuring the effective progress of the material mixing and preparation work, fully meeting the use requirements; The design of this device is reasonable, the structure is simple, the processing is convenient, and it can effectively reduce the possibility of caking during the material mixing process, ensure the mixing and processing effect between materials, improve the work process, and ensure the use stability of the device and equipment, fully meeting the use requirements.
[0020] In order to effectively complete the stirring of the materials in the reactor body and ensure the mixing effect between the materials to effectively improve the work process, small stirring blades 31 are provided on the outer periphery of the rotating shaft 3. A support rod 32 is provided on the rotating shaft 3 on one side of the small stirring blade 31. Large stirring blades 33 are provided at the corners of multiple support rods 32. A mixing plate 34 designed in a triangular shape is provided at the lower end of the rotating shaft 3. The specific description is as follows: Both the small stirring blades 31 and the large stirring blades 33 are designed in a spiral shape. They can not only stir the materials but also turn them over, thus ensuring the mixing effect between the materials in the kettle, fully enhancing the production and preparation process of the excipients, and having strong functionality.
[0021] To ensure that the device has good use tightness, the cross-section of the sandwich tank 6 is designed in an L shape. Sealing strips 13 are provided on both the upper and lower sides outside the upper part of the sandwich tank 6. The specific description is as follows: An annular groove for placing the sandwich tank 6 is opened above the inner side of the tank body 2. After the placement is completed, the upper end surface of the sandwich tank 6 is flush with the upper end surface of the tank body 2. Placement grooves are opened on both the upper and lower sides outside the upper end of the sandwich tank 6 for placing the sealing strips 13. The two sealing strips 13 are arranged in a staggered manner to a certain extent. The lower sealing strip 13 facilitates the cooperation between the sandwich tank 6 and the tank body 2, and the upper sealing strip 13 facilitates the cooperation between the tank cover 1 and the sandwich tank 6. This design realizes the sealing connection treatment between the equipment components, ensures the tightness, and ensures the effective progress of the material mixing work to meet the use requirements.
[0022] To further improve the rationality of the device, the lower end surface of the mixing plate 34 is designed in a wavy shape. The irregular design of its lower end surface can increase the contact effect with the material to a certain extent when it rotates with the rotating shaft 3. At the same time, it can also conduct the material irregularly, fully improve the mixing effect, and enhance the working process to meet the use requirements.
[0023] The above are only the preferred embodiments of the present invention, and are not intended to limit the present invention in other forms. Any person skilled in the art may use the disclosed technical content to make changes or modifications into equivalent embodiments with equivalent changes and apply them to other fields. However, as long as it does not depart from the technical solution content of the present invention, any simple modification, equivalent change, and modification made to the above embodiments based on the technical essence of the present invention still fall within the protection scope of the technical solution of the present invention.
Claims
1. A pharmaceutical excipient preparation reactor, comprising a reactor body, wherein the reactor body comprises a tank cover and a tank body which are designed to be split from top to bottom, wherein a rotating shaft is arranged on the tank cover, a feed port is arranged on one side of the tank cover, and a discharge port is arranged below the tank body, wherein: A sandwich tank is arranged in the tank body, a spirally designed protrusion is arranged on the outer periphery of the sandwich tank, a spiral feed pipe is arranged in the protrusion, a through groove which penetrates the spiral feed pipe is opened in the sandwich tank, a heating jacket is arranged on the outer side of the sandwich tank, a spiral heating pipe is arranged in the heating jacket, a diagonally arranged pipe opening is arranged on the outer side of the tank body, and a connecting pipe with a closed-end design is arranged in the pipe opening.
2. A pharmaceutical excipient preparation reaction kettle according to claim 1, characterized in that: A small stirring blade is arranged on the outer periphery of the rotating shaft, a support rod is arranged on the rotating shaft on one side of the small stirring blade, large stirring blades are arranged at the corners of the support rods, and a mixing plate with a triangular design is arranged at the lower end of the rotating shaft.
3. A pharmaceutical excipient preparation reaction kettle according to claim 2, characterized in that: The cross section of the sandwich tank is designed to be L-shaped, and sealing strips are arranged on both upper and lower sides of the upper outer portion of the sandwich tank.
4. A pharmaceutical excipient preparation reaction kettle according to claim 3, characterized in that: The lower end surface of the mixing plate is designed to be wavy.