Manual adjustment luggage carrier applied to living cell imager

Abstract

The utility model discloses a manual adjustment carrier applied to a living cell imager. The manual adjustment carrier comprises a frame main body, an objective table arranged on the frame main body and a perforated plate outer frame arranged on the objective table, the frame body is provided with an X-axis adjusting assembly for driving the perforated plate outer frame to move in the X-axis direction and a Y-axis adjusting assembly for driving the perforated plate outer frame to move in the Y-axis direction. When the device is carried on a living cell imager, the perforated plate carried on the perforated plate outer frame can be accurately adjusted in the XY axial direction, and the observation efficiency can be improved; wherein the frame main body is of a U-shaped structure, the objective table is of a thin-plate-shaped structure, a highly-symmetrical and compact structure can be formed when the objective table is carried on the living cell imager, the whole set of the objective table is smaller and more attractive on the basis that the observation efficiency can be improved, and the working distance of the living cell imager in the Z-axis direction is not affected.

Description

Technical Field

[0001] The utility model belongs to the technical field of the stage for live cell imager, and particularly relates to a manually adjustable stage applied to a live cell imager. Background Art

[0002] In the field of life sciences, a live cell imager is a device placed in an incubator for long-term real-time dynamic monitoring of biological samples. Considering the characteristics of the live cell imager working in the incubator, the imager is small and compact and only has the ability of single-well imaging.

[0003] A live cell imager usually carries a well plate for placing samples for observation. The existing open-stage of the live cell imager itself does not have the function of accurately adjusting the position of the carried well plate in the X-axis direction and the Y-axis direction, and cannot fix the well plate either. When observing samples, the operator needs to manually move the well plate to align the sample. After taking out the well plate for liquid change operation during the observation process, it is difficult to put it back to the original position for observation again, and the operator needs to adjust the position of the well plate by experience, which is time-consuming and laborious. Therefore, there is an urgent need for a stage that can move the well plate and fix the well plate for in-situ observation to improve the observation efficiency.

[0004] The information disclosed in this background art section is only intended to enhance the overall understanding of the utility model and should not be regarded as an admission or any form of suggestion that this information constitutes prior art already known to those of ordinary skill in the art. Summary of the Utility Model

[0005] The purpose of the utility model is to provide a manually adjustable stage applied to a live cell imager, so as to overcome the above-mentioned defects in the prior art.

[0006] To achieve the above purpose, the utility model provides a manually adjustable stage applied to a live cell imager, which includes a frame body, a stage arranged on the frame body, and a multi-well plate outer frame arranged on the stage; an X-axis adjustment component for driving the multi-well plate outer frame to move along the X-axis direction and a Y-axis adjustment component for moving along the Y-axis direction are arranged on the frame body.

[0007] Further, as a preference, the frame body is of a U-shaped structure, the stage is of a thin plate-like structure, the stage is arranged on the frame body, and the stage is used for being assembled to a live cell imager.

[0008] Further, preferably, the X-axis adjustment assembly includes a cross beam, an X-axis guide rail disposed within the cross beam, a first slider and a second slider disposed within the frame body and at both ends of the cross beam. An X-axis slider connected to the outer frame of the perforated plate is provided on the X-axis guide rail. An X-axis adjustment handle is provided on the first slider or the second slider. An X-axis adjustment cable assembly is provided on the X-axis adjustment handle. The X-axis adjustment cable assembly connects the first slider, the X-axis slider and the second slider;

[0009] The Y-axis adjustment assembly includes a rotating rod disposed within the frame body parallel to the cross beam, a first Y-axis guide rail and a second Y-axis guide rail perpendicular to the cross beam. The first slider is disposed on the first Y-axis guide rail, and the second slider is disposed on the second Y-axis guide rail. Two sets of Y-axis adjustment cable assemblies are provided on the rotating rod. The two sets of Y-axis adjustment cable assemblies are respectively connected to the first slider and the second slider.

[0010] Further, preferably, the X-axis adjustment cable assembly includes an X-axis adjustment cable and X-axis traction pulleys disposed on the first slider and the second slider. The X-axis adjustment cable connects the X-axis traction pulleys, the X-axis slider and the X-axis adjustment handle;

[0011] The Y-axis adjustment cable assembly includes a Y-axis adjustment cable and a Y-axis traction pulley. The Y-axis traction pulley is disposed within the frame body. The Y-axis adjustment cable connects the Y-axis traction pulley, the rotating rod, the first slider or the second slider.

[0012] Further, preferably, the frame body is provided with a set of limit grooves, and the first slider and the second slider slide within the limit groove area respectively.

[0013] Further, preferably, an X-axis damping block is further provided on the X-axis slider; a Y-axis damping block is provided on the rotating rod, and the Y-axis damping block is fixed within the frame body.

[0014] Further, preferably, an L-shaped connecting block is further provided on the X-axis slider. The L-shaped connecting block connects the outer frame of the perforated plate. The X-axis adjustment cable connects the X-axis traction pulley, the L-shaped connecting block and the X-axis adjustment handle.

[0015] Further, preferably, a cable groove is provided on the rotating rod. The Y-axis adjustment cable is located within the cable groove. The rotating rod extends outside the frame body to serve as a Y-axis adjustment handle.

[0016] Further, preferably, a perforated plate fixing member is further provided on the outer frame of the perforated plate. A spring steel wire for fixing the perforated plate is provided on the perforated plate fixing member.

[0017] Further, preferably, the stage is provided with holes for cooperating with a live cell imager.

[0018] Compared with the prior art, the utility model has the following beneficial effects:

[0019] The utility model is provided with a porous plate outer frame on the stage, and at the same time, an X-axis adjustment component and a Y-axis adjustment component are provided on the frame body. When the utility model is mounted on a live cell imager, precise adjustment of the XY axes of the porous plate outer frame can be realized, so that precise adjustment of the porous plate mounted on the porous plate outer frame in the XY axes can be realized, and the observation efficiency can be improved;

[0020] The frame body of the utility model is of a U-shaped structure, and the stage is of a thin plate structure. When mounted on a live cell imager, a highly symmetrical and compact structure can be formed, and the whole set is more compact and beautiful on the basis of improving the observation efficiency;

[0021] The X-axis adjustment of the utility model is realized through an X-axis guide rail, an X-axis slider, an X-axis adjustment pull rope and an X-axis adjustment handle. Each component is concentrated in the cross beam, which is convenient to operate and does not affect the working distance of the Z-axis of the live cell imager; the Y-axis adjustment is realized through two groups of Y-axis guide rails, two sliders, a rotating rod and a Y-axis adjustment pull rope. Each component is concentrated in the frame body. The same adjustment is convenient to operate and does not affect the working distance of the Z-axis of the live cell imager;

[0022] The utility model is provided with a group of limit grooves on the frame body, which can play a certain limiting role in the moving range of the Y-axis and improve the stability of the carrier;

[0023] The utility model is also provided with an X-axis damping block and a Y-axis damping block, which can improve the accuracy during movement and can realize self-locking after stopping movement, avoiding the problem of movement during the process of observing samples, thus affecting the observation;

[0024] The utility model is also provided with a porous plate fixing part and a spring steel wire, which can play a fixing role on the porous plate for placing samples and ensure the stability of the porous plate when observing samples;

[0025] The overall structure of the utility model and the design of the XY-axis adjustment component are both relatively ingenious, beautiful and compact. The precise positioning of the XY axes can be realized manually, and the stage will not move during the positioning process, without affecting the stability of the overall equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 is a schematic diagram of the live cell imager in the utility model;

[0027] Figure 2 is a schematic diagram of the manual adjustment carrier mounted on the live cell imager in the utility model;

[0028] Figure 3 Schematic diagram of a manually adjustable specimen stage applied to a live cell imager according to the present utility model;

[0029] Figure 4 Schematic diagram of another angle of a manually adjustable specimen stage applied to a live cell imager according to the present utility model;

[0030] Figure 5 、 Figure 6 Schematic diagram of the interior of a manually adjustable specimen stage applied to a live cell imager according to the present utility model;

[0031] Figure 7 Enlarged schematic diagram of the X-axis adjustment handle of the present utility model;

[0032] Figure 8 Enlarged schematic diagram of the X-axis damping block of the present utility model;

[0033] Figure 9 Enlarged schematic diagram of the Y-axis damping block of the present utility model;

[0034] Reference numerals: 100 - live cell imager, 1 - frame body, 101 - limiting groove, 2 - specimen stage, 201 - hole position, 3 - outer frame of multi-well plate, 301 - multi-well plate fixing member, 302 - spring wire, 4 - X-axis adjustment assembly, 401 - cross beam, 402 - X-axis guide rail, 403 - first slider, 404 - second slider, 405 - X-axis slider, 406 - X-axis adjustment handle, 407 - X-axis adjustment cable assembly, 4071 - X-axis adjustment cable, 4072 - X-axis traction pulley, 408 - X-axis damping block, 409 - L-shaped connecting block, 5 - Y-axis adjustment assembly, 501 - rotating rod, 5011 - cable groove, 5012 - Y-axis adjustment handle, 502 - first Y-axis guide rail, 503 - second Y-axis guide rail, 504 - Y-axis adjustment cable assembly, 5041 - Y-axis adjustment cable, 5042 - Y-axis traction pulley, 505 - Y-axis damping block. Detailed Description of the Invention

[0035] The following provides a detailed description of the specific embodiments of the present utility model, but it should be understood that the protection scope of the present utility model is not limited by the specific embodiments.

[0036] The following gives a brief overview of one or more aspects to provide a basic understanding of these aspects. This overview is not an exhaustive survey of all contemplated aspects, and is neither intended to identify key or decisive elements of all aspects nor to define the scope of any or all aspects. Its sole purpose is to present some concepts of one or more aspects in a simplified form as a prelude to the more detailed description to follow.

[0037] AsFigures 1-9 As shown in Figures 1-9 , a manual adjustment stage for a live cell imager includes a frame body 1, a stage 2 disposed on the frame body 1, and a multi-well plate outer frame 3 disposed on the stage 2; an X-axis adjustment assembly 4 for driving the multi-well plate outer frame 3 to move along the X-axis and a Y-axis adjustment assembly 5 for moving along the Y-axis are provided on the frame body 1.

[0038] In this embodiment, as a specific solution, the frame body 1 is of a U-shaped structure, the stage 2 is of a thin plate structure, the stage 2 is disposed on the frame body 1, and the stage 2 is used for assembly onto the live cell imager 100.

[0039] During operation, the stage 2 is installed on the live cell imager 100. The U-shaped frame body 1 surrounds three sides of the live cell imager 100, which does not affect the working distance of the imager in the Z-axis direction. Overall, a highly symmetric and compact structure is formed. The sample to be observed is placed on the multi-well plate, and then the multi-well plate is placed into the multi-well plate outer frame 3. The X-axis adjustment assembly 4 and the Y-axis adjustment assembly 5 can accurately achieve the movement of the multi-well plate outer frame 3 in the X and Y axial directions, thereby realizing the precise alignment of the sample on the multi-well plate for observing the sample.

[0040] In this embodiment, as a specific solution, the X-axis adjustment assembly 4 includes a cross beam 401, an X-axis guide rail 402 disposed within the cross beam 401, a first slider 403 and a second slider 404 disposed within the frame body 1 and at both ends of the cross beam 401. An X-axis slider 405 connected to the multi-well plate outer frame 3 is provided on the X-axis guide rail 402. An X-axis adjustment handle 406 is provided on the first slider 403 or the second slider 404. An X-axis adjustment cable assembly 407 is provided on the X-axis adjustment handle 406. The X-axis adjustment cable assembly 407 connects the first slider 403, the X-axis slider 405, and the second slider 404.

[0041] The Y-axis adjustment assembly 5 includes a rotating rod 501 disposed within the frame body 1 and parallel to the cross beam 401, a first Y-axis guide rail 502 and a second Y-axis guide rail 503 perpendicular to the cross beam 401. The first slider 403 is disposed on the first Y-axis guide rail 502, and the second slider 404 is disposed on the second Y-axis guide rail 503. Two sets of Y-axis adjustment cable assemblies 504 are provided on the rotating rod 501, and the two sets of Y-axis adjustment cable assemblies 504 are respectively connected to the first slider 403 and the second slider 404.

[0042] In this embodiment, as a more specific solution, the X-axis adjusting cable assembly 407 includes an X-axis adjusting cable 4071 and X-axis traction pulleys 4072 provided on the first slider 403 and the second slider 404. The X-axis adjusting cable 4071 is connected to the X-axis traction pulleys 4072, the X-axis slider 405, and the X-axis adjusting handle 406;

[0043] The Y-axis adjusting cable assembly 504 includes a Y-axis adjusting cable 5041 and a Y-axis traction pulley 5042. The Y-axis traction pulley 5042 is provided inside the frame body 1. The Y-axis adjusting cable 5041 is connected to the Y-axis traction pulley 5042, the rotating rod 501, the first slider 403, or the second slider 404.

[0044] Principle of operation description:

[0045] When performing X-axis movement adjustment, the operator manually turns the X-axis adjusting handle 406. Under the action of the X-axis adjusting handle 406, the X-axis adjusting cable 4071 pulls the X-axis slider 405, causing the X-axis slider 405 to move along the X-axis on the X-axis guide rail 402. The X-axis slider 405 drives the porous plate outer frame 3 connected thereto to move along the X-axis;

[0046] When performing Y-axis movement adjustment, the operator manually turns the rotating rod 501. Under the action of the rotating rod 501, the Y-axis adjusting cable 5041 pulls the first slider 403 and the second slider 404, causing the first slider 403 to move along the Y-axis on the first Y-axis guide rail 502 and the second slider 404 to move along the Y-axis on the second Y-axis guide rail 503. The first slider 403 and the second slider 404 are connected to the cross beam 401. The X-axis slider 405 is provided inside the cross beam 401, and the porous plate outer frame 3 is connected to the X-axis slider 405. Therefore, when the first slider 403 and the second slider 404 move along the Y-axis, they drive the porous plate outer frame 3 to achieve Y-axis movement.

[0047] In this embodiment, as a specific solution, the X-axis traction pulleys 4072 and the Y-axis traction pulleys 5042 can be V-shaped pulleys, which are mainly used for pulling the cables.

[0048] In this embodiment, as a specific solution, the frame body 1 is provided with a set of limit grooves 101, and the first slider 403 and the second slider 404 slide within the area of the limit grooves 101 respectively. The setting of the limit grooves 101 plays a certain limiting role in the sliding distance of the first slider 403 and the second slider 404, and can ensure that the porous plate outer frame 3 is always within the area of the loading platform 2, avoiding moving outside the loading platform 2 and thus affecting the observation.

[0049] In this embodiment, as a specific solution, an X-axis damping block 408 is further provided on the X-axis slider 405; a Y-axis damping block 505 is provided on the rotating rod 501, and the Y-axis damping block 505 is fixed within the frame main body 1; the settings of the X-axis damping block 408 and the Y-axis damping block 505 can improve the accuracy during X-axis and Y-axis movement, and can achieve self-locking after stopping the movement, avoiding the problem of movement during the process of observing the sample and thus affecting the sample observation.

[0050] In this embodiment, as a specific solution, an L-shaped connecting block 409 is further provided on the X-axis slider 405. The L-shaped connecting block 409 is connected to the outer frame 3 of the porous plate. The X-axis adjusting pull rope 4071 is connected to the X-axis traction wheel 4072, the L-shaped connecting block 409, and the X-axis adjusting handle 406; by providing the L-shaped connecting block 409, it can be ensured that the outer frame 3 of the porous plate is located above the stage 2 in a flat state.

[0051] In this embodiment, as a specific solution, a pull rope groove 5011 is provided on the rotating rod 501. The Y-axis adjusting pull rope 5041 is located within the pull rope groove 5011. The rotating rod 501 extends outside the frame main body 1 to serve as the Y-axis adjusting handle 5012; by providing the pull rope groove 5011, it can be ensured that the position of the Y-axis adjusting pull rope 5041 on the rotating rod 501 does not shift, thereby ensuring the stability during Y-axis adjustment, and the Y-axis adjusting handle 5012 is more convenient for the operator to operate.

[0052] In this embodiment, as a specific solution, a porous plate fixing member 301 is further provided on the outer frame 3 of the porous plate. A spring steel wire 302 for fixing the porous plate is provided on the porous plate fixing member 301; the porous plate placed on the outer frame 3 of the porous plate can be fixed by the spring steel wire 302 to ensure that the sample on the porous plate is in a fixed state, facilitating observation; the spring steel wire 302 can be respectively provided in the X-axis and Y-axis directions, so that fixation can be performed from two directions.

[0053] In this embodiment, as a specific solution, the stage 2 is provided with a hole position 201 for cooperating with the live cell imager 100.

[0054] In this embodiment, as a specific solution, the outer frame 3 of the porous plate can be designed into different shapes such as a square frame, a circle, a T-shape, etc. according to the situation.

[0055] The utility model can be mounted on a live cell imager to achieve precise adjustment of a multi-well plate mounted on the outer frame of the multi-well plate in the XY axes, which can improve the observation efficiency. The frame body is of a U-shaped structure, and the stage is of a thin plate structure. When mounted on a live cell imager, it can form a highly symmetric and compact structure, making the whole set more compact and beautiful on the basis of improving the observation efficiency, without affecting the working distance of the live cell imager in the Z axis.

[0056] The overall structure of the utility model and the design of the XY axis adjustment component are both quite ingenious, beautiful and compact. The precise positioning in the XY axes can be achieved manually, and the stage will not move during the positioning process, without affecting the stability of the overall device, and the device cost is also relatively low.

[0057] The foregoing description of specific exemplary embodiments of the utility model is for purposes of illustration and exemplification. These descriptions are not intended to limit the utility model to the precise forms disclosed, and obviously, many modifications and variations are possible in light of the above teachings. The purpose of selecting and describing the exemplary embodiments is to explain the specific principles of the utility model and its practical applications, so that those skilled in the art can implement and utilize various different exemplary embodiments of the utility model, as well as various different selections and modifications. The scope of the utility model is intended to be defined by the claims and their equivalents.

Claims

1. A manually adjustable specimen carrier for use in a living cell imaging instrument, characterized in that: The invention comprises a frame body, a stage arranged on the frame body and a porous plate outer frame arranged on the stage; the frame body is provided with an X-axis adjustment component for driving the porous plate outer frame to move along the X-axis direction and a Y-axis adjustment component for moving along the Y-axis direction.

2. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 1, characterized in that: The frame body is a U-shaped structure, the stage is a thin plate structure, and the stage is used to be assembled on a living cell imaging instrument.

3. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 2, characterized in that: The X-axis adjustment assembly comprises a crossbeam, an X-axis guide rail arranged in the crossbeam, a first slider and a second slider arranged in the frame body and located at both ends of the crossbeam, the X-axis guide rail is provided with an X-axis slider connected to the outer frame of the perforated plate, the first slider or the second slider is provided with an X-axis adjustment handle, the X-axis adjustment handle is provided with an X-axis adjustment rope assembly, and the X-axis adjustment rope assembly connects the first slider, the X-axis slider and the second slider; The Y-axis adjustment assembly includes a rotating rod arranged in the frame body and parallel to the crossbeam, a first Y-axis guide rail and a second Y-axis guide rail perpendicular to the crossbeam, the first slider is arranged on the first Y-axis guide rail, the second slider is arranged on the second Y-axis guide rail, and two groups of Y-axis adjustment rope assemblies are arranged on the rotating rod, and the two groups of Y-axis adjustment rope assemblies are respectively connected to the first slider and the second slider.

4. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 3, characterized in that: The X-axis adjustment rope assembly includes an X-axis adjustment rope, an X-axis traction wheel arranged on the first slider and the second slider, and the X-axis adjustment rope connects the X-axis traction wheel, the X-axis slider and the X-axis adjustment handle; The Y-axial adjustment rope assembly includes a Y-axial adjustment rope and a Y-axial traction wheel, the Y-axial traction wheel is arranged in the frame body, and the Y-axial adjustment rope is connected to the Y-axial traction wheel, the rotating rod, the first slider or the second slider.

5. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 3, characterized in that: The frame body is provided with a group of limiting grooves, and the first sliding block and the second sliding block slide in the limiting groove areas respectively.

6. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 3, characterized in that: The X-axis sliding block is also provided with an X-axis damping block; the rotating rod is provided with a Y-axis damping block, and the Y-axis damping block is fixed in the frame body.

7. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 4, characterized in that: The X-axis sliding block is also provided with an L-shaped connecting block, the L-shaped connecting block is connected to the porous plate outer frame, and the X-axis adjusting rope is connected to the X-axis traction wheel, the L-shaped connecting block and the X-axis adjusting handle.

8. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 4, characterized in that: The rotary rod is provided with a rope groove, the Y-axis adjustment rope is located in the rope groove, and the rotary rod extends outside the frame body as a Y-axis adjustment handle.

9. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 1, characterized in that: A porous plate fixing piece is also provided on the porous plate outer frame, and a spring steel wire for fixing the porous plate is provided on the porous plate fixing piece.

10. The manually adjustable specimen carrier for use in a living cell imaging instrument according to claim 1, characterized in that: The object stage is provided with holes matched with a living cell imaging instrument.

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