Ultrafiltration concentration device for preparing recombinant collagen

Abstract

The utility model discloses an ultrafiltration and concentration device for preparing recombinant collagen, which belongs to the technical field of ultrafiltration and concentration of recombinant collagen, and adopts the technical scheme that the ultrafiltration and concentration device comprises a support frame, a raw material barrel and an ultrafiltration barrel are fixedly connected to two sides of the top of the support frame respectively, and a sealing cover is fixedly connected to the top of the ultrafiltration barrel; the top of the sealing cover fixedly communicates with a conveying pipe, and a cleaning mechanism and a sealing mechanism are arranged at the bottom of the sealing cover; the cleaning mechanism comprises two electric telescopic columns, two rotating sleeves, two rotating columns, a fixing plate and cleaning cotton, the bottoms of the electric telescopic columns penetrate through the sealing cover and extend to the bottom of the sealing cover, and the interiors of the rotating sleeves are rotationally connected with the surfaces of the electric telescopic columns. The filter element in the ultrafiltration barrel needs to be replaced and maintained, and impurity particles attached to the inner wall of the ultrafiltration barrel are not easy to clean after being washed by clear water, so that the later collagen filtering efficiency is influenced, and the like.

Description

Technical Field

[0001] The utility model relates to the technical field of recombinant collagen ultrafiltration concentration, and particularly relates to an ultrafiltration concentration device for preparing recombinant collagen. Background Art

[0002] The ultrafiltration concentration device for preparing recombinant collagen is a key device specifically used in the production process of recombinant collagen.

[0003] In the current processing and production of collagen, some impurities may be mixed inside, and finally it is necessary to filter and purify them; currently, collagen is generally separated and purified by dialysis to achieve the purpose of retaining the target protein and removing impurities; however, the dialysis purification cycle is long and the purification speed is slow, resulting in low purification efficiency of collagen.

[0004] The patent with the Chinese publication number CN219186007U discloses a collagen ultrafiltration purification device, including a purification component, and the purification component includes a bottom plate, a stock solution barrel, a filtration box, a liquid outlet pipe, a booster pump, a liquid extraction pipe, an ultrafiltration barrel, a connecting hose, an annular cover and an ultrafiltration membrane; the bottom of the stock solution barrel is welded to the upper surface of the left side of the bottom plate, and the lower surface of the filtration box is welded to the upper surface of the middle part of the bottom plate. In the utility model, the collagen in the stock solution barrel is pumped out by the booster pump. When the collagen passes through the filtration box, large particle impurities in the collagen can be filtered out by means of the filter plate; then the collagen enters the annular cover in the ultrafiltration barrel, and under the boosting and conveying action of the booster pump, pure collagen passes through the ultrafiltration membrane and enters the external ultrafiltration barrel through the through holes, while small particle impurities in the collagen cannot pass through the ultrafiltration membrane and are left inside the annular cover, realizing the rapid ultrafiltration purification of impurities and pure collagen in the collagen.

[0005] In view of the above problems, the existing patent gives a solution, but there are certain defects in the actual use of the above solution. When filtering through the ultrafiltration barrel for a long time, it is necessary to replace and maintain the filter element inside the ultrafiltration barrel, and it is not easy to clean the impurity particles attached to the inner wall of the ultrafiltration barrel by flushing with clean water, thus affecting the filtration efficiency of collagen in the later stage.

[0006] Therefore, an ultrafiltration concentration device for preparing recombinant collagen is proposed. Content of the Utility Model

[0007] The purpose of the utility model is to provide an ultrafiltration concentration device for preparing recombinant collagen, which can solve the problem that when filtering through the ultrafiltration barrel for a long time, it is necessary to replace and maintain the filter element inside the ultrafiltration barrel, and it is not easy to clean the impurity particles attached to the inner wall of the ultrafiltration barrel by flushing with clean water, thus affecting the filtration efficiency of collagen in the later stage.

[0008] To achieve the above object, the present utility model provides the following technical solutions: An ultrafiltration concentration device for preparing recombinant collagen, comprising a support frame, on both sides of the top of the support frame are respectively fixedly connected with a raw material barrel and an ultrafiltration barrel, the top of the ultrafiltration barrel is fixedly connected with a cover, the top of the cover is fixedly communicated with a delivery pipe, and a cleaning mechanism and a sealing mechanism are arranged at the bottom of the cover;

[0009] The cleaning mechanism includes two electric telescopic columns, two rotating sleeves, two rotating columns, a fixing plate and a cleaning cotton. The bottom of the electric telescopic column passes through the cover and extends to the bottom of the cover. The inside of the rotating sleeve is rotatably connected to the surface of the electric telescopic column. The surface of the rotating column is fixedly connected to the inside of the rotating sleeve. The bottom of the rotating column extends into the inside of the fixing plate and is threadedly connected to the inside of the fixing plate. The surface of the fixing plate is fixedly connected to the inside of the cleaning cotton.

[0010] Preferably, a sequencing sleeve is arranged at the top of the fixing plate, the bottom of the sequencing sleeve is fixedly connected with a fixing sleeve, and the bottom of the fixing sleeve extends into the inside of the fixing plate and is threadedly connected to the inside of the fixing plate.

[0011] Preferably, the top of the sequencing sleeve is fixedly connected with a connecting sleeve, and the inside of the connecting sleeve is slidably connected to the surface of the delivery pipe.

[0012] Preferably, the bottom of the fixing sleeve is fixedly connected with a sealing sleeve, and the inside of the sealing sleeve is in close contact with the surface of the delivery pipe.

[0013] Preferably, a sealing gasket is fixedly connected to the surface of the electric telescopic column, and the surface of the sealing gasket is fixedly connected to the inside of the cover.

[0014] Preferably, a limiting groove is formed on the surface of the rotating column, and a snap spring is closely connected to the inside of the limiting groove.

[0015] Preferably, the top of the delivery pipe is fixedly communicated with the bottom of the raw material barrel, and a discharge pipe is fixedly communicated with the front side of the ultrafiltration barrel.

[0016] Preferably, the top of the delivery pipe is fixedly communicated with the bottom of the raw material barrel, and a discharge pipe is fixedly communicated with the front side of the ultrafiltration barrel.

[0017] Compared with the prior art, the beneficial effects of the present utility model are:

[0018] 1. In this application, the electric telescopic column drives the rotating sleeve to move inside the cover, so that the rotating sleeve drives the fixing plate to move inside the ultrafiltration barrel through the rotating column, which can conveniently make the fixing plate drive the cleaning cotton to clean the impurity particles attached to the inner wall of the ultrafiltration barrel, so as to facilitate the discharge through the bottom of the ultrafiltration barrel;

[0019] 2. This application drives the fixed sleeve to move by the fixed plate, so that the fixed sleeve drives the connecting sleeve to move on the surface of the conveying pipe through the sequencing sleeve, and the connecting sleeve limits the movement of the fixed plate through the fixed sleeve, so as to facilitate the close contact between the inside of the sealing sleeve and the surface of the conveying pipe, and thus facilitate the sealing of the top of the fixed plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is the overall structure diagram of the ultrafiltration concentration device for the preparation of recombinant collagen of the present utility model;

[0021] Figure 2 is the three-dimensional connection schematic diagram of the cleaning mechanism in the present utility model;

[0022] Figure 3 is the three-dimensional connection schematic diagram of the limiting groove and the snap ring in the present utility model;

[0023] Figure 4 is the three-dimensional connection schematic diagram of the sealing mechanism in the present utility model;

[0024] Figure 5 is the three-dimensional structure schematic diagram of the bottom of the cover in the present utility model.

[0025] In the figure, 1, support frame; 2, base; 3, discharge pipe; 4, ultrafiltration barrel; 5, cleaning mechanism; 501, electric telescopic column; 502, rotating sleeve; 503, rotating column; 504, fixed plate; 505, cleaning cotton; 6, conveying pipe; 7, sealing mechanism; 701, connecting sleeve; 702, sequencing sleeve; 703, fixed sleeve; 704, sealing sleeve; 8, limiting groove; 9, snap ring; 10, sealing gasket; 11, cover; 12, raw material barrel. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0026] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0027] Please refer to Figures 1-5 , the present utility model provides a technical solution:

[0028] An ultrafiltration concentration device for the preparation of recombinant collagen, including a support frame 1, a raw material barrel 12 and an ultrafiltration barrel 4 are respectively fixedly connected to both sides of the top of the support frame 1, a cover 11 is fixedly connected to the top of the ultrafiltration barrel 4, a conveying pipe 6 is fixedly communicated with the top of the cover 11, and a cleaning mechanism 5 and a sealing mechanism 7 are arranged at the bottom of the cover 11;

[0029] The cleaning mechanism 5 includes two electric telescopic columns 501, two rotating sleeves 502, two rotating columns 503, a fixing plate 504 and a cleaning cotton 505. The bottom of the electric telescopic column 501 passes through the cover 11 and extends to the bottom of the cover 11. The inside of the rotating sleeve 502 is rotatably connected to the surface of the electric telescopic column 501. The surface of the rotating column 503 is fixedly connected to the inside of the rotating sleeve 502. The bottom of the rotating column 503 extends into the inside of the fixing plate 504 and is threadedly connected to the inside of the fixing plate 504. The surface of the fixing plate 504 is fixedly connected to the inside of the cleaning cotton 505.

[0030] In this embodiment: By threadedly connecting the top of the base 2 to the surface of the ultrafiltration barrel 4, it is convenient to rotate the base 2, so that it is convenient to use the mobile base 2 to replace the filter element inside the ultrafiltration barrel 4. Thus, it is convenient for the electric telescopic column 501 to drive the rotating sleeve 502 to move inside the cover 11, so that the rotating sleeve 502 can drive the fixing plate 504 to move inside the ultrafiltration barrel 4 through the rotating column 503. Since the surface of the fixing plate 504 is fixedly connected to the inside of the cleaning cotton 505, it is convenient for the fixing plate 504 to drive the cleaning cotton 505 to clean the impurity particles attached to the inner wall of the ultrafiltration barrel 4, which is convenient to be discharged through the bottom of the ultrafiltration barrel 4.

[0031] Specifically, as Figure 2 、 Figure 4 shown, a sequencing sleeve 702 is provided at the top of the fixing plate 504. The bottom of the sequencing sleeve 702 is fixedly connected to a fixing sleeve 703. The bottom of the fixing sleeve 703 extends into the inside of the fixing plate 504 and is threadedly connected to the inside of the fixing plate 504.

[0032] Specifically, as Figure 4 shown, a connecting sleeve 701 is fixedly connected to the top of the sequencing sleeve 702. The inside of the connecting sleeve 701 is slidably connected to the surface of the conveying pipe 6.

[0033] Specifically, as Figure 2 、 Figure 4 shown, a sealing sleeve 704 is fixedly connected to the bottom of the fixing sleeve 703. The inside of the sealing sleeve 704 is in close contact with the surface of the conveying pipe 6.

[0034] In this embodiment: By the threaded connection between the surface of the fixing sleeve 703 and the fixing plate 504, it is convenient to make the inside of the sealing sleeve 704 in close contact with the surface of the conveying pipe 6, achieving the effect of sealing and protecting the inside of the fixing plate 504.

[0035] Specifically, as Figure 1 、 Figure 2 、 Figure 3 shown, a sealing gasket 10 is fixedly connected to the surface of the electric telescopic column 501. The surface of the sealing gasket 10 is fixedly connected to the inside of the cover 11.

[0036] Specifically, as Figure 3 shown, a limiting groove 8 is formed on the surface of the rotating column 503, and a snap spring 9 is closely connected inside the limiting groove 8.

[0037] In this embodiment: by making the inside of the snap spring 9 closely contact with the inside of the limiting groove 8, the snap spring 9 can limit the rotating column 503 through the limiting groove 8, achieving the effect of limiting the rotating column 503.

[0038] Specifically, as Figure 1 shown, the top of the conveying pipe 6 is fixedly communicated with the bottom of the raw material barrel 12, and a discharge pipe 3 is fixedly communicated with the front side of the ultrafiltration barrel 4.

[0039] Specifically, as Figure 1 shown, a base 2 is arranged at the bottom of the ultrafiltration barrel 4, and the top of the base 2 extends to the surface of the ultrafiltration barrel 4 and is threadedly connected with the surface of the ultrafiltration barrel 4.

[0040] In this embodiment: by making the top of the base 2 extend to the surface of the ultrafiltration barrel 4 and be threadedly connected with the surface of the ultrafiltration barrel 4, it is convenient to move and disassemble the base 2 on the surface of the ultrafiltration barrel 4, achieving the effect of facilitating the cleaning of the inside of the ultrafiltration barrel 4.

[0041] Working principle: When maintaining the inside of the ultrafiltration barrel 4, rotate the base 2 on the surface of the ultrafiltration barrel 4, and it is convenient to move the base 2, so as to facilitate the replacement of the filter element inside the ultrafiltration barrel 4 by moving the base 2. Make the electric telescopic column 501 drive the rotating sleeve 502 to move inside the cover 11, then the rotating sleeve 502 can drive the fixing plate 504 to move inside the ultrafiltration barrel 4 through the rotating column 503. Make the fixing plate 504 drive the fixing sleeve 703 to move, and the fixing sleeve 703 drives the connecting sleeve 701 to move on the surface of the conveying pipe 6 through the sequencing sleeve 702, so as to facilitate the limiting movement of the connecting sleeve 701 to the fixing plate 504 through the fixing sleeve 703, thus facilitating the close contact between the inside of the sealing sleeve 704 and the surface of the conveying pipe 6, and then facilitating the sealing of the top of the fixing plate 504, so as to facilitate the fixing plate 504 to drive the cleaning cotton 505 to clean the impurity particles attached to the inner wall of the ultrafiltration barrel 4, and then facilitate the discharge through the bottom of the ultrafiltration barrel 4, solving the problem that when the ultrafiltration barrel 4 is used for long-term filtration, it is necessary to replace and maintain the filter element inside the ultrafiltration barrel 4, and the impurity particles attached to the inner wall of the ultrafiltration barrel 4 are not easy to be cleaned by flushing with clean water, thus affecting the filtration efficiency of collagen in the later stage.

[0042] The above is only the preferred embodiment of the present invention, and it is not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An ultrafiltration concentration device for preparing recombinant collagen, comprising a support frame (1), wherein both sides of the top of the support frame (1) are respectively fixedly connected with a raw material barrel (12) and an ultrafiltration barrel (4), characterized in that: The top of the ultrafiltration barrel (4) is fixedly connected to a cover (11), the top of the cover (11) is fixedly connected to a delivery pipe (6), and the bottom of the cover (11) is provided with a cleaning mechanism (5) and a sealing mechanism (7); The cleaning mechanism (5) comprises two electric telescopic columns (501), two rotating sleeves (502), two rotating columns (503), a fixed plate (504) and cleaning cotton (505); the bottom of the electric telescopic column (501) passes through the cover (11) and extends to the bottom of the cover (11); the interior of the rotating sleeve (502) is rotatably connected to the surface of the electric telescopic column (501); the surface of the rotating column (503) is fixedly connected to the interior of the rotating sleeve (502); the bottom of the rotating column (503) extends to the interior of the fixed plate (504) and is threadedly connected to the interior of the fixed plate (504); the surface of the fixed plate (504) is fixedly connected to the interior of the cleaning cotton (505).

2. The ultrafiltration concentration device for preparing recombinant collagen according to claim 1, characterized in that: A positioning sleeve (702) is provided on the top of the fixing plate (504), and a fixing sleeve (703) is fixedly connected to the bottom of the positioning sleeve (702). The bottom of the fixing sleeve (703) extends to the inside of the fixing plate (504) and is connected to the internal thread of the fixing plate (504).

3. The ultrafiltration concentration device for preparing recombinant collagen according to claim 2, characterized in that: The top of the positioning sleeve (702) is fixedly connected to a connecting sleeve (701), and the interior of the connecting sleeve (701) is slidably connected to the surface of the conveying pipe (6).

4. The ultrafiltration concentration device for preparing recombinant collagen according to claim 2, characterized in that: The bottom of the fixed sleeve (703) is fixedly connected to a sealing sleeve (704), and the interior of the sealing sleeve (704) is in close contact with the surface of the conveying pipe (6).

5. The ultrafiltration concentration device for preparing recombinant collagen according to claim 1, characterized in that: A sealing gasket (10) is fixedly connected to the surface of the electric telescopic column (501), and the surface of the sealing gasket (10) is fixedly connected to the inside of the sealing cover (11).

6. The ultrafiltration concentration device for preparing recombinant collagen according to claim 1, characterized in that: A limiting groove (8) is provided on the surface of the rotating column (503), and a retaining spring (9) is tightly connected inside the limiting groove (8).

7. The ultrafiltration concentration device for preparing recombinant collagen according to claim 1, characterized in that: The top of the delivery pipe (6) is fixedly connected to the bottom of the raw material barrel (12), and the front side of the ultrafiltration barrel (4) is fixedly connected to a discharge pipe (3).

8. The ultrafiltration concentration device for preparing recombinant collagen according to claim 1, characterized in that: A base (2) is provided at the bottom of the ultrafiltration barrel (4), and the top of the base (2) extends to the surface of the ultrafiltration barrel (4) and is threadedly connected to the surface of the ultrafiltration barrel (4).

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